Optimization and it's influence on value of doses in HDR and PDR brachytherapy.

abstract：:A modification of the "skin window" method is proposed for investigation of delayed hypersensitivity in patients with tumors. The principle of the modified method consists in an antigen injection into the site of lesion. Patients with tumors showed a strikingly lowered lymphoid cells and eosinophilic and basophilic gr...

journal_title：Neoplasma

authors： Jansa P,Jorda V,Sternberský J

更新日期：1976-01-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) has two subtypes, i.e., mTORC1 and mTORC2, which contain the Raptor and Rictor core molecules, respectively. The effect of Raptor and Rictor on hypoxia inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor (VEGF) in colorectal cancer (CRC) is unclear. In this wo...

journal_title：Neoplasma

authors： Wen FF,Li XY,Li YY,He S,Xu XY,Liu YH,Liu L,Wu SH

更新日期：2020-05-01 00:00:00

abstract：:Podoplanin (D2-40) was shown to be expressed in cancer-associated fibroblasts (CAFs) of various malignancies. The study aimed at examining its impact on angiogenesis and lymphangiogenesis markers in invasive ductal carcinoma of the breast (IDC). The studies were performed on 104 archival cases of IDC using immunohisto...

journal_title：Neoplasma

authors： Pula B,Wojnar A,Witkiewicz W,Dziegiel P,Podhorska-Okolow M

更新日期：2013-01-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP), vimentin (Vi) and cytokeratin (CK) intermediate filament (IF) proteins were studied in glioblastoma cell line GL-15. The immunofluorescence staining revealed strong positive staining for vimentin in all cultured cells. Approximately 20% of analyzed cells showed strong and 50% mo...

journal_title：Neoplasma

authors： Perzelcová A,Máciková,Tardy M,Mráz P,Steno J,Bízik I

更新日期：2000-01-01 00:00:00

abstract：:Colorectal cancer is one of the deadliest cancers worldwide. Effective screening, surveillance and prevention can decrease its incidence, mortality and burden. This meta-analysis aims to provide a pooled estimation of 5-year survival rate for colorectal cancer based on topography codes and treatment in Iranian populat...

journal_title：Neoplasma

authors： Panahi MH,Panahi H,Mahdavi Hezaveh A,Mansournia MA,Bidhendi Yarandi R

更新日期：2019-11-01 00:00:00

abstract：UNLABELLED:The growth-regulated oncogene α (GROα) , which is also designated as CXC chemokine ligand 1 (CXCL1), was first identified as an autocrine growth factor in human malignant melanoma. It is involved in tumor development and invasion, and is highly expressed in various human cancers. However, little is known abo...

journal_title：Neoplasma

authors： Han L,Liu W,Chen Y,Wu H,Zhang Y,Jiang B

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:The current study aimed to evaluate the efficacy of sorafenib-based combined therapy against hepatocellular carcinoma (HCC). HepG2 cells were exposed to sorafenib, irinotecan, and oxaliplatin and then subjected to MTT assay to determine chemosensitivity. Flow cytometry was used to examine cell cycle distribu...

journal_title：Neoplasma

authors： Wang Z,Zhao Z,Wu T,Song L,Zhang Y

更新日期：2015-01-01 00:00:00

abstract：:Double immunofluorescence studies using both surface and cytoplasmic antigens were performed on cells of some human hematopoietic lines. We tested several permeabilization protocols in order to optimize, improve and simplify flow cytometric assay to detect the combinations of two markers present in one cell which coul...

journal_title：Neoplasma

authors： Koníková E,Kusenda J,Babusíková O,Glasová M

更新日期：1995-01-01 00:00:00

abstract：:Therapeutic cells producing amphotropic retrovirus, which are able to transduce in vivo thymidine kinase gene of Herpes simplex virus were prepared. Single-cell clone cells with high virus productivity (PA-3 17JH5c113) were obtained by cell cloning. The cells were found free of replication competent retrovirus, they w...

journal_title：Neoplasma

authors： Hlavatý J,Hlubinová K,Bies J,Altaner C

更新日期：1999-01-01 00:00:00

abstract：:In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system no longer considers the mitotic count in the a or b T1 categorization for melanoma, but it adopts a sub-stratification based on the Breslow's depth. Today, the death burden of thin melanoma is still seve...

journal_title：Neoplasma

authors： Roncati L,Piscioli F

更新日期：2018-09-19 00:00:00

abstract：:Occurrence of uveal metastases is higher, than the number of clinically diagnosed cases, furthermore all cases are not amenable to therapy. Treatment of primary cancer is permanently improving, as a result life prospective is better, with an increasing number of late distant metastases in an unusual location, as e.g. ...

journal_title：Neoplasma

authors： Bajcsay A,Kontra G,Récsán Z,Tóth J,Fodor J

更新日期：2003-01-01 00:00:00

abstract：:The aim was to analyze morphologico-functional characteristics of ductal carcinoma in situ (DCIS) in breast MRI to assess signs correlating with the degree of nuclear atypia. From 636 malignant lesions, 114 were DCIS (17.92%): 44 cases of high-grade (38.60%), 37 intermediate (32.45%), 33 low-grade (28.95%). MRI charac...

journal_title：Neoplasma

authors： Lehotska V,Rauova K,Vanovcanova L

更新日期：2018-03-14 00:00:00

abstract：:The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with non-small cell lung cancer (NSCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), or tumor response could be valid surrogate endpoints for OS after first-...

journal_title：Neoplasma

authors： Imai H,Takahashi T,Mori K,Ono A,Akamatsu H,Shukuya T,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Nakajima T,Yamamoto N

更新日期：2014-01-01 00:00:00

abstract：:Relation between the electronic structure of aromatic compounds and their carcinogenic activity has been correlated. Hypotheses of K, L regions have been employed. Possibilities of better theoretical description of carcinogenic activity have been examined by including the effect of medium and by using a more exact qua...

journal_title：Neoplasma

authors： Miertus S

更新日期：1979-01-01 00:00:00

abstract：:Molecular genetic studies have revealed mutations in a number of oncogenes and tumor suppressor genes in lung cancer. The bcl-2 gene product (bcl-2 protein) is implicated in oncogenesis by its ability to prolong cell death through the inhibition of apoptosis. We investigated expression of bcl-2 in 84 resected human no...

journal_title：Neoplasma

authors： Laudanski J,Chyczewski L,Niklińska WE,Kretowska M,Furman M,Sawicki B,Nikliński J

更新日期：1999-01-01 00:00:00

abstract：:Some mechanisms of interference developing in BALB/c mouse embryo fibroblast culture (MEC) infected with Friend leukemia virus (FLV) and 48 hours later superinfected with Sindbis virus (SV) was studied. In FLV-infected cells the amount of SV antigen formed was 2-3 times lower than in SV monoinfection, as indicated by ...

journal_title：Neoplasma

authors： Pogodina VV,Senyuta NB,Karmysheva VY,Korolev MB,Satalkina MI,Kiseleva LL,Merekalova ZI,Mazurenko NP

更新日期：1976-01-01 00:00:00

abstract：:Genetic background of high incidence of spontaneous tumors in BDX rats was investigated with respect to susceptibility to physical or chemical agents and immune response. Percentages of colony forming ability of normal embryo fibroblasts from BDX rats after exposure to various doses of ultraviolet (UV) light, X-rays a...

journal_title：Neoplasma

authors： Oikawa T,Koga Y,Tanahashi K,Saito T,Kobayashi H,Kuzumaki N

更新日期：1986-01-01 00:00:00

abstract：:Pyruvate dehydrogenase kinase 1 (PDHK1) and carbonic anhydrase IX (CAIX) are some of the most hypoxia-inducible proteins associated with tumors, implicated in glucose metabolism and pH regulation, respectively. They both appear to be necessary for model tumor growth, and their high level of expression in human tumors ...

journal_title：Neoplasma

authors： Kery M,Oravcova N,Radenkovic S,Iuliano F,Tomaskova J,Golias T

更新日期：2018-12-10 00:00:00

abstract：:Prolonged lifespan of monoclonal lymphocytes in B-cell lymphocytic leukemia (B-CLL) arises from their resistance to programmed cell death. In contrast, when cultured in vitro, B-CLL tumour cells rapidly undergo apoptosis. There is mounting evidence that P-glycoprotein (P-gp), an adenosine triphosphate-binding cassette...

journal_title：Neoplasma

authors： Jamroziak K,Smolewski P,Cebula B,Szmigielska-Kaplon A,Darzynkiewicz Z,Robak T

更新日期：2004-01-01 00:00:00

abstract：:Authors evaluated the prevalence of symptoms of the metabolic syndrome and insulin resistance in 25 patients with adrenal incidentalomas (10 men, 15 women) of the mean age 57.9+/-15 years. 15 patients had adrenal adenoma determined by CT or MR scan and 10 had unilateral or bilateral hyperplasia. The prevalence of obes...

journal_title：Neoplasma

authors： Lazúrová I,Dudásová D,Wagnerová H,Dravecká I,Petrásová D

更新日期：2006-01-01 00:00:00

abstract：:Some results of the first more complex studies in vitro on radio-sensitizing efficiency, cytotoxicity and reactivity with blood-thiols of a series of 4- or 5-nitroimidazoles substituted in the 5, 4 or 2 position with chlorine are presented. The derivatives of 4-nitroimidazole substituted in 5 position ("ortho" positio...

journal_title：Neoplasma

authors： Wideł M,Watras J,Suwiński J,Salwińska E

更新日期：1987-01-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are strongly associated with cancer biology. The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRNAs and messenger RN...

journal_title：Neoplasma

authors： Cao Y,Shi C,Li J,Liang Y,Qiu J,Yuan L,Yong Z,Zhang DX,Shi GQ

更新日期：2019-03-05 00:00:00

abstract：:Flow cytometry (FCM) was introduced for estimation of DNA content in 75 brain tumors. Among these astrocytomas (38 cases) and meningiomas (16 cases) predominated. Astrocytomas were histologically subdivided into 3 groups of malignancy grade. Aneuploid cell populations were found in 1 out of 4 cases of astrocytoma grad...

journal_title：Neoplasma

authors： Christov K,Zapryanov Z

更新日期：1986-01-01 00:00:00

abstract：:The histochemical properties of mucus in 48 diffuse type gastric carcinomas and in 46 intestinal type gastric cancers were investigated. In the diffuse type there was a prevalence of intracellular secretion of mucopolysaccharides with a significantly larger portion of sulfated mucopolysaccharides. Acid mucopolysacchar...

journal_title：Neoplasma

authors： Tichá V,Jansa P,Tichý M

更新日期：1988-01-01 00:00:00

abstract：:A series of seven monoclonal antibodies recognizing cell surface antigens of similar distribution on a panel of leukemia/lymphoma and lymphoblastoid human cell lines was prepared by hybridoma technique after immunization with non-T, non-B acute lymphoblastic leukemia cell line REH. Immune reactivity of these monoclona...

journal_title：Neoplasma

authors： Poláková K,Chorváth B,Sedlák J,Duraj J,Matoska J,Karpatová M

更新日期：1985-01-01 00:00:00

abstract：:The development of distant metastases is the final stage in the progression of solid cancer and is responsible for the majority of cancer-related deaths. Epithelial-mesenchymal transition (EMT) is involved in cancer progression and metastasis. In the present study we used different types of intracellular bacteria isol...

journal_title：Neoplasma

authors： Wachsmannova L,Stevurkova V,Ciernikova S

更新日期：2019-02-06 00:00:00

abstract：:HCC is one of the leading causes of death worldwide. Liver transplantation including living donor transplantation is the best available treatment. We have analyzed our experience with LDLT in patients with HCC and HCV in order to determine if alpha feto-protein (AFP) is a better predictor of recurrence than the tumor ...

journal_title：Neoplasma

authors： Komorowski AL,Hsu CC,Julka KD,Vasavada B,Lin CC,Wang CC,Chen CL

更新日期：2018-03-14 00:00:00

abstract：:This paper summarizes preliminary results of combining suicide gene strategy (E. coli cytosine deaminase gene--CD) with immunotherapy (murine interleukin-4 gene) for treatment of experimental B16(F10) melanomas implanted into C57Bl/6 mice. The best therapeutic results, inhibition of tumor growth and prolonged survival...

journal_title：Neoplasma

authors： Missol-Kolka E,Sochanik A,Szala S

更新日期：1998-01-01 00:00:00

abstract：:Genetic testing based on next-generation sequencing (NGS) analysis has recently been used to diagnose hereditary diseases. In this study, we explored the usefulness of our custom amplicon panel that targeted 23 genes related to hereditary tumors given in the American College of Medical Genetics and Genomics recommenda...

journal_title：Neoplasma

authors： Shinriki S,Maeshiro M,Shimamura K,Kawashima J,Araki E,Ibusuki M,Yamamoto Y,Iwase H,Miyamoto Y,Baba H,Yamaguchi M,Matsui H

更新日期：2020-07-01 00:00:00

abstract：:Although the candidemia still remains a serious health problem, the study of candidemia in cancer patients is limited. We conducted a retrospective analysis of candidemia among 31 adult patients hospitalized in one oncological center. The mean annual incidence of candidemia was 0.14±0.05/1000 patient-days (range 0.04-...

journal_title：Neoplasma

authors： Szymankiewicz M,Nowikiewicz T

更新日期：2020-11-01 00:00:00