Abstract：
:Antibiotics and photodynamic therapy (PDT) are widely employed in curing acne. However, antibiotics as an effective treatment would lead to bacterial resistance and severe side effects. In this study, we aimed to develop a novel TBO hydrogel, which could prolong the retention time of photosensitizer (TBO) at the lesion site and improve therapeutic effect. In vitro antibacterial experiments (against Staphylococcus aureus and Escherichia coli), the response surface methodology was used to optimize the formulation of TBO hydrogel. The results indicated that the optimal formulation was 0.5% (v/v) carbomer, 0.01 mg/mL TBO, 0.5% (v/v) ethanol concentration, 0.5% (v/v) Tween 80, the mass ratio of NaOH to carbomer of 0.4 (w/w). The TBO hydrogel formulation showed the strong antibacterial activity for Propionibacterium acnes. The stability, pH, and antibacterial activity of TBO hydrogel did not significantly change under 4 °C, 25 °C, and 40 °C during 6-week storage. Furthermore, TBO combined with carbomer hydrogel showed the 51.28% (4 h) and 69.80% (24 h) release. In summary, the hydrogel TBO might be a vital therapeutic strategy to promote the PDT applied in the topical therapy of acne. Graphical abstract A TBO hydrogel for photodynamic therapy in the treatment of acne.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Zheng Y,Yu E,Weng Q,Zhou L,Li Qdoi
10.1007/s10103-019-02727-2subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1535-1545issue
8eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-019-02727-2journal_volume
34pub_type
杂志文章abstract：:Scars from self-inflicted wounds, referred to as "hesitation marks," are usually linear, flat, poorly oriented, white in color, and often located on the forearm. Many patients do not undergo treatment for these due to limited available modalities. The aim of this study was to evaluate the efficacy and safety of the pi...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-1981-0
更新日期：2016-09-01 00:00:00
abstract：:A rabbit model of endophthalmitis was established to evaluate the antiinflammatory effect of low-level laser therapy (LLLT) as an adjunct to treatment for Staphylococcus epidermidis endophthalmitis. Rabbits were randomly divided into three groups to receive intravitreal injections into their left eye: group A received...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0991-1
更新日期：2012-05-01 00:00:00
abstract：:Excimer laser recanalisation of in-stent restenosis may be a viable modality for improving coronary patency. However, the presence of arterial stents modifies the thermal properties of the irradiated area and may alter temperature patterns generated during ablation. The goal of this study was to evaluate, in vitro, te...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/pl00011348
更新日期：2001-01-01 00:00:00
abstract：:Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of bisphosphonate therapy. However, its pathophysiology is not yet fully elucidated, and effective treatment of BRONJ remains unclear. The aim of this study is to investigate the effects of alendronate on oral keratinocytes and of low-level laser...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1382-6
更新日期：2015-02-01 00:00:00
abstract：:In the application of lasers in dentistry, there is a delicate balance between the benefits gained from laser treatment and the heat-related damage arising from laser irradiation. Hence, it is necessary to understand the different processes associated with the irradiation of lasers on dental materials. To obtain insig...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2251-5
更新日期：2017-08-01 00:00:00
abstract：:Oral mucositis (OM) and radiodermatitis (RD) are serious side effects of radiotherapy (RT), often leading to its suspension, need for analgesics, and enteral/parenteral nutrition. Laser therapy is becoming a recommended treatment option. This prospective study aimed at demonstrating the beneficial effect of class IV l...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-015-1857-8
更新日期：2016-04-01 00:00:00
abstract：:Bone morphogenetic proteins (BMPs) are secreted signaling molecules belonging to the transforming growth factor-beta (TGF-beta) superfamily. The objective of this study was to determine how gallium-aluminum-arsenium (GaAlAs) 650 nm laser influenced the action of BMPs on bone defects created in rat femurs. The sample c...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-008-0595-6
更新日期：2009-09-01 00:00:00
abstract：:This study aimed to analyze the effects of light-emitting diode (LED) therapy on sternotomy pain and healing in patients who underwent coronary artery bypass grafting (CABG). The patients were followed for 6 months after the surgery to determine their dehiscence. This study was conducted with 90 volunteers who electiv...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-013-1503-2
更新日期：2014-05-01 00:00:00
abstract：:Recently, investigations suggest the benefits of low-level laser (light) therapy (LLLT) in noninvasive treatment of cellulite, improvement of body countering, and control of lipid profile. However, the underlying key mechanism for such potential effects associated to aerobic plus resistance training to reduce body fat...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-015-1759-9
更新日期：2015-07-01 00:00:00
abstract：:We report results on the use of organically modified silica nanoparticles (SiNp) as a vehicle for the delivery of curcumin in human oral cancer cells for improvement of uptake and phototoxicity. Nanoformulated drug (curcumin-SiNp complex) was prepared by postloading curcumin in SiNp, and the complex was soluble in aqu...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1357-7
更新日期：2014-03-01 00:00:00
abstract：:The aim of this work is to analyze the effects of LED therapy at 940 nm or cold water immersion therapy (CWI) after an acute bout of exercise on markers of muscle damage and inflammation. Thirty-two male Wistar rats were allocated into four groups: animals kept at rest (control), exercised animals (E), exercised + CWI...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-1039-2
更新日期：2012-09-01 00:00:00
abstract：:Lasers have many favorable features as a light source owing to their monochromaticity and coherence. This study examined the mechanical properties of composite resins that were light-cured using a diode-pumped solid state (DPSS) laser. Eight composite resins were light-cured using four different light sources (one qua...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1117-0
更新日期：2013-02-01 00:00:00
abstract：:Photobiomodulation is a treatment that has been widely used in neurotrauma and neurodegenerative diseases. In the present study, low-level laser therapy was administered to patients with spinal cord injury. Twenty-five individuals were divided into two groups: placebo photobiomodulation plus physiotherapy and active p...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-018-2447-3
更新日期：2018-05-01 00:00:00
abstract：:This study aimed to evaluate the effects of low-level laser therapy (LLLT) immediately before tetanic contractions in skeletal muscle fatigue development and possible tissue damage. Male Wistar rats were divided into two control groups and nine active LLLT groups receiving one of three different laser doses (1, 3, and...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-014-1560-1
更新日期：2014-09-01 00:00:00
abstract：:Photodynamic therapy (PDT) with photosensitizer is one of the promising modalities for cancer treatment. For clinical use of PDT, screening process should be preceded to enhance sensitivity to PDT. Thus, we investigated a molecular biomarker to determine the sensitivity to pheophorbide a (Pa)-PDT in immortalized human...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1350-1
更新日期：2015-02-01 00:00:00
abstract：:The potential of laser-induced fluorescence (LIF) spectroscopy for the characterization of different stages of dental caries using 404-nm diode laser excitation was investigated. In vitro spectra from 16 sound, 10 noncavitated carious and 10 cavitated carious molar teeth were recorded on a miniature fibre-optic spectr...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-010-0771-3
更新日期：2011-05-01 00:00:00
abstract：:The present work reports the photo-biomodulatory effect of red (632.8 nm) and near infrared (785 and 830 nm) lasers on burn injury in Swiss albino mice. Animals were induced with a 15-mm full thickness burn injury and irradiated with various fluences (1, 2, 3, 4, and 6 J/cm2) of each laser wavelength under study havin...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-2044-2
更新日期：2016-12-01 00:00:00
abstract：:Benzene is volatile organic hydrocarbon which is widely used in a wide range of industries. Studies have shown that exposure to benzene consequences serious health risks for human. Understanding the effect and risks of environmental hazard materials in the laser therapy of skin is interesting which can show useful or ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-020-03211-y
更新日期：2021-01-07 00:00:00
abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of infections in humans. Photodynamic therapy using blue light (450 nm) could possibly be used to reduce MRSA on different human tissue surfaces without killing the human cells. It could be less harmful than 300-400 nm light or common disinfectan...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02774-9
更新日期：2019-12-01 00:00:00
abstract：:Laser angioplasty has been evaluated for coronary applications since the early 1980s. Early complications of dissection, perforation and thermal injury led to a loss of enthusiasm for this technique. Recent advances in catheter development, including optimally spaced laser fibres, athermic 308 nm wave-length catheters...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/pl00011338
更新日期：2001-01-01 00:00:00
abstract：:Our previous in vitro study has shown that toluidine blue (TB)-mediated lethal photosensitization of periodontal pathogens (PPs) from periodontal patients is possible. The purpose of this study was to investigate whether TB-mediated photosensitization exerted damaging effects on periodontal tissues in mice. Twenty-fou...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0513-3
更新日期：2009-03-01 00:00:00
abstract：:Laser micromachining with ultrashort pulses has shown great promise for clean, safe surgical treatment of bone tissue. However, comparisons of performance and development of "best practice" have been hampered by the difficulty of comparing results across a wide variety of experimental approaches and under surgically i...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02899-x
更新日期：2020-08-01 00:00:00
abstract：:5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) provides a novel and promising treatment for esophageal cancer. However, its specific mechanism has not been fully elucidated and its efficacy is remarkably varied. This study investigated the effect of ALA-PDT on esophageal squamous carcinoma cell line Eca...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-010-0810-0
更新日期：2011-01-01 00:00:00
abstract：:The objective of this study was to determine the efficacy and safety of a novel method of facial rejuvenation using a 2940-nm erbium:YAG laser with Spatially Modulated Ablation™. A pilot study was performed in 16 women with moderate to severe signs of facial aging relative to chronological age, who underwent two treat...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-016-2010-z
更新日期：2016-09-01 00:00:00
abstract：:This in vitro study evaluated the role of photobiomodulation therapy (PBMT) on viability and migration of human dental pulp stem cells (hDPSCs) and its association to epigenetic mechanisms such as histone acetylation. The hDPSCs were characterized and assigned into control and PBMT groups. For the PBMT, five laser irr...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02931-0
更新日期：2020-04-01 00:00:00
abstract：:The Achilles tendon has a high incidence of rupture, and the healing process leads to a disorganized extracellular matrix (ECM) with a high rate of injury recurrence. To evaluate the effects of different conditions of low-level laser (LLL) application on partially tenotomized tendons, adult male rats were divided into...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1236-7
更新日期：2013-09-01 00:00:00
abstract：:In root canal therapy, irrigating solutions are essential to assist in debridement and disinfection. Their spread and action is often restricted by canal anatomy, requiring some form of activation. Lasers have been shown to be promising tools for this purpose (laser-activated irrigation (LAI)). For LAI to be effective...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1307-4
更新日期：2014-09-01 00:00:00
abstract：:The aim of this study was to determine whether it is safe to use photo-activated disinfection (PAD) during root canal treatment without heating the periodontal tissues. Root canals of 30 freshly extracted single-rooted teeth were prepared using ProFiles up to size ISO 40 and then filled with photo-sensitiser: tolonium...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0526-y
更新日期：2009-01-01 00:00:00
abstract：:The aim of this study was to evaluate the degree of conversion (DC) and to identify the viscoelastic properties: storage modulus (E'), loss modulus (E"), tangent delta (tan δ), and glass transition temperature (T g ) of a microhybrid resin-composite light-activated by three different protocols. A Filtek Z250 (3 M ESPE...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-014-1572-x
更新日期：2015-05-01 00:00:00
abstract：:The aim of this study was to evaluate the shear bond strength (SBS) of a microhybrid composite resin bonded with three different adhesive systems to Er:YAG laser- (EL) or bur-prepared dentin surfaces and to analyze the quality and ultrastructure of the adhesive-dentin interfaces by scanning electron microscopy (SEM). ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1424-0
更新日期：2015-02-01 00:00:00
