Abstract:
:We report 14 normal peripheral blood stem cell (PBSC) donors > or = 60 years of age who had cytokine mobilization followed by PBSC apheresis for allogeneic transplantation. Mobilization was achieved with filgrastim (6 microg/kg twice daily). Their median age was 63.5 years (range 60-77), and 43% had a positive medical history, mainly hypertension and/or cardiac problems. Their median pre-apheresis leucocyte count (x 10(9)/l) was 38.6 (range 29.6-63.4). The median apheresis yield (x 10(6) CD34+ cells/litre blood processed, first apheresis) was 27.9 (range 1.6-54.8). The target cell dose (> or = 4 x 10(6) CD34+ cells/kg recipient) was reached with one procedure in eight (57%) donors. Filgrastim-related adverse events were acceptable and apheresis was well tolerated. When compared to younger donors (< 60 years of age), a trend to a lower CD34+ apheresis yield and a requirement for more than one apheresis to achieve the collection target (> or = 4 x 10(6) CD34+ cells/kg) was evident. Although older (> or = 60 years) donors seem to mobilize less effectively, these data suggest that PBSC collection from them is feasible and has an acceptable short-term safety profile.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Anderlini P,Przepiorka D,Lauppe J,Seong D,Giralt S,Champlin R,Körbling Mdoi
10.1046/j.1365-2141.1997.302677.xsubject
Has Abstractpub_date
1997-05-01 00:00:00pages
485-7issue
2eissn
0007-1048issn
1365-2141journal_volume
97pub_type
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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