Abstract：
:Alopecia areata (AA) is a common autoimmune disease that presents with non-scarring alopecia. It is characterized by intra- or peri-follicular lymphocytic infiltrates composed of CD4+ and CD8+ T-cells on histology. To this day, few treatments are effective for AA. Here we present findings of using a low-level laser comb to alleviate the symptoms of AA in a C3H/HeJ mouse model for AA. Fourteen C3H/HeJ mice with induced AA were used in this study. Two were killed to confirm AA through histology. The remaining 12 mice were randomized into two groups; group I received HairMax LaserComb (wavelength: 655 nm, beam diameter <5 mm; divergence 57 mrad; nine lasers) for 20 s daily, three times per week for a total of 6 weeks; group II was treated similarly, except that the laser was turned off (sham-treated). After 6 weeks of LaserComb treatment, hair regrowth was observed in all the mice in group I (laser-treated) but none in group II (sham-treated). On histology, increased number of anagen hair follicles was observed in laser-treated mice. On the other hand, sham-treated mice demonstrated hair follicles in the telogen phase with no hair shaft. LaserComb seems to be an effective and convenient device for the treatment of AA in the C3H/HeJ mouse model. Human studies are required to determine the efficacy and safety of this device for AA therapy.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Wikramanayake TC,Rodriguez R,Choudhary S,Mauro LM,Nouri K,Schachner LA,Jimenez JJdoi
10.1007/s10103-011-0953-7subject
Has Abstractpub_date
2012-03-01 00:00:00pages
431-6issue
2eissn
0268-8921issn
1435-604Xjournal_volume
27pub_type
杂志文章abstract：:This study aimed to assess the effect of toluidine blue (TB)-mediated photodynamic inactivation of periodontal pathogens (PP) from periodontopathic patients. Photodynamic therapy (PDT) was carried out using TB and 635 nm laser light irradiation. The bactericidal effect was evaluated, and important PDT parameters inclu...
journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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abstract：:According to the standard Arrhenius relation, tissue damage is linearly dependent on the duration of exposure to elevated temperatures and exponentially dependent on the temperature itself. However, recently published measurements of damage threshold temperatures at extremely short exposure times (commonly present dur...
journal_title：Lasers in medical science
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journal_title：Lasers in medical science
pub_type： 杂志文章
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abstract：:There are many laser technologies that are being tested that claim to support hair regrowth for patients with alopecia areata (AA). In this paper, we will determine whether the body of evidence supports the use of devices using monochromatic light sources to treat AA. Articles were gathered from PubMed, Embase, and th...
journal_title：Lasers in medical science
pub_type： 杂志文章,meta分析,评审
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
pub_type： 杂志文章
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
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更新日期：2011-11-01 00:00:00
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
pub_type： 杂志文章,评审
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
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journal_title：Lasers in medical science
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journal_title：Lasers in medical science
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