The expression of ABH antigens during in vitro megakaryocyte maturation: origin of heterogeneity of antigen density.

abstract：:A total of 622 consecutive patients with acute promyelocytic leukaemia (APL) treated within the Gruppo Italiano per le Malattie Ematologiche dell'Adulto (GIMEMA) group during 1989-97 have been reviewed to assess the clinical effectiveness of all-trans retinoic acid (ATRA) on the incidence of early haemorrhagic deaths ...

journal_title：British journal of haematology

authors： Di Bona E,Avvisati G,Castaman G,Luce Vegna M,De Sanctis V,Rodeghiero F,Mandelli F

更新日期：2000-03-01 00:00:00

abstract：:A mechanism has been proposed in which nitric oxide (NO) may bind to cysteine beta93 and be transported by haemoglobin from the lungs to the tissues and modify vascular tone. In addition, it has been reported that treatment of sickle cell anaemia blood with 80 p.p.m. NO gas in air shifts the oxygen affinity, as measur...

journal_title：British journal of haematology

authors： Hrinczenko BW,Alayash AI,Wink DA,Gladwin MT,Rodgers GP,Schechter AN

更新日期：2000-08-01 00:00:00

abstract：:During definitive erythropoiesis, erythroid precursors undergo differentiation through multiple nucleated states to an enucleated reticulocyte, which loses its residual RNA/organelles to become a mature erythrocyte. Over the course of these transformations, continuous changes in membrane proteins occur, including shif...

journal_title：British journal of haematology

authors： Kodippili GC,Spector J,Kang GE,Liu H,Wickrema A,Ritchie K,Low PS

更新日期：2010-09-01 00:00:00

abstract：:Prior case-control studies reported that levels of the soluble form of the endothelial protein C receptor (sEPCR) were strongly controlled by the PROCR 6963A/G polymorphism and higher levels were a risk factor for venous thromboembolism (VTE). We sought to prospectively examine the association of sEPCR and the 6963A/G...

journal_title：British journal of haematology

authors： Yamagishi K,Cushman M,Heckbert SR,Tsai MY,Folsom AR

更新日期：2009-04-01 00:00:00

abstract：:The EGFP-tk retroviral vector, encoding enhanced green fluorescent protein (EGFP) and the herpes simplex virus thymidine kinase (HSV-tk) packaged in a Phoenix amphotropic cell line, was used to transduce healthy donor T lymphocytes. Infection yielded a mean of 41.8 +/- 9.3% SD (range 31.1-48.4%) EGFP-positive cells an...

journal_title：British journal of haematology

authors： Di Florio S,Sebastiani C,Fagioli M,Di Ianni M,Alfonsi D,Venditti G,Pelicci PG,Tabilio A

更新日期：2000-09-01 00:00:00

abstract：:In recent years, the most common cause of infection in neutropenic patients has shifted from Gram-negative to Gram-positive bacteria. To compare the efficacy and toxicity of teicoplanin and vancomycin in neutropenic patients, we conducted a prospective study of 151 adult leukaemic patients hospitalized for intensive c...

journal_title：British journal of haematology

authors： Cony-Makhoul P,Brossard G,Marit G,Pellegrin JL,Texier-Maugein J,Reiffers J

更新日期：1990-12-01 00:00:00

abstract：:Previous studies have reported that megakaryocyte progenitors in myeloproliferative disorders (MPD) formed spontaneous megakaryocyte colonies without the addition of megakaryocyte colony-stimulating factor (Meg-CSF). To determine whether this spontaneous colony formation is due to autocrine proliferation of MPD megaka...

journal_title：British journal of haematology

authors： Kobayashi S,Teramura M,Hoshino S,Motoji T,Oshimi K,Mizoguchi H

更新日期：1993-04-01 00:00:00

abstract：:We present the results of a novel method developed for evaluation of in situ amplification, a molecular genetic method at the cellular level. Reverse transcription polymerase chain reaction (RT-PCR) was used to study bcr-abl transcript levels in individual cells from patients with chronic myelogenous leukaemia (CML). ...

journal_title：British journal of haematology

authors： Pachmann K,Zhao S,Schenk T,Kantarjian H,El-Naggar AK,Siciliano MJ,Guo JQ,Arlinghaus RB,Andreeff M

更新日期：2001-03-01 00:00:00

abstract：:The transformation of lymphocytes in cultures with phytohaemagglutinin (PHA) or with pokeweed mitogen (PWM) was carried out during treatment on 28 patients with paraproteinaemia and on 20 control subjects. 78.5% of the peripheral blood lymphocyte short-term cultures from the treated patients showed a subnormal PHA-ind...

journal_title：British journal of haematology

authors： Campbell AE,De Vine J,Azam L,Hamid J,Delamore IW,McFarlane H

更新日期：1975-01-01 00:00:00

abstract：:Duffy blood group negative erythrocytes from blacks are refractory to invasion by Plasmodium knowlesi merozoites in vitro, and blacks with this genotype are resistant to infection by P. vivax in vivo. In order to evaluate in a direct manner the role of Duffy blood group determinants in invasion by P. knowlesi merozoit...

journal_title：British journal of haematology

authors： Mason SJ,Miller LH,Shiroishi T,Dvorak JA,McGinniss MH

更新日期：1977-07-01 00:00:00

abstract：:We report 14 normal peripheral blood stem cell (PBSC) donors > or = 60 years of age who had cytokine mobilization followed by PBSC apheresis for allogeneic transplantation. Mobilization was achieved with filgrastim (6 microg/kg twice daily). Their median age was 63.5 years (range 60-77), and 43% had a positive medical...

journal_title：British journal of haematology

authors： Anderlini P,Przepiorka D,Lauppe J,Seong D,Giralt S,Champlin R,Körbling M

更新日期：1997-05-01 00:00:00

abstract：:Folate analogues were added to human bone marrow cells to determine their effect on deoxyuridine utilization in the deoxyuridine suppression test. Formyltetrahydrofolates fully corrected the impairment of dU utilization in pernicious anaemia marrows but tetrahydrofolate was relatively ineffective. All these analogues ...

journal_title：British journal of haematology

authors： Deacon R,Chanarin I,Perry J,Lumb M

更新日期：1980-12-01 00:00:00

abstract：:This study was designed to determine the incidence of relapse and factors predictive for relapse in 719 patients with severe aplastic anaemia (SAA) after immunosuppressive treatment (IS). Patients developing myelodysplasia or acute leukaemia after IS, and patients receiving a transplant, were excluded from this analys...

journal_title：British journal of haematology

authors： Schrezenmeier H,Marin P,Raghavachar A,McCann S,Hows J,Gluckman E,Nissen C,van't Veer-Korthof ET,Ljungman P,Hinterberger W

更新日期：1993-10-01 00:00:00

abstract：:Low concentrations of collagen and anticardiolipin antibodies (ACLA), which were raised in rabbits by immunization with cardiolipin (CL), co-operatively activated human gel-filtrated platelets (GFP). GFP activated by adding ACLA 5 min prior to collagen (ACLA + Col) showed strong responses in cytosolic Ca2+ mobilizatio...

journal_title：British journal of haematology

authors： Wang L,Su CY,Chou KY,Wang CT

更新日期：2002-09-01 00:00:00

abstract：:Calcium uptake into isolated membrane vesicles from two patients with a grey platelet syndrome has been investigated. An increase in calcium transport appears in both patients when compared to controls. Determination of the kinetic parameters of the calcium transport system gave similar apparent affinity for calcium a...

journal_title：British journal of haematology

authors： Enouf J,Lebret M,Bredoux R,Levy-Toledano S,Caen JP

更新日期：1987-04-01 00:00:00

abstract：:Patients with solid tumours undergoing high-dose chemotherapy with autologous bone marrow transplantation use an average of 10 units of packed red blood cells (PRBC) while awaiting haemopoietic reconstitution. They are also known to have inappropriately low endogenous erythropoietin levels for their degree of anaemia....

journal_title：British journal of haematology

authors： Ayash LJ,Elias A,Hunt M,Demetri G,Wheeler C,Tepler I,Schwartz G,Mazanet R,Reich E,McCauley M

更新日期：1994-05-01 00:00:00

abstract：:In whole blood from splenectomized subjects (n = 20), red cells showed a significant increase of mean surface area (MSA), mean cell volume (MCV), MSA/MCV-ratio and osmotic resistance, with the mean cell haemoglobin concentration (MCHC) being decreased. Studies on red cell populations of different cell age revealed tha...

journal_title：British journal of haematology

authors： de Haan LD,Werre JM,Ruben AM,Huls HA,de Gier J,Staal GE

更新日期：1988-05-01 00:00:00

abstract：:Ernest Beutler was one of the preeminent haematologists of the last half of the 20th and the early 21st century. In a career that spanned six decades, his research interests included such diverse areas as red cell metabolism, blood preservation, glycolipid storage diseases, leukaemias and iron metabolism. Indeed, he w...

journal_title：British journal of haematology

authors： Beutler S,Beutler B

更新日期：2011-03-01 00:00:00

abstract：:The putative natural killer (NK) cell lymphomas/leukaemias are a group of recently characterized haematolymphoid malignancies sharing an immunophenotype of CD3/Leu4- CD3epsilon+ CD56+, and a genotype of germline T-cell receptor genes. They frequently present in extranodal sites and exhibit a highly aggressive clinical...

journal_title：British journal of haematology

authors： Wong KF,Chan JK,Kwong YL

更新日期：1997-09-01 00:00:00

abstract：:Surgical interventions in patients suffering from haemophilia A require infusions of large doses of factor VIII (F VIII) concentrates. These are expensive and may pose a burden on the immune system, which is already compromised in many haemophiliacs. F VIII is usually given as bolus injections, although there are repo...

journal_title：British journal of haematology

authors： Martinowitz U,Schulman S,Gitel S,Horozowski H,Heim M,Varon D

更新日期：1992-12-01 00:00:00

abstract：:A 43-year-old man with chronic myeloid leukaemia underwent a second transplant with CD34+ bone marrow cells selected from his two-loci HLA-mismatched sibling after rejection of the first graft from an HLA-matched unrelated donor. By immunomagnetic positive selection, CD34+ marrow cells at 0.95 x 10(6)/kg with 97% puri...

journal_title：British journal of haematology

authors： Fujimori Y,Kanamaru A,Hashimoto N,Okamoto T,Okada M,Kawaguchi K,Mori A,Saheki K,Takatsuka H,Wada H,Takemoto Y,Kohsaki M,Imai N,Kakishita E,Nagai K

更新日期：1996-07-01 00:00:00

abstract：:Therapy for a first episode of venous thromboembolism (VTE) typically includes a vitamin K antagonist, such as warfarin, for 3-6 months at an international normalized ratio (INR) of 2-3. After the cessation of warfarin therapy, unprovoked VTE is associated with a recurrence rate of 5-15% per year. Prolonging initial t...

journal_title：British journal of haematology

authors： Bauer KA

更新日期：2004-10-01 00:00:00

abstract：:Multiple myeloma cell lines express functional receptors for insulin-like growth factors (IGFs) and several cell types that make up the bone marrow microenvironment produce these cytokines. This suggests that IGFs may play a role in survival and/or expansion of the malignant clone within the marrow in patients with mu...

journal_title：British journal of haematology

authors： Xu F,Gardner A,Tu Y,Michl P,Prager D,Lichtenstein A

更新日期：1997-05-01 00:00:00

abstract：:We have identified a novel polymorphism located in intron 1a of the human factor VII gene, caused by the nucleotide change G to A at position + 73. In a population of 128 healthy individuals from northern Italy, the variant A73 allele had a frequency of 0.21, whereas the frequency of the previously reported 10 bp inse...

journal_title：British journal of haematology

authors： Peyvandi F,Mannucci PM,Bucciarelli P,Zeinali S,Akhavan S,Sacchi E,Merlini PA,Perry DJ

更新日期：2000-02-01 00:00:00

abstract：:Both atypical haemolytic uraemic syndrome (aHUS) and the HELLP syndrome (haemolytic anaemia, elevated liver enzymes, and low platelets) are thrombotic microangiopathies characterized by microvascular endothelial activation, cell injury and thrombosis. aHUS is a disease of complement dysregulation, specifically a gain ...

journal_title：British journal of haematology

authors： Fang CJ,Richards A,Liszewski MK,Kavanagh D,Atkinson JP

更新日期：2008-11-01 00:00:00

abstract：:Primary familial and congenital polycythaemia (PFCP) is a disease characterized by increased red blood cell mass, and can be associated with mutations in the intracellular region of the erythropoietin (EPO) receptor (EPOR). Here we explore the mechanisms by which EPOR mutations induce PFCP, using an experimental syste...

journal_title：British journal of haematology

authors： Gross M,Ben-Califa N,McMullin MF,Percy MJ,Bento C,Cario H,Minkov M,Neumann D

更新日期：2014-05-01 00:00:00

abstract：:Microparticles are circulating, phospholipid rich, submicron particles released from the membranes of endothelial cells, platelets, leucocytes and erythrocytes. Investigation into their biological activity has revealed diverse actions in coagulation, cell signalling and cellular interactions. These actions are mediate...

journal_title：British journal of haematology

authors： Lynch SF,Ludlam CA

更新日期：2007-04-01 00:00:00

abstract：:The localization of adenylate cyclase (AC) in rat bone marrow was studied at the ultrastructural level using a cytochemical technique with adenosine triphosphate (ATP) as substrate. The strongest precipitate occurred around cytoplasmic membranes of cells of granulocytic lineage. Around cells of erythrocytic lineage, a...

journal_title：British journal of haematology

authors： Krzysztofowicz E,Dabrowski Z

更新日期：1984-11-01 00:00:00

abstract：:Comparative genomic hybridization (CGH) was used to analyse 34 follicular lymphoma (FL) samples. 27 samples showed DNA sequence copy number changes of at least one genomic region (26 samples with at least one gain and nine with at least one loss). Some chromosomes or chromosomal regions were preferentially involved. T...

journal_title：British journal of haematology

authors： Avet-Loiseau H,Vigier M,Moreau A,Mellerin MP,Gaillard F,Harousseau JL,Bataille R,Milpied N

更新日期：1997-04-01 00:00:00

abstract：:Hodgkin's lymphoma (HL) can be cured in most of the patients, but in case of refractory disease or relapse after autologous stem cell transplantation (SCT) the prognosis becomes very poor. In these patients a consensus about the standard approach has not been achieved so far and only allogeneic SCT has shown a long-te...

journal_title：British journal of haematology

authors： Corradini P,Sarina B,Farina L

更新日期：2011-02-01 00:00:00