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Amplified segment in the 'Down syndrome critical region' on HSA21 shared between Down syndrome and euploid AML-M0 excludes RUNX1, ERG and ETS2.

Abstract：

:Children with Down syndrome have a 20- to 50-fold increased risk of acute lymphocytic or myeloid leukaemia. Whole or partial gains of chromosome 21 have been described in multiple childhood leukaemias, and have recently been reported as a likely primary event in B-precursor-acute lymphoblastic leukaemia. It is unclear which amplified gene(s) on chromosome 21 play a key role in leukaemia progression. We describe a minimal amplified segment within the so-called 'Down syndrome critical region' shared between two cases of AML-M0; a Down syndrome, and a constitutionally normal individual. Interestingly, the amplified region does not include the oncogenes RUNX1, ETS2 and ERG.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Canzonetta C,Hoischen A,Giarin E,Basso G,Veltman JA,Nacheva E,Nizetic D,Groet J

doi

10.1111/j.1365-2141.2011.08985.x

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

197-200

issue

2

eissn

0007-1048

issn

1365-2141

journal_volume

157

pub_type

杂志文章

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