Abstract：
:Our previous in vitro study has shown that toluidine blue (TB)-mediated lethal photosensitization of periodontal pathogens (PPs) from periodontal patients is possible. The purpose of this study was to investigate whether TB-mediated photosensitization exerted damaging effects on periodontal tissues in mice. Twenty-four mice were randomly divided into four groups; the experimental photodynamic therapy (PDT) group was treated with 1 mg/ml TB and light irradiation (60 J/cm(2), 635 nm, 337 s). Those in control groups were subjected to 140 J/cm(2) laser irradiation alone or to 2.5 mg/ml TB alone or received neither TB nor light exposure. All the mice were killed 72 h after they had been subjected to PDT, and periodontal tissue samples were taken for histological examination. During the 72 h observation period, no mice showed any distress. No necrotic or inflammatory changes were found in the gingiva, dentin, dental pulp or alveolar bone of the mice in any of the groups in this study. The results suggest that TB-mediated PDT is a safe antimicrobial approach for the treatment of periodontopathy without damaging effects to adjacent normal tissues.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Luan XL,Qin YL,Bi LJ,Hu CY,Zhang ZG,Lin J,Zhou CNdoi
10.1007/s10103-007-0513-3subject
Has Abstractpub_date
2009-03-01 00:00:00pages
162-6issue
2eissn
0268-8921issn
1435-604Xjournal_volume
24pub_type
杂志文章abstract：:The goal of this study was to assess the ablation, coagulation, and carbonization characteristics of the holmium:YAG (Ho:YAG) laser and thulium fiber lasers (TFL). The Ho:YAG laser (100 W av.power), the quasi-continuous (QCW) TFL (120 W av.power), and the SuperPulsed (SP) TFL (50 W av.power) were compared on a non-fro...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-020-03189-7
更新日期：2020-11-11 00:00:00
abstract：:Photosensitizers belonging to the boron-dipyrromethenes (BODIPYs) class were recently found endowed with good efficacy in the antibacterial photodynamic therapy (aPDT) against both Gram-positive and Gram-negative bacteria. In this paper, we report on the remarkable adjuvant effect exerted in this respect by linear pol...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2345-0
更新日期：2018-08-01 00:00:00
abstract：:The purpose of this in vitro study was to observe the morphological changes and apical dye penetration at apical dentin surfaces after apicoectomy with conventional techniques and laser beam. Sixty single-rooted extracted teeth were selected for the study. The crowns were resected below the cemento-enamel junction. Th...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0497-z
更新日期：2008-10-01 00:00:00
abstract：:The purpose of this study was to evaluate the surface and intrapulpal temperatures after treatments with different bleaching gels subjected to different types of light activation. A K-type thermocouple and infrared thermometer were used to measure the temperature increase during the 15- or 30-min treatment period. Lig...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1366-6
更新日期：2015-02-01 00:00:00
abstract：:The aim of the study was to investigate the effect of low-level 809 nm laser irradiation on the proliferation rate of human larynx carcinoma cells in vitro. Epithelial tumor cells were obtained from a laryngeal carcinoma and cultured under standard conditions. For laser treatment the cells were spread on 96-well tissu...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-003-0265-7
更新日期：2003-01-01 00:00:00
abstract：:Low-level laser therapy (LLLT) is a form of photon therapy which can be a non-invasive therapeutic procedure in cancer therapy using low-intensity light in the range of 450-800 nm. One of the main functional features of laser therapy is the photobiostimulation effects of low-level lasers on various biological systems ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-2049-x
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:Acne scarring represents a common problem that negatively impacts patients' quality of life. Different types of treatments are currently available for this dermatological condition. This study evaluates the efficacy of a new 675-nm laser source system on acne scars with the use of established parameters that gu...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-020-03063-6
更新日期：2021-02-01 00:00:00
abstract：:A novel skin phantom is described that is constructed with quantifiable amounts of skin pigments, as well as a light scattering medium in the form of barium sulphate suspension. The two predominant skin pigments (melanin and haemoglobin) are varied in controlled amounts within the phantoms to simulate skin colour in d...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0495-1
更新日期：2008-10-01 00:00:00
abstract：:The Achilles tendon has a high incidence of rupture, and the healing process leads to a disorganized extracellular matrix (ECM) with a high rate of injury recurrence. To evaluate the effects of different conditions of low-level laser (LLL) application on partially tenotomized tendons, adult male rats were divided into...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1236-7
更新日期：2013-09-01 00:00:00
abstract：:This study aimed to analyze the effects of light-emitting diode (LED) therapy on sternotomy pain and healing in patients who underwent coronary artery bypass grafting (CABG). The patients were followed for 6 months after the surgery to determine their dehiscence. This study was conducted with 90 volunteers who electiv...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-013-1503-2
更新日期：2014-05-01 00:00:00
abstract：:The aim of the present study was to investigate the effects of photobiomodulation (PBM) therapy on the expression of heat shock protein 70 (HSP70) and tissue repair in an experimental model of collagenase-induced Achilles tendinitis. Thirty Wistar rats (aged 12 weeks) were randomly distributed among control group (n =...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-020-03155-3
更新日期：2020-10-10 00:00:00
abstract：:Nonablative skin rejuvenation using laser, intense pulsed lights (IPLs), or radiofrequency techniques are becoming increasingly popular. In this paper, a novel protocol that integrates IPL sessions, low intense light and vitamin C, low-weight hyaluronic acid, betaglucan dermal injection versus IPL photorejuvenation as...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s10103-007-0456-8
更新日期：2008-04-01 00:00:00
abstract：:The present work reports the photo-biomodulatory effect of red (632.8 nm) and near infrared (785 and 830 nm) lasers on burn injury in Swiss albino mice. Animals were induced with a 15-mm full thickness burn injury and irradiated with various fluences (1, 2, 3, 4, and 6 J/cm2) of each laser wavelength under study havin...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-2044-2
更新日期：2016-12-01 00:00:00
abstract：:Acupuncture is a form of traditional Chinese medicine that has developed over thousands of years. We studied the effects of laser puncture, needle acupuncture, and light stimulation on cerebral blood flow in 15 healthy volunteers (mean age 25.0±1.9 years, 5 female, 10 male) with non-invasive transcranial Doppler sonog...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s101030050048
更新日期：2000-01-01 00:00:00
abstract：:The potential of laser-induced fluorescence (LIF) spectroscopy for the characterization of different stages of dental caries using 404-nm diode laser excitation was investigated. In vitro spectra from 16 sound, 10 noncavitated carious and 10 cavitated carious molar teeth were recorded on a miniature fibre-optic spectr...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-010-0771-3
更新日期：2011-05-01 00:00:00
abstract：:The objective of this study was to determine the efficacy and safety of a novel method of facial rejuvenation using a 2940-nm erbium:YAG laser with Spatially Modulated Ablation™. A pilot study was performed in 16 women with moderate to severe signs of facial aging relative to chronological age, who underwent two treat...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-016-2010-z
更新日期：2016-09-01 00:00:00
abstract：:The Nd:YAG laser efficacy associated with conventional treatment for bacterial reduction has been investigated throughout literature. The purpose of this study was to evaluate the bacterial reduction after Nd:YAG laser irradiation associated with scaling and root planning in class II furcation defects in patients with...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s10103-007-0482-6
更新日期：2008-10-01 00:00:00
abstract：:The traditional needle cricothyroidotomy procedure is performed blindly without any medical equipment. Complications including posterior tracheal wall perforation, accidental vessel puncture, and missed tracheal puncture are reported. Therefore, we proposed a dual-wavelength fiber-optic technique based on the techniqu...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-020-03065-4
更新日期：2020-07-23 00:00:00
abstract：:Burn scars are known for their tendency to worsen with hypertrophy and contracture, causing esthetic and functional problems. The objective is to analyze the effectiveness of low-level laser therapy on post-burn hypertrophic scar tissue in children. A randomized controlled study included 15 children, ranging from 2 to...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-018-2572-z
更新日期：2018-12-01 00:00:00
abstract：:We evaluate the safety, efficacy, and oncological outcomes of early palliative photoselective vaporization of the prostate (PVP) by GreenLight high-performance system (HPS) 120-W laser in patients with acute urinary retention (AUR) induced by advanced prostate cancer (PCa). A total of 39 advanced PCa patients with AUR...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1252-7
更新日期：2013-09-01 00:00:00
abstract：:The aim of the present study was to investigate laser-fluorescence effects on the root surface. The possibility of detecting subgingival calculus should be evaluated to control complete calculus removal after scaling and root planing. Twenty freshly extracted human teeth, partially covered with calculus on the root su...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-002-0241-7
更新日期：2003-01-01 00:00:00
abstract：:Papacarie Duo™ is clinically used and has proven effectiveness; however, it is necessary to improve its antimicrobial action. The combined treatment of Papacarie Duo™ with Urucum (Bixa Orellana) could create a potential tool for dental caries treatment; its extract obtained from the seeds' pericarp contains a water-so...
journal_title：Lasers in medical science
pub_type： 信件
doi：10.1007/s10103-019-02857-7
更新日期：2020-04-01 00:00:00
abstract：:Reepithelialization and wound closure are the desired outcome for several ulcerative conditions. Such resolution reduces the possibility of wound contamination and maintenance of the injury and improves the reestablishment of tissue morphology and functions. Investigators are seeking adjuvant therapies that can accele...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2176-z
更新日期：2018-02-01 00:00:00
abstract：:Antibiotics and photodynamic therapy (PDT) are widely employed in curing acne. However, antibiotics as an effective treatment would lead to bacterial resistance and severe side effects. In this study, we aimed to develop a novel TBO hydrogel, which could prolong the retention time of photosensitizer (TBO) at the lesio...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02727-2
更新日期：2019-10-01 00:00:00
abstract：:The bactericidal activity of a pulsed fibre-optic Nd-YAP laser on various strains of oral bacteria: Prevotella nigrescens, Streptococcus sanguis, Actinomyces viscosus (i), Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans and Peptostreptococcus micros (i) was evaluated. A 200-μm optical fibre was placed in...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s101030050010
更新日期：1998-12-01 00:00:00
abstract：:Low-intensity laser therapy (LILT) has been considered as a treatment modality in diabetic distal symmetric polyneuropathy (DSP). The aim of this study is to determine the effectiveness of LILT on DSP. We examined 107 subjects with type 2 diabetes for detection of DSP using the Michigan Neuropathy Screening Instrument...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0977-z
更新日期：2011-11-01 00:00:00
abstract：:Tissue characterisation by fluorescence imaging, using exogenous fluorophores, is a promising method for cancer detection. Histochemical alterations in the composition of mucins, when neoplastic transformations occur, could be exploited to derive more selective fluoroprobes indicative of early malignant transformation...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/pl00011361
更新日期：2001-01-01 00:00:00
abstract：:Osteoarthritis (OA) is a chronic joint disease that leads to pain and functional incapacity. The aim of the study is to investigate the effects of the incorporation of photobiomodulation (PBM) (via cluster) into a physical exercise program on the level of pain, lower limb muscle strength, and physical capacity, in pat...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-019-02807-3
更新日期：2020-02-01 00:00:00
abstract：:Alopecia areata (AA) is a common autoimmune disease that presents with non-scarring alopecia. It is characterized by intra- or peri-follicular lymphocytic infiltrates composed of CD4+ and CD8+ T-cells on histology. To this day, few treatments are effective for AA. Here we present findings of using a low-level laser co...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0953-7
更新日期：2012-03-01 00:00:00
abstract：:The aim of this study was to identify biochemical changes in sciatic nerve (SN) after crush injury and low-level laser therapy (LLLT) with 660 nm and 808 nm by Raman spectroscopy (RS) analysis. A number of 32 Wistar rats were used, divided into four groups (control 1, control 2, LASER 660 nm, and LASER 808 nm). All an...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-018-2627-1
更新日期：2019-04-01 00:00:00
