Identification of a tissue kallikrein in human polymorphonuclear leucocytes.

abstract：:We examined major histocompatibility complex (MHC) class II expression in B cells, peripheral blood monocytes, activated T cells, epidermal Langerhans cells, monocyte-derived dendritic cells, dermal microvascular endothelial cells (DMEC) and fibroblasts of twin brothers with MHC class II deficiency. Although residual ...

journal_title：British journal of haematology

authors： Wolf HM,Thon V,Gulle H,Lechleitner S,Eibl MM,Petzelbauer P

更新日期：2001-11-01 00:00:00

abstract：:We report four patients with relapsed or refractory follicular (three) and lymphoplasmacytic (one) lymphoma who achieved complete remission (CR) with fludarabine (FDR) lasting from 3.2 to 6 years. One had stage III and three stage IV and were resistant to chlorambucil and/or anthracycline. FDR was well tolerated, the ...

journal_title：British journal of haematology

authors： Sternberg AJ,Matutes E,Killick S,Wotherspoon AC,Catovsky D

更新日期：1998-07-01 00:00:00

abstract：:A rapid, non-radioactive, PCR-based method to genotype the XbaI restriction fragment length polymorphism of the human factor VIII gene is described. The method uses long-distance PCR followed by XbaI restriction digestion and agarose gel electrophoresis. The 6.6 kb amplification product includes a constant XbaI site, ...

journal_title：British journal of haematology

authors： De Brasi CD,Bowen DJ,Collins PW,Larripa IB

更新日期：1999-12-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, is characterized by the accumulation of CD1A(+) /CD207(+) mononuclear phagocytes within granulomatous lesions that can affect nearly all organ systems. Historically, LCH has been presumed to arise from transformed or pathologically activated ep...

journal_title：British journal of haematology

authors： Berres ML,Merad M,Allen CE

更新日期：2015-04-01 00:00:00

abstract：:The US National Cancer Institute's Surveillance, Epidemiology and End Results program was used to develop aetiological clues for hairy cell leukaemia (HCL). Descriptive techniques (age-adjusted incidence trends, age-specific incidence rates (IR), and age distributions-at-diagnosis) were supplemented with mathematical ...

journal_title：British journal of haematology

authors： Dores GM,Matsuno RK,Weisenburger DD,Rosenberg PS,Anderson WF

更新日期：2008-07-01 00:00:00

abstract：:A proportion of patients receiving allogeneic bone marrow transplants (BMT) for chronic myeloid leukaemia (CML) in first chronic phase relapse; most of these relapses show features of chronic phase disease. We report here a series of five patients seen at a single institution over a 10 year period who developed blast ...

journal_title：British journal of haematology

authors： Cullis JO,Marks DI,Schwarer AP,Barrett AJ,Hows JM,Swirsky DM,Goldman JM

更新日期：1992-07-01 00:00:00

abstract：:Myelofibrosis is an enigmatic myeloproliferative neoplasm, despite noteworthy strides in understanding its genetic underpinnings. Driver mutations involving JAK2, CALR or MPL in 90% of patients mediate constitutive JAK-STAT signaling which, in concert with epigenetic alterations (ASXL1, DNMT3A, SRSF2, EZH2, IDH1/2 mut...

journal_title：British journal of haematology

authors： Gangat N,Tefferi A

更新日期：2020-10-01 00:00:00

abstract：:The Abl kinase inhibitor STI571 (imatinib mesylate) induces haematological remissions in many patients with chronic myeloid leukaemia (CML) but advanced stage CML usually becomes resistant to STI571. We describe a patient in whom progressive resistance to STI571 correlated with the appearance of a mutation in the Bcr-...

journal_title：British journal of haematology

authors： Barthe C,Gharbi MJ,Lagarde V,Chollet C,Cony-Makhoul P,Reiffers J,Goldman JM,Melo JV,Mahon FX

更新日期：2002-10-01 00:00:00

abstract：:Analysis of factor IX gene polymorphisms is considered the best approach for prenatal diagnosis and carrier detection of haemophilia B when the identification of the gene mutation is not possible. Studies involving factor IX gene polymorphisms in Black populations are scarce and essentially restricted to the North-Ame...

journal_title：British journal of haematology

authors： Figueiredo MS,Bowen DJ,Silva Júnior WA,Zago MA

更新日期：1994-08-01 00:00:00

abstract：:The E4BP4 basic leucine zipper (bZIP) transcription factor is regulated by interleukin-3 (IL-3) in pro-B cells and has been reported to promote survival of the murine IL-3-dependent pro-B cell lines, FL5.12 and Baf-3. The E2A-HLF oncoprotein arises from a t(17;19) translocation in childhood pro-B cell acute lymphoblas...

journal_title：British journal of haematology

authors： Yeung J,O'Sullivan E,Hubank M,Brady HJ

更新日期：2004-06-01 00:00:00

abstract：:Lymphoproliferative diseases of large granular lymphocytes (LDGL) may arise from either CD3+ T cells or CD3- natural killer (NK) cells. LDGL with clonal proliferation of large granular lymphocytes (LGL) is defined as LGL leukaemia. The number of patients with NK-LGL leukaemia reported is limited and the pathogenesis o...

journal_title：British journal of haematology

authors： Chou WC,Chiang IP,Tang JL,Su IJ,Huang SY,Chen YC,Liu MC,Lee FY,Wang CH,Shen MC,Chuang SM,Tien HF

更新日期：1998-12-01 00:00:00

abstract：:The phenotypic expression and functional capacity of natural killer (NK) T-lymphocytes (E+, OKT3+) were analysed in a series of untreated patients with B-cell chronic lymphocytic leukaemia (B-CLL). The mean value of NK activity of B-CLL T-lymphocytes, tested against the K562 cell line, was significantly depressed (P l...

journal_title：British journal of haematology

authors： Foa R,Lauria F,Lusso P,Giubellino MC,Fierro MT,Ferrando ML,Raspadori D,Matera L

更新日期：1984-11-01 00:00:00

abstract：:Autologous transplantation has an established role in the treatment of lymphoproliferative disorders, but allogeneic transplantation remains controversial. In an attempt to reduce the high procedure-related mortality reported with allografting in lymphoma, we have used BEAM (BCNU, etoposide, cytarabine and melphalan),...

journal_title：British journal of haematology

authors： Cull GM,Haynes AP,Byrne JL,Carter GI,Miflin G,Rebello P,Hale G,Waldmann H,Russell NH

更新日期：2000-03-01 00:00:00

abstract：:The PFA-100 measures platelet plug formation under shear stress and is strongly dependent on von Willebrand Factor (VWF) levels in plasma. We therefore hypothesized that elevated VWF levels, possibly as a result of acute inflammation, adversely influence PFA-100 results. Healthy volunteers received either 2 ng/kg endo...

journal_title：British journal of haematology

authors： Homoncik M,Blann AD,Hollenstein U,Pernerstorfer T,Eichler HG,Jilma B

更新日期：2000-12-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) and the mixed myelodysplastic/myeloproliferative disorder juvenile myelomonocytic leukaemia (JMML) are rare haematopoietic stem cell diseases in children. While MDS-initiating events remain largely obscure, a growing body of clinical, genetic and laboratory evidence suggests that JMML i...

journal_title：British journal of haematology

authors： Niemeyer CM,Kratz CP

更新日期：2008-03-01 00:00:00

abstract：:We have previously shown that polymorphonuclear leucocytes (PMN) harvested from children with cancer and exposed to chemotherapy exhibit defective bactericidal activities against both Gram-positive and Gram-negative microorganisms as well as accelerated apoptosis. In this study, PMN from children with cancer were eval...

journal_title：British journal of haematology

authors： Lejeune M,Cantinieaux B,Harag S,Ferster A,Devalck C,Sariban E

更新日期：1999-09-01 00:00:00

abstract：:A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases entered into clinical trials, and could provide a reference standard when newly developed cell-surface markers believed to characterize specific cell types...

journal_title：British journal of haematology

authors： Bennett JM,Catovsky D,Daniel MT,Flandrin G,Galton DA,Gralnick HR,Sultan C

更新日期：1976-08-01 00:00:00

abstract：:In this study, quiescent bone marrow-derived CD34+ erythroid burst-forming units (BFU-E) were found to be resistant to the inhibitory effects of tumour necrosis factor (TNF)-alpha and -beta as well as interferon (IFN)-alpha, -beta and -gamma, in contrast to those stimulated by a combination of erytrhropoietin (Epo) pl...

journal_title：British journal of haematology

authors： Ratajczak J,Kucia M,Reca R,Zhang J,Machalinski B,Ratajczak MZ

更新日期：2003-10-01 00:00:00

abstract：:Two new variants of erythrocytic glucose-6-phosphate dehydrogenase have been found in one German patient and in another patient of Turkish origin. The enzymes were partially purified 165-fold and 111-fold respectively. Both revealed reduced activity, increased thermolability and a pH-optimum in the alkaline region (8....

journal_title：British journal of haematology

authors： Gahr M,Bornhalm D,Schröter W

更新日期：1976-07-01 00:00:00

abstract：:Radiolabelled antiCD-20 antibodies have demonstrated single agent activity in relapsed diffuse large B-cell lymphoma (DLBCL). The S0433 clinical trial enrolled patients with newly diagnosed, advanced stage or bulky stage II, histologically confirmed DLBCL. Patients received six cycles of R-CHOP (rituximab, cyclophosph...

journal_title：British journal of haematology

authors： Friedberg JW,Unger JM,Burack WR,Gopal AK,Raju RN,Nademanee AP,Kaminski MS,Li H,Press OW,Miller TP,Fisher RI

更新日期：2014-08-01 00:00:00

abstract：:We studied the outcome of 24 peripheral blood stem cell (PBSC) graft recipients, who were T-cell depleted (TCD) with either 20 mg (n = 14) or 10 mg (n = 10) Campath-1H in vitro, in comparison with a retrospective cohort of 23 unmanipulated (UM) PBSC recipients. While the neutrophil engraftment was similar, the platele...

journal_title：British journal of haematology

authors： Chakrabarti S,MacDonald D,Hale G,Holder K,Turner V,Czarnecka H,Thompson J,Fegan C,Waldmann H,Milligan DW

更新日期：2003-04-01 00:00:00

abstract：:We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resul...

journal_title：British journal of haematology

authors： Specchia G,Albano F,Anelli L,Storlazzi CT,Cimino G,Liso A,Zagaria A,Liso V,Rocchi M

更新日期：2002-11-01 00:00:00

abstract：:Combined lenalidomide and dexamethasone is a standard-of-care therapy for the treatment of older adults with multiple myeloma. Lenalidomide monotherapy has not been evaluated in newly diagnosed myeloma patients. We conducted a phase II study, evaluating a response-adapted therapy for older adults newly diagnosed with ...

journal_title：British journal of haematology

authors： Baz R,Naqvi SMH,Lee JH,Brayer J,Hillgruber N,Fridley BL,Shain KH,Sullivan DM,Alsina M

更新日期：2019-03-01 00:00:00

abstract：:A patient with pure red cell aplasia (PRCA) and autoimmune haemolytic anaemia (AIHA), associated with a thymoma which had already been removed, was studied in order to investigate the pathogenesis of PRCA and AIHA. The autoantibody eluted from the surface of the patient's red blood cells (RBC) reacted with the large E...

journal_title：British journal of haematology

authors： Taniguchi S,Shibuya T,Morioka E,Okamura T,Okamura S,Inaba S,Niho Y

更新日期：1988-04-01 00:00:00

abstract：:The impact of age, ethnicity and socio-economic deprivation in the era of novel anti-myeloma agents is unclear. Using linked national data from New Zealand, we evaluated the incidence, prevalence and overall survival (OS) of individuals who were diagnosed with myeloma between 2004 and 2016. The crude incidence rate in...

journal_title：British journal of haematology

authors： Chan HSH,Milne RJ

更新日期：2020-03-01 00:00:00

abstract：:Inhibitors of heat-shockprotein 90 (Hsp90) have been proposed as a novel therapeutic option for Chronic Lymphocytic Leukaemia (CLL), particularly as their mechanism of action appears independent of mutations of ATM or TP53. We investigated the activity of a novel Hsp90 inhibitor, SNX7081, against a panel of eight haem...

journal_title：British journal of haematology

authors： Best OG,Singh N,Forsyth C,Mulligan SP

更新日期：2010-10-01 00:00:00

abstract：:Notwithstanding the improvement in treatment results for paediatric T cell acute lymphoblastic leukaemia (T-ALL) it remains important to understand if genetic aberrations influence therapy response. PTEN tumour suppressor gene inactivation is a frequent event in T-ALL but its effect on patient therapy response is deba...

journal_title：British journal of haematology

authors： Paganin M,Grillo MF,Silvestri D,Scapinello G,Buldini B,Cazzaniga G,Biondi A,Valsecchi MG,Conter V,Te Kronnie G,Basso G

更新日期：2018-09-01 00:00:00

abstract：:The availability of a preparation of recombinant human erythropoietin (rEp) prompted us to investigate the role of Ep in the regulation of megakaryocytopoiesis in mice, using experimental procedures by which the effects on the mitotic and post-mitotic compartment of megakaryocytes could be evaluated separately. In aga...

journal_title：British journal of haematology

authors： Grossi A,Vannucchi AM,Rafanelli D,Rossi Ferrini P

更新日期：1989-04-01 00:00:00

abstract：:Hypercalcaemia complicating acute myelogenous leukaemia is a rare but well-recognized phenomenon. In most cases the pathogenetic mechanism causing the hypercalcaemia remains poorly understood. We recently studied in detail two patients with acute myelogenous leukaemia who developed hypercalcaemia during the course of ...

journal_title：British journal of haematology

authors： Gewirtz AM,Stewart AF,Vignery A,Hoffman R

更新日期：1983-05-01 00:00:00

abstract：:Hepatitis E virus (HEV) is increasingly found to cause hepatitis in allogeneic haematopoietic stem cell transplantation (HSCT) patients. However, little is known about HEV infection in patients receiving haploidentical HSCT (haplo-HSCT). Here, we retrospectively evaluate the incidence and clinical course of HEV infect...

journal_title：British journal of haematology

authors： Tang FF,Mo XD,Wang Y,Yan CH,Chen YH,Chen H,Han W,Chang YJ,Zhang HY,Xie YD,Ma H,Wei L,Xu LP,Huang XJ,Zhang XH

更新日期：2019-03-01 00:00:00