Abstract:
:Recent studies have demonstrated the beneficial effect of low-power lasers and polarized light on wound healing, inflammation, and the treatment of rheumatologic and neurologic disorders. The overall effect of laser irradiation treatment is still controversial due to the lack of studies on the biochemical mechanisms and the optimal parameters for the incident light that should be chosen for particular applications. Here, we study how NIH/3T3 fibroblasts respond to irradiation with linearly polarized light at different polarization angles. In particular, we examined vascular endothelial growth factor (VEGF) secretion, differentiation to myofibroblasts, and collagen organization in response to 800 nm polarized light at 0°, 45°, 90°, and 135° with a power density of 40 mW/cm2 for 6 min every day for 6 days. Additional experiments were conducted in which the polarization angle of the incident was changed every day to induce an isotropic distribution of collagen. The data presented here shows that polarized light can upregulate VEGF production, myofibroblast differentiation, and induce different collagen organization in response to different polarization angles of the incident beam. These results are encouraging and demonstrate possible methods for controlling cell response through the polarization angle of the laser light, which has potential for the treatment of wounds.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Akilbekova D,Boddupalli A,Bratlie KMdoi
10.1007/s10103-017-2398-0subject
Has Abstractpub_date
2018-04-01 00:00:00pages
539-547issue
3eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-017-2398-0journal_volume
33pub_type
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journal_title:Lasers in medical science
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doi:10.1007/s10103-017-2301-z
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journal_title:Lasers in medical science
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