The Duffy blood group determinants: their role in the susceptibility of human and animal erythrocytes to Plasmodium knowlesi malaria.

abstract：:Thrombocytopenia is typically observed in patients undergoing cord blood transplantation. We hypothesized that delayed recovery of the platelet count might be caused by defects in the megakaryocytic differentiation pathway of cord blood progenitors. To test this hypothesis, we compared the features of in vitro megakar...

journal_title：British journal of haematology

authors： Miyazaki R,Ogata H,Iguchi T,Sogo S,Kushida T,Ito T,Inaba M,Ikehara S,Kobayashi Y

更新日期：2000-03-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role ...

journal_title：British journal of haematology

authors： Campa D,Martino A,Sainz J,Buda G,Jamroziak K,Weinhold N,Vieira Reis RM,García-Sanz R,Jurado M,Ríos R,Szemraj-Rogucka Z,Marques H,Lesueur F,Bugert P,Moreno V,Szemraj J,Orciuolo E,Gemignani F,Rossi AM,Dumontet C,Pet

更新日期：2012-05-01 00:00:00

abstract：:Hydroxycarbamide (HC) (or hydroxyurea) has been reported to increase fetal haemoglobin levels and improve clinical symptoms in sickle cell anaemia (SCA) patients. However, the complete pathway by which HC acts remains unclear. To study the mechanisms involved in the action of HC, global gene expression profiles were o...

journal_title：British journal of haematology

authors： Costa FC,da Cunha AF,Fattori A,de Sousa Peres T,Costa GG,Machado TF,de Albuquerque DM,Gambero S,Lanaro C,Saad ST,Costa FF

更新日期：2007-01-01 00:00:00

abstract：:A Children's Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (<30 years) treated with two to four cycles of IVB. The primary endpoint was anatomic complete respo...

journal_title：British journal of haematology

authors： Horton TM,Drachtman RA,Chen L,Cole PD,McCarten K,Voss S,Guillerman RP,Buxton A,Howard SC,Hogan SM,Sheehan AM,López-Terrada D,Mrazek MD,Agrawal N,Wu MF,Liu H,De Alarcon PA,Trippet TM,Schwartz CL

更新日期：2015-07-01 00:00:00

abstract：:Amiodarone has been implicated as a cause of thrombocytopenia but the responsible mechanism is unknown. We performed studies in three patients to characterize the pathogenesis of this complication. No amiodarone-dependent, platelet-reactive antibodies were identified using conventional serological techniques. However,...

journal_title：British journal of haematology

authors： Sahud MA,Caulfield M,Clarke N,Koch R,Bougie D,Aster R

更新日期：2013-10-01 00:00:00

abstract：:The objective of the present study was to further disclose the autoantigenic repertoire carried by the platelet glycoprotein (GP) IIb/IIIa complex. IgG-F(ab')2 fragments were prepared from two prototype ITP patients, and their ability to block the binding of GPIIb/IIIa reactive antibodies derived from other patients w...

journal_title：British journal of haematology

authors： Hou M,Stockelberg D,Kutti J,Wadenvik H

更新日期：1995-12-01 00:00:00

abstract：:Karyotypic studies of bone marrow were conducted in 79 previously untreated patients with multiple myeloma who received a standard programme of chemotherapy. An abnormal karyotype was observed in 46% of patients, virtually all showing multiple abnormalities consistent with a long period of preclinical clonal evolution...

journal_title：British journal of haematology

authors： Seong C,Delasalle K,Hayes K,Weber D,Dimopoulos M,Swantkowski J,Huh Y,Glassman A,Champlin R,Alexanian R

更新日期：1998-04-01 00:00:00

abstract：:Children with Down syndrome have a 20- to 50-fold increased risk of acute lymphocytic or myeloid leukaemia. Whole or partial gains of chromosome 21 have been described in multiple childhood leukaemias, and have recently been reported as a likely primary event in B-precursor-acute lymphoblastic leukaemia. It is unclear...

journal_title：British journal of haematology

authors： Canzonetta C,Hoischen A,Giarin E,Basso G,Veltman JA,Nacheva E,Nizetic D,Groet J

更新日期：2012-04-01 00:00:00

abstract：:Major histocompatibility complex class I molecule expression is reduced in some malignant tumours permitting escape from immune surveillance and is therefore associated with a poor prognosis. Seven cases of non-Hodgkin lymphomas out of 300 cases of malignant lymphoproliferative disorders totally lacked expression of c...

journal_title：British journal of haematology

authors： Amiot L,Onno M,Lamy T,Dauriac C,Le Prise PY,Fauchet R,Drenou B

更新日期：1998-03-01 00:00:00

abstract：:To clarify the clinical and biological significance of serum thymidine kinase (TK) in adult T-cell leukaemia (ATL) associated with human lymphotropic virus type-I (HTLV-I) and in acute myeloid leukaemia (AML), TK was measured in 52 patients with ATL (acute ATL, 35 patients; lymphoma ATL, two patients; chronic ATL, 12 ...

journal_title：British journal of haematology

authors： Sadamori N,Ichiba M,Mine M,Hakariya S,Hayashibara T,Itoyama T,Nakamura H,Tomonaga M,Hayashi K

更新日期：1995-05-01 00:00:00

abstract：:Both the 2001 World Health Organisation (WHO) classification of haematopoietic neoplasms and the 2008 WHO classification revision include a distinctive diagnostic category, refractory anaemia with ring sideroblasts and thrombocytosis (RARS-T), to describe those rare patients who have both >or=15% ring sideroblasts and...

journal_title：British journal of haematology

authors： Wardrop D,Steensma DP

更新日期：2009-03-01 00:00:00

abstract：:In this population-based survey covering two geographically distinct UK regions, we evaluated the number of myeloma patients aged < or =65 years who have not undergone transplantation. The combined data from both of these regions showed that 57% of age-eligible patients were not transplanted. While early death and com...

journal_title：British journal of haematology

authors： Morris TC,Velangi M,Jackson G,Marks DI,Ranaghan L,Northern Ireland Regional Haematology Group.,Northern Regional Haematologists Group.,Clinical Trials Committee of The British Scoiety for Blood and Marrow Transplantation.

更新日期：2005-02-01 00:00:00

abstract：:We examined the role of the ligand for c-mpl. thrombopoietin (TPO). in murine early haemopoiesis. using a serum-free culture system. TPO in combination with the ligand for c-kit (SF) or interleukin-3 (IL-3) supported colony formation by marrow cells of 5-fluorouracil (5-FU)-treated mice whereas TPO alone yielded no co...

journal_title：British journal of haematology

authors： Itoh R,Katayama N,Kato T,Mahmud N,Masuya M,Ohishi K,Minami N,Miyazaki H,Shiku H

更新日期：1996-08-01 00:00:00

abstract：:The retinoids: all-transretinoic acid (tretinoin), 13-cis retinoic acid (isotretinoin) and the aromatic retinoids etretinate and acitretin have a preventive and therapeutic effect on chemically-induced tumours. Clinically, retinoids have shown variable effectiveness in therapy and/or prevention of oncological diseases...

journal_title：British journal of haematology

authors： Bollag W

更新日期：1991-10-01 00:00:00

abstract：:Management of the acute painful crisis (APC) of sickle cell disease (SCD) remains unsatisfactory despite advances in the understanding and management of acute pain in other clinical settings. One reason for this is an unsophisticated approach to the use of opioid analgesics for pain management. This applies to haemato...

journal_title：British journal of haematology

authors： Telfer P,Bahal N,Lo A,Challands J

更新日期：2014-07-01 00:00:00

abstract：:During the 3 years 1984-86, 314 cases of multiple myeloma were diagnosed in the Health Care Region of Western Sweden. 180 of these cases were included in a clinical trial; 71 were notified to the trial but excluded; 49 cases were not reported to the trial; 14 were diagnosed post mortem. The crude incidence rate of mye...

journal_title：British journal of haematology

authors： Hjorth M,Holmberg E,Rödjer S,Westin J

更新日期：1992-01-01 00:00:00

abstract：:This study investigated the relationship between duodenal mucosal mRNA levels of the transcription factor, NF-E2, H-ferritin (a putative NF-E2 regulated gene) and iron absorption in mice. CD1-strain mice with normal and altered iron metabolism (hypoxic, iron-deficient, iron-loaded) and animals with genetic defects of ...

journal_title：British journal of haematology

authors： Raja KB,Gerard B,McKie AT,Simpson RJ,Peters TJ,Grandchamp B,Beaumont C

更新日期：1995-10-01 00:00:00

abstract：:A new method of in vivo bioassay for erythropoietin (EPO) is described. This method is based on the measurement of immature reticulocytes in EPO-treated mice using an automatic microcell counter, and is simpler and more precise than the existing methods of polycythaemic mouse assay and starved rat assay. Normal mice w...

journal_title：British journal of haematology

authors： Kawamura A,Imai N,Kawaguchi T,Hayakawa T

更新日期：1991-03-01 00:00:00

abstract：:Enteric coated aspirin (ECA) at doses of 325-1300 mg is an effective alternative to regular aspirin for inhibition of platelet activity while avoiding gastric irritation. The objectives of this study were to determine: (1) the lowest chronic dose of ECA providing effective inhibition of platelet activities, (2) the ti...

journal_title：British journal of haematology

authors： Jakubowski JA,Stampfer MJ,Vaillancourt R,Deykin D

更新日期：1985-08-01 00:00:00

abstract：:Mutations of the p53 tumour suppressor gene occur in 20% of chronic myeloid leukaemia (CML) patients in blastic crisis, but it is still uncertain whether this inactivation plays a role in the pathogenesis of blastic transformation or in maintaining the leukaemic proliferation in CML, as it does in several solid tumour...

journal_title：British journal of haematology

authors： Lanza F,Bi S,Moretti S,Castoldi G,Goldman JM

更新日期：1995-05-01 00:00:00

abstract：:A new putative hepatitis virus has recently been discovered and termed GB virus C (GBV-C). We investigated the prevalence of this virus among 50 haemophiliacs treated with non-virus-inactivated clotting factor concentrates prior to 1985 and 21 haemophiliacs treated exclusively with virus-inactivated clotting factor co...

journal_title：British journal of haematology

authors： Uhle C,Zimmermann R,Goeser T,Seelig R

更新日期：1997-12-01 00:00:00

abstract：:The Medical Research Council acute lymphoblastic leukaemia trials (UKALL X and XI) recruited 3,702 children with ALL between January 1985 and March 1997. Seventy-nine children had central nervous system (CNS) involvement in their first two relapses. Fourteen children survived at a median follow-up of 22 months from se...

journal_title：British journal of haematology

authors： Morris EC,Harrison G,Bailey CC,Hann IM,Hill FG,Gibson BE,Richards S,Webb DK,Medical Research Council Childhood Leukaemia Working Party.

更新日期：2003-03-01 00:00:00

abstract：:The peripheral T-cell neoplasms are a biologically and clinically heterogeneous group of rare disorders that result from clonal proliferation of mature post-thymic lymphocytes. Natural killer (NK) cell neoplasms are included in this group. The World Health Organization classification of haemopoietic malignancies has d...

journal_title：British journal of haematology

authors： Dearden CE,Johnson R,Pettengell R,Devereux S,Cwynarski K,Whittaker S,McMillan A,British Committee for Standards in Haematology.

更新日期：2011-05-01 00:00:00

abstract：:To investigate the relationship between normal B-cells, B-cell chronic lymphocytic leukaemia (B-CLL) cells and hairy cell leukaemia (HCL) cells the three cell types were incubated with phorbol myristic acetate (PMA). The parameters studied were morphology, immunophenotype and tartrate resistant acid phosphatase (TRAP)...

journal_title：British journal of haematology

authors： Visser L,Poppema S

更新日期：1990-07-01 00:00:00

abstract：:The aim of the present work was to investigate the effect of selective beta-I-blockade on the exchangeable splenic platelet pool (ESPP). Therefore, 50 mg of metoprolol (a selective beta-I-receptor blocking agent) was given by mouth to three groups of subjects: (1) 15 healthy volunteers, (2) five asplenic subjects, and...

journal_title：British journal of haematology

authors： Kutti J,Fredén K,Melberg PE,Lundborg P

更新日期：1977-10-01 00:00:00

abstract：:Induction of fetal haemoglobin (HbF) is a promising therapeutic approach for the treatment of β-thalassaemia and sickle cell disease (SCD). Several pharmacological agents, such as hydroxycarbamide (HC) and butyrates, have been shown to induce the γ-globin genes (HBG1, HBG2). However, their therapeutic use is limited d...

journal_title：British journal of haematology

authors： Ronzoni L,Sonzogni L,Fossati G,Modena D,Trombetta E,Porretti L,Cappellini MD

更新日期：2014-06-01 00:00:00

abstract：:There is little information published comparing peripheral blood stem cells (PBSC) with bone marrow (BM) as the stem cell source in the long-term outcome in recipients of T-cell depleted (TCD) unrelated donor (UD) transplants. We present retrospective outcome data on 306 recipients of myeloablative, human leucocyte an...

journal_title：British journal of haematology

authors： Shaw BE,Apperley JF,Russell NH,Craddock C,Liakopoulou E,Potter MN,Wynn R,Gibson B,Pearce RM,Kirkland K,Lee J,Madrigal JA,Cook G,Byrne JL

更新日期：2011-04-01 00:00:00

abstract：:Hydroxyurea increases fetal haemoglobin in many patients with sickle cell anaemia, but its effectiveness in thalassaemia appears to be less consistent. We describe the response to hydroxyurea in an adult male with homozygous beta thalassaemia, symptomatic paraspinal extramedullary haemopoiesis, bone pain, and progress...

journal_title：British journal of haematology

authors： Saxon BR,Rees D,Olivieri NF

更新日期：1998-06-01 00:00:00

abstract：:Acute Human Parvovirus B19 (HPV B19) infection is the major cause of transient red cell aplasia (TRCA) and acute anaemia in patients with sickle cell disease (SCD). We report three cases of patients who developed nephrotic syndrome (NS) with chronic sequelae after initially presenting with HPV B19-associated TRCA. The...

journal_title：British journal of haematology

authors： Quek L,Sharpe C,Dutt N,Height S,Allman M,Awogbade M,Rees DC,Zuckerman M,Thein SL

更新日期：2010-04-01 00:00:00

abstract：:Increasing demand for population screening for the haemoglobinopathies gives rise to a requirement for high throughput systems, which allow for cost effective, rapid, sensitive and specific screening of clinically significant haemoglobins. We have developed a practical and efficient approach using tryptic digestion an...

journal_title：British journal of haematology

authors： Daniel YA,Turner C,Haynes RM,Hunt BJ,Dalton RN

更新日期：2005-08-01 00:00:00