Abstract：
:Human leukocyte antigen - G (HLA-G) is a non-classical HLA class I antigen with restricted distribution in normal tissues. Ectopic HLA-G expression observed at some pathological circumstances as malignant transformation might be triggered by epigenetic modifications such as DNA demethylation. Recently it was demonstrated that DNA methyltransferase inhibitor 5-aza-2 - deoxycytidine (AdC) induces/enhances HLA-G transcription in many leukemia cell lines of different origin. Here we investigated the effect of AdC on HLA-G expression in malignant hematopoetic cells isolated from patients with acute myeloid leukemia (AML) and chronic lymphocytic leukemia (B-CLL). We detected HLA-G expression in untreated cells from some patients. Nevertheless treatment with 5-aza-2 - deoxycytidine enhanced HLA-G transcription and concomitantly HLA-G protein synthesis in some leukemia cells.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Polakova K,Bandzuchova E,Sabty FA,Mistrik M,Demitrovicova L,Russ Gdoi
10.4149/neo_2009_06_514subject
Has Abstractpub_date
2009-01-01 00:00:00pages
514-20issue
6eissn
0028-2685issn
1338-4317journal_volume
56pub_type
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