Medroxyprogesterone acetate versus tamoxifen in the therapy of advanced breast cancer.

Abstract:

:A comparison of efficacies of medroxyprogesterone acetate (MPA) and the antiestrogen tamoxifen (TX) in the therapy for advanced breast cancer in patients who had already previously been intensely treated showed that, as to the objective remissions, the two drugs can be looked upon as equivalent. Nevertheless, with MPA a better analgetic and anabolic effect--a marked improvement in the performance status (Karnofsky index)--was achieved.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Lorenz I,Mechl Z

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

119-24

issue

1

eissn

0028-2685

issn

1338-4317

journal_volume

32

pub_type

杂志文章
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    abstract::Serum concentration of alpha1-proteinase inhibitor (alpha1-PI) was determined by nephelometric method in forty seven patients with liver cirrhosis (LC) and fifteen patients with hepatocellular carcinoma (HCC). Our data show an increase in the concentration of alpha1-PI in the group with decompensated LC by 17% and in ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Dabrowska M,Mantur M,Panasiuk A,Prokopowicz J

    更新日期:1997-01-01 00:00:00

  • Autologous Hsp70 immunization induces anti-tumor immunity and increases longevity and survival of tumor-bearing mice.

    abstract::Heat Shock proteins 70 (Hsp70) is a family of highly conserved molecules that maintain the function of crucial cellular pathways during stress. Hsp70 derived from tumor cells is bound with tumor antigenic peptides from the diverse antigen cytosolic pool. Tumor-derived Hsp70 preparations after ex vivo administration pe...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2009_03_259

    authors: Kumar S,Deepak P,Acharya A

    更新日期:2009-01-01 00:00:00

  • Prognostic significance of lymphocytic infiltration in radiation-treated uterine cervix carcinoma.

    abstract::In a retrospective series of 45 patients with uterine cervix carcinoma Stage Ib and IIa who had been treated by radiation, biopsy material obtained prior to treatment was reevaluated for the presence of lymphocytic infiltration. The analysis based on 5 degrees of the intensity of stromal reaction has shown that the pr...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Boljesíková E,Siracká E,Kubovcáková N,Gyarfásová M

    更新日期:1984-01-01 00:00:00

  • Structural changes in DNA of human breast carcinoma.

    abstract::Rearrangement and loss of genetic material in DNA of human ductal breast carcinoma was analyzed by restriction enzyme digestion, agarose gel electrophoresis and Southern blot hybridization using 32P labeled c-Ha-ras-1 and multilocus, minisatellite 15.1.11.4 as a probe. In several cases an allelic loss of c-Ha-ras-1 lo...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Mackiewicz M,Choina B,Kadlof A,Szala S

    更新日期:1988-01-01 00:00:00

  • Comparison of two non-anthracycline-containing regimens for elderly patients with diffuse large-cell non Hodgkin's lymphoma--possible pitfalls in results reporting and interpretation.

    abstract::Age over 65 years is a risk factor per se for doxorubicin administration, and coexisting diseases pose additional problems. There is still controversy whether chemotherapy regimens for elderly patients with aggressive NHL should be full-dose doxorubicin containing or whether development of non-anthracycline containing...

    journal_title:Neoplasma

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Jelić S,Milanović N,Tomasević Z,Matković S,Gavrilović D

    更新日期:1999-01-01 00:00:00

  • Effect of pentoxifylline on P-glycoprotein mediated vincristine resistance of L1210 mouse leukemic cell line.

    abstract::Effect of pentoxifylline (PTX) on vincristine (VCR) resistance of multidrug resistant L1210/VCR mouse leukemic cell line was studied. Reversal effect of PTX (in concentration 50-150 mg/l) on vincristine resistance, i.e. potentiation of vincristine cytotoxicity on L1210/VCR cells by PTX was found. PTX alone in the abov...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Breier A,Barancík M,Stefanková Z,Uhrík B,Tribulová N

    更新日期:1994-01-01 00:00:00

  • Application of NMR spectroscopy in biochemical studies of tumor cells sensitive and resistant to anticancer drugs.

    abstract::Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and in vitro. The results of in vivo and in vitro 1H, 13...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Hanusovská E,Dovinová I,Tkác I,Novotný L

    更新日期:1998-01-01 00:00:00

  • The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.

    abstract::The inhibition of incorporation of 3H-thymidine and the changes of the rate of nascent DNA chain elongation were investigated in CHO Chinese hamster cells treated with (S)-(3-hydroxy-2-phosphonomethoxypropyl) (HPMP) and N-(2-phosphonomethoxyethyl) (PME) derivatives of adenine (A), guanine (G) and 2,6-diaminopurine (DA...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Stĕtina R,Votruba I,Holý A,Merta A

    更新日期:1993-01-01 00:00:00

  • Studies on the release of interleukin-1 (IL-1), tumor necrosis factor (TNF) and lysozyme from human non-adherent mononuclear cells (nMNC) in vitro after treatment with cisplatin and other biological response modifiers.

    abstract::The supernatants collected from cisplatin, lipopolysaccharide (LPS), muramyl dipeptide (MDP) or recombinant interferon gamma (rIFN-gamma) treated non-adherent mononuclear cells (with NK cell activity) enhanced thymocyte proliferation by a submitogenic concentration of concanavalin A as compared to untreated nMNC. Supe...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Sodhi A,Pai K

    更新日期:1992-01-01 00:00:00

  • Inhibitory effect of human urinary extract on the growth of DMBA-induced mammary tumors in Holtzman rat.

    abstract::The effect of a crude protein fraction from human urine having gonadotropin inhibitory activity (GGIM) was observed on the growth of 7,12-dimethylbenz(a)anthracene induced mammary tumors in Holtzman rat. Results show that while in 12 out 13 tumors, tumor growth was retarded/regressed following 2--4 weeks of CGIM treat...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Sarkar S,Shah PN,Bagli NP

    更新日期:1981-01-01 00:00:00

  • Expression of CD147 in advanced non-small cell lung cancer correlated with cisplatin-based chemotherapy resistance.

    abstract::CD147, a widely expressed cell surface glycoprotein in cancer, is associated with tumor invasiveness and chemotherapy resistance. Recently, CD147 is also regarded as a potential therapeutic target for cancer therapy. The aim of the study was to investigate CD147 expression in non-small cell lung cancer (NSCLC), and ev...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2011_05_449

    authors: Zeng HZ,Qu YQ,Liang AB,Deng AM,Zhang WJ,Xiu B,Wang H,Wang H

    更新日期:2011-01-01 00:00:00

  • Clodronate in the management of bone metastases: a clinical study of 91 patients.

    abstract::The aim of our study was to evaluate the efficacy of oral clodronate supplementing systemic therapy and/or palliative irradiation in 91 patients with painful bone metastases. Clodronate was administered at a daily dose of 1600-3200 mg for a median of 11 months (range 3--36 months). Partial or complete pain relief was ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Serkies K,Jereczek-Fossa B,Badzio A,Jassem J

    更新日期:1999-01-01 00:00:00

  • Chromosomal characteristics and non-random distribution of sister chromatid exchanges in lymphoblastoid cell lines isolated from acute leukemias.

    abstract::Serial cytogenetic characteristics of four lymphoblastoid cell lines derived from the peripheral blood of four patients with acute leukemia are presented, including G and C banding techniques and the analysis of sister chromatid exchanges by means of FPG technique. One of these lines turned into predominantly diploid ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Michalová K,Málková J,Cinátl J,Placerová J

    更新日期:1977-01-01 00:00:00

  • Calf serum- and cell surface proteins released from cultured avian sarcoma virus-transformed and untransformed rat fibroblasts.

    abstract::Cell surface and calf serum proteins were released in vitro from cultured virus-transformed, chemically transformed and normal rat embryo fibroblasts in 0.2 M urea containing serum-free culture medium. Fibronectin (LETS protein) was found in considerably higher amount in medium from normal rat embryo fibroblasts than ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Duraj J,Chorváth B,Simkovic D

    更新日期:1979-01-01 00:00:00

  • GRK5 promotes tumor progression in renal cell carcinoma.

    abstract::GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the nucleus. Thus, GRK5 is involved in the development and progression of several pathological conditions ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_180621N409

    authors: Zhao TL,Gan XX,Bao Y,Wang WP,Liu B,Wang LH

    更新日期:2019-02-06 00:00:00

  • MicroRNA-584-3p reduces the vasculogenic mimicry of human glioma cells by regulating hypoxia-induced ROCK1 dependent stress fiber formation.

    abstract::We report in this study that microRNA-584-3p (miR-584-3p) is related to the vasculogenic mimicry (VM) of human glioma cells. Unsurprisingly, the postoperative survival time was significantly prolonged in those glioma patients without VM phenomena compared with those with positive VM. miR-584-3p may function as a poten...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2017_102

    authors: Xu S,Zhang J,Xue H,Guo X,Han X,Li T,Guo X,Gao X,Liu Q,Li G

    更新日期:2017-01-01 00:00:00

  • Prevalent expression of MHC class I chain-related molecule A in human osteosarcoma.

    abstract::MHC class I chain-related molecule A (MICA) is one of the major ligands for activating immune-receptor NKG2D which is expressed on NK cells and cytotoxic T lymphocytes. The release and sustained expression of MICA protein can impair NKG2D-mediated cytotoxic activity by reducing NKG2D receptor on immune effector cells....

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Lu SM,Xiao P,Xue L,Che LH,Yang P,Li Y,Qiao H

    更新日期:2008-01-01 00:00:00

  • Some results and prospects of transplacental carcinogenesis studies.

    abstract::Analysis of literary data and the author's findings have shown that the transplacental action of most of the compounds tested in experiments on rats manifested itself by a neurotropic carcinogenic effect. A marked neurotropism in transplacental carcinogenesis in rats is characteristic even for such drugs (e.g. dimethy...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Alexandrov VA

    更新日期:1976-01-01 00:00:00

  • Reaction of various human normal and leukemic cells and cells of different cell lines with rabbit antisera prepared against membrane fraction of B and T cell lines.

    abstract::Serological analysis of human membrane antigens have been performed using rabbit xenosera against membrane fraction obtained from different cells (B cell lines: RAJI, RAMOS, DAUDI, UHKT-2: T cell line: MOLT-3, as well as normal pooled lymphocytes). The direct cytotoxicity testing demonstrated that xenogeneic rabbit B ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Koubek K

    更新日期:1983-01-01 00:00:00

  • Factors associated with prognosis in human breast cancer. I. Predictors for rate of evolution and relapse.

    abstract::The associations of several clinical factors with general survival, percentage of relapse and survival in the group of patients who relapsed were analyzed in a series of 399 Stage II breast cancer patients operated and irradiated at the Institute of Oncology and Radiobiology in Havana. In another series of 187 patient...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Lage A,Rodriguez M,Pascual MR,Diaz JW,Fernandez L

    更新日期:1983-01-01 00:00:00

  • Assessment of coagulation disorders and cancer procoagulant activity in patients with myelodysplastic syndromes.

    abstract::Hemostatic disorders mainly due to thrombocytopenia represent an important clinical problem in patients with myelodysplastic syndromes (MDS). Much less is known about the possible coagulation abnormalities. Thirty patients with MDS were studied. Activity of cancer procoagulant (CP), concentrations of activation marker...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Chojnowski K,Treliński J,Wawrzyniak E,Sobolewska M,Mielicki W

    更新日期:2002-01-01 00:00:00

  • The effect of repeated dose of x-irradiation on the progress of HeLa cells through the cell cycle.

    abstract::In contradistinction to the increased fraction of HeLa S 3 cells in S phase after irradiation by a single dose in a range of 25--200 R, cultures irradiated by a second dose at time of morphologic restitution of mitotic activity exhibited decreased fraction of cells in S phase. The interpretation is that passage from G...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Siracká E

    更新日期:1976-01-01 00:00:00

  • Estradiol and progesterone receptors in human breast cancer.

    abstract::The concentration of estradiol and progesterone receptors in tumor cytosol from human breast cancer patients represents an important factor for the selection of patients for endocrine therapy and for the prognosis of the disease. This report presents results obtained by measurement of estradiol receptor in 157 breast ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Mureşan Z,Voiculetz N

    更新日期:1985-01-01 00:00:00

  • Association among an autocrine parameter (EGF-R) and endocrine parameters (ER and PR) in locoregional breast cancer.

    abstract::Sixty-three locoregional breast cancer biopsies were examined for association among epidermal growth factor receptors (as parameter of autocrine growth control), and estrogen and progesterone receptors (as endocrine parameters of estrogen responsiveness). In the tumor group with similar steroid receptor levels, low (0...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Nikolić-Vukosavljević D,Kanjer K,Branković-Magić M,Spuzić I

    更新日期:1994-01-01 00:00:00

  • Training of prescreening cytotechnicians. A report on 10-year experience.

    abstract::Institutional training of prescreening cytotechnicians started in 1972 in the Research Institute of Oncopathology, Budapest. Up to 1983 ten classes, i.e. 230 students have been trained. Authors acknowledge the good achievements of their students and state that the diagnostic reliability of the qualified cytotechnician...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Arva P,Bodó M,Sugár J

    更新日期:1984-01-01 00:00:00

  • Distribution of subclasses in a series of 62 sera with IgA paraprotein.

    abstract::IgA1-2 subclass distribution was determined in a series of 62 sera with diagnosed IgA paraprotein. Throughout the series the participation of IgA1 : IgA2 subclasses showed a ratio 9 : 1 even after division of the series into myeloma and nonmyeloma paraproteinemias. On dividing the series according to the antigenic typ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Tichý M,Hrncír Z

    更新日期:1986-01-01 00:00:00

  • Expression of putative stem marker nestin and CD133 in advanced serous ovarian cancer.

    abstract::It is hypothesized that "cancer stem cells" are responsible for the resistance to chemotherapy of cancer cells in ovarian cancers. The objective of the studies was to explore if the stem cell biomarkers could be used to predict the tumor chemotherapy-resistance in serous ovarian cancer patients. Expression of two puta...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2012_040

    authors: Qin Q,Sun Y,Fei M,Zhang J,Jia Y,Gu M,Xia R,Chen S,Deng A

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  • Large-scale screening of the population of early detection of malignant tumors in the USSR.

    abstract::Some selected data on cancer statistics in the USSR and results of the nationwide cancer screening activities are presented. The usefullness of some new methods in prophylactic examination is discussed. ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Alexandrov NN

    更新日期:1975-01-01 00:00:00

  • Assay design and optimization of mutant-enriched PCR based method for detection of K-ras gene mutations in pancreatic carcinoma.

    abstract::The aim of our work was to develop a fast, reliable and sensitive PCR method to detect K-ras mutations in various clinical samples. There is a need for an unimpeachable method for early diagnosis and/or screening of pancreatic cancer (PC). We optimized and subsequently analyzed four methods based on mutant-enriched PC...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Ugorcáková J,Hlavatý T,Babál P,Janega P,Bukovská G,Halgasová N,Hlavatá A,Timko J,Duris I

    更新日期:2006-01-01 00:00:00

  • Epidemiologic aspects of malignant skin melanoma in Slovakia.

    abstract::The trends of age-adjusted incidence rates of malignant skin melanoma in Slovakia from 1968 to 1977 showed important increase with an annual increment of 5.8% in males and 3.2% in females. The mortality rates during this period remained lower and their increase was less expressed. The study of geographic patterns of i...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Plesko I,Somogyi J,Dimitrova E,Havránková M,Kiss J

    更新日期:1985-01-01 00:00:00