Abstract：
:The effect of dibutyryl cyclic nucleotides, dbcAMP and dbcGMP, on the growth of BSC-1 cells has been studied in the presence and absence of kidney epithelial cell growth inhibitor. The growth response of the cells was dependent on concentrations of the dibutyryl cyclic nucleotides and on the presence or absence of serum in the medium. In the presence of serum, a high concentration (10(-3) M) of dbcGMP largely overcame the action of the kidney epithelial cell growth inhibitor. In the absence of serum, a high concentration (10(-3) M) of dbcAMP increased growth inhibition observed with the growth inhibitor. In the presence of serum, low concentrations of dbcAMP were growth stimulatory and partially overcame the action of the growth inhibitor.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Fremuth F,Holley RW,Baldwin JHsubject
Has Abstractpub_date
1982-01-01 00:00:00pages
295-300issue
3eissn
0028-2685issn
1338-4317journal_volume
29pub_type
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