Abstract:
:Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine mammary gland. However, it is not clear currently whether Notch signaling is frequently expressed and activated in breast cancers. Here we show that Notch signaling is overexpressed and highly activated in breast cancers. More significantly, the attenuation of Notch signaling by gamma-secretase inhibitor can inhibit the proliferation of breast cancer cells by both causing cell cycle arrest and apoptosis. Thus, targeting Notch signaling may be of therapeutic value in breast cancers.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Zang S,Ji Ch,Qu X,Dong X,Ma D,Ye J,Ma R,Dai J,Guo Dsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
304-10issue
4eissn
0028-2685issn
1338-4317journal_volume
54pub_type
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