CD52-negative T cells predict acute graft-versus-host disease after an alemtuzumab-based conditioning regimen.

abstract：:This review will focus on the strengths and limitations associated with the current standard of care for primary prevention of ischaemic strokes in children with sickle cell anaemia (SCA) - transcranial Doppler ultrasound (TCD) screening followed by regular blood transfusion therapy when TCD measurement is above a thr...

journal_title：British journal of haematology

authors： Jordan LC,Casella JF,DeBaun MR

更新日期：2012-04-01 00:00:00

abstract：:The role of serum macrophage inflammatory protein-1 alpha (MIP-1alpha) in bone disease and survival was evaluated in 85 newly diagnosed multiple myeloma (MM) patients. MIP-1alpha was elevated in MM patients and correlated with the extent of bone disease, bone resorption markers and levels of soluble receptor activator...

journal_title：British journal of haematology

authors： Terpos E,Politou M,Szydlo R,Goldman JM,Apperley JF,Rahemtulla A

更新日期：2003-10-01 00:00:00

abstract：:Iron chelators are increasingly combined clinically but the optimal conditions for cellular iron mobilization and mechanisms of interaction are unclear. Speciation plots for iron(III) binding of paired combinations of the licensed iron chelators desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX) suggest co...

journal_title：British journal of haematology

authors： Vlachodimitropoulou Koumoutsea E,Garbowski M,Porter J

更新日期：2015-09-01 00:00:00

abstract：:This retrospective study aimed to analyse the impact on overall survival (OS) and event-free survival (EFS) of chimaerism status and kinetics following allogeneic conventional and reduced-intensity conditioning haematopoietic stem cell transplantation, and to compare this with the impact of other well-known factors. W...

journal_title：British journal of haematology

authors： Michallet AS,Fürst S,Le QH,Dubois V,Praire A,Nicolini F,Thomas X,Rafii H,Gebuhrer L,Michallet M

更新日期：2005-03-01 00:00:00

abstract：:We describe three cases of relapsed hairy cell leukaemia (HCL) treated with pentostatin plus rituximab. All three achieved bone marrow complete remission but had persistent splenomegaly and hypersplenism. Because of the clinical uncertainty of its significance, they were all splenectomized. The spleen histology showed...

journal_title：British journal of haematology

authors： Sarid N,Ahmad HN,Wotherspoon A,Dearden CE,Else M,Catovsky D

更新日期：2015-12-01 00:00:00

abstract：:This study compared how Enoxaparin and unfractionated (UF) heparin influenced in vivo coagulation in patients randomized to receive, by twice daily subcutaneous injections, either 30 mg of Enoxaparin or 7500 I.U. of UF heparin after elective hip surgery. These two regimens were equally effective in reducing the incide...

journal_title：British journal of haematology

authors： Ofosu FA,Levine M,Craven S,Dewar L,Shafai S,Blajchman MA

更新日期：1992-10-01 00:00:00

abstract：:Follicular lymphoma (FL) constitutes a significant proportion of lymphomas and shows frequent relapses. Beyond conventional chemotherapy, new therapeutic approaches have emerged, focussing on the interplay between lymphoma cells and the microenvironment. Here we report the immunophenotypic investigation of the microen...

journal_title：British journal of haematology

authors： Menter T,Tzankov A,Zucca E,Kimby E,Hultdin M,Sundström C,Beiske K,Cogliatti S,Banz Y,Cathomas G,Karjalainen-Lindsberg ML,Grobholz R,Mazzucchelli L,Sander B,Hawle H,Hayoz S,Dirnhofer S

更新日期：2020-05-01 00:00:00

abstract：:Simultaneous evaluation of coagulation and fibrinolysis facilitates an overall understanding of normal and pathological haemostasis. We established an assay for assessing clot formation and fibrinolysis simultaneously using clot waveform analysis by the trigger of a mixture of activated partial thromboplastin time rea...

journal_title：British journal of haematology

authors： Nogami K,Matsumoto T,Sasai K,Ogiwara K,Arai N,Shima M

更新日期：2019-11-01 00:00:00

abstract：:Factor VIII (FVIII) inhibitors appear in 3-20% of haemophilia A patients after injection of FVIII concentrates. However, autoantibodies to FVIII are also reported in non-haemophiliacs. In these patients FVIII inhibitor disappears spontaneously or diminishes in response to immunosuppressive therapy. However, a few pati...

journal_title：British journal of haematology

authors： Sunagawa T,Uezu Y,Kadena K,Tokuyama K,Kinjo F,Saito A

更新日期：1999-03-01 00:00:00

abstract：:Venesection of 10% of whole blood volume or plateletpheresis was performed in nine patients with chronic myeloproliferative disorders and in five normal control subjects. Before venesection, the patients showed impaired platelet aggregation in 33% of tests, most often in response to stimulation with 9 mumol adrenaline...

journal_title：British journal of haematology

authors： Boughton BJ

更新日期：1978-08-01 00:00:00

abstract：:Acute promyelocytic leukaemia (APL) is a rare subtype of acute myeloid leukaemia. The outcome of paediatric APL has improved substantially over the past 20 years; cure rates above 80% are expected when all-trans retinoic acid (ATRA) is given with anthracycline-based regimens. The presenting features of paediatric APL ...

journal_title：British journal of haematology

authors： Abla O,Ribeiro RC

更新日期：2014-01-01 00:00:00

abstract：:Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis (EBV-HLH) is one of the most common subtypes of secondary HLH. However, more than 30% of patients do not respond to traditional treatment. Here, we investigated the efficacy and safety of the L-DEP regimen as a salvage therapy for paediatric refractory ...

journal_title：British journal of haematology

authors： Zhao Y,Li Z,Zhang L,Lian H,Ma H,Wang D,Zhao X,Zhang Q,Wang T,Zhang R

更新日期：2020-11-01 00:00:00

abstract：:The TH line was established by bringing tumour cells from a multiple myeloma patient into suspension culture and subsequently cloning them by limiting dilution. The cultured cells show marked heterogeneity; there are ultrastructural differences between small and large TH cells, particularly with respect to the rough e...

journal_title：British journal of haematology

authors： Weinreich SS,von dem Borne AE,van Lier RA,Feltkamp CA,Slater RM,Wester MR,Zeijlemaker WP

更新日期：1991-10-01 00:00:00

abstract：:Polycomb group (PcG) proteins are involved in the stable transmittance of the repressive state of their gene targets throughout the cell cycle. Mis-expression of PcG proteins can lead to proliferative defects and tumorigenesis. There are two separate multimeric PcG protein complexes: an EED-EZH2-containing complex and...

journal_title：British journal of haematology

authors： Visser HP,Gunster MJ,Kluin-Nelemans HC,Manders EM,Raaphorst FM,Meijer CJ,Willemze R,Otte AP

更新日期：2001-03-01 00:00:00

abstract：:A novel long-term cultured interleukin (IL)-3-dependent human myelodysplastic cell line, MDS92, was shown to contain several myeloid-lineage cells such as neutrophils, macrophages, eosinophils, and a small number of megakaryocyte-lineage cells. Therefore this cell line possesses at least bipotential characteristics of...

journal_title：British journal of haematology

authors： Tohyama K,Tohyama Y,Nakayama T,Ueda T,Nakamura T,Yoshida Y

更新日期：1995-12-01 00:00:00

abstract：:The frequency and prognostic relevance of translocations t(11;14) and t(4;14), the most common translocations involving the immunoglobulin heavy chain (IgH) gene in multiple myeloma (MM), were investigated in 128 patients treated with intensive chemotherapy and autologous stem cell transplant. Myeloma cells were ident...

journal_title：British journal of haematology

authors： Chang H,Sloan S,Li D,Zhuang L,Yi QL,Chen CI,Reece D,Chun K,Keith Stewart A

更新日期：2004-04-01 00:00:00

abstract：:During a trial using recombinant human interleukin-2 (rhIL-2) immunotherapy for acute myeloblastic leukaemia (AML) in remission, eosinophilia was observed in all patients. We used in-vitro clonogenic assays to investigate the mechanism of the eosinophilia in five patients. The mean eosinophil count increased from 0.05...

journal_title：British journal of haematology

authors： Macdonald D,Gordon AA,Kajitani H,Enokihara H,Barrett AJ

更新日期：1990-10-01 00:00:00

abstract：:The prevalence, clinical associations and pathogenic role of newly identified autoantibodies to the erythropoietin receptor (EPOR) in patients with anaemia were investigated. Sera from 203 patients with immune-related or chronic kidney diseases were screened for anti-EPOR antibodies by enzyme-linked immunosorbent assa...

journal_title：British journal of haematology

authors： Hara A,Furuichi K,Higuchi M,Iwata Y,Sakai N,Kaneko S,Wada T

更新日期：2013-01-01 00:00:00

abstract：:Thrombocytopenia can be a complication of hepatitis C viral (HCV) infection. However, there is little published data regarding the clinical and laboratory manifestations of HCV-related thrombocytopenia (HCV-TP) compared with adult chronic immune thrombocytopenic purpura (CITP). We reviewed the medical records for all ...

journal_title：British journal of haematology

authors： Rajan SK,Espina BM,Liebman HA

更新日期：2005-06-01 00:00:00

abstract：:The sensitivity of populations of human granulocyte precursors to factors with colony stimulating activity (CSA) was assessed in agar culture in vitro. The mean threshold of stimulation was estimated by analysis of dose-response curves of clone growth against concentration of CSA. This method of assessment has the adv...

journal_title：British journal of haematology

authors： Francis GE,Berney JJ,Chipping PM,Hoffbrand AV

更新日期：1979-04-01 00:00:00

abstract：:Investigations of naturally occurring mutations, such as the deletional thalassaemias and hereditary persistence of fetal haemoglobins (HPFHs), have brought many insights into human globin switching, but limited data have been reported so far. We selected 15 individuals with elevated fetal haemoglobin (HbF) levels (>5...

journal_title：British journal of haematology

authors： Lee ST,Yoo EH,Kim JY,Kim JW,Ki CS

更新日期：2010-01-01 00:00:00

abstract：:We investigated the relationship between the complement lysis sensitivity test and two-colour flow cytometric analysis using monoclonal antibodies to decay accelerating factor (DAF) and CD59/membrane attack complex inhibitory factor (MACIF) in patients with paroxysmal nocturnal haemoglobinuria (PNH) and other haematol...

journal_title：British journal of haematology

authors： Shichishima T,Terasawa T,Saitoh Y,Hashimoto C,Ohto H,Maruyama Y

更新日期：1993-10-01 00:00:00

abstract：:Experiments were performed to investigate the relative role of phospholipase A2 (PLA2) in the activation and cytokine-mediated priming of neutrophil superoxide production. PLA2 activity was measured with a radiometric assay which discriminates between PLA2 and the downstream enzyme, 5-lipoxygenase. In cells that had n...

journal_title：British journal of haematology

authors： Roberts PJ,Williams SL,Linch DC

更新日期：1996-03-01 00:00:00

abstract：:Imatinib mesylate (IM, STI 571, Glivec) can induce a high rate of complete cytogenetic response (CCR) in chronic myeloid leukaemia (CML) patients, although to date the majority of patients continue to have detectable disease by sensitive reverse transcription polymerase chain reaction (RT-PCR). It is therefore possibl...

journal_title：British journal of haematology

authors： Drummond MW,Marin D,Clark RE,Byrne JL,Holyoake TL,Lennard A,United Kingdom Chronic Myeloid Leukaemia (UK CML) Working Party.

更新日期：2003-11-01 00:00:00

abstract：:We have previously established a serum-free (SF) culture medium, which supports normal haemopoietic progenitor cell growth for at least 4 weeks as does conventional serum dependent (SD) medium. In the present study, we investigated the efficacy of such a defined SF liquid medium which sustained in vitro residual norma...

journal_title：British journal of haematology

authors： Da WM,Douay L,Barbu V,Fabrega S,Allieri MA,Drouet X,Deloux J,Giarratana MC,Ozsahin H,van den Akker J,Vanhaeke D,Gorin NC

更新日期：1991-05-01 00:00:00

abstract：:Mantle cell lymphoma is a distinct clinicopathological entity associated with t(11;14) and cyclin D1 overexpression. The majority of cases show uniform morphological and phenotypic features characterized by a monotonous proliferation of small-to-medium-sized irregular B cells that express CD5 and bright surface immuno...

journal_title：British journal of haematology

authors： Pittaluga S,Tierens A,Pinyol M,Campo E,Delabie J,De Wolf-Peeters C

更新日期：1998-09-01 00:00:00

abstract：:Using a reverse transcription-polymerase chain reaction (RT-PCR), we identified a patient with typical clinical features of chronic myelogenous leukaemia (CML) in the chronic phase who showed no amplification of the CML-type BCR/ABL transcript. RT-PCR with primers detecting the acute lymphoid leukaemia (ALL)-type tran...

journal_title：British journal of haematology

authors： Okamoto K,Karasawa M,Sakai H,Ogura H,Morita K,Naruse T

更新日期：1997-03-01 00:00:00

abstract：:Oxygen dissociation studies were carried out on red cells and lysates from a patient heterozygous for Hb Hammersmith. The oxygen affinity of the cells at pH 7.1 was decreased, partly by an increased cellular concentration of 2,3-DPG and more importantly by an intrinsic low affinity of Hb Hammersmity. Haem-haem interac...

journal_title：British journal of haematology

authors： May A,Huehns ER

更新日期：1975-06-01 00:00:00

abstract：:The putative natural killer (NK) cell lymphomas/leukaemias are a group of recently characterized haematolymphoid malignancies sharing an immunophenotype of CD3/Leu4- CD3epsilon+ CD56+, and a genotype of germline T-cell receptor genes. They frequently present in extranodal sites and exhibit a highly aggressive clinical...

journal_title：British journal of haematology

authors： Wong KF,Chan JK,Kwong YL

更新日期：1997-09-01 00:00:00

abstract：:To investigate the role of retinoblastoma susceptibility (RB) gene inactivation in leukaemogenesis, we evaluated 36 bone marrow specimens of acute leukaemia for RB protein expression by immunoprecipitation and Western blot analysis. 15 patients had no detectable RB protein at initial screening. However, nine of them w...

journal_title：British journal of haematology

authors： Tang JL,Yeh SH,Chen PJ,Lin MT,Tien HF,Chen YC

更新日期：1992-11-01 00:00:00