Abstract：
:We report results on the use of organically modified silica nanoparticles (SiNp) as a vehicle for the delivery of curcumin in human oral cancer cells for improvement of uptake and phototoxicity. Nanoformulated drug (curcumin-SiNp complex) was prepared by postloading curcumin in SiNp, and the complex was soluble in aqueous solution. Cellular uptake studied by fluorescence microscopy and spectroscopy showed that curcumin accumulation was higher when cells were incubated with curcumin-SiNp complex as against free curcumin. Studies carried out on incubation time-dependent cytotoxicity, inhibition of NF-κB activity, suppression of NF-κB-regulated proteins involved in invasion (MMP-9), angiogenesis (VEGF), and inflammation (TNF-α) showed that curcumin-SiNp leads to significant improvement over free curcumin in dark as well as on exposure to light.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Singh SP,Sharma M,Gupta PKdoi
10.1007/s10103-013-1357-7subject
Has Abstractpub_date
2014-03-01 00:00:00pages
645-52issue
2eissn
0268-8921issn
1435-604Xjournal_volume
29pub_type
杂志文章abstract：:Photofrin photodynamic therapy (PDT) is a licenced treatment for Barrett's oesophagus (BE) with high-grade dysplasia (HGD) but causes strictures and photosensitivity and complete reversal of dysplasia (CR-HGD) by 50 % at 5 years. 5-Aminolaevulinic acid (ALA) is an alternative treatment with non-randomised data suggest...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-012-1132-1
更新日期：2013-05-01 00:00:00
abstract：:Use of the CO(2) laser (λ = 10.6 μm, continuous wave, defocused) is an established procedure for the treatment of premalignant lesions. Through employment of the sp-mode as well as scanners, thermal laser effects can be reduced but, on the other hand, a lesser degree of destruction of dysplastic cells could lead to an...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-011-0910-5
更新日期：2012-01-01 00:00:00
abstract：:We report the results of endoscopic laser therapy on 59 patients with upper gastrointestinal vascular ectasia. After 300 sessions, complications were two nonbleeding and three bleeding ulcers, treated successfully with endoscopic therapy. After treatment, blood transfusions were abolished in 61% and reduced in 22% of ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-006-0389-7
更新日期：2006-09-01 00:00:00
abstract：:To evaluate the efficacy of short-term subthreshold micropulse yellow laser photocoagulation (SMYLP) on eyes with diabetic macular edema (DME) with different central foveal thicknesses (CFT). Eighty eyes of 40 patients who had previously undergone ranibizumab treatment for DME and who subsequently had recurrent macula...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-018-2672-9
更新日期：2019-07-01 00:00:00
abstract：:Biostimulatory effect of cell proliferation and bone formation by laser irradiation has been reported, however, very little is known about the molecular basis of mechanisms. We previously constructed the cDNA library of mouse osteoblastic cells (MC3T3-E1) which enhanced gene expression by laser irradiation using a sub...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/pl00011357
更新日期：2001-01-01 00:00:00
abstract：:To evaluate the efficacy and safety of holmium laser enucleation of prostate (HoLEP) for treating urinary retention in patients with advanced prostate cancer. Thirty-eight cases of advanced prostate cancer with urinary retention were enrolled in this retrospective study. All the 38 patients were treated with CAB as a ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02913-2
更新日期：2020-08-01 00:00:00
abstract：:The purpose of this study was to evaluate the thickness and qualitative characteristics of the hybrid layer after two cavity preparation methods, using Er:YAG laser in QSP mode and conventional carbide burs. Additionally, two different adhesive techniques were investigated using etch-and-rinse and self-etch adhesive s...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-018-2575-9
更新日期：2019-02-01 00:00:00
abstract：:Quantitative characterization of skin collagen on photo-thermal response and its regeneration process is an important but difficult task. In this study, morphology and spectrum characteristics of collagen during photo-thermal response and its light-induced remodeling process were obtained by second-harmonic generation...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1296-3
更新日期：2014-01-01 00:00:00
abstract：:The purposes of the study were to evaluate the bond strength of bioceramic TotalFill root repair material (RRM) in retrograde cavities prepared using Er:YAG and Er,Cr:YSGG laser and steel bur, and to analyze failure modes. The root canals of 30 single-rooted teeth were endodontically treated, their root-ends were rese...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02835-z
更新日期：2020-02-01 00:00:00
abstract：:The use of the CO(2) laser in the management of oral dysplastic lesions has become a more common practice. Very few studies have evaluated recurrence, residual disease malignant transformation, and overall outcome in patients undergoing such a procedure. In this prospective study, a total of 123 oral dysplastic lesion...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-011-0916-z
更新日期：2012-01-01 00:00:00
abstract：:Low-level laser therapy (LLLT), widely used in physiotherapy, has been known to enhance wound healing and stimulate cell proliferation, including fibroblast and endothelial cells. Applying LLLT can increase cell proliferation in many kinds of cells including fibroblasts and endothelial cells. However, the protective m...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2364-x
更新日期：2018-02-01 00:00:00
abstract：:We assess the long-term effect of pulsed high-intensity laser therapy (HILT) in the treatment of the post-mastectomy pain syndrome (PMPS). A total of 61 women participated in this study (30 in the laser group and 31 in the placebo laser group), with a mean age of 53.56 ± 1.11 years. Patients who were randomly assigned...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-015-1780-z
更新日期：2015-08-01 00:00:00
abstract：:The aim of the present study was to investigate and compare the effects of high intensity laser therapy (HILT) and low level laser therapy (LLLT) on the treatment of patients with Bell's palsy. Forty-eight patients participated in and completed this study. The mean age was 43 ± 9.8 years. They were randomly assigned i...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-013-1352-z
更新日期：2014-01-01 00:00:00
abstract：:Low-level laser therapy (LLLT) induces anti-inflammatory and angiogenic activities in wound healing. However, the mechanism of action and optimal parameters require further clarification. In this study, we investigated the effects of LLLT on wound healing matrix metalloproteinase (MMP)-2 immunoexpression and angiogeni...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-2080-y
更新日期：2017-01-01 00:00:00
abstract：:The in vivo photodynamic activities of four poly(ethylene glycol) (PEG) conjugates of the photosensitiser 5,10,15,20-tetrakis-(m-hydroxyphenyl)chlorin (mTHPC, temoporfin, Foscan(®)) were compared with that of mTHPC over a range of drug-light intervals using acute tumour necrosis and skeletal muscles swelling in a mous...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s101030050019
更新日期：1999-03-01 00:00:00
abstract：:Precise nerve localization is of major importance in both surgery and regional anesthesia. Optically based techniques can identify tissue through differences in optical properties, like absorption and scattering. The aim of this study was to evaluate the potential of optical spectroscopy (diffuse reflectance spectrosc...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2433-1
更新日期：2018-04-01 00:00:00
abstract：:Bothropic venom contains a range of biologically active substances capable of causing severe local and systemic envenoming symptomatology within its victims. The snake anti-venom is effective against systemic effects but has no neutralizing effect against the fast developing local effects. Herein, mice gastrocnemius i...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2252-4
更新日期：2017-08-01 00:00:00
abstract：:The objective of this study was to investigate the effect of Er:YAG laser irradiation on shear bond strength and microleakage between resin cements and yttrium-stabilized tetragonal zirconia (Y-TZP) ceramics. Eighty disc specimens of Y-TZP ceramics (6 mm × 4 mm) were prepared. The specimens were divided into two group...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0883-4
更新日期：2012-03-01 00:00:00
abstract：:Down syndrome (DS) has characteristics that include mental retardation, a characteristic phenotype, congenital heart defects, immune disorders, and increased risk of periodontal disease (PD). Antimicrobial photodynamic therapy (aPDT) is the combined use of photosensitizers associated with low-level laser (LLL) and oxy...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-016-2020-x
更新日期：2016-12-01 00:00:00
abstract：:Microvascular surgery is time consuming and requires high expertise. Laser-assisted vascular anastomosis (LAVA) is a promising sutureless technique that has the potential to facilitate this procedure. In this study, we evaluate the handling of our soldering material and the 1-week patency rate in a porcine model. Six ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2250-6
更新日期：2017-08-01 00:00:00
abstract：:The objective of this study was to evaluate the safety and efficacy of flexible ureteroscopy (FURS) and holmium:YAG laser lithotripsy for the treatment of upper urinary tract stones in patients on active oral anticoagulants. The records of 1081 patients who underwent flexible ureteroscopic holmium:YAG (Ho:YAG) laser l...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2289-4
更新日期：2017-09-01 00:00:00
abstract：:Onychomycosis is a fungal infection of the nail. The aim of this randomized controlled clinical trial was to compare the efficacy of 2940-nm Er:YAG laser treatment combined with a 5% amorolfine lacquer versus amorolfine monotherapy for treating onychomycosis. In this study, patients with onychomycosis of the great toe...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-020-03054-7
更新日期：2021-02-01 00:00:00
abstract：:Detection of demineralization of root surface caries is an important issue since preventive approaches prolong tooth life. Quantitative light-induced fluorescence (QLF) has been shown to be useful for the laboratory assessment of demineralization of root surfaces. The aim of this study was to determine the demineraliz...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0899-9
更新日期：2012-03-01 00:00:00
abstract：:Candida albicans is an opportunistic pathogen commensal in the oral cavity, vagina, and healthy skin. Common therapeutic options for fungal infections are topical or systemic antifungal drugs. Recently, in cutaneous pathologies, lasers and light-based treatments have emerged showing few contraindications and minimal s...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2407-3
更新日期：2018-07-01 00:00:00
abstract：:The neodymium/yttrium-aluminum-garnet (Nd/YAG) laser has been suggested to repair broken prostheses in the mouth. This study investigated the effects of different dentin thicknesses and air cooling on pulpal temperature rise during laser welding. Three intact human maxillary molars were prepared for full-veneer crown....
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1108-1
更新日期：2013-01-01 00:00:00
abstract：:Acne vulgaris is one of the most common dermatologic disorders encountered in everyday practice. Treatment options for this often psychologically scarring disease are numerous and, for many individuals, provide relief from the disorder. However, factors such as antibiotic resistance and slow onset of action from many ...
journal_title：Lasers in medical science
pub_type： 杂志文章,评审
doi：10.1007/s10103-006-0420-z
更新日期：2007-06-01 00:00:00
abstract：:The molecular changes in gene expression following ablative laser treatment of skin lesions, such as atrophic scars and UV-damaged skin, are not completely understood. A standardized in vitro model of human skin, to study the effects of laser treatment on human skin, has been recently developed. Therefore, the aim of ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2175-0
更新日期：2017-05-01 00:00:00
abstract：:Recent studies have demonstrated the beneficial effect of low-power lasers and polarized light on wound healing, inflammation, and the treatment of rheumatologic and neurologic disorders. The overall effect of laser irradiation treatment is still controversial due to the lack of studies on the biochemical mechanisms a...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2398-0
更新日期：2018-04-01 00:00:00
abstract：:Two-photon excited fluorescence (TPEF) microscopy, based on signal from cells, can provide detailed information on tissue architecture and cellular morphology in unstained histological sections to generate subcellular-resolution images from tissue directly. In this paper, we used TPEF microscopy to image microstructur...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-014-1652-y
更新日期：2015-01-01 00:00:00
abstract：:Epithelial cells play an important role in reparative events. Therefore, therapies that can stimulate the proliferation and metabolism of these cells could accelerate the healing process. To evaluate the effects of low-level laser therapy (LLLT), human keratinocytes were irradiated with an InGaAsP diode laser prototyp...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1057-8
更新日期：2013-02-01 00:00:00
