Combination of a mitogen-activated protein kinase inhibitor with the tyrosine kinase inhibitor pacritinib combats cell adhesion-based residual disease and prevents re-expansion of FLT3-ITD acute myeloid leukaemia.

abstract：:Two non-anaemic subjects, a father and daughter, with a new form of congenital dyserythropoiesis are reported. The features of their disorder are: (1) an abnormal blood film with basophilic stippling of red cells and oval macrocytes, (2) various dysplastic changes in the erythroblasts, including internuclear chromatin...

journal_title：British journal of haematology

authors： Wickramasinghe SN,Spearing RL,Hill GR

更新日期：1998-12-01 00:00:00

abstract：:We performed a retrospective analysis of outcome in 45 patients with multiple myeloma receiving unrelated donor stem cell transplants (UD-SCT) in the UK between 1993 and 2002; 17 received myeloablative conditioning regimens and 28 received reduced intensity conditioning (RIC) protocols. Forty patients received pretran...

journal_title：British journal of haematology

authors： Shaw BE,Peggs K,Bird JM,Cavenagh J,Hunter A,Alejandro Madrigal J,Russell NH,Sirohi B,Towlson K,Williams CD,Marks DI,Clinical Trials Committee of the British Society of Blood and Marrow Transplantation.

更新日期：2003-12-01 00:00:00

abstract：:We report a patient with uterine myoma (leiomyoma) and erythrocytosis in whom erythropoietin (Epo) production in the leiomyoma tissue was identified by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). A 48-year-old Japanese woman with uterine myoma showed marked e...

journal_title：British journal of haematology

authors： Suzuki M,Takamizawa S,Nomaguchi K,Suzu S,Yamada M,Igarashi T,Sato I

更新日期：2001-04-01 00:00:00

abstract：:We studied the trends of the Epstein-Barr virus (EBV) positivity rate in Hodgkin's disease (HD) between 1955 and 1999. The overall positivity rate gradually decreased over time [12 out of 23 (52%) in 1955-69; 18 out of 39 (46%) in 1970-84; 13 out of 44 (35%) in 1985-99; P = 0.135]. Interestingly, a marked decrease in ...

journal_title：British journal of haematology

authors： Takeuchi K,Morishita Y,Fukayama M,Mori S

更新日期：2001-05-01 00:00:00

abstract：:We have investigated the control of lysozyme gene expression in HL-60 cells induced to differentiate into macrophage-like cells with phorbol myristate acetate (PMA). Differentiation, as evidenced by cellular adherence, and morphological changes corresponded temporally to an increase in nonspecific esterase activity. T...

journal_title：British journal of haematology

authors： Polansky DA,Yang A,Brader K,Miller DM

更新日期：1985-05-01 00:00:00

abstract：:Knowledge of the absolute and relative risk of venous thromboembolism (VTE) in and around pregnancy would be crucial in identifying when to commence and cease thromboprophylaxis in women who would benefit from such intervention. We addressed this hypothesis using a large prospective primary care database from the Unit...

journal_title：British journal of haematology

authors： Sultan AA,West J,Tata LJ,Fleming KM,Nelson-Piercy C,Grainge MJ

更新日期：2012-02-01 00:00:00

abstract：:Double-negative (DN) regulatory T cells (Tregs) are specialized T lymphocytes involved in the down-modulation of immune responses, resulting in allotolerance after allogeneic haematopoietic stem cell transplantation (HSCT). Most of the properties of DN Tregs were identified in murine models, including the unique abili...

journal_title：British journal of haematology

authors： McIver Z,Serio B,Dunbar A,O'Keefe CL,Powers J,Wlodarski M,Jin T,Sobecks R,Bolwell B,Maciejewski JP

更新日期：2008-04-01 00:00:00

abstract：:The bcl-2 gene is rearranged in most cases of follicular lymphoma and the breakpoint clusters into two specific regions: mbr and mcr. Rearrangements to immunoglobulin heavy chain genes (IgH) result in a deregulation of the gene and increased transcription of mRNA for the bcl-2 protein. In chronic lymphocytic leukaemia...

journal_title：British journal of haematology

authors： Merup M,Spasokoukotskaja T,Einhorn S,Smith CI,Gahrton G,Juliusson G

更新日期：1996-03-01 00:00:00

abstract：:In an attempt to compare the sensitivity of bone radiographs and bone marrow magnetic resonance (MR) imaging for bone lesion detection in patients with stage III multiple myeloma (MM) and to evaluate the possible consequences of the replacement of the conventional radiographic skeletal survey (RSS) by an MR survey of ...

journal_title：British journal of haematology

authors： Lecouvet FE,Malghem J,Michaux L,Maldague B,Ferrant A,Michaux JL,Vande Berg BC

更新日期：1999-07-01 00:00:00

abstract：:In order to standardize and assess the quality of immunophenotyping of leukaemias and lymphomas for diagnostic purposes, a cooperative study group in the Netherlands, SIHON, has formulated guidelines for the composition of antibody panels to be applied and guidelines for the interpretation of the marker analysis. To a...

journal_title：British journal of haematology

authors： van't Veer MB,Kluin-Nelemans JC,van der Schoot CE,van Putten WL,Adriaansen HJ,van Wering ER

更新日期：1992-04-01 00:00:00

abstract：:Cooley's original description of beta-thalassaemia major included marked bone deformities as a characteristic feature. These were thought to be due to expansion of haemopoiesis attempting to compensate for the congenital anaemia. Regular blood transfusions from infancy prevents these skeletal problems. Nevertheless, s...

journal_title：British journal of haematology

authors： Jensen CE,Tuck SM,Agnew JE,Koneru S,Morris RW,Yardumian A,Prescott E,Hoffbrand AV,Wonke B

更新日期：1998-12-01 00:00:00

abstract：:In 1997, the Italian Ministry of Health created a special programme for the controlled distribution of deferiprone to collect data and to evaluate its safety and effectiveness in long-term use. Five hundred and thirty-two thalassaemia patients from 86 treatment centres were enrolled in this programme. One hundred and ...

journal_title：British journal of haematology

authors： Ceci A,Baiardi P,Felisi M,Cappellini MD,Carnelli V,De Sanctis V,Galanello R,Maggio A,Masera G,Piga A,Schettini F,Stefàno I,Tricta F

更新日期：2002-07-01 00:00:00

abstract：:Duffy blood group negative erythrocytes from blacks are refractory to invasion by Plasmodium knowlesi merozoites in vitro, and blacks with this genotype are resistant to infection by P. vivax in vivo. In order to evaluate in a direct manner the role of Duffy blood group determinants in invasion by P. knowlesi merozoit...

journal_title：British journal of haematology

authors： Mason SJ,Miller LH,Shiroishi T,Dvorak JA,McGinniss MH

更新日期：1977-07-01 00:00:00

abstract：:In previous trials, the orally active iron chelator deferiprone (L1) has been associated with sporadic agranulocytosis, milder forms of neutropenia and other side-effects. To determine the incidence of these events, we performed a multicentre prospective study of the chelator. Blood counts were performed weekly, and c...

journal_title：British journal of haematology

authors： Cohen AR,Galanello R,Piga A,Dipalma A,Vullo C,Tricta F

更新日期：2000-02-01 00:00:00

abstract：:Impaired switching from fetal haemoglobin (HbF) to adult globin gene expression leads to hereditary persistence of fetal haemoglobin (HPFH) in adult life. This is of prime interest because elevated HbF levels ameliorate β-thalassaemia and sickle cell anaemia. Fetal haemoglobin levels are regulated by complex mechanism...

journal_title：British journal of haematology

authors： Petruzzelli R,Gaudino S,Amendola G,Sessa R,Puzone S,Di Concilio R,d'Urzo G,Amendolara M,Izzo P,Grosso M

更新日期：2010-09-01 00:00:00

abstract：:A cohort of 341 symptomless anti-human immunodeficiency virus (HIV)-1 positive individuals was screened over a 6-year period to detect a serum monoclonal gammopathy (MG) and to approach the prognostic significance of such anomaly in HIV infection. Eleven individuals with a MG were followed-up over a mean period of 50 ...

journal_title：British journal of haematology

authors： Lefrère JJ,Debbia M,Lambin P

更新日期：1993-05-01 00:00:00

abstract：:Interferon(rIFN)-alpha, a successful therapeutic agent in the control of thrombocytosis, has been shown to suppress human megakaryopoiesis. We investigated bone marrow biopsies from 12 patients with thrombocytosis due to chronic myeloproliferative disorders. Prior to treatment as well as during rIFN-alpha-2c therapy, ...

journal_title：British journal of haematology

authors： Chott A,Gisslinger H,Thiele J,Fritz E,Linkesch W,Radaszkiewicz T,Ludwig H

更新日期：1990-01-01 00:00:00

abstract：:We examined the in vivo effects and safety of the third generation bisphosphonate, zoledronate (ZOL) alone and combined with imatinib mesylate against primary Philadelphia chromosome positive (Ph+) leukaemic cells. ZOL inhibited the prenylation of Rap1A in leukaemic cells in vitro and synergised with imatinib to enhan...

journal_title：British journal of haematology

authors： Segawa H,Kimura S,Kuroda J,Sato K,Yokota A,Kawata E,Kamitsuji Y,Ashihara E,Yuasa T,Fujiyama Y,Ottmann OG,Maekawa T

更新日期：2005-08-01 00:00:00

abstract：:Epistaxis is a common problem amongst anti-coagulated patients. Application of first-aid principles can control the majority of bleeds. In our sample of 60 patients attending the anticoagulant clinic, 40% were unable to think of a single measure that would be helpful in controlling a nose bleed. 6 weeks after being gi...

journal_title：British journal of haematology

authors： Lavy J

更新日期：1996-10-01 00:00:00

abstract：:Prior studies indicate that neutrophil extracellular traps (NETs) are associated with arterial thromboembolism (ATE) and mortality. We investigated the association between NET formation biomarkers (citrullinated histone H3 [H3Cit], cell-free DNA [cfDNA], and nucleosomes) and the risk of ATE and all-cause mortality in ...

journal_title：British journal of haematology

authors： Grilz E,Mauracher LM,Posch F,Königsbrügge O,Zöchbauer-Müller S,Marosi C,Lang I,Pabinger I,Ay C

更新日期：2019-07-01 00:00:00

abstract：:The interaction of rare Hb variants with beta(0)-thalassaemia results in a quasihomozygous state where the erythrocytes contain the variant as the only major adult Hb component. Such a situation is a unique model that enables functional studies even in the case of a neutral variant that could not be isolated from Hb A...

journal_title：British journal of haematology

authors： Vassilopoulos G,Papassotiriou I,Voskaridou E,Stamoulakatou A,Premetis E,Kister J,Marden M,Griffon N,Poyart C,Wajcman H

更新日期：1995-11-01 00:00:00

abstract：:Dendritic cell (DC) differentiation was investigated in samples from two acute promyelocytic leukaemia (APL) patients with classic translocation t(15;17)(q22;q21). After 18 d of culture in the presence of granulocyte-macrophage colony-stimulating factor, interleukin 4 and tumour necrosis factor alpha, 10-15% of pathol...

journal_title：British journal of haematology

authors： Rigolin GM,Della Porta M,Bigoni R,Tieghi A,Cuneo A,Castoldi G

更新日期：2001-09-01 00:00:00

abstract：:A novel mutation of the N-RAS gene of T-ALL blast cells was detected by a direct sequencing of in vitro amplified exon-1 of the N-RAS gene. Threonine (ACA) was substituted for alanine (GCA) at codon 11. This mutation would have been overlooked by conventional probe hybridization techniques. A search for other mutation...

journal_title：British journal of haematology

authors： Bar-Eli M,Ahuja H,Foti A,Cline MJ

更新日期：1989-05-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMNC) from 23 healthy subjects and 39 patients with B-cell chronic leukaemia (B-CLL) were assayed for ribonuclease H activity using as substrate the filter-immobilized synthetic homopolymer hybrid 3H-poly(rA):poly(dT). In 69% of the leukaemia patients examined enzyme activities wer...

journal_title：British journal of haematology

authors： Papaphilis AD,Kamper EF,Kattamis C,Pangalis GA

更新日期：1988-11-01 00:00:00

abstract：:We studied erythrocyte calcium levels and uptake in a group of patients with sickle haemoglobinopathies of different clinical severity in an attempt to relate these measurements to the production of irreversibly sickled cells and disease severity. Erythrocyte calcium levels were measured by atomic absorption spectrosc...

journal_title：British journal of haematology

authors： Steinberg MH,Eaton JW,Berger E,Coleman MB,Oelshlegel FJ

更新日期：1978-12-01 00:00:00

abstract：:International guidance has recently recommended serial proximal compression ultrasound (CUS) as first line imaging for suspected deep vein thrombosis (DVT). Single whole-leg CUS is a routine alternative diagnostic strategy that can reduce repeated attendances and identify alternative pathology. We conducted a prospect...

journal_title：British journal of haematology

authors： Horner D,Hogg K,Body R,Jones S,Nash MJ,Mackway-Jones K

更新日期：2014-02-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) were recently demonstrated to exist in human cord blood. Phytohaemagglutinin (PHA), a potent mitogen for mononuclear cells was used to induce EPCs from unsorted cord blood mononuclear cells (CBMCs). Adherent cells in clusters appeared approximately 24 h after CBMCs were cultured in ...

journal_title：British journal of haematology

authors： Kang HJ,Kim SC,Kim YJ,Kim CW,Kim JG,Ahn HS,Park SI,Jung MH,Choi BC,Kimm K

更新日期：2001-06-01 00:00:00

abstract：:The aim of this study was to evaluate the role of markers of bone remodelling, and osteoclast activation/function in patients with monoclonal gammopathy of undetermined significance (MGUS). We have measured serum levels of soluble RANKL (sRANKL), osteoprotegerin (OPG), macrophage inflammatory protein-1alpha (MIP-1alph...

journal_title：British journal of haematology

authors： Politou M,Terpos E,Anagnostopoulos A,Szydlo R,Laffan M,Layton M,Apperley JF,Dimopoulos MA,Rahemtulla A

更新日期：2004-09-01 00:00:00

abstract：:The effects of donor T cells, or their CD8+ subset, on engraftment and tolerance induction in fetal transplantation were evaluated using an F1-into-parent mouse-model that does not permit a graft-versus-host effect. Gestational day 13 C57BL/6 (H-2Kb) fetuses were transplanted with B6D2F1 (H-2Kb/d) light density bone m...

journal_title：British journal of haematology

authors： Chen JC,Chang ML,Lee H,Muench MO

更新日期：2004-08-01 00:00:00

abstract：:Leucine-rich repeats are conserved structural motifs present in the four components of the human platelet glycoprotein Ib/IX/V complex receptor for the adhesive protein von Willebrand factor. The absence or abnormality of this complex is responsible for Bernard-Soulier disease, an autosomal recessive bleeding disorder...

journal_title：British journal of haematology

authors： de la Salle C,Baas MJ,Lanza F,Schwartz A,Hanau D,Chevalier J,Gachet C,Briquel ME,Cazenave JP

更新日期：1995-02-01 00:00:00