Abstract:
:Bladder cancer (BCa) is a common carcinoma of the urinary tract which occurs in the bladder mucosa. In recent years, people have recognized that epigenetic changes such as DNA methylation play important roles in the development of BCa, but the specific mechanism is unclear. In this study we detected the methylation rates in SOCS1 gene of 490 subjects (including 247 patients with BCa, and 243 healthy controls) using the MassARRAY EpiTYPER system. Principal component analysis (PCA) was conducted with the aim of identifying common underlying patterns that could explain the largest part of common variance in methylation across units. Logistic regression model was used to assess the relation of SOCS1 methylation patterns with factors related to BCa risk. The methylation rates varied for different CpG units and were significantly difference in cases compared to controls. Six principal component factors were extracted by combining initial eigenvalue, explanatory power and Scree Plot. After adjusting for age, gender, family history of bladder cancer, smoking, and drinking, we observed that Factor 1 (OR=0.051, 95%CI: 0.015-0.178, p<0.001), Factor 2 (OR=0.146, 95%CI: 0.073-0.295, p<0.001), Factor 3 (OR=0.346, 95%CI: 0.198-0.606, p<0.001), and Factor 4 (OR=0.270, 95%CI: 0.135-0.537, p<0.001) were associated with BCa. Based on follow-up results, we found that the 1-, 3-, 5-year survival rates in hypermethylated group were lower than then in hypomethylated group. We found that several CpG units in methylation patterns were associated with the incidence of BCa, revealed the important DNA methylation patterns for BCa pathogenesis. Our findings provided new insights into understanding this disease and new potential targets for therapeutic intervention for BCa patients in the future.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Guan H,Lu J,Qu M,Meng L,Guo Y,Li X,Shen Hdoi
10.4149/neo_2020_200928N1035subject
Has Abstractpub_date
2021-01-14 00:00:00eissn
0028-2685issn
1338-4317pii
200928N1035pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract::In contradistinction to the increased fraction of HeLa S 3 cells in S phase after irradiation by a single dose in a range of 25--200 R, cultures irradiated by a second dose at time of morphologic restitution of mitotic activity exhibited decreased fraction of cells in S phase. The interpretation is that passage from G...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Combination of corticosteroids with new purine analogs such as cladribine 2-chlorodeoxyadenosine, (2-CdA) and fludarabine (FAMP) is controversial. The possibility of potentiation of antineoplastic activity of 2-CdA or FAMP by corticosteroids has not been documented so far. On the other hand, such combination may incre...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Research indicates that after EGFR-tyrosine kinase inhibitors (EGFR-TKIs) treatment of non-small cell lung cancer (NSCLC), patient immune function significantly improved, and that circulating tumor cells (CTCs) measurements and peripheral blood epidermal growth factor receptor (EGFR) mutation data can guide TKIs treat...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2017_418
更新日期:2017-01-01 00:00:00
abstract::The antineoplastic effect of 5-(2-dimethyl-aminoethoxy)-7-oxo-7H-benzo(c) fluorene, substance VUFB 13 468, was studied in leukemia L1210 and leukemia La. It was found that the test substance, in the form of base and in the form of hydrochloride, influenced favorably the survival of leukemic mice, in which the life spa...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::A modification of the "skin window" method is proposed for investigation of delayed hypersensitivity in patients with tumors. The principle of the modified method consists in an antigen injection into the site of lesion. Patients with tumors showed a strikingly lowered lymphoid cells and eosinophilic and basophilic gr...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::In the presented study we analysed the effect of histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) on human plasma cell leukemia (PCL) cell line UHKT-944 in the presence of bone marrow microenvironment (BMM). For the analysis, the cells were cultured alone, with bone...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2017_209
更新日期:2017-01-01 00:00:00
abstract::A comparison of efficacies of medroxyprogesterone acetate (MPA) and the antiestrogen tamoxifen (TX) in the therapy for advanced breast cancer in patients who had already previously been intensely treated showed that, as to the objective remissions, the two drugs can be looked upon as equivalent. Nevertheless, with MPA...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Multiple myeloma (MM) is a hematological malignancy caused by clonal proliferation of malignant plasma cells (PC). The aim of the work is to determine prognostic significance of morphological subtypes of PC in relation to overall treatment response, long-term survival and other conventional prognostic parameters. One ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2011_06_554
更新日期:2011-01-01 00:00:00
abstract::The persistent hyperinsulinemic hypoglycemia may be caused either by a solitary tumor of the pancreas secreting excessive amount of insulin, known as insulinoma or, rarely, by nesidioblastosis. Nesidioblastosis is a rare cause of persistent hyperinsulinemic hypoglycemia in adults. The incidence of nesidioblastosis in ...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:10.4149/neo_2014_047
更新日期:2014-01-01 00:00:00
abstract::Vincristine sensitive (L1210) and resistant (L1210/VCR) L1210 mouse leukemia cells were studied from morphological and histochemical point of view. The morphological and histochemical findings reflected differences in membrane structure and in physiological state of sensitive and resistant cells. Numerous villous proj...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The aim of our study was to evaluate the efficacy of oral clodronate supplementing systemic therapy and/or palliative irradiation in 91 patients with painful bone metastases. Clodronate was administered at a daily dose of 1600-3200 mg for a median of 11 months (range 3--36 months). Partial or complete pain relief was ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Comparative studies on the presence and immunological reactivity of CEA and CEA-like antigens in lung and digestive tract cancers were performed. Specific goat and rabbit anti-CEA immune sera were used. Immunofluorescence studies revealed in histologically different types of the lung carcinomas the presence of the cro...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract:UNLABELLED:microRNA-24 has been reported to participate in tumorgenesis and progression by several signaling pathways in various tumors. However, its potential as a serum diagnostic factor and predictive biomarker for esophageal squamous cell carcinoma (ESCC) has not been studied. In the present study, serum samples we...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2015_030
更新日期:2015-01-01 00:00:00
abstract::The relationship of pretreatment immunologic status in terms of skin tests to prognosis within stages was studied in 152 breast cancer patients. DNCB and PPD testing was used. As for DNCB, no relationship was found at early stages of the disease. In locoregionally advanced disease, patients with stronger test grades h...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The distribution study of zinc phthalocyanine disulfonate (ZnPcS2) in nude mice bearing mammary carcinoma (T50/80) revealed a rapid uptake of the dye by tumor. In experimental photodynamic therapy (PDT), the tumors were exposed to laser radiation (670 nm, 100 mW/cm2, 150 J/ /cm2) after intravenous administration of Zn...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The direct effect of selected cytostatic drugs on natural killer (NK) cell activity was evaluated. Peripheral blood mononuclear cells from healthy donors were tested for their cytolytic activity in vitro in the presence of adriamycin, methotrexate, leucovorin, vincristin, cytosine arabinoside and teniposide. Most of t...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Knowledge of biological properties of natural compounds allows to understand their therapeutic value, efficacy and security. We investigated: composition of Lavandula angustifolia (LA) and Rosmarinus officinalis (RO) extracts, their antioxidant capacity, cytotoxicity and genotoxicity, their DNA-protective potential ag...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2017_607
更新日期:2017-01-01 00:00:00
abstract::Alteration of the p53 tumor suppressor gene is the most common genetic defect known to occur in human tumors. Germ-line p53 mutations significantly increase the risk of developing diverse malignancies. FASAY is a simple functional assay for germ-line and somatic mutations in the p53 gene altering the transactivation c...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::In a series of 25 patients with cervical carcinoma and 35 patients with vulvar carcinoma, clinically classified (FIGO) as Stage I and Ib, respectively, DNA ploidy and S-phase cell fraction were estimated in paraffin-embedded samples of the primary tumors and their metastases by means of flow cytometry (FCM). The two g...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The polarographic reduction of six synthetic 1,3,6-triazine (6-aza) nucleosides with 6-azauracil as the nucleoside base in the strictly anhydrous solutions was studied in the absence and presence of alpha-lipoic acid. The values of the half-wave potentials E1/2 and the parameter of potential carcinogenicity tg alpha w...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::DNA-mediated introduction of genes into mammalian cells promises to be a powerful method for detecting sequences that control cell growth, confer resistance to toxic drugs, code for surface receptor proteins, or, indeed alter cell phenotype in any clearly defined way. The identification and molecular cloning of human ...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::Genetic background of high incidence of spontaneous tumors in BDX rats was investigated with respect to susceptibility to physical or chemical agents and immune response. Percentages of colony forming ability of normal embryo fibroblasts from BDX rats after exposure to various doses of ultraviolet (UV) light, X-rays a...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:To explore the expression of the TRAV gene in peripheral blood mononuclear cells (PBMCs) and in tumor-infiltrating lymphocytes (TILs) in the patients with breast cancer using a DNA melting curve (FQ-PCR) technique for T cell receptor (TCR) alpha chain CDR3 spectratyping. Peripheral blood samples and tissue samp...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2012_088
更新日期:2012-01-01 00:00:00
abstract::Cysteine proteinases cathepsin (Cath) B and L and their endogenous inhibitors stefin (Stef) A and B concentrations were measured using a quantitative immunosorbent assay (ELISA; KRKA d.d., Novo mesto, Slovenia) in serum samples from 35 patients with primary and 7 patients with recurrent squamous cell carcinoma of the ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Presented study aimed to prepare A10 aptamer-modified poly (D,L-lactic-co-glycolic acid) (PLGA) nanoparticles loaded with triplex forming oligonucleotides(TFO) for targeted prostate cancer therapy. We first synthesized a PLGA-PEG-Apt copolymer. The PLGA-PEG-Apt nanoparticles (NP-Apt) were loaded with TFO using double ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2016_410
更新日期:2016-01-01 00:00:00
abstract::Presence of antibodies to the structural proteins of the feline leukemia virus and the feline oncornavirus-associated cell membrane antigen FOCMA was analyzed in sera of 120 cats from household environments. In our experiments 35% of the sera tested were positive with the viable cells of FL-74 feline lymphoma cell lin...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Circular RNAs (circRNAs) are a class of newly-identified non-coding RNA molecules. CircRNAs are conserved across different species and display specific organization, sequence, and expression in disease. Moreover, circRNAs' closed ring structure, insensitivity to RNase, and stability are advantages over linear RNAs in ...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:10.4149/neo_2017_301
更新日期:2017-01-01 00:00:00
abstract::To monitor the specific antitumor immunity to patients with malignant melanoma of the uveal tissue, use was made of the 20-hr modification of the leukocyte adherence inhibition (LAI) test. Simultaneously, changes in the proportionally of T (total and active) and B lymphocytes in peripheral blood were followed in the s...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Nodal metastasis is an important prognostic indicator in head and neck cancers, including salivary carcinomas. In these, the risk for lymph node metastasis is variable and strongly associated with the tumor histologic type. The aim of the current study was to evaluate the lymphatic vessel density (LVD) and expressions...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2011_04_331
更新日期:2011-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a particularly lethal form of cancer. Overall survival evenafter liver surgery is unsatisfactory due to high metastatic capacity and recurrence rates. Cancer stem cells (CSCs) were recently proposed to elucidate the molecular mechanism of HCC metastasis and recurrence. In our study, w...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2015_068
更新日期:2015-01-01 00:00:00