The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients.

abstract：:Advances in multiple myeloma support the notion that the associated bone disease, characterized by increased osteoclastogenesis and suppressed osteoblastogenesis, is both a consequence and necessity of tumour progression. Osteoblastogenesis is suppressed by secreted inhibitors and dysregulation of cell-surface 'coupli...

journal_title：British journal of haematology

authors： Yaccoby S

更新日期：2010-05-01 00:00:00

abstract：:A prospective study was undertaken to determine the effectiveness of an empirical antibiotic therapy regimen in 34 neutropenic patients undergoing bone marrow transplantation or remission-induction chemotherapy for leukaemia. Throughout the study period a total of 90 pyrexial episodes were monitored in which organisms...

journal_title：British journal of haematology

authors： Barnes RA,Rogers TR

更新日期：1987-05-01 00:00:00

abstract：:Acquired haemophilia A (AHA) is a rare bleeding disorder characterized by the sudden generation of autoantibodies against factor VIII (FVIII) in individuals with no previous history of abnormal haemostasis. Understanding the pathogenesis of this disease has been hampered by the rarity of the patients and the difficult...

journal_title：British journal of haematology

authors： Mahendra A,Padiolleau-Lefevre S,Kaveri SV,Lacroix-Desmazes S

更新日期：2012-01-01 00:00:00

abstract：:A highly sensitive Y-microsatellite amplification system was developed for the detection of post bone marrow transplantation (BMT) chimaerism. The system is able to detect the DNA equivalent of a single male cell in a background of 10(5) female cells. For clinical applications it has the distinct advantage that the po...

journal_title：British journal of haematology

authors： Lo YM,Noakes L,Roux E,Jeannet M,Chapuis B,Fleming KA,Wainscoat JS

更新日期：1995-03-01 00:00:00

abstract：:The number of novel therapies for the treatment of myeloma is rapidly increasing, as are the clinical trials evaluating them in combination with other novel and established therapies. Proteasome inhibitors, immunomodulatory agents and monoclonal antibodies are the most well known and studied classes of novel agents ta...

journal_title：British journal of haematology

authors： Wallington-Beddoe CT,Sobieraj-Teague M,Kuss BJ,Pitson SM

更新日期：2018-07-01 00:00:00

abstract：:Umbilical cord blood is an alternative stem cell source for patients without matched family donors. In this study, we examined several parameters that have not been studied in detail -- radiation dose, cell dose, age of mice, and maternal and neonatal characteristics of the cord blood donor -- that affect engraftment ...

journal_title：British journal of haematology

authors： Ballen KK,Valinski H,Greiner D,Shultz LD,Becker PS,Hsieh CC,Stewart FM,Quesenberry PJ

更新日期：2001-07-01 00:00:00

abstract：:The presence of oestrogen receptors (ER) and type II oestrogen binding sites (type II EBS) have been investigated by a whole cell assay in seven cases of acute lymphoid leukaemia (ALL) and 16 cases of acute myeloid leukaemia (AML). ER were detected in 6/7 ALL patients with values ranging between 133 and 2268 sites/cel...

journal_title：British journal of haematology

authors： Larocca LM,Piantelli M,Leone G,Sica S,Teofili L,Panici PB,Scambia G,Mancuso S,Capelli A,Ranelletti FO

更新日期：1990-08-01 00:00:00

abstract：:Abnormal adhesive interaction between bone marrow stroma and progenitors, one of the causes of unregulated proliferation in chronic myelocytic leukaemia (CML), may be caused by some alterations in adhesion molecules on CML progenitors. We investigated the expression of adhesion molecules (CD44, VLA-5, VLA-4, LFA-1, IC...

journal_title：British journal of haematology

authors： Kawaishi K,Kimura A,Katoh O,Sasaki A,Oguma N,Ihara A,Satow Y

更新日期：1996-05-01 00:00:00

abstract：:We have identified a tissue kallikrein in polymorphonuclear (PMN) leucocytes of normal human blood and bone marrow by immunocytochemistry, radioimmunoassay and enzymology. Immunoreactive tissue kallikrein was visualized in the mature neutrophil leucocytes and in immature forms such as metamyelocytes and myelocytes. No...

journal_title：British journal of haematology

authors： Figueroa CD,MacIver AG,Bhoola KD

更新日期：1989-07-01 00:00:00

abstract：:Duffy blood group negative erythrocytes from blacks are refractory to invasion by Plasmodium knowlesi merozoites in vitro, and blacks with this genotype are resistant to infection by P. vivax in vivo. In order to evaluate in a direct manner the role of Duffy blood group determinants in invasion by P. knowlesi merozoit...

journal_title：British journal of haematology

authors： Mason SJ,Miller LH,Shiroishi T,Dvorak JA,McGinniss MH

更新日期：1977-07-01 00:00:00

abstract：:Paediatric non-Hodgkin lymphomas (pNHL) are a diverse group of malignancies characterised by nodal and/or extranodal involvement. Less common pNHL forms include those derived from mature T- and natural killer (NK) cells. Much of our current understanding of paediatric mature (non-anaplastic) T/NK-cell lymphomas with r...

journal_title：British journal of haematology

authors： Xavier AC,Suzuki R

更新日期：2019-06-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is released to circulating blood after intravenous (i.v.) and subcutaneous (s.c.) injections of heparins, and may thus contribute to the antithrombotic effect of heparins. We have recently shown that total TFPI activity, plasma free TFPI antigen, and heparin releasable TFPI were ...

journal_title：British journal of haematology

authors： Bendz B,Hansen JB,Andersen TO,Ostergaard P,Sandset PM

更新日期：1999-12-01 00:00:00

abstract：:An unusual variant of congenital dyserythropoietic anaemia is described presenting as mild haemolytic anaemia with multinucleated erythroblasts in the marrow of the proband. The outcome of her non-consanguineous pregnancy was a third trimester, in utero, fetal demise. The hydropic fetus had dyserythropoiesis with circ...

journal_title：British journal of haematology

authors： Roberts DJ,Nadel A,Lage J,Rutherford CJ

更新日期：1993-07-01 00:00:00

abstract：:While proteasome inhibition is a validated therapeutic approach for multiple myeloma (MM), inhibition of individual constitutive proteasome (c20S) and immunoproteasome (i20S) subunits has not been fully explored owing to a lack of effective tools. We utilized the novel proteasome constitutive/immunoproteasome subunit ...

journal_title：British journal of haematology

authors： Lee SJ,Levitsky K,Parlati F,Bennett MK,Arastu-Kapur S,Kellerman L,Woo TF,Wong AF,Papadopoulos KP,Niesvizky R,Badros AZ,Vij R,Jagannath S,Siegel D,Wang M,Ahmann GJ,Kirk CJ

更新日期：2016-06-01 00:00:00

abstract：:A murine monoclonal IgM erythrocyte antibody appeared to have anti-P (anti-globoside) specificity. The antibody was a relatively weak cold agglutinin, but a strong haemolysin and its reactivity with red cells was markedly enhanced by enzyme treatment. This antibody was used to study the cell and tissue distribution of...

journal_title：British journal of haematology

authors： von dem Borne AE,Bos MJ,Joustra-Maas N,Tromp JF,van't Veer MB,van Wijngaarden-du Bois R,Tetteroo PA

更新日期：1986-05-01 00:00:00

abstract：:The major pathways of glucose metabolism in the malaria parasite, Plasmodium falciparum, have now been elucidated, and the structures and properties of parasite-specific enzymes are presently being investigated. Little is known, however, about the enzymes catalysing monosaccharide interconversions in the parasite. In ...

journal_title：British journal of haematology

authors： Weidanz JA,Campbell P,Moore D,DeLucas LJ,Rodén L,Thompson JN,Vezza AC

更新日期：1996-12-01 00:00:00

abstract：:Deficiency in DNA repair capability is considered to be responsible for oncogenesis. Hereditary and sporadic cancers in various tissues have been reported to have mutations at the DNA repair genes. In this study we analysed two excision repair genes (ERCC1 and XPCC) and two mismatch repair genes (hMSH2 and hMTH1) in t...

journal_title：British journal of haematology

authors： Lin YW,Kubota M,Koishi S,Sawada M,Usami I,Watanabe K,Akiyama Y

更新日期：1998-11-01 00:00:00

abstract：:Association between HLA haplotypes and long survival was investigated in 116 children with acute lymphoblastic leukaemia. It was found that patients with A2 B12 and/or A2 B40 haplotypes survived longer than patients wtihout these two haplotypes. Since all children were treated with transfer factor obtained from their ...

journal_title：British journal of haematology

authors： De Bruyère M,Cornu G,Heremans-Bracke T,Malchaire J,Sokal G

更新日期：1980-02-01 00:00:00

abstract：:We report on quantitative analyses of C5b-9 binding to target red blood cells (RBC) lysed through the action of drug (nomifensine)-dependent antibodies (ddab) and anti-RBC antibodies (warm plus cold agglutinins). Immunoradiometric assays showed that, at any given degree of haemolysis, more C5b-9 was bound to cells sen...

journal_title：British journal of haematology

authors： Salama A,Mueller-Eckhardt C,Boschek B,Bhakdi S

更新日期：1987-02-01 00:00:00

abstract：:The dependence of survival time on a set of prognostic factors was explored by means of Cox's regression model in 137 cases of myelofibrosis with myeloid metaplasia (MMM). The following parameters recorded at diagnosis proved to be important independent indicators of a poor prognosis: a higher value for age, a lower v...

journal_title：British journal of haematology

authors： Barosi G,Berzuini C,Liberato LN,Costa A,Polino G,Ascari E

更新日期：1988-12-01 00:00:00

abstract：:We describe three cases of relapsed hairy cell leukaemia (HCL) treated with pentostatin plus rituximab. All three achieved bone marrow complete remission but had persistent splenomegaly and hypersplenism. Because of the clinical uncertainty of its significance, they were all splenectomized. The spleen histology showed...

journal_title：British journal of haematology

authors： Sarid N,Ahmad HN,Wotherspoon A,Dearden CE,Else M,Catovsky D

更新日期：2015-12-01 00:00:00

abstract：:In 2019 the UK Myeloma Research Alliance introduced the Myeloma Risk Profile (MRP) for prediction of outcome in patients with newly diagnosed multiple myeloma (MM), ineligible for autologous stem cell transplantation. To validate the MRP in a population-based setting we performed a study of the entire cohort of transp...

journal_title：British journal of haematology

authors： Redder L,Klausen TW,Vangsted AJ,Gregersen H,Andersen NF,Pedersen RS,Szabo AG,Frederiksen M,Frølund UC,Helleberg C,Nielsen LK,Pedersen PT,Salomo M,Gimsing P,Frederiksen H,Abildgaard N

更新日期：2020-06-09 00:00:00

abstract：:To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in...

journal_title：British journal of haematology

authors： Miller CH,Rice AS,Garrett K,Stein SF

更新日期：2014-06-01 00:00:00

abstract：:The molecular basis of the three major alleles (Fy(a)/Fy(b)/Fy) of the Duffy (FY) blood group system has recently been established but the Fy(x) phenotype associated with weak expression of the Fy(b) and other FY antigens is poorly understood. In the Fy(x) genes of five unrelated British and Swedish donors with the Fy...

journal_title：British journal of haematology

authors： Olsson ML,Smythe JS,Hansson C,Poole J,Mallinson G,Jones J,Avent ND,Daniels G

更新日期：1998-12-01 00:00:00

abstract：:The CDKN2 gene, encoding the cyclin-dependent kinase-4 inhibitor p16, is a putative tumour-suppressor gene because it is frequently altered in many malignant tumours. We analysed the CDKN2 gene in 44 cases of adult T-cell leukaemia (ATL) by Southern blot analysis, polymerase chain reaction-mediated single-strand confo...

journal_title：British journal of haematology

authors： Uchida T,Kinoshita T,Watanabe T,Nagai H,Murate T,Saito H,Hotta T

更新日期：1996-09-01 00:00:00

abstract：:The organelle pathology of neutrophils in chronic granulocytic leukaemia (CGL) was investigated by analytical subcellular fractionation. There were minor reductions in activity of some granule enzymes with an abnormal distribution in sucrose density gradients of the specific granules. There was a marked reduction of 5...

journal_title：British journal of haematology

authors： Rustin GJ,Peters TJ

更新日期：1979-04-01 00:00:00

abstract：:Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by remodelling of the bone marrow, including progressive myelofibrosis and exaggerated angiogenesis. Advanced PMF frequently shows a full-blown fibre meshwork, which avoids aspiration of cells, and the expression profile of genes related to str...

journal_title：British journal of haematology

authors： Bock O,Muth M,Theophile K,Winter M,Hussein K,Büsche G,Kröger N,Kreipe H

更新日期：2009-09-01 00:00:00

abstract：:No episodes of clinically significant in vivo haemolysis have been reported in individuals with a novel form of decay accelerating factor (DAF) deficiency (Inab phenotype), nor do functional in vitro assays for complement-mediated haemolysis show the extreme sensitivity to lysis characteristic of paroxysmal nocturnal ...

journal_title：British journal of haematology

authors： Merry AH,Rawlinson VI,Uchikawa M,Daha MR,Sim RB

更新日期：1989-10-01 00:00:00

abstract：:Post-transfusion graft-versus-host disease (PTGVHD) is one of the most severe side-effects of blood transfusion. To characterize the effector cells causing this disease, we cloned lymphocytes from a PTGVHD patient's peripheral blood. T-cell and B-cell clones were established, the origins of which were proven to be tra...

journal_title：British journal of haematology

authors： Nishimura M,Uchida S,Mitsunaga S,Tokunaga K,Tadokoro K,Juji T

更新日期：1996-03-01 00:00:00

abstract：:The following diagnostic criteria are proposed to classify four clinical subtypes of HTLV-1 associated adult T-cell leukaemia-lymphoma (ATL): (1) Smouldering type, 5% or more abnormal lymphocytes of T-cell nature in PB, normal lymphocyte level (less than 4 x 10(9)/l), no hypercalcaemia (corrected calcium level less th...

journal_title：British journal of haematology

authors： Shimoyama M

更新日期：1991-11-01 00:00:00