Abstract：
:A group of 54 patients with the original diagnosis of polycythemia vera were subjected to cytogenetic examination. Six (17.6%) of the 34 cases examined in the period of the advanced phase of the polycythemia vera had a chromosomal change. Thirteen (65%) of the 20 patients undergoing the cytogenetic examination in the period when the polycythemia vera turned into another myeloproliferative disease showed chromosomal aberration. This suggests a relationship between the number of chromosomal changes and the transformation of the disease. No connection between the cytogenetic changes and myelosuppressive cures could be confirmed in our material. The chromosomal change 20q- considered to be the most frequent kind in the polycythemia vera was not discovered until in patients with the polycythemia vera transformed into a different myeloproliferative disease.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Jarosová M,Indrák K,Dusek J,Kapustová Msubject
Has Abstractpub_date
1988-01-01 00:00:00pages
221-8issue
2eissn
0028-2685issn
1338-4317journal_volume
35pub_type
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