Essential role for T cells in human B-cell lymphoproliferative disease development in severe combined immunodeficient mice.

abstract：:Erythroid regeneration is an important and separate element in the engraftment process in allogeneic and autologous bone marrow transplantation (alloBMT, autoBMT). Qualitative visual reticulocyte counting has proved inadequate in the evaluation of erythropoiesis after BMT but automated flow cytometry now allows the re...

journal_title：British journal of haematology

authors： Davies SV,Cavill I,Bentley N,Fegan CD,Poynton CH,Whittaker JA

更新日期：1992-05-01 00:00:00

abstract：:It has been proposed that when ABO unmatched platelets are transfused circulating immune complexes (CIC) may be formed between the patient's soluble ABH antigens and the transfused antibodies. Platelets might then be destroyed by bystander mechanisms or by the binding of CIC to the Fc receptor or to C3 binding membran...

journal_title：British journal of haematology

authors： Heal JM,Masel D,Rowe JM,Blumberg N

更新日期：1993-11-01 00:00:00

abstract：:Type 3 von Willebrand disease, a recessive autosomally inherited bleeding disorder, refers to complete deficiency of von Willebrand factor (VWF). The novel Q1311X mutation was detected in the homozygous state in four Spanish patients from two apparently unrelated families of gypsy origin. The lack of specific amplific...

journal_title：British journal of haematology

authors： Casaña P,Martínez F,Haya S,Lorenzo JI,Espinós C,Aznar JA

更新日期：2000-11-01 00:00:00

abstract：:We describe a case of congenital dyserythropoietic anaemia (CDA) presenting at week 20 of pregnancy with hydrops fetalis and very severe anaemia. Fetal blood examination showed marked erythroblastosis with morphologic alterations while the basic haematological and biochemical tests were in the normal range. The fetus ...

journal_title：British journal of haematology

authors： Cantù-Rajnoldi A,Zanella A,Conter U,Faccini P,Soligo D,Gornati G,Vegni C,Nicolini U

更新日期：1997-03-01 00:00:00

abstract：:Peripheral blood stem cell autografts for the treatment of chronic myeloid leukaemia (CML) are currently under evaluation. A patient with CML received intensive chemotherapy followed by granulocyte colony-stimulating factor prior to the collection of peripheral blood derived stem cells. He developed unusually severe, ...

journal_title：British journal of haematology

authors： Clark RE,Lee ES

更新日期：1995-06-01 00:00:00

abstract：:An oscillatory pattern of platelet agglutination-disagglutination in response to Ristocetin (R) at narrow concentration ranges was observed in citrated platelet rich plasma (PRP) of 10 patients with Glanzmann's thrombasthenia. The cyclic pattern decreased in intensity over time, was reproducible, and was not pH depend...

journal_title：British journal of haematology

authors： Chediak J,Telfer MC,Vander Laan B,Maxey B,Cohen I

更新日期：1979-09-01 00:00:00

abstract：:Thrombocytopenia and neutropenia are common among neonates in intensive care units. Bone marrow aspirations are sometimes performed as part of their evaluation. However, marrow biopsies have not been reported from living neonates. Since architecture and cellularity cannot generally be accurately assessed from marrow a...

journal_title：British journal of haematology

authors： Sola MC,Rimsza LM,Christensen RD

更新日期：1999-11-01 00:00:00

abstract：:The number of granulocyte-macrophage clones formed in agar culture of bone marrow is dependent on levels of colony stimulating activity (CSA) a proposed in vivo haemopoietic regulator. A dose-response relationship for stimulation of human haemopoietic cells by CSA is demonstrated, which could be explained by threshold...

journal_title：British journal of haematology

authors： Francis GE,Berney JJ,Hoffebrand AV

更新日期：1977-04-01 00:00:00

abstract：:A collaborative study on factor VIII related antigen (VIII R:Ag) has been carried out, involving 11 laboratories in the U.K. Samples of two different freeze-dried plasmas were assayed against participants' own local standards by the Laurell electroimmunoassay method. There was reasonably good agreement on the relative...

journal_title：British journal of haematology

authors： Kirkwood TB,Barrowcliffe TW

更新日期：1980-11-01 00:00:00

abstract：:Clonal heterogeneity in multisited or recurrent lymphoid neoplasms is a phenomenon that has been increasingly studied in recent years. However, in mucosa-associated lymphoid tissue (MALT) lymphomas it remains largely unexplored. Patients diagnosed at our institution with multisited MALT lymphoma, from January 2009 to ...

journal_title：British journal of haematology

authors： Condom M,Climent F,Fernández D,Colomer D,Lopez-Guerra M,Varela M,Carro I,Maluquer C,Mercadal S,Oliveira AC,Pané M,Matias-Guiu X,González-Barca E,Sureda A,Domingo-Domenech E

更新日期：2020-05-23 00:00:00

abstract：:The 'high and low responder phenomenon' of monocyte tissue factor (MTF) activity has been attributed to effects on monocytes by granulocytes, platelets and lipopolysaccharide (LPS). To study the possible contribution of plasma to the high and low responder phenomenon, we measured the MTF activity in isolated cryoprese...

journal_title：British journal of haematology

authors： Nijziel M,van Oerle R,van 't Veer C,van Pampus E,Lindhout T,Hamulyák K

更新日期：2001-01-01 00:00:00

abstract：:A 29-year-old man in remission from acute myeloblastic leukaemia was treated by chemoradiotherapy and transplantation of bone marrow (BMT) collected from his HLA identical brother. Engraftment was documented on D12. Transient acute GVHD (grade II) appeared from D34. No infection complicated the BMT. Nevertheless sever...

journal_title：British journal of haematology

authors： Bierling P,Cordonnier C,Fromont P,Rodet M,Tanzer J,Vernant JP,Bracq C,Duedari N

更新日期：1985-04-01 00:00:00

abstract：:Site-specific deletions of the 5' part of the TAL1 gene (tal(d)) are among the most frequent non-random genetic abnormalities in T-cell acute lymphoblastic leukaemia (T-ALL). They are usually detected by PCR from DNA with several primer pairs or by Southern blot analysis. Since tal(d) lead to expression of a SIL-TAL1 ...

journal_title：British journal of haematology

authors： Delabesse E,Bernard M,Landman-Parker J,Davi F,Leboeuf D,Varet B,Valensi F,Macintyre EA

更新日期：1997-12-01 00:00:00

abstract：:In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). Moreover, little is known about prognostic factors in patients transplanted for transform...

journal_title：British journal of haematology

authors： Armand P,Welch S,Kim HT,LaCasce AS,Jacobsen ED,Davids MS,Jacobson C,Fisher DC,Brown JR,Coughlin E,Freedman AS,Chen YB

更新日期：2013-03-01 00:00:00

abstract：:Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal diseas...

journal_title：British journal of haematology

authors： Cullis JO,Fitzsimons EJ,Griffiths WJ,Tsochatzis E,Thomas DW,British Society for Haematology.

更新日期：2018-05-01 00:00:00

abstract：:The addition of radioimmunotherapy to conventional and reduced-intensity conditioning has been shown to be feasible and effective. Within an ongoing prospective phase II trial, 22 patients with advanced myeloid malignancies and a median age of 65 years (range 54-76) received anti-CD66 Rhenium radioimmunotherapy follow...

journal_title：British journal of haematology

authors： Lauter A,Strumpf A,Platzbecker U,Schetelig J,Wermke M,Radke J,Kiani A,Wunderlich G,Thiede C,Ehninger G,Kotzerke J,Bornhäuser M

更新日期：2010-03-01 00:00:00

abstract：:We report a Lancashire family with mild haemophilia B associated with a -6 G to A mutation in the factor IX promoter. This mutation has been reported previously in Britain in one other affected family. The factor IX haplotype of these two unrelated patients was determined by PCR analysis of seven polymorphic sites wit...

journal_title：British journal of haematology

authors： Stowell KM,Figueiredo MS,Brownlee GG,Jones P,Bolton-Maggs PH

更新日期：1993-09-01 00:00:00

abstract：:Diamond-Blackfan anaemia (DBA) is an inherited bone marrow failure syndrome (IBMFS) characterized by red cell aplasia. Mutations in ribosomal genes are found in more than 50% of cases. Elevated erythrocyte adenosine deaminase (eADA) was first noted in DBA in 1983. In this study we determined the value of eADA for the ...

journal_title：British journal of haematology

authors： Fargo JH,Kratz CP,Giri N,Savage SA,Wong C,Backer K,Alter BP,Glader B

更新日期：2013-02-01 00:00:00

abstract：:Tissue specimens from 26 cases of Hodgkin's disease (HD) and six HD-derived cell lines were analysed for tumour necrosis factor (TNF), lymphotoxin (LT), and interleukin (IL)-6 RNA transcripts by in situ hybridization, in some cases subsequent to immunohistology for CD30 antigen. LT and TNF transcripts were found in tu...

journal_title：British journal of haematology

authors： Foss HD,Herbst H,Oelmann E,Samol J,Grebe M,Blankenstein T,Matthes J,Qin ZH,Falini B,Pileri S

更新日期：1993-08-01 00:00:00

abstract：:Using artificial receptors, it is possible to redirect the specificity of immune cells to tumour-associated antigens, which is expected to provide a useful strategy for cancer immunotherapy. Given that B-cell non-Hodgkin lymphoma (B-NHL) cells invariably express CD19 and CD38, these antigens may be suitable molecular ...

journal_title：British journal of haematology

authors： Mihara K,Yanagihara K,Takigahira M,Kitanaka A,Imai C,Bhattacharyya J,Kubo T,Takei Y,Yasunaga S,Takihara Y,Kimura A

更新日期：2010-10-01 00:00:00

abstract：:In this paper we describe the placental transport of [3H]vitamin K1 in pregnant rats during the first 24 h after the oral administration of the vitamin. Vitamin K1 in the fetal livers ranged from 0.13% (3 h) to 2% (24 h) of the values found in the corresponding maternal livers. In spite of the low placental transfer o...

journal_title：British journal of haematology

authors： Hamulyák K,de Boer-van den Berg MA,Thijssen HH,Hemker HC,Vermeer C

更新日期：1987-03-01 00:00:00

abstract：:B cell receptor (BCR) signalling is an important pathway in diffuse large B cell lymphoma (DLBCL). In response to BCR triggering, normal and malignant B cells secrete the chemokines CCL3 and CCL4 to attract accessory cells to the tissue microenvironment. We measured CCL3 and CCL4 serum concentrations in 102 patients w...

journal_title：British journal of haematology

authors： Takahashi K,Sivina M,Hoellenriegel J,Oki Y,Hagemeister FB,Fayad L,Romaguera JE,Fowler N,Fanale MA,Kwak LW,Samaniego F,Neelapu S,Xiao L,Huang X,Kantarjian H,Keating MJ,Wierda W,Fu K,Chan WC,Vose JM,O'Brien S,Davi

更新日期：2015-12-01 00:00:00

abstract：:Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding disorder, caused by a quantitative or qualitative defect of the GPIIb-IIIa integrin (alpha IIb beta 3), which functions as the platelet fibrinogen receptor. We report a case of type I GT due to a homozygous mutation resulting in Ser 870 to stop codon...

journal_title：British journal of haematology

authors： Vinciguerra C,Khelif A,Alemany M,Morle F,Grenier C,Uzan G,Gulino D,Dechavanne M,Negrier C

更新日期：1996-11-01 00:00:00

abstract：:The contribution of red cell size (mean cell volume) to the clinical and haematological manifestations of homozygous sickle cell (SS) disease has been investigated by comparing the features of two groups of patients with low (less than or equal to 80 fl) and high (greater than 95 fl) MCV values after matching for age,...

journal_title：British journal of haematology

authors： Serjeant GR,Foster K,Serjeant BE

更新日期：1981-07-01 00:00:00

abstract：:We investigated the origin of bone marrow fibroblasts in three bone marrow transplant recipients with aplastic anaemia and leukaemia who received grafts from HLA-identical siblings of opposite sex. The patients were conditioned for transplantation with high doses of cytotoxic drugs and 300--1000 rads total body irradi...

journal_title：British journal of haematology

authors： Golde DW,Hocking WG,Quan SG,Sparkes RS,Gale RP

更新日期：1980-02-01 00:00:00

abstract：:Mucormycosis has emerged as an increasingly important cause of morbidity and mortality in immunocompromised patients, but contemporary data in children are lacking. We conducted a nationwide multicentre study to investigate the characteristics of mucormycosis in children with haematological malignancies. The cohort in...

journal_title：British journal of haematology

authors： Elitzur S,Arad-Cohen N,Barg A,Litichever N,Bielorai B,Elhasid R,Fischer S,Fruchtman Y,Gilad G,Kapelushnik J,Kharit M,Konen O,Laor R,Levy I,Raviv D,Shachor-Meyouhas Y,Shvartser-Beryozkin Y,Toren A,Yaniv I,Nirel R,I

更新日期：2020-04-01 00:00:00

abstract：:Antibodies (Abs) that block factor VIII (FVIII) activity occur in hemophilia A patients treated with FVIII replacement therapy and severely impair treatment. In this work, we designed and synthesized ten peptides whose sequences are found in putative epitopes at the surface of a1 and C2 domains of the FVIII molecule. ...

journal_title：British journal of haematology

authors： Chaves DG,Velloso-Rodrigues C,Moreau V,Nguyen C,Villard S,Belisário AR,Granier C,Santoro MM

更新日期：2008-05-01 00:00:00

abstract：:Human umbilical vein endothelial cells (HUVEC) in primary confluent cultures lost their normal polygonal shape and assumed a 'contracted' appearance as judged by phase contrast microscopy when exposed to highly purified bovine thrombin (2 N.I.H. u/ml). Total actin in thrombin-exposed cells did not differ from that of ...

journal_title：British journal of haematology

authors： Galdal KS,Evensen SA,Høglund AS,Nilsen E

更新日期：1984-12-01 00:00:00

abstract：:Three patients with probable congenital erythrocytosis were studied to determine the role of erythropoietin (ESF) in their disease. In addition, haemoglobin function was measured and ESF excretion determined in response to reduction in the haemoglobin concentration. In two cases ESF excretion was clearly elevated abov...

journal_title：British journal of haematology

authors： Whitcomb WH,Peschle C,Moore M,Nitschke R,Adamson JW

更新日期：1980-01-01 00:00:00

abstract：:The purpose of the present work were to identify the initial characteristics associated with long-term survival in chronic granulocytic leukaemia (CGL) and to analyse the accuracy of prognostic models in identifying long-term survivors. 813 Philadelphia (Ph) chromosome-positive, nonblastic CGL patients from six Americ...

journal_title：British journal of haematology

authors： Cervantes F,Robertson JE,Rozman C,Baccarani M,Tura S,Gómez GA,Braun TJ,Clarkson BD,Pereira A

更新日期：1994-06-01 00:00:00