Plasma microparticles and vascular disorders.

abstract：:Platelet and cell stimulation lead to plasma membrane remodelling, resulting in phosphatidylserine (PS) externalisation in the outer leaflet of the membrane, associated with the shedding of PS-rich microparticles (MPs), and contributes to thrombin generation by promoting the assembly of coagulation enzyme complexes. A...

journal_title：British journal of haematology

authors： Proulle V,Hugel B,Guillet B,Grunebaum L,Lambert T,Freyssinet JM,Dreyfus M

更新日期：2005-11-01 00:00:00

abstract：:Human IgG monoclonal antibodies (mabs) against the Rh D antigen have considerable potential for the prophylaxis of haemolytic disease of the newborn. We have carried out in vitro testing for cross-reactions with tissue components by screening two such mabs against animal tissues and a wide panel of human organs from n...

journal_title：British journal of haematology

authors： Thorpe SJ,Bailey SW

更新日期：1993-02-01 00:00:00

abstract：:The blood-related cancer leukaemias were the first diseases where human cancer stem cells, or leukaemic stem cells (LSC), were isolated. The haematopoietic system is one of the best tissues for investigating cancer stem cells, because the developmental hierarchy of normal blood formation is well defined. Leukaemias ca...

journal_title：British journal of haematology

authors： Bonnet D

更新日期：2005-08-01 00:00:00

abstract：:Karyotypic analysis was performed in a total of 69 patients with well-characterized idiopathic myelofibrosis. Karyotypic abnormalities were detected in 46% of cases examined during the chronic phase (29/63); with three abnormalities, del(13q), del(20q) and partial trisomy 1q, accounting for 75% of all abnormalities at...

journal_title：British journal of haematology

authors： Reilly JT,Wilson G,Barnett D,Watmore A,Potter A

更新日期：1994-11-01 00:00:00

abstract：:Tellurite (K2TeO3) has been suggested as a potential anti-sickling compound because it causes a selective increase in the water content of RBC. To investigate the conditions underlying the increase in RBC volume due to tellurite, normal RBCs were incubated with the compound in a physiological medium and the cells wash...

journal_title：British journal of haematology

authors： Kurantsin-Mills J,Klug RK,Lessin LS

更新日期：1988-11-01 00:00:00

abstract：:The level of venous thrombosis risk in women who experience spontaneous or induced pregnancy loss has previously been uncertain. However, recent data indicate that the risk of venous thrombosis in women undergoing pregnancy termination in the first trimester is increased two-fold compared to non-pregnant women but red...

journal_title：British journal of haematology

authors： Bagot CN,Pavord S,Hunt BJ,British Society of Haematology Obstetric Haematology Special Interest Group.

更新日期：2020-07-01 00:00:00

abstract：:The in vitro haemostatic functions of fresh whole blood (FWB) are well preserved after cold storage. This study aimed to determine whether platelets derived from FWB and stored whole blood (SWB) contribute to clot formation in tissue injury after transfusion into coagulopathic rats with polytrauma/haemorrhage (T/H). T...

journal_title：British journal of haematology

authors： Wu X,Darlington DN,Montgomery RK,Liu B,Keesee JD,Scherer MR,Benov A,Chen J,Cap AP

更新日期：2017-12-01 00:00:00

abstract：:Two patients with acute immune haemolytic anaemia caused by diclofenac are described. Both patients had developed IgG drug-independent autoantibodies and drug-dependent antibodies. The drug-dependent antibodies in one patient reacted with red blood cells (RBC) only in the presence of urine from patients receiving dicl...

journal_title：British journal of haematology

authors： Salama A,Göttsche B,Mueller-Eckhardt C

更新日期：1991-04-01 00:00:00

abstract：:The Kidd (JK) blood group system is of importance in transfusion medicine. The Jk(null) phenotype is associated with absence of the urea transporter in erythrocytes and moderately reduced ability to concentrate urine. We and others recently reported different molecular alterations in the silenced Jkb-like alleles of P...

journal_title：British journal of haematology

authors： Irshaid NM,Eicher NI,Hustinx H,Poole J,Olsson ML

更新日期：2002-02-01 00:00:00

abstract：:We present an immunocompetent patient with transfusion-associated graft-versus-host disease (GVHD), in which chimaerism of peripheral blood lymphocytes was demonstrated by analysis of a highly polymorphic genome. The patient was treated successfully with anti-CD3 monoclonal antibody, OKT3 and cyclosporin A. Although i...

journal_title：British journal of haematology

authors： Yasukawa M,Shinozaki F,Hato T,Takada K,Ishii Y,Tamai T,Takamatsu H,Shiobara S,Yoshizaki K,Fujita S

更新日期：1994-04-01 00:00:00

abstract：:A retrospective analysis of CD20 expression following rituximab for B-cell non-Hodgkin's lymphoma demonstrated a significant change in immunophenotype in 6/25 (24%) patients with persistent bone marrow (BM) infiltration. In three out of six patients, the B cells were uniformly CD20-/CD79alpha+, consistent with frank l...

journal_title：British journal of haematology

authors： Foran JM,Norton AJ,Micallef IN,Taussig DC,Amess JA,Rohatiner AZ,Lister TA

更新日期：2001-09-01 00:00:00

abstract：:The role of apoptotic pathways in the development and function of the megakaryocyte lineage has generated renewed interest in recent years. This has been driven by the advent of BH3 mimetic drugs that target BCL2 family proteins to induce apoptosis in tumour cells: agents such as ABT-263 (navitoclax, which targets BCL...

journal_title：British journal of haematology

authors： Kile BT

更新日期：2014-04-01 00:00:00

abstract：:A chromogenic factor Xa generation method has been developed for comparing the co-factor activity of factor VIII concentrates at physiological factor VIII concentrations (1 iu/ml). In the presence of thrombin all concentrates gave similar rapid rates of factor Xa generation, but in the absence of thrombin there were m...

journal_title：British journal of haematology

authors： Kemball-Cook G,Tubbs JE,Dawson NJ,Barrowcliffe TW

更新日期：1993-06-01 00:00:00

abstract：:T-cells from patients with B-cell chronic lymphocytic leukaemia (B-CLL) have abnormal T4/T8 ratios and functions. Previously, we demonstrated that peripheral blood (PB) mononuclear cells from B-CLL patients secrete significant amounts of interleukin 2 (IL2) with an apparent dysregulation of accessory cells controlling...

journal_title：British journal of haematology

authors： Rossi JF,Klein B,Commes T,Jourdan M,Janbon C

更新日期：1988-02-01 00:00:00

abstract：:The molecular basis of severe type I factor (F)VII deficiency was investigated in two Algerian patients. One patient, a 13-year-old-girl who has suffered from severe bleeding since birth, was homozygous for a 7-bp deletion (nt 7774-7780) and a 251-bp insertion (nt 7773-7781) of mitochondrial origin, in IVS 4 acceptor ...

journal_title：British journal of haematology

authors： Borensztajn K,Chafa O,Alhenc-Gelas M,Salha S,Reghis A,Fischer AM,Tapon-Bretaudière J

更新日期：2002-04-01 00:00:00

abstract：:An 18-month-old child, who had no evidence of liver disease, malabsorption, or chronic ingestion of coumarin compounds, was found to have plasma deficiencies of factors II, VII, IX and X. Assays for factor II and X by immunological techniques (antibody neutralization and immunoelectrophoresis) revealed normal or eleva...

journal_title：British journal of haematology

authors： Johnson CA,Chung KS,McGrath KM,Bean PE,Roberts HR

更新日期：1980-03-01 00:00:00

abstract：:The process of tumorigenesis is frequently associated with resistance to growth inhibition by physiological regulators of normal cells. Murine macrophage-like cell lines BAC1.2F5, RAW264, J774.1A and PU5/1.8 were resistant to growth inhibition by bacterial lipopolysaccharide (LPS) and pertussis toxin, agents that bloc...

journal_title：British journal of haematology

authors： Xie Y,von Gavel S,Cassady AI,Stacey KJ,Dunn TL,Hume DA

更新日期：1993-07-01 00:00:00

abstract：:We performed a retrospective study analysing the effect of sorafenib, an oral fms-Like Tyrosine Kinase 3 (FLT3)/multikinase inhibitor, as post-transplant maintenance in adult patients with FLT3-internal tandem duplication (ITD) acute myeloid leukaemia (AML). We identified consecutive patients with FLT3-ITD AML diagnos...

journal_title：British journal of haematology

authors： Brunner AM,Li S,Fathi AT,Wadleigh M,Ho VT,Collier K,Connolly C,Ballen KK,Cutler CS,Dey BR,El-Jawahri A,Nikiforow S,McAfee SL,Koreth J,Deangelo DJ,Alyea EP,Antin JH,Spitzer TR,Stone RM,Soiffer RJ,Chen YB

更新日期：2016-11-01 00:00:00

abstract：:Patients with Down syndrome have been found to have characteristic in vivo and in vitro methotrexate toxicity. The in vitro methotrexate toxicity characteristic of Down syndrome can be diminished by the in vivo administration of supplemental high doses of folic acid. A possible explanation for the increased sensitivit...

journal_title：British journal of haematology

authors： Peeters MA,Rethore MO,Lejeune J

更新日期：1995-03-01 00:00:00

abstract：:Prior case-control studies reported that levels of the soluble form of the endothelial protein C receptor (sEPCR) were strongly controlled by the PROCR 6963A/G polymorphism and higher levels were a risk factor for venous thromboembolism (VTE). We sought to prospectively examine the association of sEPCR and the 6963A/G...

journal_title：British journal of haematology

authors： Yamagishi K,Cushman M,Heckbert SR,Tsai MY,Folsom AR

更新日期：2009-04-01 00:00:00

abstract：:AML1/RUNX1, which encodes a transcription factor essential for definitive haematopoiesis, is a frequent target of leukaemia-associated chromosome translocations. Point mutations of this gene have also recently been associated with leukaemia and myelodysplastic syndrome (MDS). To further define the frequency and biolog...

journal_title：British journal of haematology

authors： Nakao M,Horiike S,Fukushima-Nakase Y,Nishimura M,Fujita Y,Taniwaki M,Okuda T

更新日期：2004-06-01 00:00:00

abstract：:A sensitive F-cell assay has been used to examine the production of fetal haemoglobin (Hb F) in a group of 77 adult patients with myelodysplastic syndrome (MDS), and a control group composed of 100 normal blood donors. Although the mean F-cell percentage in the MDS group (6.0%) is not statistically different from that...

journal_title：British journal of haematology

authors： Craig JE,Sampietro M,Oscier DG,Contreras M,Thein S

更新日期：1996-06-01 00:00:00

abstract：:The World Health Organization (WHO) lymphoma classification recognises anaplastic large cell lymphoma (ALCL), angioimmunoblastic lymphoma (AIL) and peripheral T-cell lymphoma, unspecified (PTCU) as nodal mature T-cell lymphomas. Little is known about long-term outcome and prognostic factors of these diseases. A retros...

journal_title：British journal of haematology

authors： Sonnen R,Schmidt WP,Müller-Hermelink HK,Schmitz N

更新日期：2005-05-01 00:00:00

abstract：:In vitro colony formation of bone-marrow erythroid progenitor cells in patients with paroxysmal nocturnal haemoglobinuria (PNH) was examined. The numbers of early and late erythroid progenitors (BFU-E and CFU-E) showed wide variations; two cases out of eight cases of PNH showed decreased erythroid colony formation, bu...

journal_title：British journal of haematology

authors： Urabe A,Fujioka S

更新日期：1982-02-01 00:00:00

abstract：:Follicular lymphoma (FL) is a heterogeneous disease; therefore, reliable prognostic tools are needed to plan treatment strategies. The FL International Prognostic Index (FLIPI) was developed before the rituximab era, while the PRIMA-PI was built on rituximab chemotherapy. Our objective was to evaluate these two progno...

journal_title：British journal of haematology

authors： Kimby E,Lockmer S,Holte H,Hagberg H,Wahlin BE,Brown P,Østenstad B

更新日期：2020-05-14 00:00:00

abstract：:Among 80 hereditary spherocytosis (HS) kindreds studied using denaturing electrophoretic separation of solubilized eythrocyte membrane proteins, we recognized three prominent subsets: HS with isolated spectrin deficiency, HS with combined spectrin and ankyrin deficiency, and HS with band 3 deficiency These three subse...

journal_title：British journal of haematology

authors： Dhermy D,Galand C,Bournier O,Boulanger L,Cynober T,Schismanoff PO,Bursaux E,Tchernia G,Boivin P,Garbarz M

更新日期：1997-07-01 00:00:00

abstract：:Umbilical cord blood transplant (UCBT) is associated with impaired early immune reconstitution. This might be explained by a lower T-cell dose infused, the naivety of cord blood T-cells and the use of in vivo T-cell depletion. We studied the pattern of early immune reconstitution and the clinical outcome of children u...

journal_title：British journal of haematology

authors： Chiesa R,Gilmour K,Qasim W,Adams S,Worth AJ,Zhan H,Montiel-Equihua CA,Derniame S,Cale C,Rao K,Hiwarkar P,Hough R,Saudemont A,Fahrenkrog CS,Goulden N,Amrolia PJ,Veys P

更新日期：2012-03-01 00:00:00

abstract：:A number of studies have demonstrated induction of the unfolded protein response (UPR) in patients with severe congenital neutropenia (CN) harbouring mutations of ELANE, encoding neutrophil elastase. Why UPR is not activated in patients with cyclic neutropenia (CyN) carrying the same ELANE mutations is unclear. We eva...

journal_title：British journal of haematology

authors： Nustede R,Klimiankou M,Klimenkova O,Kuznetsova I,Zeidler C,Welte K,Skokowa J

更新日期：2016-01-01 00:00:00

abstract：:Ernest Beutler was one of the preeminent haematologists of the last half of the 20th and the early 21st century. In a career that spanned six decades, his research interests included such diverse areas as red cell metabolism, blood preservation, glycolipid storage diseases, leukaemias and iron metabolism. Indeed, he w...

journal_title：British journal of haematology

authors： Beutler S,Beutler B

更新日期：2011-03-01 00:00:00

abstract：:Crude barium chloride eluates prepared from 12 unrelated patients with cross-reacting material positive (CRM+) haemophilia B were activated with celite eluate, the reaction products resolved after reduction by 13% SDS-PAGE, and factor IX antigenic material detected by probing with radiolabelled immunopurified rabbit a...

journal_title：British journal of haematology

authors： Liddell MB,Peake IR,Taylor SA,Lillicrap DP,Giddings JC,Bloom AL

更新日期：1989-08-01 00:00:00