Clonal evolution of karyotype in blastic phase of CML.

Abstract:

:A patient with chronic myelocytic leukemia (CML) had a Philadelphia chromosome--Ph1(t(9q +; 22q--)) in all evaluated bone marrow cells at the time of diagnosis. After 29 months of intermittent therapy (chemotherapy and immunotherapy) and 2 months before clinical signs of blastic phase developed, three additional cell lines in bone marrow and peripheral blood appeared: one line with extra chromosome Ph1, another one in which chromosome Y disappeared, and the third line with extra chromosome No. 13, evidently derived from the X-monosomie cell line. Five weeks before death a variable hypodiploidy was found in more than 50% mitoses. The patient died 47 months after the establishment of CML and seven months after the onset of the blastic phase.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Izakovic V,Horák I,Krizan P

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

613-23

issue

5

eissn

0028-2685

issn

1338-4317

journal_volume

29

pub_type

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