Abstract：
:There are many laser technologies that are being tested that claim to support hair regrowth for patients with alopecia areata (AA). In this paper, we will determine whether the body of evidence supports the use of devices using monochromatic light sources to treat AA. Articles were gathered from PubMed, Embase, and the Cochrane database using these keywords: lasers, excimer laser, low-level laser therapy (LLLT), low-level light therapy, alopecia, alopecia areata, and hair loss with a category modifier of English. Ten clinical trials and seven case reports/abstracts were assessed. Eight clinical trials and two case reports demonstrated hair regrowth with the 308-nm excimer laser/light in men, women, and children. One case report demonstrated hair regrowth with the ALBA 355® laser. One clinical trial and two case reports demonstrated hair regrowth with LLLT. While two case reports demonstrated hair regrowth with fractional laser therapy, one clinical trial showed no improvement. The 308-nm excimer laser is a safe and effective treatment for men, women, and children with refractory AA of the scalp and beard. Larger, double-blinded clinical trials should be conducted to compare excimer laser therapy to standard treatments. More data is needed to determine the efficacy of LLLT and fractional laser therapy in the treatment of AA.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Darwin E,Arora H,Hirt PA,Wikramanayake TC,Jimenez JJdoi
10.1007/s10103-017-2412-6subject
Has Abstractpub_date
2018-02-01 00:00:00pages
435-444issue
2eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-017-2412-6journal_volume
33pub_type
杂志文章,meta分析,评审abstract：:In root canal therapy, irrigating solutions are essential to assist in debridement and disinfection. Their spread and action is often restricted by canal anatomy, requiring some form of activation. Lasers have been shown to be promising tools for this purpose (laser-activated irrigation (LAI)). For LAI to be effective...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-013-1307-4
更新日期：2014-09-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of cavity preparation with Er:YAG laser on dentin adjacent to restorations submitted to cariogenic challenge in situ, by subsuperficial microhardness analysis. Bovine incisors were sectioned, flattened, and polished, resulting in 40 dentin slabs. The slabs were randomly...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-016-2136-z
更新日期：2017-02-01 00:00:00
abstract：:The aim of this in vitro study was to assess the effect of Er:YAG laser surface treatment on the tensile bond strength of a sealant in permanent teeth. A total of 30 sound third molars were selected and embedded in cold-cure acrylic resin. The enamel surfaces were flattened by a grinding. The teeth were randomly divid...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-010-0869-7
更新日期：2012-03-01 00:00:00
abstract：:The Achilles tendon has a high incidence of rupture, and the healing process leads to a disorganized extracellular matrix (ECM) with a high rate of injury recurrence. To evaluate the effects of different conditions of low-level laser (LLL) application on partially tenotomized tendons, adult male rats were divided into...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1236-7
更新日期：2013-09-01 00:00:00
abstract：:Laser beam deflection is a useful tool for studying the dynamics of the pulsed laser ablation mechanism, and has the advantage of being used as an in situ laser damage monitoring technique for both bulk and thin film polymeric and biological tissue samples. This work employs the photothermal deflection technique to st...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/BF02767153
更新日期：1997-12-01 00:00:00
abstract：:A novel skin phantom is described that is constructed with quantifiable amounts of skin pigments, as well as a light scattering medium in the form of barium sulphate suspension. The two predominant skin pigments (melanin and haemoglobin) are varied in controlled amounts within the phantoms to simulate skin colour in d...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0495-1
更新日期：2008-10-01 00:00:00
abstract：:The purpose of this in vitro study was to observe the morphological changes and apical dye penetration at apical dentin surfaces after apicoectomy with conventional techniques and laser beam. Sixty single-rooted extracted teeth were selected for the study. The crowns were resected below the cemento-enamel junction. Th...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-007-0497-z
更新日期：2008-10-01 00:00:00
abstract：:Transoral laser microsurgery (TLM) is an emerging technique for the management of laryngeal and other head and neck malignancies. It is increasingly being used in place of traditional open surgery because of lower morbidity and improved organ preservation. Since the surgery is performed from the inside working outward...
journal_title：Lasers in medical science
pub_type： 杂志文章,评审
doi：10.1007/s10103-010-0834-5
更新日期：2011-01-01 00:00:00
abstract：:Oral lichen planus (OLP) is an inflammatory disease that can be painful, mainly in the atrophic and erosive forms. Numerous drugs have been used with dissimilar results, but most treatments are empirical. However, to date, the most commonly employed and useful agents for the treatment of OLP are topical corticosteroid...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-013-1313-6
更新日期：2014-01-01 00:00:00
abstract：:Nonablative skin rejuvenation using laser, intense pulsed lights (IPLs), or radiofrequency techniques are becoming increasingly popular. In this paper, a novel protocol that integrates IPL sessions, low intense light and vitamin C, low-weight hyaluronic acid, betaglucan dermal injection versus IPL photorejuvenation as...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s10103-007-0456-8
更新日期：2008-04-01 00:00:00
abstract：:The aim of this study was to investigate the effect of different working modes (pulsed and micropulsed) and power settings of a standardized 980-nm diode laser on collateral thermal soft-tissue damage. A total of 108 bovine liver samples were cut with a diode laser at various settings in pulsed and micropulsed mode an...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-1007-x
更新日期：2012-09-01 00:00:00
abstract：:Precise nerve localization is of major importance in both surgery and regional anesthesia. Optically based techniques can identify tissue through differences in optical properties, like absorption and scattering. The aim of this study was to evaluate the potential of optical spectroscopy (diffuse reflectance spectrosc...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2433-1
更新日期：2018-04-01 00:00:00
abstract：:The efficacy of intense pulsed light (IPL) in remodeling the extracellular matrix of aged skin had been proven by an increasing number of clinical trials. However, because of the lack of research about the underlying molecular and signaling mechanisms, its efficiency had not been accepted universally. A potential mech...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-010-0870-1
更新日期：2011-05-01 00:00:00
abstract：:The bond strength of resin composite to Er,Cr:YSGG laser-irradiated enamel and dentin has been evaluated in only a few studies. Therefore, we measured and compared the micro-shear bond strength of composite restorations to enamel and dentin using two different cavity-preparation tools and conditioning methods. One hun...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0961-7
更新日期：2012-07-01 00:00:00
abstract：:Endometriosis is a chronic disease affecting mainly women of the reproductive age. Its most common manifestations include impaired fecundity, pelvic pain, and dyschezia. Laparoscopic removal of endometriotic foci remains to be the gold standard for the treatment of endometriosis. More effective techniques of endoscopi...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-014-1630-4
更新日期：2015-01-01 00:00:00
abstract：:This study evaluated the microhardness and polymerization shrinkage of flowable resins that are cured using different light sources. Seven flowable resins and two light sources (diode-pumped solid-state (DPSS) laser (LAS) and Optilux 501 (OP)) were chosen for the study. To evaluate the microhardness, a mold (height: 2...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0964-4
更新日期：2012-07-01 00:00:00
abstract：:Laser therapy has proved effective in the treatment of different tissue injuries but little is known about its effect on the testis. The aim of this review was to synthesize research on the in vivo effect of low-level laser therapy on the seminiferous epithelium. A search was performed in the PubMed/Medline, Scopus, W...
journal_title：Lasers in medical science
pub_type： 杂志文章,评审
doi：10.1007/s10103-020-03122-y
更新日期：2020-08-19 00:00:00
abstract：:The aim of this study was to identify biochemical changes in sciatic nerve (SN) after crush injury and low-level laser therapy (LLLT) with 660 nm and 808 nm by Raman spectroscopy (RS) analysis. A number of 32 Wistar rats were used, divided into four groups (control 1, control 2, LASER 660 nm, and LASER 808 nm). All an...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-018-2627-1
更新日期：2019-04-01 00:00:00
abstract：:Onychomycosis is a fungal infection of the nail. The aim of this randomized controlled clinical trial was to compare the efficacy of 2940-nm Er:YAG laser treatment combined with a 5% amorolfine lacquer versus amorolfine monotherapy for treating onychomycosis. In this study, patients with onychomycosis of the great toe...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-020-03054-7
更新日期：2021-02-01 00:00:00
abstract：:Inflammation of synovial membrane and degeneration of articular cartilage in osteoarthritis (OA) lead to major changes in joint space width (JSW) and biochemical components such as collagen-II telopeptide (CTX-II) and matrix metallo protineases (MMP-3, 8, and 13). Low-level laser therapy (LLLT) is thought to have an a...
journal_title：Lasers in medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10103-016-2114-5
更新日期：2017-02-01 00:00:00
abstract：:Physical stimulation of body surface points is known to affect various organ functions. In traditional Chinese medicine, so-called acupoints were defined. These points can be physically stimulated to effectively treat various diseases. Here we describe for the first time the effect of CO(2) laser stimulation at the ac...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-011-0973-3
更新日期：2012-03-01 00:00:00
abstract：:Lasers have many favorable features as a light source owing to their monochromaticity and coherence. This study examined the mechanical properties of composite resins that were light-cured using a diode-pumped solid state (DPSS) laser. Eight composite resins were light-cured using four different light sources (one qua...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-012-1117-0
更新日期：2013-02-01 00:00:00
abstract：:This study aimed to investigate the influence of low-power gallium-aluminium-arsenide (GaAlAs) laser [830 nm, continuous wave (CW), 40 mW and fluence 4 J/cm(2)] on the healing of surgically created bone defects in rats treated with bioactive glass graft material. Surgical bone defects were created in the mandibles of ...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-008-0590-y
更新日期：2009-07-01 00:00:00
abstract：:Delivery of intradermally focused nanosecond laser pulses with small energy as an alternate technique applicable to clinical procedures in dermatological and plastic surgery is an area of relatively new interest with multiple potential applications. We assessed this approach on common tattoo pigments in dermis in an i...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s101030200025
更新日期：2002-01-01 00:00:00
abstract：:Macular amyloidosis (MA) is a common form of primary localized cutaneous amyloidosis, characterized by the eruption of brown pigments of the skin with a rippled pattern. MA can be of cosmetic concern for patients, and its treatment is challenging. In this study, we aimed to find new effective approaches for MA treatme...
journal_title：Lasers in medical science
pub_type： 临床试验,杂志文章
doi：10.1007/s10103-020-02954-y
更新日期：2020-07-01 00:00:00
abstract：:In an in vitro study, the effect of light polarization on the efficiency of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) of basal cell carcinoma (BCC) was investigated. Three states of light polarization (non-polarized, linearly polarized, and circularly polarized) were considered. Cells were exposed to gre...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s10103-017-2369-5
更新日期：2018-02-01 00:00:00
abstract：:The bactericidal activity of a pulsed fibre-optic Nd-YAP laser on various strains of oral bacteria: Prevotella nigrescens, Streptococcus sanguis, Actinomyces viscosus (i), Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans and Peptostreptococcus micros (i) was evaluated. A 200-μm optical fibre was placed in...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s101030050010
更新日期：1998-12-01 00:00:00
abstract：:Acne vulgaris is one of the most common dermatologic disorders encountered in everyday practice. Treatment options for this often psychologically scarring disease are numerous and, for many individuals, provide relief from the disorder. However, factors such as antibiotic resistance and slow onset of action from many ...
journal_title：Lasers in medical science
pub_type： 杂志文章,评审
doi：10.1007/s10103-006-0420-z
更新日期：2007-06-01 00:00:00
abstract：:Acupuncture is a form of traditional Chinese medicine that has developed over thousands of years. We studied the effects of laser puncture, needle acupuncture, and light stimulation on cerebral blood flow in 15 healthy volunteers (mean age 25.0±1.9 years, 5 female, 10 male) with non-invasive transcranial Doppler sonog...
journal_title：Lasers in medical science
pub_type： 杂志文章
doi：10.1007/s101030050048
更新日期：2000-01-01 00:00:00
abstract：:Knee osteoarthritis (KOA) is a common degenerative disease in which several treatments and treatment associations have been investigated. This review analyzed the efficacy of the association of photobiomodulation therapy (PBMT) and exercises for people with KOA in randomized controlled clinical trials. PubMed, Scopus,...
journal_title：Lasers in medical science
pub_type： 杂志文章,评审
doi：10.1007/s10103-020-03223-8
更新日期：2021-01-03 00:00:00
