Abstract：
:Hypoxia is one of the basic characteristics of the colorectal cancer and HIF1 plays a central role in tumor hypoxia adaptation and controls the expression of a variety of genes. But it had not reached a comprehensive understanding of them in colorectal cancer in hypoxia. This study silenced HIF1-alpha, which is the regulatory subunit of HIF1, and established two dimensional gel electrophoresis profiles for human SW480siHIF1-alpha and SW480N cells to identified proteins with differential expressions. Ten down-regulated proteins and nine up-regulated proteins were identified by HPLC-Chip-MS/MS. Down-regulated proteins including PLD2, ANXA2. HIF1-alpha had a clear positive correlation with PLD2 and ANXA2 in colon adenocarcinoma samples. There proteins might have a direct or indirect contact HIF1-alpha, and play a critical role in apoptosis, signal transduction and hypoxia adaptation.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Wu XY,Fu ZX,Wang XH,Shen Wdoi
10.4149/neo_2010_04_299subject
Has Abstractpub_date
2010-01-01 00:00:00pages
299-305issue
4eissn
0028-2685issn
1338-4317journal_volume
57pub_type
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