Abstract:
:Papacarie Duo™ is clinically used and has proven effectiveness; however, it is necessary to improve its antimicrobial action. The combined treatment of Papacarie Duo™ with Urucum (Bixa Orellana) could create a potential tool for dental caries treatment; its extract obtained from the seeds' pericarp contains a water-soluble primary pigment (cis-bixin) with smaller amounts of other carotenoids. The dicarboxylic acid salts of cis-norbixin and trans-norbixin occur in heated alkaline solutions. To analyze the absorption spectra and cytotoxicity (with human dermal fibroblasts) in different concentrations of Urucum, associated or not with Papacarie Duo™, we performed this in vitro study. The effects of pure Urucum, Papacarie Duo™, and PapaUrucum™ on the microstructure of collagen were also analyzed. The application of papain-based gel with Urucum did not present cytotoxicity, its exhibit UV absorption spectrum peak around 460 ± 20 nm. Also, it showed that the compound used did not alter the chemical structure of collagen. Consequently, this product could be used as a chemomechanical method to remove dentin caries as well as being a potential product for antimicrobial photodynamic therapy (aPDT) application.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Silva ZS Jr,França CM,Araújo Prates R,Botta SB,Ferrari RAM,Ana PA,Pavani C,Fernandes KPS,de Fátima Teixeira da Silva D,Hamblin MR,Bussadori SKdoi
10.1007/s10103-019-02857-7subject
Has Abstractpub_date
2020-04-01 00:00:00pages
767-775issue
3eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-019-02857-7journal_volume
35pub_type
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