Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian cancer cells.

abstract：:The purpose of the present paper was to demonstrate the antitumor activity of lymphocytes and antibodies in the antibody-dependent cell-mediated cytotoxicity test (ADCC) in relation to the tumor growth in adult and aging rats bearing a methylcholanthrene-induced sarcoma (MC-Sa). In the syngeneic system using the ADCC ...

journal_title：Neoplasma

authors： Nowak JJ,Ziółkowska M,Ryzewska A

更新日期：1987-01-01 00:00:00

abstract：:Metadherin (MTDH) is an oncoprotein and is expressed at high levels in a wide variety of human carcinomas, which represents an important genetic determinant and regulates multiple events in tumorigenesis. MTDH promotes breast cancer cell proliferation and tumorigenesis through the activation of numerous signaling path...

journal_title：Neoplasma

authors： Chen X,Li XY,Long M,Wang X,Gao ZW,Cui Y,Ren J,Zhang Z,Liu C,Dong K,Zhang H

更新日期：2018-01-01 00:00:00

abstract：:Institutional training of prescreening cytotechnicians started in 1972 in the Research Institute of Oncopathology, Budapest. Up to 1983 ten classes, i.e. 230 students have been trained. Authors acknowledge the good achievements of their students and state that the diagnostic reliability of the qualified cytotechnician...

journal_title：Neoplasma

authors： Arva P,Bodó M,Sugár J

更新日期：1984-01-01 00:00:00

abstract：:Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease mimicking carcinoma and puerperal or non-puerperal mastitis. The primary purpose of this prospectively performed case control study was to compare clinical and imaging signs of IGM with the reference group of nonspecific, non- puerperal mast...

journal_title：Neoplasma

authors： Vanovcanova L,Lehotska V,Machalekova K,Waczulikova I,Minarikova E,Rauova K,Kajo K

更新日期：2019-07-23 00:00:00

abstract：:Pyruvate dehydrogenase kinase 1 (PDHK1) and carbonic anhydrase IX (CAIX) are some of the most hypoxia-inducible proteins associated with tumors, implicated in glucose metabolism and pH regulation, respectively. They both appear to be necessary for model tumor growth, and their high level of expression in human tumors ...

journal_title：Neoplasma

authors： Kery M,Oravcova N,Radenkovic S,Iuliano F,Tomaskova J,Golias T

更新日期：2018-12-10 00:00:00

abstract：:Multiple myeloma (MM) is a hematological malignancy caused by clonal proliferation of malignant plasma cells (PC). The aim of the work is to determine prognostic significance of morphological subtypes of PC in relation to overall treatment response, long-term survival and other conventional prognostic parameters. One ...

journal_title：Neoplasma

authors： Al-Sahmani M,Trnavska I,Sevcikova S,Antosova M,Antosova L,Kissova J,Adam Z,Pour L,Nemec P,Greslikova H,Krejci M,Zahradova L,Bulikova A,Penka M,Hajek R

更新日期：2011-01-01 00:00:00

abstract：:MHC class I chain-related molecule A (MICA) is one of the major ligands for activating immune-receptor NKG2D which is expressed on NK cells and cytotoxic T lymphocytes. The release and sustained expression of MICA protein can impair NKG2D-mediated cytotoxic activity by reducing NKG2D receptor on immune effector cells....

journal_title：Neoplasma

authors： Lu SM,Xiao P,Xue L,Che LH,Yang P,Li Y,Qiao H

更新日期：2008-01-01 00:00:00

abstract：:Six established human sarcoma cell lines (giant cell tumor of bone B-5GT, fibrosarcoma, B-6FS, cystosarcoma phylloides B-19CS, synovial sarcoma U-4SS and two osteogenic sarcomas U-20S and U-393OS) have been studied and compared to the normal B-41FB fibroblastic cells and the HeLa cells. For cytogenetic and isoenzyme c...

journal_title：Neoplasma

authors： Phan Thu A,Zajac V,Kuliffay P,Popović M

更新日期：1980-01-01 00:00:00

abstract：:The phorbolester (TPA)-induced homotypic aggregation of human monoblastoid U-937 cells was completely abolished by staurosporine, but not by a new selective protein kinase C inhibitor, benzoylated staurosporine derivative CGP 41,251, a compound with known anti-tumor and drug resistance modulating activity. Staurospori...

journal_title：Neoplasma

authors： Sedlák J,Sulíková M,Hunáková L,Chorváth B

更新日期：1995-01-01 00:00:00

abstract：:Serum concentration of alpha1-proteinase inhibitor (alpha1-PI) was determined by nephelometric method in forty seven patients with liver cirrhosis (LC) and fifteen patients with hepatocellular carcinoma (HCC). Our data show an increase in the concentration of alpha1-PI in the group with decompensated LC by 17% and in ...

journal_title：Neoplasma

authors： Dabrowska M,Mantur M,Panasiuk A,Prokopowicz J

更新日期：1997-01-01 00:00:00

abstract：:Loss of heterozygosity (LOH) has been shown to be an important prognostic factor in a variety of malignant neoplasm's. Cervical cancer develops as result of multiple genetic alterations. The aim of this study was to analyze presence of LOH in cervical cancer and to identify the correlation between LOH and survival and...

journal_title：Neoplasma

authors： Kozlowski L,Filipowski T,Rucinska M,Pepinski W,Janica J,Skawronska M,Poznanski J,Wojtukiewicz MZ

更新日期：2006-01-01 00:00:00

abstract：:A modification of the "skin window" method is proposed for investigation of delayed hypersensitivity in patients with tumors. The principle of the modified method consists in an antigen injection into the site of lesion. Patients with tumors showed a strikingly lowered lymphoid cells and eosinophilic and basophilic gr...

journal_title：Neoplasma

authors： Jansa P,Jorda V,Sternberský J

更新日期：1976-01-01 00:00:00

abstract：:A 65-kDa tumor-associated protein (P65) is a potential non- specific tumor marker expressed by many types of tumor cells. Our recent studies indicate that P65 gene expression is connected with poor prognosis for the patients with colorectal cancer. In the present study P65 gene expression was determined by means of RT...

journal_title：Neoplasma

authors： Balcerczak E,Jankowski T,Becht A,Balcerczak M,Janiuk R,Jesionek-Kupnicka D,Sztompka J,Mirowski M

更新日期：2005-01-01 00:00:00

abstract：:The influence of 13-cis-retinoic acid on the light-caused injury of hematoporphyrin-pretreated nontransformed 10 T1/2 fibroblasts and N2a neuroblastoma cells was investigated. Retinoid reduced the percentage of damaged cells as assessed by the plating efficiency assay. N2a neuroblastoma cells were found to be better p...

journal_title：Neoplasma

authors： Szaniawska B,Janik P,Ostrowski J,Graczyk A

更新日期：1988-01-01 00:00:00

abstract：:Authors evaluated the prevalence of symptoms of the metabolic syndrome and insulin resistance in 25 patients with adrenal incidentalomas (10 men, 15 women) of the mean age 57.9+/-15 years. 15 patients had adrenal adenoma determined by CT or MR scan and 10 had unilateral or bilateral hyperplasia. The prevalence of obes...

journal_title：Neoplasma

authors： Lazúrová I,Dudásová D,Wagnerová H,Dravecká I,Petrásová D

更新日期：2006-01-01 00:00:00

abstract：:Liver cancer is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Adriamycin (ADR) resistance, which often leads to the progression of malignant tumors, is a major treatment obstacle for liver cancer. It has been confirmed that miR-155-5p could reverse drug resistance in h...

journal_title：Neoplasma

authors： Yu Q,Xu XP,Yin XM,Peng XQ

更新日期：2021-01-01 00:00:00

abstract：:Sera from 51 melanoma patients and from 55 healthy donors were examined for the presence of immune complexes (ICs) by the EA-rosette forming cell inhibition assay. Using a cut-off point of 5% rosette inhibition, ICs were found in 144 out of 213 sera from patients with melanoma (67.6%) and in 11 out of 55 control subje...

journal_title：Neoplasma

authors： Sztaba-Kania M,Jassem J,Piskorzyńska M,Kondrat W

更新日期：1981-01-01 00:00:00

abstract：:The expression of cytokeratins 7, 8, 14, 18, 19 and vimentin was examined in 100 cases of ductal invasive breast carcinomas. While the predominantly diffuse immunohistological positivity of simple epithelia cytokeratins 7 (in 93), 8 (in 100), 18 (in 100) and 19 (in 97) cases represents a constant feature of these tumo...

journal_title：Neoplasma

authors： Rejthar A,Nenutil R

更新日期：1997-01-01 00:00:00

abstract：:Cancer cells share numerous characteristics with pluripotent stem cells which develop normally, contributing to the tumor cell plasticity. So we investigated the effect of human embryonic germ cells (hEGCs) on SKOV3 cells. We examined the efficacy of hEGCs through coculturing SKOV3 with hEGCs, detecting tunel apoptosi...

journal_title：Neoplasma

authors： Song X,Kong B,Li D,Yang Q

更新日期：2009-01-01 00:00:00

abstract：:Acyclic nucleotide analogs (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) were phosphorylated in the presence of ribonucleoside 5'-triphosphates by the crude extract from mouse leukemia cells L1210 affording the respective mono- and diphosphoryl derivatives. T...

journal_title：Neoplasma

authors： Merta A,Veselý J,Votruba I,Rosenberg I,Holý A

更新日期：1990-01-01 00:00:00

abstract：:Polymorphisms in tobacco carcinogen metabolizing enzymes may generate interindividual variations towards the risk of developing prostate cancer. One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. The activity of...

journal_title：Neoplasma

authors： Sivonova MK,Dobrota D,Matakova T,Dusenka R,Grobarcikova S,Habala V,Salagovic J,Tajtakova M,Pidanicova A,Valansky L,Lachvacs L,Kliment J Jr,Nagy V,Kliment J

更新日期：2012-01-01 00:00:00

abstract：:Human immediate early response 2 (IER2) has been implicated in tumor cell motility and metastasis; however, the underlying mechanisms in hepatocellular carcinoma (HCC) metastasis remain to be clarified. In this study, we demonstrate that dysregulation of IER2 was shown in HCC clinical samples, and IER2 expression resu...

journal_title：Neoplasma

authors： Xu X,Zhou W,Chen Y,Wu K,Wang H,Zhang J,Zhou Y,Zeng J,Yang J,Deng Z,Zhang Y,Shen W

更新日期：2020-05-01 00:00:00

abstract：:A coordination complex cis-dichlorodiamminedihydroxoplatinum (IV) (oxoplatinum) was first synthesized in the USSR by Chugaev and Khlopin in 1927 [3]. Its marked antitumor properties were revealed by one of the authors of this article at the All-Union Cancer Research Center of the Academy of Medical Sciences of the USS...

journal_title：Neoplasma

authors： Presnov MA,Konovalova AL,Kozlov AM,Brovtsyn VK,Romanova LF

更新日期：1985-01-01 00:00:00

abstract：:In the blood of 39 women with endometrial carcinoma the FSH, LH, estrone, androstendion, estradiol and dehydroepiandrosterone were determined by the RIA method. Compared to the control group the estrone (303.3 +/- 44.3 pmol/l), estradiol (165.2 +/- 29.4 pmol/l) and the androstendion (5.24 +/- 0.44 nmol/l) were signifi...

journal_title：Neoplasma

authors： Gimes G,Szarvas Z,Siklósi G

更新日期：1986-01-01 00:00:00

abstract：UNLABELLED:Breast cancer is one of the most common cancer affecting women and the recent research is focused on identifying new genetic and epigenetic prognostic and predictive factors. Glutathione S-transferase P1 (GSTP1) is abiotransformation enzyme expressed in normal breast epithelial cells which can be epigenetica...

journal_title：Neoplasma

authors： Lasabova Z,Tilandyova P,Kajo K,Zubor P,Burjanivova T,Danko J,Plank L

更新日期：2010-01-01 00:00:00

abstract：:Age over 65 years is a risk factor per se for doxorubicin administration, and coexisting diseases pose additional problems. There is still controversy whether chemotherapy regimens for elderly patients with aggressive NHL should be full-dose doxorubicin containing or whether development of non-anthracycline containing...

journal_title：Neoplasma

authors： Jelić S,Milanović N,Tomasević Z,Matković S,Gavrilović D

更新日期：1999-01-01 00:00:00

abstract：:The effect of oxoplatinum on blastic transformation of human peripheral blood mononuclear cells (PBMC) was monitored following phytohemagglutinin (PHA) stimulation. The results were compared with those published in part III of the present work as well as with the effect of cisplatinum and carboplatinum on the blastic ...

journal_title：Neoplasma

authors： Kanková-Vancurová M,Procházková J

更新日期：1991-01-01 00:00:00

abstract：:Extranodal NK/T-cell lymphoma nasal type (ENKTL) is a subtype of T cell lymphoma with poor prognosis. In this study, we designed a new prognostic model specifically for ENKTL to improve the risk stratification. In 29 ENKTL patients, we screened mutations in 9 ENKTL-associated genes using next-generation sequencing (NG...

journal_title：Neoplasma

authors： Gao Y,Li Y,Ma G,Zhao G,Liu H

更新日期：2020-05-01 00:00:00

abstract：UNLABELLED:Survivin is highly expressed in human gastric cancer and correlated with chemoresistance and poor prognosis. In this study, we explored the effect of adeno-associated virus (AAV)-mediated survivin dominant mutant Thr34Ala (rAAV-Sur-Mut(T34A)) on gastric cancer growth. AAV-Sur-Mut (T34A) virus was generated a...

journal_title：Neoplasma

authors： Dang SC,Feng S,Wang PJ,Cui L,Qu JG,Zhang JX

更新日期：2015-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...

journal_title：Neoplasma

authors： Szatmáry Z

更新日期：1999-01-01 00:00:00