Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning.


:The use of allogeneic haematopoietic stem cell transplantation (Allo-HSCT) is a standard treatment option for many patients with haematological malignancies. Historically, patients requiring intensive care unit (ICU) admission for transplant-related toxicities have fared extremely poorly, with high ICU mortality rates. Little is known about the impact of reduced intensity Allo-HSCT conditioning regimens in older patients on the ICU and subsequent long-term outcomes. A retrospective analysis of data collected from 164 consecutive Allo-HSCT recipients admitted to ICU for a total of 213 admissions, at a single centre over an 11·5-year study period was performed. Follow-up was recorded until 31 March 2011. Autologous HSCT recipients were excluded. In this study we report favourable ICU survival following Allo-HSCT and, for the first time, demonstrate significantly better survival for patients who underwent Allo-HSCT with reduced intensity conditioning compared to those treated with myeloablative conditioning regimens. In addition, we identified the need for ventilation (invasive or non-invasive) as an independently significant adverse factor affecting short-term ICU outcome. For patients surviving ICU admission, subsequent long-term overall survival was excellent; 61% and 51% at 1 and 5 years, respectively. Reduced intensity Allo-HSCT patients admitted to ICU with critical illness have improved survival compared to myeloablative Allo-HSCT recipients.


Br J Haematol


Townsend WM,Holroyd A,Pearce R,Mackinnon S,Naik P,Goldstone AH,Linch DC,Peggs KS,Thomson KJ,Singer M,Howell DC,Morris EC




Has Abstract


2013-05-01 00:00:00












  • Haemostatic and rheological factors in intermittent claudication: the influence of smoking and extent of arterial disease.

    abstract::Patients with intermittent claudication have been reported to have disturbances in blood rheology and haemostasis. Whether these disturbances are a result of, or largely independent of, smoking history and arterial narrowing has not yet been established. The levels of whole blood and plasma viscosity, haematocrit, von...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Lee AJ,Fowkes FG,Rattray A,Rumley A,Lowe GD

    更新日期:1996-01-01 00:00:00

  • Challenges and opportunities in the assessment of measurable residual disease in multiple myeloma.

    abstract::Treatment response assessment in multiple myeloma (MM) relies on the detection of paraprotein in serum and/or urine, bone marrow morphology and immunohistochemistry. With remarkable advances in therapy, particularly in the newly diagnosed setting, achievement of complete remission became frequent, creating the need to...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Bal S,Weaver A,Cornell RF,Costa LJ

    更新日期:2019-09-01 00:00:00

  • The significance of TP53 in lymphoid malignancies: mutation prevalence, regulation, prognostic impact and potential as a therapeutic target.

    abstract::The tumour suppressor TP53 (previously termed p53) mediates a pathway that is considered to be one of the most important mechanisms in the maintenance of genomic stability. The function of TP53 can be abrogated by genomic deletion, mutation, or deregulation of upstream and downstream participants in the TP53 pathway. ...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Cheung KJ,Horsman DE,Gascoyne RD

    更新日期:2009-08-01 00:00:00

  • Severe hypophosphataemia during stem cell harvesting in chronic myeloid leukaemia.

    abstract::Peripheral blood stem cell autografts for the treatment of chronic myeloid leukaemia (CML) are currently under evaluation. A patient with CML received intensive chemotherapy followed by granulocyte colony-stimulating factor prior to the collection of peripheral blood derived stem cells. He developed unusually severe, ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Clark RE,Lee ES

    更新日期:1995-06-01 00:00:00

  • In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia.

    abstract::Tumour necrosis factor-α (TNF) is an inflammatory cytokine that is elevated in a number of autoimmune diseases including immune thrombocytopenia (ITP), a bleeding disorder characterized by low platelet counts. In vitro TNF blockade increases expansion of the regulatory T cell (Treg) IKZF2 (also termed Helios) subset i...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Zhong H,Bussel J,Yazdanbakhsh K

    更新日期:2015-01-01 00:00:00

  • Prognostic factors for patients with diffuse large B cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation in the positron emission tomography era.

    abstract::In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). Moreover, little is known about prognostic factors in patients transplanted for transform...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Armand P,Welch S,Kim HT,LaCasce AS,Jacobsen ED,Davids MS,Jacobson C,Fisher DC,Brown JR,Coughlin E,Freedman AS,Chen YB

    更新日期:2013-03-01 00:00:00

  • VLA-4 blockade by natalizumab inhibits sickle reticulocyte and leucocyte adhesion during simulated blood flow.

    abstract::Very Late Antigen-4 (VLA-4, α4β1-integrin, ITGA4) orchestrates cell-cell and cell-endothelium adhesion. Given the proposed role of VLA-4 in sickle cell disease (SCD) pathophysiology, we evaluated the ability of the VLA-4 blocking antibody natalizumab to inhibit SCD blood cell adhesion. Natalizumab recognized surface V...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: White J,Krishnamoorthy S,Gupta D,Lancelot M,Moore N,Sarnaik S,Hobbs WE 2nd,Light DR,Hines P

    更新日期:2016-09-01 00:00:00

  • Comparative analyses of megakaryocytes derived from cord blood and bone marrow.

    abstract::Thrombocytopenia is typically observed in patients undergoing cord blood transplantation. We hypothesized that delayed recovery of the platelet count might be caused by defects in the megakaryocytic differentiation pathway of cord blood progenitors. To test this hypothesis, we compared the features of in vitro megakar...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Miyazaki R,Ogata H,Iguchi T,Sogo S,Kushida T,Ito T,Inaba M,Ikehara S,Kobayashi Y

    更新日期:2000-03-01 00:00:00

  • Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease.

    abstract::Defects in glycoprotein (GP)IIb-IIIa or in its activation may cause abnormal platelet aggregation and a bleeding diathesis. We report studies in a 67-year-old man with a myeloproliferative disease and markedly abnormal platelet responses. By flow cytometry, platelet binding of two complex-specific anti-GPIIb-IIIa mono...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kaplan R,Gabbeta J,Sun L,Mao GF,Rao AK

    更新日期:2000-12-01 00:00:00

  • The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin.

    abstract::The process of tumorigenesis is frequently associated with resistance to growth inhibition by physiological regulators of normal cells. Murine macrophage-like cell lines BAC1.2F5, RAW264, J774.1A and PU5/1.8 were resistant to growth inhibition by bacterial lipopolysaccharide (LPS) and pertussis toxin, agents that bloc...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Xie Y,von Gavel S,Cassady AI,Stacey KJ,Dunn TL,Hume DA

    更新日期:1993-07-01 00:00:00

  • Two new mutations of the glucose-6-phosphate dehydrogenase (G6PD) gene associated with haemolytic anaemia: clinical, biochemical and molecular relationships.

    abstract::In two unrelated Spanish males with glucose-6-phosphate dehydrogenase (G6PD) deficiency and haemolytic anaemia, and two different novel point mutations in the G6PD gene, have been identified. A C to T transition at nucleotide 406 resulting in a (136) Arg to Cys substitution and a C to G transition at nucleotide 1155 r...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Zarza R,Pujades A,Rovira A,Saavedra R,Fernandez J,Aymerich M,Vives Corrons JL

    更新日期:1997-09-01 00:00:00

  • Disorders of red cell membrane.

    abstract::Studies during the last three decades have enabled the development of detailed molecular insights into the structural basis of altered function in various inherited red cell membrane disorders. This review highlights our current understanding of molecular and mechanistic insights into various inherited red cell membra...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: An X,Mohandas N

    更新日期:2008-05-01 00:00:00

  • Establishment and characterization of a plasma cell leukaemia cell line dependent for growth on IL-6 and a bi-phenotypic subclone dependent upon both IL-3 and IL-6.

    abstract::A human plasma cell leukaemia cell line (HSM-2) and a subclone (HSM-2.3) have been established from the bone marrow of a patient with bi-phenotypic leukaemia. Proliferation assays using a variety of cytokines demonstrated that HSM-2 proliferated in response to recombinant interleukin-6 (rIL-6), but did not respond to ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kobayashi M,Miyagishima T,Imamura M,Maeda S,Gotohda Y,Iwasaki H,Sakurada K,Miyazaki T

    更新日期:1991-06-01 00:00:00

  • Impact of genetic variants on haematopoiesis in patients with thrombocytopenia absent radii (TAR) syndrome.

    abstract::Thrombocytopenia absent radii (TAR) syndrome is clearly defined by the combination of radial aplasia and reduced platelet counts. The genetics of TAR syndrome has recently been resolved and comprises a microdeletion on Chromosome 1 including the RBM8A gene and a single nucleotide polymorphism (SNP) either at the 5' un...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Manukjan G,Bösing H,Schmugge M,Strauß G,Schulze H

    更新日期:2017-11-01 00:00:00

  • PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation.

    abstract::Despite its' central role, the precise mechanisms of the phosphoinositide 3-kinase/Akt (PI3K)/Akt pathway activation in acute myeloid leukaemia (AML) have not been elucidated. Recently, a recurrent novel AKT1 pleckstrin homology domain (PHD) mutation leading to membrane translocation, constitutive AKT activation and l...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Tibes R,Kornblau SM,Qiu Y,Mousses SM,Robbins C,Moses T,Carpten JD

    更新日期:2008-02-01 00:00:00

  • FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations.

    abstract::FLT3-internal tandem duplication (ITD) mutations are heterogeneous with regards to length and proportion of DNA harbouring the mutation and the expression level of FLT3 also varies widely, however very little is known about the biological effects of these variables. We studied FLT3-associated biological parameters in ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Seedhouse CH,Pallis M,Grundy M,Shang S,Russell NH

    更新日期:2009-12-01 00:00:00

  • Acquired Pseudoxanthoma elasticum-like syndrome in beta-thalassaemia patients.

    abstract::A significant number of patients diagnosed with beta-thalassaemia develop clinical and histopathological manifestations similar to those of an inherited disorder called Pseudoxanthoma elasticum (PXE). The inherited PXE is caused by mutations in the ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (ABCC6) gene an...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Hamlin N,Beck K,Bacchelli B,Cianciulli P,Pasquali-Ronchetti I,Le Saux O

    更新日期:2003-09-01 00:00:00

  • A simplified statistical method for local INR using linear regression. European Concerted Action on Anticoagulation.

    abstract::A simplified method of International Normalized Ratio (INR) derivation using linear regression of certified INR plotted against local prothrombin time (PT) results has been compared with INR from conventional orthogonal regression. Linear regression assumes error only with the local PT results whereas orthogonal regre...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Poller L,Barrowcliffe TW,van den Besselaar AM,Jespersen J,Tripodi A,Houghton D

    更新日期:1997-09-01 00:00:00

  • Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemia.

    abstract::Steady-state haemoglobin (Hb) desaturation is a common finding in sickle cell anaemia (Hb SS) that could predispose to stroke by limiting oxygen delivery to the brain. To determine its association with the risk of overt stroke, we examined the relationship between daytime Hb saturation measured by pulse oximetry (SpO(...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Quinn CT,Variste J,Dowling MM

    更新日期:2009-05-01 00:00:00

  • Isolation and culture of endothelial cells from human bone marrow.

    abstract::Adhesive interactions between haemopoietic progenitor cells and bone marrow sinusoidal endothelium are potentially important in the homing of these cells back to the extravascular compartment of the marrow to re-establish haemopoiesis following stem cell transplantation. A simple method for the isolation and culture o...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Masek LC,Sweetenham JW

    更新日期:1994-12-01 00:00:00

  • Reduced-intensity conditioning followed by T-cell depleted allogeneic stem cell transplantation for patients with chronic myeloid leukaemia and minimal residual disease at the time of transplant: high risk of molecular relapse.

    abstract::A pilot trial was initiated for chronic myeloid leukaemia patients, which employed imatinib for remission induction, followed by reduced-intensity conditioning and an in vivo T-cell depleted graft. Out of nine patients, six experienced a molecular relapse and one patient had a haematological relapse at a median interv...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Ringhoffer M,Harsdorf Sv,Schmitt M,Wiesneth M,Zenz T,Stilgenbauer S,Greiner J,Döhner K,Marx M,Döhner H,Bunjes D

    更新日期:2007-01-01 00:00:00

  • Chronic granulocytic leukaemia presenting with an extramedullary T lymphoblastic crisis.

    abstract::A 33-year-old man presented with hepatosplenomegaly and lymphadenopathy. Bone marrow findings were consistent with Philadelphia-positive accelerated-phase chronic granulocytic leukaemia (CGL). Lymph node histology and immunhistochemistry were diagnostic of T lymphoblastic lymphoma. Molecular studies on lymph node DNA ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Jacob A,Rowlands DC,Patton N,Holmes JA

    更新日期:1994-10-01 00:00:00

  • Biological and clinical features of acute lymphoblastic leukaemia with cytoplasmic granules or inclusions: description of eight cases.

    abstract::We describe eight patients (four children and four adults) with an acute lymphoblastic leukaemia (ALL) with cytoplasmic granules or inclusions. The incidence of this variant of acute leukaemia in our whole series of patients with ALL is 1.8%. The granules or inclusions were usually positive for aspecific esterases (AN...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Cantù-Rajnoldi A,Invernizzi R,Biondi A,Banfi P,Zoia A,De Fazio P,Polli N

    更新日期:1989-11-01 00:00:00

  • Stimulation of human haemopoietic cells by colony stimulating factors: sensitivity of leukaemia cells.

    abstract::The sensitivity of populations of human granulocyte precursors to factors with colony stimulating activity (CSA) was assessed in agar culture in vitro. The mean threshold of stimulation was estimated by analysis of dose-response curves of clone growth against concentration of CSA. This method of assessment has the adv...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Francis GE,Berney JJ,Chipping PM,Hoffbrand AV

    更新日期:1979-04-01 00:00:00

  • Long-term stability of international reference preparations for thromboplastins.

    abstract::Three certified reference materials for thromboplastins are available from the Community Bureau of Reference (BCR) of the European Commission for calibration of commercial thromboplastins used for control of oral anticoagulant therapy. The long-term stability of these reference materials has been monitored by two inde...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: van den Besselaar AM,Hermans J,Beeser H,Loeliger EA

    更新日期:1988-03-01 00:00:00

  • Quantitative evaluation of erythropoietic activity in dysmyelopoietic syndromes.

    abstract::Based on the morphological appearances of the bone marrow and peripheral blood, 43 patients with dysmyelopoietic syndromes were categorized into four types: refractory anaemia with excess of blasts, chronic myelomonocytic leukaemia, primary acquired sideroblastic anaemia and refractory anaemia with cellular marrow, wi...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Cazzola M,Barosi G,Berzuini C,Dacco M,Orlandi E,Stefanelli M,Ascari E

    更新日期:1982-01-01 00:00:00

  • Differential dose-related haematological effects of GM-CSF in pancytopenia: evidence supporting the advantage of low- over high-dose administration in selected patients.

    abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional haematopoietin which can promote production of several blood cell lineages, though the predominant target cells are neutrophils, monocytes, and their precursors. Occasional undesirable clinical effects include eosinophilia, an increase in b...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kurzrock R,Talpaz M,Gomez JA,Estey EH,O'Brien S,Hirsch-Ginsberg C,Koller C,Freireich EJ,Gutterman JU

    更新日期:1991-07-01 00:00:00

  • The value of education and self-monitoring in the management of warfarin therapy in older patients with unstable control of anticoagulation.

    abstract::Of 125 patients aged 65 years or over, with atrial fibrillation taking warfarin for at least 12 months, with a standard deviation (SD) of prothrombin time, expressed as the International Normalized Ratio (INR) >0.5 over the previous 6 months, 40 were randomized to continue with usual clinic care and 85 to receive educ...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Khan TI,Kamali F,Kesteven P,Avery P,Wynne H

    更新日期:2004-08-01 00:00:00

  • Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives.

    abstract::The effects of oral contraceptive (OC) usage on platelet responsiveness to arachidonic acid metabolites was investigated. Platelets obtained from women who had been taking oral contraceptives for at least 3 months were compared with those of age-matched controls. Both the basal and prostacyclin (PGI2)-stimulated plate...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Pan IQ,Hall ER,Wu KK

    更新日期:1984-10-01 00:00:00

  • Absence of platelet response after eradication of Helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura.

    abstract::Eradication of Helicobacter pylori infection has been associated with the correction of thrombocytopenia in patients with idiopathic thrombocytopenic purpura (ITP). We have analysed the response to eradication of H. pylori in a series of 56 adult patients with chronic ITP. Forty patients had H. pylori infection (71%) ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Jarque I,Andreu R,Llopis I,De la Rubia J,Gomis F,Senent L,Jiménez C,Martín G,Martínez JA,Sanz GF,Ponce J,Sanz MA

    更新日期:2001-12-01 00:00:00