Gain-of-function mutations in CARD11 promote enhanced aggregation and idiosyncratic signalosome assembly.

abstract：:The immediate effects and mechanisms of desensitization of contact sensitivity to 2,4-dinitro-1-fluorobenzene (DNFB) were investigated. Mice were sensitized with DNFB, desensitized with antigen 2 weeks later, and challenged 1 day after desensitization. Significant inhibition (approximately 50%) of contact sensitivity ...

journal_title：Cellular immunology

authors： Mekori YA,Claman HN

更新日期：1984-11-01 00:00:00

abstract：:Previous studies established that low in vitro temperatures (27 degrees C, termed nonpermissive) suppressed murine primary thymus-dependent (TD), but not primary thymus-independent (TI) or secondary TD, antibody responses. Suppression was rescued by the addition of oleic acid (18:1), recombinant interleukin (rIL)-2 an...

journal_title：Cellular immunology

authors： Wooten RM,Clem LW,Bly JE

更新日期：1993-11-01 00:00:00

abstract：:Avirulent clones of Leishmania braziliensis were produced by treatment of parental parasite stock with the mutagen N-methyl-N'-methyl-N'-nitro-N-nitrosoguanidine and selection for growth at 19 degrees C. These clones have a clear preference for infection and growth in vitro at 19 degrees C rather than the normal 28 de...

journal_title：Cellular immunology

authors： Gorczynski RM

更新日期：1985-08-01 00:00:00

abstract：:CD48, the murine homolog of human CD58, binds to CD2 in rats and mice. Whereas inhibition of CD2 signaling leads to profound immunosuppression, no information is available on CD48-targeted therapy in the rat. We could show that anti-CD2 treatment (OX34) efficiently inhibited TCR-driven as well as CD2-mediated prolifer...

journal_title：Cellular immunology

authors： Sido B,Otto G,Zimmermann R,Müller P,Meuer SC,Dengler TJ

更新日期：1997-11-25 00:00:00

abstract：:During normal lymphocyte recirculation and in chronic inflammation, lymphocytes emigrate from blood into the perivascular tissue. The mechanism of lymphocyte migration through the endothelial cell (EC) layer of blood vessels is poorly understood. To identify factors that control lymphocyte emigration, a method has bee...

journal_title：Cellular immunology

authors： Oppenheimer-Marks N,Ziff M

更新日期：1988-07-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is a T-cell-mediated autoimmune disease characterized by demyelination and mononuclear cell infiltration of the peripheral nervous system. It is induced in Lewis rats by administration of myelin P2 protein or a synthetic peptide (SP-26) corresponding to amino acid residues 53-78 ...

journal_title：Cellular immunology

authors： Gregorian SK,Lee WP,Beck LS,Rostami A,Amento EP

更新日期：1994-06-01 00:00:00

abstract：:Treatment of human blood mononuclear cells with nanomolar concentrations of phorbol 12,13-dibutyrate (P(Bu)2) induced their aggregation. The phenomenon was seen within a few minutes and reached its maximum manifestation after 20 min. At this time, 20-30% of unfractionated and nylon wool-passed mononuclear leukocytes w...

journal_title：Cellular immunology

authors： Patarroyo M,Biberfeld P,Klein E,Klein G

更新日期：1983-01-01 00:00:00

abstract：:The kinetic and the H-2 requirements for the induction of nucleoside-specific suppression were examined in several strains of mice; specifically, whether adenosine (A)-coupled spleen cells given intravenously suppress the primary response to adenosine-KLH. The adenosine system was chosen because C57Bl/6 mice were orig...

journal_title：Cellular immunology

authors： Giroir BP,Raps EC,Cookson E,Borel Y

更新日期：1983-02-01 00:00:00

abstract：:Aging influences the host immune responses in various ways. In aging mice we have studied the antibody responses to two unrelated bacterial antigens. Streptococcus pneumoniae R36a vaccine (Pn) and TNP coupled to Brucella abortus (TNP-BA). Aged animals (20-24 months old) of the C57BL/6 strain had markedly reduced numbe...

journal_title：Cellular immunology

authors： Nicoletti C,Cerny J

更新日期：1991-03-01 00:00:00

abstract：:We tested the impact of interleukin-12 (IL-12) and of cytotoxic leukocytes (particularly natural killer (NK) cells) from normal and HIV-1-infected subjects on lysis of human monocytes infected with Mycobacterium tuberculosis. Nylon wool nonadherent cells stimulated with interleukin-2 (IL-2) or with IL-12 developed sig...

journal_title：Cellular immunology

authors： Denis M

更新日期：1994-07-01 00:00:00

abstract：:Chronic allotype suppression was generated in M-1 (C mu), G-1 (C gamma) heterozygous B14 line chickens either by embryonal injection or by maternal transfer of anti-M-1b allotype antibodies. Using a sensitive radioimmunoassay to detect the suppressed IgM-1b, a striking disparity was observed between the degree of supp...

journal_title：Cellular immunology

authors： Ratcliffe MJ

更新日期：1984-01-01 00:00:00

abstract：:Lenalidomide, a daughter molecule of Thalidomide, and IMIDs are immunomodulatory drugs that have been described as having immunomodulatory properties and anti-tumor activity. The effect of Lenalidomide towards Peripheral Blood Mononuclear Cells (PBMC) has been studied and direct effects towards T cells have been descr...

journal_title：Cellular immunology

authors： Dauguet N,Fournié JJ,Poupot R,Poupot M

更新日期：2010-01-01 00:00:00

abstract：:T cell hybridomas that are deathless upon TCR crosslinking were generated from lpr mice. The deathless hybridomas (1.4 and 5D5) expressed extremely low Fas even after anti-CD3 activation, whereas activation-induced cell death (AICD) was observed for Fas-expressing hybridomas. The deathless hybridomas were activated to...

journal_title：Cellular immunology

authors： Cui H,el-Khatib M,Sherr DH,Ettinger R,Sy MS,Marshak-Rothstein A,Ju ST

更新日期：1996-02-01 00:00:00

abstract：:T-Cell subsets identified by polyclonal and monoclonal antibodies to dipeptidyl peptidase IV (DP IV) were investigated. Analysis in a cytofluorograf revealed 63 +/- 7% positive scatter-gated T lymphocytes. DP IV-positive cells were found to be T11+, 74-81% OKT4+, and 12-19% OKT8+. DP IV-negative cells were T11+ and co...

journal_title：Cellular immunology

authors： Scholz W,Mentlein R,Heymann E,Feller AC,Ulmer AJ,Flad HD

更新日期：1985-06-01 00:00:00

abstract：:Modification of cytokine production by gender hormones has been postulated to affect disease susceptibility and outcome. Here we investigate the effect of gender and the menstrual cycle on production of cytokines. Mononuclear cells were isolated every week for 10 consecutive weeks from healthy pre-menopausal women and...

journal_title：Cellular immunology

authors： Temple SE,Pham K,Glendenning P,Phillips M,Waterer GW

更新日期：2008-02-01 00:00:00

abstract：:Receptors for the Fc domain of IgG mediate target recognition, signal transduction, and effector functions including antibody-dependent cytolysis, phagocytosis, and phagolysosome formation. To better understand FcR-mediated functions and to identify potential therapeutic strategies, we employed cell-penetrating ("Troj...

journal_title：Cellular immunology

authors： Clark AJ,Petty HR

更新日期：2010-01-01 00:00:00

abstract：:Differences in gender immune response have resulted in differences in immune protection and susceptibility to inflammatory diseases. Cultured peripheral blood mononuclear cells (PBMC) are widely used in immunomodulation studies, yet the influence of gender is usually not considered. We examined the effect of in vitro ...

journal_title：Cellular immunology

authors： Abdullah M,Chai PS,Chong MY,Tohit ER,Ramasamy R,Pei CP,Vidyadaran S

更新日期：2012-01-01 00:00:00

abstract：:We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs(10,11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory...

journal_title：Cellular immunology

authors： Masucci MG,Stam NJ,Torsteinsdottir S,Neefjes JJ,Klein G,Ploegh HL

更新日期：1989-05-01 00:00:00

abstract：:Humans with autoimmune disease and autoimmune mouse strains such as NZB have been shown to produce reduced levels of the cytokines interleukin 1 and interleukin 2. The NZB X C58 recombinant inbred (N X 8 RI) strains exhibit certain of the autoimmune characteristics of the NZB strain. Their abilities to produce interle...

journal_title：Cellular immunology

authors： Bocchieri MH,Knittweis L,Seaton DS

更新日期：1984-10-15 00:00:00

abstract：:Strong delayed-type hypersensitivity (DTH) to Babesia microti was elicited when intraerythrocytic parasites (IEP) were inoculated subcutaneously into the flank of normal mice 6 to 14 days before challenge in the ipsilateral footpad with 10(8) IEP. Intraperitoneal or intravenous administration of antigen did not sensit...

journal_title：Cellular immunology

authors： Ruebush MJ,Troutman EH,Kennedy DA

更新日期：1986-04-01 00:00:00

abstract：:We previously showed that DT-5461a, a lipid A analog, has antitumor activity and relatively low toxicity in animals. To clarify its immunostimulatory effect we have studied the cytokine inducibility of DT-5461a and the mechanism involved in the cytokine expression in macrophages. While the activity is lower than that ...

journal_title：Cellular immunology

authors： Akahane K,Someya K,Tsutomi Y,Akimoto T,Tohgo A

更新日期：1994-04-15 00:00:00

abstract：:The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 -1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with...

journal_title：Cellular immunology

authors： Hussein YM,Alzahrani SS,Alharthi AA,Ghonaim MM,Alhazmi AS,Eed EM,Shalaby SM

更新日期：2014-05-01 00:00:00

abstract：:Idiotypic immunoglobulin, which can be considered to bear tumour-associated antigens in the context of B-cell lymphoma, has been obtained from the splenic A31 tumour, purified, and used to immunise syngeneic mice. On subsequent exposure to a lethal challenge of lymphoma cells, the mice showed no overt tumour developme...

journal_title：Cellular immunology

authors： Dyke RJ,McBride H,George AJ,Hamblin TJ,Stevenson FK

更新日期：1991-01-01 00:00:00

abstract：:Toll-like receptors are a family of pattern-recognition receptors that contribute to the innate immune response. Toll-like receptor 3 (TLR3) signals in response to foreign, endogenous and synthetic ligands including viral dsRNA, bacterial RNA, mitochondrial RNA, endogenous necrotic cell mRNA and the synthetic dsRNA an...

journal_title：Cellular immunology

authors： Duffy KE,Lamb RJ,San Mateo LR,Jordan JL,Canziani G,Brigham-Burke M,Korteweg J,Cunningham M,Beck HS,Carton J,Giles-Komar J,Duchala C,Sarisky RT,Mbow ML

更新日期：2007-08-01 00:00:00

abstract：:CXCL10 production is a critical step in limiting mycobacterial infection. Although induction of this chemokine by mycobacteria in epithelial cells has been reported, it is still unclear how CXCL10 is regulated in Mycobacterium bovis BCG-infected epithelial cells. In this study, we demonstrate that phosphatidylinoditol...

journal_title：Cellular immunology

authors： Méndez-Samperio P,Pérez A,Rivera L

更新日期：2009-01-01 00:00:00

abstract：:The lineage of lymphokine-activated killer (LAK) cells is poorly understood. To examine the relationship between LAK and natural killer (NK) cells we utilized two congenitally immunodeficient mice, namely severe combined immunodeficient (scid) and athymic (nude) mice that lack T cells but have normal NK cells. LAK act...

journal_title：Cellular immunology

authors： Hasui M,Saikawa Y,Miura M,Takano N,Ueno Y,Yachie A,Miyawaki T,Taniguchi N

更新日期：1989-04-15 00:00:00

abstract：:Alveolar macrophages are thought to play an important role in ongoing tissue breakdown and repair processes in the normal lung. The secretion and regulation of cathepsin D (important for the final breakdown of collagen) and fibronectin (involved in the healing process) in human peripheral blood monocytes (PBM) and pul...

journal_title：Cellular immunology

authors： Rossman MD,Maida BT,Douglas SD

更新日期：1990-04-01 00:00:00

abstract：:Curcumin has commonly been used for the treatment of various allergic diseases. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In the present study, the effect of curcumin on allergic responses in ovalbumin (OVA)-induced allergic rhinitis mouse was investigated. We explored the effect...

journal_title：Cellular immunology

authors： Zhang N,Li H,Jia J,He M

更新日期：2015-11-01 00:00:00

abstract：:A variety of thymus hormone preparations, as well as drugs known to perturb cell differentiation, were tested for their ability to induce nonfunctional cortical thymocytes to become functional precursor cells. Murine cortical thymocytes, defined as the high peanut agglutinin (PNA) binding or as the low H-2K, major [86...

journal_title：Cellular immunology

authors： Andrews P,Shortman K,Scollay R,Potworowski EF,Kruisbeek AM,Goldstein G,Trainin N,Bach JF

更新日期：1985-04-01 00:00:00

abstract：:Although ligation of the T-cell antigen receptor (TCR) is central to the responsiveness and antigen specificity of T-cells, it is insufficient to elicit a response. To determine whether the need for costimulation reflects inadequate strength of signal transduction through the TCR or an absolute block of signaling in t...

journal_title：Cellular immunology

authors： Adler B,Ashkar S,Cantor H,Weber GF

更新日期：2001-05-25 00:00:00