Abstract:
:This study assessed the effect of curcumin as a photosensitizer in antimicrobial photodynamic therapy (aPDT) for the treatment of induced periodontitis in rats. Periodontitis was induced via a ligature around the mandibular first molar on the left side of 96 rats. The ligature was removed 7 days later, and the animals were randomized into four groups: NT, no local treatment; CUR, irrigation with curcumin solution (40 μM); LED, irradiation with a light-emitting diode (LED, InGaN, 465-485 nm, 200 mW/cm2, 60 s); and aPDT, irrigation with curcumin solution (40 μM) followed by irradiation with LED. Eight animals from each group were euthanized at 7, 15, and 30 days post-treatment. Treatments were assessed using alveolar bone loss (ABL) in the furcation region using histological, histometric, and immunohistochemical analyses. Rats treated with aPDT exhibited less ABL at 7 days compared to the NT group, moderate pattern immunolabeling for osteoprotegerin at 30 days, and a pattern of immunolabeling for RANKL from moderate to low. Treatments resulted in smaller numbers of TRAP-positive cells compared to the NT group. aPDT as monotherapy using curcumin as a photosensitizer and LED as the light source was effective in the treatment of induced periodontitis in rats.
journal_name
Lasers Med Scijournal_title
Lasers in medical scienceauthors
Theodoro LH,Ferro-Alves ML,Longo M,Nuernberg MAA,Ferreira RP,Andreati A,Ervolino E,Duque C,Garcia VGdoi
10.1007/s10103-017-2261-3subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1783-1791issue
8eissn
0268-8921issn
1435-604Xpii
10.1007/s10103-017-2261-3journal_volume
32pub_type
杂志文章abstract::Recent studies have shown that direct laser metal sintering (DLMS) produces structures with complex geometry and consequently that allow better osteoconductive properties. The aim of this patient report was to evaluate the early bone response to DLMS implant surface retrieved from human jaws. Four experimental DLMS im...
journal_title:Lasers in medical science
pub_type: 杂志文章
doi:10.1007/s10103-010-0831-8
更新日期:2011-01-01 00:00:00
abstract::There are many laser technologies that are being tested that claim to support hair regrowth for patients with alopecia areata (AA). In this paper, we will determine whether the body of evidence supports the use of devices using monochromatic light sources to treat AA. Articles were gathered from PubMed, Embase, and th...
journal_title:Lasers in medical science
pub_type: 杂志文章,meta分析,评审
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abstract::In order to design and manufacture a reliable biomedical sensor, sensitive tests have to be performed. This is of superlative importance as it has to be used for the general public. Keeping this into account, the test mechanism of such an extremely sensitive sensor is being done that involves exhaustive protocols rega...
journal_title:Lasers in medical science
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journal_title:Lasers in medical science
pub_type: 临床试验,杂志文章
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abstract::A two-dimensional model including the effects of dynamic changes in the physical properties on tissue temperature and damage was developed to describe laser energy transport, heat transfer, and damage accumulation during laser-induced interstitial thermotherapy (LITT). The Monte Carlo method was used to simulate photo...
journal_title:Lasers in medical science
pub_type: 杂志文章
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abstract::Low-power laser therapy has become popular in clinical applications including promoting wound healing and pain relief. However, effects of this photoradiation on human hepatoma cells are rarely studied. Previously, we found 808 nm gallium aluminum arsenide (GaAlAs) continuous wave laser had an inhibitory effect on the...
journal_title:Lasers in medical science
pub_type: 杂志文章
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journal_title:Lasers in medical science
pub_type: 杂志文章,随机对照试验
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journal_title:Lasers in medical science
pub_type: 杂志文章
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journal_title:Lasers in medical science
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journal_title:Lasers in medical science
pub_type: 杂志文章
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journal_title:Lasers in medical science
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Lasers in medical science
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doi:10.1007/s10103-015-1804-8
更新日期:2015-12-01 00:00:00
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journal_title:Lasers in medical science
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journal_title:Lasers in medical science
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更新日期:2009-05-01 00:00:00
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journal_title:Lasers in medical science
pub_type: 杂志文章
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journal_title:Lasers in medical science
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journal_title:Lasers in medical science
pub_type: 杂志文章
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journal_title:Lasers in medical science
pub_type: 杂志文章
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journal_title:Lasers in medical science
pub_type: 杂志文章,评审
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