Alterations in size, shape and osmotic behaviour of red cells after splenectomy: a study of their age dependence.

abstract：:To date, there is a lack of long-term safety and efficacy data for iron chelation therapy in transfusion-dependent patients with sickle cell disease (SCD). To evaluate the long-term safety and efficacy of deferasirox (a once-daily oral iron chelator), patients with SCD completing a 1-year, Phase II, randomized, defero...

journal_title：British journal of haematology

authors： Vichinsky E,Bernaudin F,Forni GL,Gardner R,Hassell K,Heeney MM,Inusa B,Kutlar A,Lane P,Mathias L,Porter J,Tebbi C,Wilson F,Griffel L,Deng W,Giannone V,Coates T

更新日期：2011-08-01 00:00:00

abstract：:Myeloablative conditioning prior to allogeneic stem cell transplantation causes a rapid increase in transferrin saturation and potentially toxic non-transferrin-bound iron (NTBI) in plasma. We have studied the ability of repeatedly administered apotransferrin to maintain this iron in a transferrin-bound form. Twenty a...

journal_title：British journal of haematology

authors： Parkkinen J,Sahlstedt L,von Bonsdorff L,Salo H,Ebeling F,Ruutu T

更新日期：2006-10-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease (BLPD)-like lesions develop in severe combined immunodeficient (SCID) mice inoculated with peripheral blood mononuclear cells (PBMCs) from EBV-seropositive donors. We used this model to investigate the pathogenesis of EBV-associated BLPD. Tumour inci...

journal_title：British journal of haematology

authors： Johannessen I,Asghar M,Crawford DH

更新日期：2000-06-01 00:00:00

abstract：:Non-endemic Burkitt lymphoma (BL) is a rare germinal centre B-cell-derived malignancy with the genetic hallmark of MYC gene translocation and with rapid tumour growth as a distinct clinical feature. To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunoc...

journal_title：British journal of haematology

authors： Jakobsen LH,Ellin F,Smeland KB,Wästerlid T,Christensen JH,Jørgensen JM,Josefsson PL,Øvlisen AK,Holte H,Blaker YN,Grauslund JH,Bjørn J,Molin D,Lagerlöf I,Smedby KE,Colvin K,Thanarajasingam G,Maurer MJ,Habermann TM,So

更新日期：2020-05-01 00:00:00

abstract：:Death during the induction phase of chemotherapy remains a common event in patients with aggressive non-Hodgkin's lymphoma (NHL). In a series of patients with aggressive NHL homogeneously treated with intensive induction chemotherapy [ACVB (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) regimen], we ...

journal_title：British journal of haematology

authors： Dumontet C,Mounier N,Munck JN,Bosly A,Morschauser F,Simon D,Marit G,Casasnovas O,Reman O,Molina T,Reyes F,Coiffier B

更新日期：2002-07-01 00:00:00

abstract：:The present study analysed whether autologous peripheral blood stem cell transplantation (PSCT) improves engraftment, quality of life and cost-effectiveness when compared with autologous bone marrow transplantation (ABMT). Relapsing progressive lymphoma patients (n = 204; non-Hodgkin's lymphoma n = 166; Hodgkin's dise...

journal_title：British journal of haematology

authors： Vellenga E,van Agthoven M,Croockewit AJ,Verdonck LF,Wijermans PJ,van Oers MH,Volkers CP,van Imhoff GW,Kingma T,Uyl-de Groot CA,Fibbe WE

更新日期：2001-08-01 00:00:00

abstract：:Simultaneous evaluation of coagulation and fibrinolysis facilitates an overall understanding of normal and pathological haemostasis. We established an assay for assessing clot formation and fibrinolysis simultaneously using clot waveform analysis by the trigger of a mixture of activated partial thromboplastin time rea...

journal_title：British journal of haematology

authors： Nogami K,Matsumoto T,Sasai K,Ogiwara K,Arai N,Shima M

更新日期：2019-11-01 00:00:00

abstract：:The existence of a phenomenon of rebound hypercoagulability after cessation of oral anticoagulant therapy is controversial. The sensitive procoagulant markers for in vivo thrombin and fibrin formation are potential tools for the reassessment of the presence of each a phenomenon. We examined 19 patients anticoagulated ...

journal_title：British journal of haematology

authors： Genewein U,Haeberli A,Straub PW,Beer JH

更新日期：1996-02-01 00:00:00

abstract：:Expression of the mdr1 (multidrug resistance), mrp (multidrug resistance associated protein), and lrp (lung resistance related protein) genes is associated with transport related MDR (multidrug resistance). We quantified mRNA levels of these genes using competitive reverse transcription polymerase chain reaction (RT-P...

journal_title：British journal of haematology

authors： Xu D,Areström I,Virtala R,Pisa P,Peterson C,Gruber A

更新日期：1999-09-01 00:00:00

abstract：:An indirect immunofluorescence technique with single and double labelling has been used to examine cultured human megakaryocytes for ABH antigens. This technique demonstrated the presence of these antigens on megakaryocytes and a population of small mononuclear cells that probably represent the differentiated precurso...

journal_title：British journal of haematology

authors： Dunstan RA

更新日期：1986-03-01 00:00:00

abstract：:Rats were rendered anaemic by a single bleeding or by a single injection of phenylhydrazine. At various times after the onset of anaemia they were nephrectomized and challenged with a 6 h exposure to hypoxia. The erythropoietin titre observed at the end of this hypoxic period was corrected for renal erythropoietin ind...

journal_title：British journal of haematology

authors： Erslev AJ,Caro J,Kansu E,Silver R

更新日期：1980-05-01 00:00:00

abstract：:Nasal T/natural killer (NK) cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe. The clonal nature of the infiltrating lymphoid cells is difficult to demonstrate because of the lack of immunologic markers for clonality and the absence of clonal T-cell recepto...

journal_title：British journal of haematology

authors： Tien HF,Su IJ,Tang JL,Liu MC,Lee FY,Chen YC,Chuang SM

更新日期：1997-06-01 00:00:00

abstract：:This study reports the characterization of a spontaneous lymphoblastoid cell line (LCL) raised from the peripheral blood of a patient with Kostmann's congenital neutropenia. The LCL was composed of EBV-infected polyclonal B cells and displayed surface markers and pattern of growth in vitro typical of normal LCLs. The ...

journal_title：British journal of haematology

authors： Corcione A,Roncella S,Cutrona G,Mori PG,Ferrarini M,Pistoia V

更新日期：1993-12-01 00:00:00

abstract：:A single immunoglobulin light chain lambda was identified in the blast cells of two out of 12 patients with common acute lymphoblastic leukaemia (C-ALL) using the alkaline phosphatase/anti-alkaline phosphatase (APAAP) technique. Inhibition at the cell surface proved that the reaction was a genuine anti-lambda reaction...

journal_title：British journal of haematology

authors： Markey GM,Alexander HD,Nolan RL,Morris TC,Robertson JH

更新日期：1989-01-01 00:00:00

abstract：:We identified two patients with a t(2;4)(p24;q12) and a t(4;12)(q2?3;p1?2), respectively, in association with BCR-ABL and FIP1L1-PDGFRA negative chronic eosinophilic leukaemia. Molecular analysis revealed a novel STRN-PDGFRA fusion for the t(2;4) and ETV6-PDGFRA for the t(4;12). The fusions were confirmed by specific ...

journal_title：British journal of haematology

authors： Curtis CE,Grand FH,Musto P,Clark A,Murphy J,Perla G,Minervini MM,Stewart J,Reiter A,Cross NC

更新日期：2007-07-01 00:00:00

abstract：:Major ABO mismatching is not considered a contraindication to allogeneic haematopoietic stem cell transplantation (HSCT). Modern reduced-intensity conditioning and reduced-toxicity regimens cause much less myeloablation than conventional myeloablative regimens, such as cyclophosphamide with busulfan or total body irra...

journal_title：British journal of haematology

authors： Aung FM,Lichtiger B,Bassett R,Liu P,Alousi A,Bashier Q,Ciurea SO,de Lima MJ,Hosing C,Kebriaei P,Nieto Y,Oran B,Parmar S,Qazilbash M,Shah N,Khouri I,Champlin RE,Popat U

更新日期：2013-03-01 00:00:00

abstract：:The Scott syndrome is a rare inherited haemorrhagic disorder characterized by the inability of blood cells to expose aminophospholipids and to shed microparticles. We have had the opportunity to study a recently reported French patient with this syndrome and have confirmed by means of a fluorescence assay for transbil...

journal_title：British journal of haematology

authors： Dachary-Prigent J,Pasquet JM,Fressinaud E,Toti F,Freyssinet JM,Nurden AT

更新日期：1997-12-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) remains a major complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT). The emergence of different immuno-prophylaxis strategies, such as post-transplant cyclophosphamide or anti-thymocyteglobulin has reduced the incidence of acute GVHD in recent years...

journal_title：British journal of haematology

authors： Zeiser R

更新日期：2019-12-01 00:00:00

abstract：:We examined major histocompatibility complex (MHC) class II expression in B cells, peripheral blood monocytes, activated T cells, epidermal Langerhans cells, monocyte-derived dendritic cells, dermal microvascular endothelial cells (DMEC) and fibroblasts of twin brothers with MHC class II deficiency. Although residual ...

journal_title：British journal of haematology

authors： Wolf HM,Thon V,Gulle H,Lechleitner S,Eibl MM,Petzelbauer P

更新日期：2001-11-01 00:00:00

abstract：:We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal B...

journal_title：British journal of haematology

authors： McElroy EA Jr,Witzig TE,Gertz MA,Greipp PR,Kyle RA

更新日期：1998-02-01 00:00:00

abstract：:The molecular basis accounting for the peculiar clinical and biological features of hairy cell leukaemia (HCL) is currently unknown. Deregulation of cell cycle genes plays a significant role in oncogenesis and there is considerable evidence suggesting that Cdk inhibitors (Ckis) function as tumour suppressors. We and o...

journal_title：British journal of haematology

authors： Chilosi M,Chiarle R,Lestani M,Menestrina F,Montagna L,Ambrosetti A,Prolla G,Pizzolo G,Doglioni C,Piva R,Pagano M,Inghirami G

更新日期：2000-10-01 00:00:00

abstract：:β- thalassaemia is a disorder of globin gene synthesis resulting in reduced or absent production of the β-globin chain in red blood cells. In this study, haematopoietic stem cells were isolated from the peripheral blood of six transfusion dependent β-thalassaemia patients and six healthy controls. Following 7 and 14 d...

journal_title：British journal of haematology

authors： Forster L,McCooke J,Bellgard M,Joske D,Finlayson J,Ghassemifar R

更新日期：2015-07-01 00:00:00

abstract：:Platelet aggregation is commonly used to investigate patients with possible dense granule storage pool deficiency (delta SPD), but recent studies have shown that this investigation is not specific or sensitive for this disorder. We describe a simple one-step technique to detect mepacrine loaded platelets by flow cytom...

journal_title：British journal of haematology

authors： Gordon N,Thom J,Cole C,Baker R

更新日期：1995-01-01 00:00:00

abstract：:Adult T-cell leukaemia (ATL) is caused by human T-cell leukaemia virus type I (HTLV-I). It has been suggested that cytokines play a role in the development and in the neoplastic cell growth of ATL. However, the precise mechanism involved in this process still remains unclear. Interleukin-21 (IL-21) and its receptor (I...

journal_title：British journal of haematology

authors： Ueda M,Imada K,Imura A,Koga H,Hishizawa M,Uchiyama T

更新日期：2005-01-01 00:00:00

abstract：:The phenotypic expression and functional capacity of natural killer (NK) T-lymphocytes (E+, OKT3+) were analysed in a series of untreated patients with B-cell chronic lymphocytic leukaemia (B-CLL). The mean value of NK activity of B-CLL T-lymphocytes, tested against the K562 cell line, was significantly depressed (P l...

journal_title：British journal of haematology

authors： Foa R,Lauria F,Lusso P,Giubellino MC,Fierro MT,Ferrando ML,Raspadori D,Matera L

更新日期：1984-11-01 00:00:00

abstract：:Increased haemoglobin (Hb) A2 levels associated with reduced mean corpuscular volume (MCV) and Hb content per cell (MCH) are the most typical features of heterozygous beta thalassaemia. However, double heterozygotes for alpha and beta thalassaemia may have normal MCV and MCH but Hb A2 always in the carrier range. In t...

journal_title：British journal of haematology

authors： Gasperini D,Cao A,Paderi L,Barella S,Paglietti E,Perseu L,Loi D,Galanello R

更新日期：1993-05-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF)-induced alteration of phosphoprotein during differentiation of HL-60 cells was studied. From the two-dimensional gel electrophoresis analysis of phosphoproteins, a 45 kD phosphoprotein in the cytosolic fraction of DMSO-pretreated HL-60 cells was rapidly dephosphorylated by...

journal_title：British journal of haematology

authors： Yamaguchi T,Oshizawa T,Yamaguchi T,Suzuki K,Yamamoto Y,Hayakawa T

更新日期：1998-08-01 00:00:00

abstract：:Interleukin-12 (IL-12), a heterodimeric cytokine with potent biological activity, was evaluated for effects on proliferation of human immature progenitor cells in vitro. In vitro proliferation of 5-FU-resistant CD34+ (G0) peripheral blood stem cells (PBSC) in response to sequential cytokine stimulation was examined in...

journal_title：British journal of haematology

authors： Grafte-Faure S,Leveque C,Vasse M,Soria C,Vannier JP

更新日期：1999-04-01 00:00:00

abstract：:Two patients are described who had evidence of both multiple myeloma and chronic neutrophilic leukaemia at or near the time of presentation. Descriptions of five similar patients were found in the literature supporting an association between the two disorders. This association is further evidence of a link between mye...

journal_title：British journal of haematology

authors： Lewis MJ,Oelbaum MH,Coleman M,Allen S

更新日期：1986-05-01 00:00:00

abstract：:A woman with Ph-positive chronic myeloid leukaemia (CML) with an atypical e1a3 BCR-ABL hybrid gene is described. To our knowledge, this is the first report of this transcript type as a unique naturally occurring BCR-ABL fusion in a CML patient. This case was characterized by a low leucocyte count and a very indolent c...

journal_title：British journal of haematology

authors： Roman J,Jimenez A,Barrios M,Castillejo JA,Maldonado J,Torres A

更新日期：2001-09-01 00:00:00