Application of a polymorphic Y microsatellite to the detection of post bone marrow transplantation chimaerism.

abstract：:Classical Hodgkin lymphoma (cHL) is characterized by a paucity of neoplastic Hodgkin/Reed Sternberg (HRS) cells within a complex cellular milieu that is rendered immunologically incapable of reacting against CD30(+) HRS cells due to a plethora of immune escape mechanisms initiated by the neoplastic cells. Accounting f...

journal_title：British journal of haematology

authors： Venkataraman G,Mirza MK,Eichenauer DA,Diehl V

更新日期：2014-05-01 00:00:00

abstract：:SAn ageing population and the continuing expansion of clinical indications for coumadin therapy have increased pressure on hospital anticoagulant clinics. One solution is patient self-testing (PST) of the international normalized ratio (INR) using capillary blood samples on point-of-care coagulation monitors at home. ...

journal_title：British journal of haematology

authors： Gardiner C,Williams K,Mackie IJ,Machin SJ,Cohen H

更新日期：2005-01-01 00:00:00

abstract：:We investigated the molecular basis for haemoglobin H disease in 50 Sardinian patients by restriction endonuclease analysis. We found that the majority (78% of the cases) are due to gene deletion (- -/- alpha). Among those with a combination of deletion and nondeletion defects (- -/alpha alpha th), the most prevalent ...

journal_title：British journal of haematology

authors： Paglietti E,Galanello R,Moi P,Pirastu M,Cao A

更新日期：1986-07-01 00:00:00

abstract：:In this population-based survey covering two geographically distinct UK regions, we evaluated the number of myeloma patients aged < or =65 years who have not undergone transplantation. The combined data from both of these regions showed that 57% of age-eligible patients were not transplanted. While early death and com...

journal_title：British journal of haematology

authors： Morris TC,Velangi M,Jackson G,Marks DI,Ranaghan L,Northern Ireland Regional Haematology Group.,Northern Regional Haematologists Group.,Clinical Trials Committee of The British Scoiety for Blood and Marrow Transplantation.

更新日期：2005-02-01 00:00:00

abstract：:The role of antiphospholipid antibodies in the pathogenesis of the thrombocytopenia observed during primary antiphospholipid antibody syndrome (APAS) and systemic lupus erythematosus (SLE) remains controversial. We have used the MAIPA test to examine the frequency and specificity of anti-platelet antibodies directed a...

journal_title：British journal of haematology

authors： Macchi L,Rispal P,Clofent-Sanchez G,Pellegrin JL,Nurden P,Leng B,Nurden AT

更新日期：1997-08-01 00:00:00

abstract：:A double-blind, crossover, placebo-controlled study of the effect of vitamin E on platelet functions was performed on nine splenectomized and 16 non-splenectomized beta-thalassaemia/haemoglobin E (beta-thalassaemia/HbE) patients. The patients were supplemented with a daily dose of vitamin E (525 IU) for 3 months. The ...

journal_title：British journal of haematology

authors： Unchern S,Laoharuangpanya N,Phumala N,Sipankapracha P,Pootrakul P,Fucharoen S,Wanachivanawin W,Chantharaksri U

更新日期：2003-11-01 00:00:00

abstract：:The potential role of the infused B cell subset after Hematopoietic Stem Cell Transplantation has not been yet studied. The present study analyzed the impact of B cells on transplant outcome in 254 patients who received a bone marrow graft from a human leucocyte antigen-identical sibling donor. The influence of B line...

journal_title：British journal of haematology

authors： Michonneau D,Peffault de Latour R,Porcher R,Robin M,Benbunan M,Rocha V,Ribaud P,Ferry C,Devergie A,Vanneaux V,Gluckman E,Marolleau JP,Socié G,Larghero J

更新日期：2009-04-01 00:00:00

abstract：:T cells modified with anti-CD19 chimeric antigen receptor (CAR) containing either CD28 or 4-1BB (also termed TNFRSF9, CD137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia (ALL). However, the difference between CD28 and 4-1BB costimulatory signalling in CAR-T trea...

journal_title：British journal of haematology

authors： Li S,Zhang J,Wang M,Fu G,Li Y,Pei L,Xiong Z,Qin D,Zhang R,Tian X,Wei Z,Chen R,Chen X,Wan J,Chen J,Wei X,Xu Y,Zhang P,Wang P,Peng X,Yang S,Shen J,Yang Z,Chen J,Qian C

更新日期：2018-05-01 00:00:00

abstract：:We used a murine model to determine the impact of donor lymphocyte subsets on the incidence of primary marrow graft failure after transplantation of lymphocyte-depleted bone marrow. After lethal irradiation with 7.5 Gy, Balb/c mice received 1 x 10(5) to 4 x 10(7) GvH-nonreactive (C57 x Balb)F1 or GvH-reactive C57Bl/6 ...

journal_title：British journal of haematology

authors： Uharek L,Glass B,Gaska T,Gassmann W,Loeffler H,Mueller-Ruchholtz W

更新日期：1994-09-01 00:00:00

abstract：:Post-transplantation lymphoproliferative disorders (PTLDs) are a well-recognized and potentially life-threatening complication of solid organ transplantation. While the vast majority of PTLDs are B-cell lymphoproliferations, T-cell PTLDs are rarely seen. Among 898 patients receiving cardiac transplants between 1990 an...

journal_title：British journal of haematology

authors： Draoua HY,Tsao L,Mancini DM,Addonizio LJ,Bhagat G,Alobeid B

更新日期：2004-11-01 00:00:00

abstract：:A murine monoclonal IgM erythrocyte antibody appeared to have anti-P (anti-globoside) specificity. The antibody was a relatively weak cold agglutinin, but a strong haemolysin and its reactivity with red cells was markedly enhanced by enzyme treatment. This antibody was used to study the cell and tissue distribution of...

journal_title：British journal of haematology

authors： von dem Borne AE,Bos MJ,Joustra-Maas N,Tromp JF,van't Veer MB,van Wijngaarden-du Bois R,Tetteroo PA

更新日期：1986-05-01 00:00:00

abstract：:Thrombotic events are common in patients with multiple myeloma (MM), smouldering myeloma (SM) and monoclonal gammopathy of undetermined significance (MGUS). Previous studies have indicated platelet hyperactivation as a feature of thrombotic risk in MM, but there is a dearth of data in MGUS. In the present study, multi...

journal_title：British journal of haematology

authors： O'Sullivan LR,Meade-Murphy G,Gilligan OM,Mykytiv V,Young PW,Cahill MR

更新日期：2021-01-01 00:00:00

abstract：:Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis (EBV-HLH) is one of the most common subtypes of secondary HLH. However, more than 30% of patients do not respond to traditional treatment. Here, we investigated the efficacy and safety of the L-DEP regimen as a salvage therapy for paediatric refractory ...

journal_title：British journal of haematology

authors： Zhao Y,Li Z,Zhang L,Lian H,Ma H,Wang D,Zhao X,Zhang Q,Wang T,Zhang R

更新日期：2020-11-01 00:00:00

abstract：:Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell (HPC) transplant patients. Although it is now possible to collect much larger numbers of neutrophils (PMNs) from donors stimulated with granulocyte colony-stimulating factor + corticosteroids, the efficacy ...

journal_title：British journal of haematology

authors： Strauss RG

更新日期：2012-08-01 00:00:00

abstract：:The contribution of red cell size (mean cell volume) to the clinical and haematological manifestations of homozygous sickle cell (SS) disease has been investigated by comparing the features of two groups of patients with low (less than or equal to 80 fl) and high (greater than 95 fl) MCV values after matching for age,...

journal_title：British journal of haematology

authors： Serjeant GR,Foster K,Serjeant BE

更新日期：1981-07-01 00:00:00

abstract：:Marked changes in the concentration and proliferative state of circulating granulocytic progenitor cells (colony forming units in culture; CFUc) were observed in female patients following surgical trauma. Within one day of an abdominal hysterectomy there was an abrupt fall in the number of blood CFUc to between 10% an...

journal_title：British journal of haematology

authors： Philip MA,Standen G,Fletcher J

更新日期：1980-02-01 00:00:00

abstract：:Reported here is the first example of a partial D antigen stimulating the production of anti-D: stimulation was of fetal origin. During her second pregnancy, anti-D developed in the serum of a D-negative mother who had received Rh immunoglobulin after the birth of her first D-positive child. Her second baby had modera...

journal_title：British journal of haematology

authors： Mayne K,Bowell P,Woodward T,Sibley C,Lomas C,Tippett P

更新日期：1990-12-01 00:00:00

abstract：:Transient myeloproliferative disorder (TMD) of the newborn and acute megakaryoblastic leukaemia (AMKL) in children with Down syndrome (DS) represent paradigmatic models of leukaemogenesis. Chromosome 21 gene dosage effects and truncating mutations of the X-chromosomal transcription factor GATA1 synergize to trigger TM...

journal_title：British journal of haematology

authors： Haemmerling S,Behnisch W,Doerks T,Korbel JO,Bork P,Moog U,Hentze S,Grasshoff U,Bonin M,Rieß O,Janssen JW,Jauch A,Bartram CR,Reinhardt D,Koch KA,Bandapalli OR,Kulozik AE

更新日期：2012-04-01 00:00:00

abstract：:The economic impact of using prophylactic clodronate as an adjunct to chemotherapy in the management of multiple myeloma for the first 4 years following diagnosis was established from the perspective of the National Health Service (NHS). A state-transition model of the course of multiple myeloma was constructed using ...

journal_title：British journal of haematology

authors： Bruce NJ,McCloskey EV,Kanis JA,Guest JF

更新日期：1999-02-01 00:00:00

abstract：:210 patients, with a history of venous thrombosis, have undergone prothrombotic investigations. In nine cases a consistent deficiency of antithrombin was identified. In five there was a reduction in the plasma antigenic concentration of antithrombin and in a further four cases deficiency was due to the presence of a d...

journal_title：British journal of haematology

authors： Harper PL,Luddington RJ,Daly M,Bruce D,Williamson D,Edgar PF,Perry DJ,Carrell RW

更新日期：1991-03-01 00:00:00

abstract：:Five monoclonal antibodies have been tested for their ability to bind to myeloid precursor cells in normal human bone marrow. Indirect immunofluorescence and the fluorescence activated cell sorter was used to separate cells according to their reactivity for trial culture in vitro in order to grow granulocyte-macrophag...

journal_title：British journal of haematology

authors： Crawford DH,Francis GE,Wing MA,Edwards AJ,Janossy G,Hoffbrand AV,Prentice HG,Secher D,McConnell I,Kung PC,Goldstein G

更新日期：1981-10-01 00:00:00

abstract：:Chromosomal rearrangements involving the MECOM (MDS1 and EVI1 complex) locus are recurrent genetic events in myeloid leukaemia and are associated with poor prognosis. In this study, we assessed the role of MECOM locus protein EVI1 in the transcriptional regulation of microRNAs (miRNAs) involved in the leukaemic phenot...

journal_title：British journal of haematology

authors： De Weer A,Van der Meulen J,Rondou P,Taghon T,Konrad TA,De Preter K,Mestdagh P,Van Maerken T,Van Roy N,Jeison M,Yaniv I,Cauwelier B,Noens L,Poirel HA,Vandenberghe P,Lambert F,De Paepe A,Sánchez MG,Odero M,Verhasselt

更新日期：2011-08-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) have a significant frequency of evolution into acute myeloid leukaemia (AML). Approximately 30% of MDS patients show activating mutations of the N-RAS proto-oncogene, and these patients are at increased risk of leukaemic evolution. Long-term survivors of aplastic anaemia (AA) and pa...

journal_title：British journal of haematology

authors： White JR,Josten KM,Chopra R,Tooze J,Saso R,Gordon-Smith EC,Rutherford TR

更新日期：1995-12-01 00:00:00

abstract：:During a survey of typical, dominant hereditary spherocytosis (HS) patients, we identified a frameshift mutation of the ankyrin gene in three unrelated probands. All three probands, who were from different ethnic backgrounds, suffered from severe HS requiring splenectomy. Analysis of both intragenic and flanking polym...

journal_title：British journal of haematology

authors： Gallagher PG,Ferreira JD,Costa FF,Saad ST,Forget BG

更新日期：2000-12-01 00:00:00

abstract：:'….Alright, but apart from the sanitation, medicine, education, wine, public order, irrigation, the roads, fresh water and public health………………what have the Romans ever done for us?' From Monty Python's Life of Brian An organizational review of the British Society for Haematology (BSH) was started in November 2013 and ...

journal_title：British journal of haematology

authors： Baglin T,Carrington P,Jackson G,Board of Trustees of the BSH.

更新日期：2015-05-01 00:00:00

abstract：:The expression of Fc(IgG) and C3b membrane receptors by granulocytes and their precursors was examined in 23 cases of megaloblastic anaemia which were graded I-III according to morphological severity. Fractionated bone marrow and peripheral blood granulocyte receptors were assessed by rosette formation with optimally ...

journal_title：British journal of haematology

authors： Scott CS,Bynoe AG,Roberts BE,Hough D

更新日期：1982-11-01 00:00:00

abstract：:Thrombocytopenia can be a complication of hepatitis C viral (HCV) infection. However, there is little published data regarding the clinical and laboratory manifestations of HCV-related thrombocytopenia (HCV-TP) compared with adult chronic immune thrombocytopenic purpura (CITP). We reviewed the medical records for all ...

journal_title：British journal of haematology

authors： Rajan SK,Espina BM,Liebman HA

更新日期：2005-06-01 00:00:00

abstract：:Hepatitis B virus (HBV) reactivation of various degrees of severity, including fulminant hepatitis, may develop in 20-50% of hepatitis B virus surface antigen (HbsAg)-positive patients undergoing immunosuppressive or cytostatic treatment. Lamivudine is a nucleoside analogue that can directly suppress HBV replication. ...

journal_title：British journal of haematology

authors： Rossi G,Pelizzari A,Motta M,Puoti M

更新日期：2001-10-01 00:00:00

abstract：:The iron chelator deferasirox (DFX) prevents complications related to transfusional iron overload in several haematological disorders characterized by marrow failure. It is also able to induce haematological responses in a percentage of treated patients, particularly in those affected by myelodysplastic syndromes. The...

journal_title：British journal of haematology

authors： Tataranni T,Agriesti F,Mazzoccoli C,Ruggieri V,Scrima R,Laurenzana I,D'Auria F,Falzetti F,Di Ianni M,Musto P,Capitanio N,Piccoli C

更新日期：2015-07-01 00:00:00

abstract：:Ninety consecutive patients with acute promyelocytic leukaemia were investigated for promoter methylation of CDKN2B (alias p15) and CDKN2A (alias p16) in disease relapse and progression. CDKN2B methylation was significantly more frequent at first relapse (30/36, 83%) than at presentation (48/77, 62%) (P=0.025), while ...

journal_title：British journal of haematology

authors： Au WY,Fung AT,Ma ES,Chan CH,Wong KF,Chim CS,Liang RH,Kwong YL

更新日期：2005-12-01 00:00:00