当前位置： SCI文献检索 > LASERS IN MEDICAL SCIENCE期刊下所有文献 > CO2 laser of oral dysplasia: clinicopathological features of recurrence and malignant transformation.

CO2 laser of oral dysplasia: clinicopathological features of recurrence and malignant transformation.

Abstract：

:The use of the CO(2) laser in the management of oral dysplastic lesions has become a more common practice. Very few studies have evaluated recurrence, residual disease malignant transformation, and overall outcome in patients undergoing such a procedure. In this prospective study, a total of 123 oral dysplastic lesions from 77 consecutive patients were treated with the CO(2) laser (resection and/or ablation). The average age was 58 ± 4.8 years. The patients' recovery was uneventful and no complications were reported. Comparisons with the clinical and histopathological features and rate of recurrence as well as malignant transformation were made. The patients were followed-up for a mean of 6.4 years, and biopsies taken in case of changes suggestive of malignant development. Homogenous leukoplakias were identified in 31 patients, non-homogenous leukoplakias in 34 patients, whereas 12 patients had erythroplakias. Ex- and life-long smokers formed 88.3% of the recruited patients. While people who currently smoke and drink formed 55.8% of the cohort. Erythroplakias were solely identified in heavy life-long smokers. The most common identified primary anatomical locations were the lateral border of tongue, floor of mouth, and buccal mucosa. Moderate dysplasia was identified in 42 patients while 18 patients had severe dysplasia. Laser resection margins in selected cases (68 patients) were clear in 53 and showed mild-moderate dysplasia in the involved margins. The rate of recurrence had no significant association with the location but the severity of epithelial dysplasia. The rate of first recurrence after laser surgery was approximately 19.5%. Malignant transformation was observed in eight patients (10.4%), in the tongue and the floor of mouth. Recurrence and malignant transformation was mainly identified in erythroplakias and non-homogenous leukoplakias. Laser resection/ablation is recommended for oral dysplasia to prevent not only recurrence and malignant transformation but also postoperative oral dysfunction encountered by other conventional modalities.

journal_name

Lasers Med Sci

journal_title

Lasers in medical science

authors

Jerjes W,Upile T,Hamdoon Z,Al-Khawalde M,Morcos M,Mosse CA,Hopper C

doi

10.1007/s10103-011-0916-z

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

169-79

issue

eissn

0268-8921

issn

1435-604X

journal_volume

pub_type

临床试验,杂志文章

在线工具

CO2 laser of oral dysplasia: clinicopathological features of recurrence and malignant transformation.