Abstract：
:Family history of colorectal cancer is recognized as a risk factor for the disease and the development of colorectal cancer represents a suitable model for illustrating multistep tumor development. Bleomycin induced chromosome sensitivity studies were done in 7 colorectal cancer families consisting of 12 colorectal cancer patients and their 34 first degree relatives and 12 sporadic colorectal patients for comparison and identification of high risk family members with genetic instability. All patients and 4 unaffected relatives showed increased bleomycin sensitivity, which might be due to defective DNA repair system. These four relatives may be classified as high risk (without cancer at present) individuals. The study is being continued in more number of familial colorectal cancer patients and their relatives to arrive at definite conclusions.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Jyothish B,Ankathil R,Chandini R,Vinodkumar B,Nayar GS,Roy DD,Madhavan J,Nair MKsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
258-62issue
4eissn
0028-2685issn
1338-4317journal_volume
44pub_type
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