Abstract:
:Some selected data on cancer statistics in the USSR and results of the nationwide cancer screening activities are presented. The usefullness of some new methods in prophylactic examination is discussed.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Alexandrov NNsubject
Has Abstractpub_date
1975-01-01 00:00:00pages
559-62issue
5eissn
0028-2685issn
1338-4317journal_volume
22pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract::A 10-year old Nigerian boy was admitted to hospital with a history of swelling in the neck, change of voice, dysphagia and dyspnoea of 2 weeks duration. He died on the 2nd day of admission. Autopsy revealed a thymoma infiltrating the thyroid, trachea and neck muscles and transforming the tracheal lumen into a slit lik...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::The phorbolester (TPA)-induced homotypic aggregation of human monoblastoid U-937 cells was completely abolished by staurosporine, but not by a new selective protein kinase C inhibitor, benzoylated staurosporine derivative CGP 41,251, a compound with known anti-tumor and drug resistance modulating activity. Staurospori...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Circulating tumor cells (CTCs) represent a potential non-invasive substitute for real-time tissue biopsy. Moreover, detection of CTCs in breast cancer patients has been reported as a strong prognostic factor. Biomarkers on CTCs have been analysed and correlated to tissue biopsies from breast cancer patients. Discordan...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:10.4149/neo_2016_003
更新日期:2016-01-01 00:00:00
abstract::Flow cytometry (FCM) was introduced for estimation of DNA content in 75 brain tumors. Among these astrocytomas (38 cases) and meningiomas (16 cases) predominated. Astrocytomas were histologically subdivided into 3 groups of malignancy grade. Aneuploid cell populations were found in 1 out of 4 cases of astrocytoma grad...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Cytogenetic studies in Chinese hamster ovary (CHO) cells using aqueous and organic extracts of pan masalas, as well as genomic damage observed among pan masala consumers have conclusively shown genotoxic potential of pan masala-a dry complex mixture of areca nut, lime, catechu, cardamom, unspecified flavoring agent, e...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Transplacental effect of benzo(a)pyrene was studied in organ cultures of embryonic lung tissue explanted from mouse donors injected by the carcinogen. Hyperplastic alteration of epithelium, followed by adenomatous changes were seen in embryonic lung tissue cultures from donor mice injected by benzo(a)pyrene. No altera...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::The aim of the study was to evaluate the expression of activated mammalian rapamycin (mTOR) and its downstream effectors, phosphorylated p70 ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1), in intrahepatic cholangiocarcinomas (ICC), in order to strengthen the rational...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2012_018
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:The growth-regulated oncogene α (GROα) , which is also designated as CXC chemokine ligand 1 (CXCL1), was first identified as an autocrine growth factor in human malignant melanoma. It is involved in tumor development and invasion, and is highly expressed in various human cancers. However, little is known abo...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2015_020
更新日期:2015-01-01 00:00:00
abstract::The relationship between malignant tumors and blood coagulation disorders is generally well known. The authors studied blood coagulation in patients with colorectal cancer and evaluated some prothrombotic markers. The authors analyzed by latex-aglutination method, ProC Global test, Asserachrom PAI-1 test and Enzygnost...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2011_03_235
更新日期:2011-01-01 00:00:00
abstract::A patient with chronic myelocytic leukemia (CML) had a Philadelphia chromosome--Ph1(t(9q +; 22q--)) in all evaluated bone marrow cells at the time of diagnosis. After 29 months of intermittent therapy (chemotherapy and immunotherapy) and 2 months before clinical signs of blastic phase developed, three additional cell ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Germline mutations in the BRCA1 and BRCA2 genes are required for the initiation of the development of hereditary forms of breast and ovarian cancer, which represent 10-15% of all cases. The course of the disease varies from case to case that can be due even to the possibility of multiple genetic changes including inac...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:UNLABELLED:Antiangiogenic drugs are approved for many cancer types for longer than a decade. Furthermore, several antiangiogenic agents are approved for local application in ophthalmology for treatment of macular degeneration, venous retinal occlusion and diabetic retinopathy. Knowing that antiangiogenic agents are act...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:2016-01-01 00:00:00
abstract::The oral cavity is continually exposed to various traumas due to the effect of thermal, mechanical and chemical stimuli, which when accompanied by inflammatory states may promote the growth of neoplastic changes. Numerous studies have revealed a correlation between the expression of p53 and Bcl-2 proteins and the prog...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Osteosarcoma (OS) is a common malignant bone tumor that occurs in adolescents or children under the age of 20, which is extremely difficult to cure and has a high recurrence rate. Recent studies showed that cell division cycle 20 (CDC20) overexpression is associated with poor prognosis in patients with osteosarcoma. H...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200614N629
更新日期:2020-10-30 00:00:00
abstract::DNA repair synthesis following dimethylnitrosamine (DMN) treatment in mouse liver was detected in vivo by means of histoautoradiography. This phenomenon was more significant around the acinus center (practically in all hepatocytes) than around the portobiliary space. Besides this also a decrease in semiconservative DN...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::The efficacy of cis-platinum in the treatment of recurrent advanced malignant melanoma is discussed and also the so far unpublished clinical data have been summed up. On account of the considerable differences among these data the clinical study of Stage II had been started which should contribute to the elucidation o...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::There is some evidence that prostaglandin (PGE)-secreting cells may have a role in immunosuppression in cancer patients. In this work we investigated the effects of indomethacin--a PGE synthesis inhibitor, on PHA-induced lymphoproliferative response in vitro. Twenty patients with lung cancer before therapy were includ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::The aim of our study was to evaluate the efficacy of oral clodronate supplementing systemic therapy and/or palliative irradiation in 91 patients with painful bone metastases. Clodronate was administered at a daily dose of 1600-3200 mg for a median of 11 months (range 3--36 months). Partial or complete pain relief was ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Factors influencing circulating miRNA as a diagnostic marker of hepatocellular carcinoma (HCC) are still unknown. We used two kits to extract total RNA of 90 paired serum and plasma samples of volunteers in different statuses including healthy, hepatitis, cirrhosis and HCC. U6, miR-183 and cel-miR-39 expression levels...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2015_096
更新日期:2015-01-01 00:00:00
abstract::The study was aimed at the proper detection of surface and cytoplasmic clonal Ig light/heavy chains in the frame of multiparameter flow cytometry analysis of some B-cell malignancies. An exact direct evidence has been obtained that the leukemia cells following staining by antibodies to immunoglobulins will need to be ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Relative content of membrane sectors of ATPase complex in rat liver and Zajdela hepatoma mitochondria and the ability of mitochondrial membrane of the two sources to bind isolated soluble (F1) ATPase were examined. Approximately equal concentrations of oligomycin were required for 50% inhibition of ATPase activity in ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Zinc finger protein 139(ZNF139), a member of zinc finger protein family, is a transcription factor. Our previous research showed ZNF139 was overexpressed in gastric cancer cells. The purpose of present study is to explore impact and mechanism of ZNF139 on metastasis by regulating invasive ability of gastric cancer cel...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2014_037
更新日期:2014-01-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a rare malignancy in the Czech Republic and Slovakia, with the standardized incidence rate of < 1:100000 person-years. Viral status of NPC in these non-endemic Eastern European regions is currently unknown. In a retrospective study, we evaluated the presence of EBV and HPV in 62 NPC c...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2016_013
更新日期:2016-01-01 00:00:00
abstract::Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G-CSF did not influence the proliferativ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The present communication is a comparative survey of the histological specimens derived from the dysplastic or neoplastic lesion of the uterine cervix of 400 women comprising two age-matched series (200 women in each) collected from two Finnish hospitals. Special emphasis was placed on the detection of the newly descr...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::The cancer chemotherapeutic efficacy of 3,4-dihydroxybenzylamine (DHBA), a dopamine analog with reduced neurotoxic effects, was evaluated in strain A mice bearing transplantable Ehrlich's ascites carcinoma. The analog was administered intraperitoneally on day 1 post-transplantation at dose schedules of 50, 100 and 200...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Mode of releasing of associated 4S RNA species was studied during a controlled transition of aggregate structure of high-molecular-weight AMV-RNA. It has been found that associated 4S RNA constitutes 2.5% of 60S AMV-RNA complex. Approximately 60% of associated 4S RNA is successively released during treatment of viral ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Antisera against tumor-associated and organ-specific antigens of human mammary glands, as well as mammary carcinoma patient sera were used in cross-reactions with the test-system for a nucleoid antigen of Hep-2 retravirus. None of the antigens, revealed in mammary carcinomas and human milk seems to be either viral str...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::The neuroleptics, well known as stimulants of prolactin release, are supposed to increase breast cancer incidence. To verify this hypothesis, we selected a group of 853 deaths of female inpatients with mental diseases recorded in the Dr. G. Marinescu Hospital between 1929 and 1978. Using proportionally and indirect st...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00