Photobiomodulation with 808-nm diode laser enhances gingival wound healing by promoting migration of human gingival mesenchymal stem cells via ROS/JNK/NF-κB/MMP-1 pathway.

Abstract:

:Photobiomodulation (PBM) has been shown to improve wound healing by promoting mesenchymal stem cell migration and proliferation. However, it remains unknown whether an 808-nm diode laser can influence human gingival mesenchymal stem cells (HGMSCs), and which dose this works well. In the present study, it was found that PBM could promote the migration of HGMSCs but not the proliferation. Furthermore, PBM could activate mitochondrial ROS, which could elevate the phosphorylation levels of JNK and IKB in HGMSCs, and further activate NF-κB as the nuclear translocation of p65 is elevated. Taken together, these present results indicate that PBM might promote cell migration via the ROS/JNK/NF-κB pathway.

journal_name

Lasers Med Sci

authors

Feng J,Li X,Zhu S,Xie Y,Du J,Ge H,Bai Y,Liu Y,Guo L

doi

10.1007/s10103-020-03040-z

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1831-1839

issue

8

eissn

0268-8921

issn

1435-604X

pii

10.1007/s10103-020-03040-z

journal_volume

35

pub_type

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