Abstract:
:Increased expression of STMN1 has been observed in many tumor forms, but its expression and potential biological role in pancreatic cancer is still unknown. In this study, we demonstrated that STMN1 was expressed to a large extent in pancreatic cancer tissues and cell lines as compared to normal pancreatic tissues. Suppression of STMN1 expression via transfection with STMN1-specific siRNA could not only significantly inhibit the proliferation, migration and invasion ability of Panc-1 cells, but also enhance the apoptosis of Panc-1 cells. In addition, downregulation of STMN1 obviously enhanced the acetylation level of α-tubulin. All these results indicated that STMN1 plays an important role in pancreatic cancer development, and might serve as a potential therapeutic target for pancreatic cancer.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Li J,Hu GH,Kong FJ,Wu KM,He B,Song K,Sun WJdoi
10.4149/neo_2014_020subject
Has Abstractpub_date
2014-01-01 00:00:00pages
144-52issue
2eissn
0028-2685issn
1338-4317journal_volume
61pub_type
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