Abstract：
:The in vivo photodynamic activities of four poly(ethylene glycol) (PEG) conjugates of the photosensitiser 5,10,15,20-tetrakis-(m-hydroxyphenyl)chlorin (mTHPC, temoporfin, Foscan(®)) were compared with that of mTHPC over a range of drug-light intervals using acute tumour necrosis and skeletal muscles swelling in a mouse model in order to ascertain the influence of linking group stability and PEG chain length on the photodynamic activity. The four compounds examined contained either PEG 2000 or PEG 5000 attached by carbonate or triazine linkages at the phenol hydroxyl groups of the mTHPC.All compounds tested caused tumour necrosis at drug-light intervals of between one and four days. mTHPC produced tumour necrosis of over 5 mm at drug-light intervals of 1 and 2 days with limited muscle damage at early drug-light intervals. The relatively labile carbonate-linked conjugates gave tumour necrosis similar to mTHPC but produced severe muscle and systemic phototoxicity on irradiation at 4-24 h after injection. The more stable triazine-linked conjugates produced no significant muscle damage at any of the drug-light intervals tested, but gave only limited tumour necrosis under the conditions tested. PEG chain length had relatively little effect on the patterns of bioactivity.It is concluded that both classes of mTHPC PEG conjugates may be suitable for photodynamic therapy if the problems of stability and early photosensitivity in the case of the carbonates and reduced potency in the case of the triazines can be overcome through improved formulations and PDT treatment regimens.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Grahn MF,Giger A,McGuinness A,de Jode ML,Stewart JC,Ris HB,Altermatt HJ,Williams NSdoi
10.1007/s101030050019subject
Has Abstractpub_date
1999-03-01 00:00:00pages
40-6issue
1eissn
0268-8921issn
1435-604Xjournal_volume
14pub_type
杂志文章abstract：:We report the use of spectral domain polarization sensitive optical coherence tomography for ex-vivo imaging of human oral mandibular tissue samples. Our results show that compared to the changes observed in the epithelium thickness and the decay constant of A-scan intensity profile, a much larger degree of change was...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-2096-3
更新日期：2017-01-01 00:00:00
abstract：:The bond strength of resin composite to Er,Cr:YSGG laser-irradiated enamel and dentin has been evaluated in only a few studies. Therefore, we measured and compared the micro-shear bond strength of composite restorations to enamel and dentin using two different cavity-preparation tools and conditioning methods. One hun...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0961-7
更新日期：2012-07-01 00:00:00
abstract：:This study aimed to assess the effect of toluidine blue (TB)-mediated photodynamic inactivation of periodontal pathogens (PP) from periodontopathic patients. Photodynamic therapy (PDT) was carried out using TB and 635 nm laser light irradiation. The bactericidal effect was evaluated, and important PDT parameters inclu...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0454-x
更新日期：2008-01-01 00:00:00
abstract：:Facial freckles are a cosmetic concern to Egyptians, particularly young females. Several therapeutic lines exist with variable response rates and limitations. Fractional carbon dioxide (FCO2) laser provides minimal ablation and therefore less down time and less side effects. The efficacy and safety of this laser techn...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-014-1610-8
更新日期：2014-11-01 00:00:00
abstract：:Papacarie Duo™ is clinically used and has proven effectiveness; however, it is necessary to improve its antimicrobial action. The combined treatment of Papacarie Duo™ with Urucum (Bixa Orellana) could create a potential tool for dental caries treatment; its extract obtained from the seeds' pericarp contains a water-so...
journal_title：Lasers in medical science
pub_type： 信件
doi：10.1007/s10103-019-02857-7
更新日期：2020-04-01 00:00:00
abstract：:Compensatory hypertrophy (CH) occurs due to excessive mechanical load on a muscle, promoting an increase in the size of muscle fibers. In clinical practice, situations such as partial nerve injuries, denervation, and muscle imbalance caused by trauma to muscles and nerves or diseases that promote the loss of nerve con...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-020-03095-y
更新日期：2020-07-07 00:00:00
abstract：:Bothropic venom contains a range of biologically active substances capable of causing severe local and systemic envenoming symptomatology within its victims. The snake anti-venom is effective against systemic effects but has no neutralizing effect against the fast developing local effects. Herein, mice gastrocnemius i...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2252-4
更新日期：2017-08-01 00:00:00
abstract：:The purpose of this in vitro study was to observe the morphological changes and apical dye penetration at apical dentin surfaces after apicoectomy with conventional techniques and laser beam. Sixty single-rooted extracted teeth were selected for the study. The crowns were resected below the cemento-enamel junction. Th...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0497-z
更新日期：2008-10-01 00:00:00
abstract：:The effect of low-level laser therapy (LLLT) on the cardiovascular system is not fully established. Since the endothelium is an important endocrine element, establishing the mechanisms of LLLT action is an important issue.The aim of the study was to evaluate the effect of transdermal LLLT on endothelial function.In th...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-016-1971-2
更新日期：2016-09-01 00:00:00
abstract：:The aim of this study is to analyze the effect of agitation of ethylenediaminetetraacetic acid (EDTA) with diode laser at different agitation times on root dentin microhardness. Eighty-four specimens were divided randomly into seven groups, as follows: (1) distilled water, (2) 17% EDTA, (3) EDTA with 60 s ultrasonic a...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1364-8
更新日期：2015-02-01 00:00:00
abstract：:Liquid-assisted hard tissue ablation by infrared lasers has extensive clinical application. However, detailed studies are still needed to explore the underlying mechanism. In the present study, the dynamic process of bubble evolution induced by Ho:YAG laser under water without and with bone tissue at different thickne...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-1931-x
更新日期：2016-07-01 00:00:00
abstract：:The present study aimed to evaluate in vitro whether the low-level laser (LLL) delivering fractionated total energy (multiple irradiation) or single irradiation stimulates regeneration-associated events (viability and proliferation) in stem cells from human exfoliated deciduous teeth (SHED). Cells received LLL irradia...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-019-02836-y
更新日期：2019-12-01 00:00:00
abstract：:Photodynamic therapy (PDT) is used for the prevention and treatment of non-melanoma skin cancer. Until recently, clinically approved indications have been restricted to actinic keratoses, nodular and superficial basal cell carcinoma, and, since 2006, Bowen disease. However, the range of indications has been expanding ...
journal_title：Lasers in medical science
pub_type： 杂志文章,评审
doi：10.1007/s10103-009-0716-x
更新日期：2009-11-01 00:00:00
abstract：:Bone morphogenetic proteins (BMPs) are secreted signaling molecules belonging to the transforming growth factor-beta (TGF-beta) superfamily. The objective of this study was to determine how gallium-aluminum-arsenium (GaAlAs) 650 nm laser influenced the action of BMPs on bone defects created in rat femurs. The sample c...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-008-0595-6
更新日期：2009-09-01 00:00:00
abstract：:Since the introduction of laser in clinical practice, different wavelengths have been used for oral surgery on the basis of the different characteristics and affinities of each one. The aim of this study was a comparison of different laser wavelengths in relation to both thermal increase and "histological quality" in ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1081-8
更新日期：2013-02-01 00:00:00
abstract：:Candida albicans is an opportunistic pathogen commensal in the oral cavity, vagina, and healthy skin. Common therapeutic options for fungal infections are topical or systemic antifungal drugs. Recently, in cutaneous pathologies, lasers and light-based treatments have emerged showing few contraindications and minimal s...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2407-3
更新日期：2018-07-01 00:00:00
abstract：:The objective of this study was to evaluate the microbiological and clinical outcomes following nonsurgical treatment by either scaling and root planing, combination of Nd:YAG and Er:YAG lasers, or by Er:YAG laser treatment alone. The study involved 60 patients with generalized chronic periodontitis, randomly assigned...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-018-2491-z
更新日期：2018-09-01 00:00:00
abstract：:Photosensitizers belonging to the boron-dipyrromethenes (BODIPYs) class were recently found endowed with good efficacy in the antibacterial photodynamic therapy (aPDT) against both Gram-positive and Gram-negative bacteria. In this paper, we report on the remarkable adjuvant effect exerted in this respect by linear pol...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2345-0
更新日期：2018-08-01 00:00:00
abstract：:High-intensity focused ultrasound (HIFU) can be applied noninvasively to create focused zones of tissue coagulation on various skin layers. We performed a comparative study of HIFU, evaluating patterns of focused tissue coagulation and ablation upon application thereof. A tissue-mimicking (TM) phantom was prepared wit...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-015-1804-8
更新日期：2015-12-01 00:00:00
abstract：:The present investigation focuses on understanding the role of photobiomodulation in enhancing tissue proliferation. Circular excision wounds of diameter 1.5 cm were created on Swiss albino mice and treated immediately with 2 J/cm2 and 10 J/cm2 single exposures of the Helium-Neon laser along with sham-irradiated contr...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-020-03202-z
更新日期：2020-11-27 00:00:00
abstract：:Low-level laser therapy (LLLT) is a form of photon therapy which can be a non-invasive therapeutic procedure in cancer therapy using low-intensity light in the range of 450-800 nm. One of the main functional features of laser therapy is the photobiostimulation effects of low-level lasers on various biological systems ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-2049-x
更新日期：2016-12-01 00:00:00
abstract：:Our previous in vitro study has shown that toluidine blue (TB)-mediated lethal photosensitization of periodontal pathogens (PPs) from periodontal patients is possible. The purpose of this study was to investigate whether TB-mediated photosensitization exerted damaging effects on periodontal tissues in mice. Twenty-fou...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0513-3
更新日期：2009-03-01 00:00:00
abstract：:Skin flaps are still a matter of concern among surgeons, as failures can occur leading to flap necrosis. However, low-level laser irradiation has been reported as an effective tool to improve the viability of ischemic flaps, yet its mechanisms of action remain unclear. We investigated the effect of low-level laser irr...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-1011-1
更新日期：2012-05-01 00:00:00
abstract：:Minimal hepatic encephalopathy (MHE) has been shown to affect daily functioning, quality of life, driving and overall mortality. However, little is known about treating or diagnosing early impairments involved in MHE. We studied one of its precipitating factors, portal hypertension. The purpose was to evaluate an enha...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-016-2042-4
更新日期：2016-11-01 00:00:00
abstract：:The authors tested the diagnostic potential of the portable autofluorescence optical system that was developed in the preoperative evaluation of resection margins, and thus of the resection line safety in patients with low-positioned colorectal carcinoma. A total of 217 spectral measurements of the fluorescence proper...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-010-0847-0
更新日期：2011-05-01 00:00:00
abstract：:The aim of this study was to histologically and biochemically analyze the effects of light-emitting diode therapy (LEDT) associated with resistance training to prevent sarcopenia in ovariectomized rats. Forty female Wistar rats (12 months old, 295-330 g) were bilaterally ovariectomized and divided into four groups (n ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1251-8
更新日期：2013-11-01 00:00:00
abstract：:Endometriosis is a chronic disease affecting mainly women of the reproductive age. Its most common manifestations include impaired fecundity, pelvic pain, and dyschezia. Laparoscopic removal of endometriotic foci remains to be the gold standard for the treatment of endometriosis. More effective techniques of endoscopi...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-014-1630-4
更新日期：2015-01-01 00:00:00
abstract：:Laser angioplasty has been evaluated for coronary applications since the early 1980s. Early complications of dissection, perforation and thermal injury led to a loss of enthusiasm for this technique. Recent advances in catheter development, including optimally spaced laser fibres, athermic 308 nm wave-length catheters...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/pl00011338
更新日期：2001-01-01 00:00:00
abstract：:The objective of this study was to assess the effects of 780-nm low-level laser therapy at different periods of 7, 14 and 21 days after cryolesion, including the dose (10 or 50 J/cm(2)), to promote a better muscle repair evidenced by histopathological and immunohistochemical analyses. Fifty-four male rats were divided...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1277-6
更新日期：2014-01-01 00:00:00
abstract：:This study aimed to analyze the effects of light-emitting diode (LED) therapy on sternotomy pain and healing in patients who underwent coronary artery bypass grafting (CABG). The patients were followed for 6 months after the surgery to determine their dehiscence. This study was conducted with 90 volunteers who electiv...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-013-1503-2
更新日期：2014-05-01 00:00:00
