Abstract：
:Low-level laser therapy (LLLT) induces anti-inflammatory and angiogenic activities in wound healing. However, the mechanism of action and optimal parameters require further clarification. In this study, we investigated the effects of LLLT on wound healing matrix metalloproteinase (MMP)-2 immunoexpression and angiogenic processes. Twenty female Wistar rats were randomly divided into four groups (n = 5) according to the treatments as follows. CG7 and CG14 were control groups at days 7 and 14, respectively, which received physiological saline (0.9 % NaCl daily). LG7 and LG14 were laser therapy groups at days 7 and 14, respectively, which received two (LG7) or four (LG14) LLLT applications (40 mW; 660 nm; 4 J/cm2). A dorsal skin sample in the wound area (measuring 2 cm2) was removed after the experimental period, and then the animals were euthanized. The specimens were processed for qualitative and quantitative histological analyses and measurement of MMP-2 expression in the dermis and epidermis. A persistent crust and moderate number of inflammatory cells were found in CG7 and CG14 groups. In the LG14 group, wounds demonstrated complete re-epithelization at the remodeling phase. Angiogenesis and MMP-2 expression were higher in LLLT-treated groups, particularly the LG14 group, which correlated according to the Spearman correlation test. LLLT improves wound healing by enhancing neocollagenesis, increasing the amount of new vessels formed in the tissue (neoangiogenesis), and modulating MMP-2 expression. Epidermal overexpression of MMP-2 was correlated to angiogenic processes.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
de Medeiros ML,Araújo-Filho I,da Silva EM,de Sousa Queiroz WS,Soares CD,de Carvalho MG,Maciel MAdoi
10.1007/s10103-016-2080-ysubject
Has Abstractpub_date
2017-01-01 00:00:00pages
35-43issue
1eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-016-2080-yjournal_volume
32pub_type
杂志文章abstract：:Fungal infection of nails, onychomycosis, is predominantly caused by Trichophyton rubrum. This infection is an important public health concern due to its persistent nature and high recurrence rates. Alternative treatments are urgently required. One such alternative is phototherapy involving the action of photothermal ...
journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
pub_type： 杂志文章,meta分析
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abstract：:Previous in vivo and in vitro studies have reported that low-level diode laser therapy induces a biostimulatory effect, such as cell proliferation. The aim of the present study was to evaluate whether the laser irradiation of osteoblast-like cells (MG-63) can modify alkaline phosphatase activity (ALP), antigenic profi...
journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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更新日期：2014-11-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2301-z
更新日期：2017-09-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1057-8
更新日期：2013-02-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0964-4
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journal_title：Lasers in medical science
pub_type： 杂志文章,评审
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更新日期：2021-01-03 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s101030050036
更新日期：1999-06-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
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更新日期：2015-12-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2010-09-01 00:00:00
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
abstract：:Low-level red laser (LLRL)-tissue interactions have a wide range of medical applications and are garnering increased attention. Although the positive effects of low-level laser therapy (LLLT) have frequently been reported and enhanced collagen accumulation has been identified as one of the most important mechanisms in...
journal_title：Lasers in medical science
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