Abstract:
:Diamond-Blackfan anaemia (DBA) is an inherited bone marrow failure syndrome (IBMFS) characterized by red cell aplasia. Mutations in ribosomal genes are found in more than 50% of cases. Elevated erythrocyte adenosine deaminase (eADA) was first noted in DBA in 1983. In this study we determined the value of eADA for the diagnosis of DBA compared with other IBMFS; the association of eADA in DBA with age, gender or other haematological parameters; and the association with known DBA-related gene mutations. For the diagnosis of DBA compared with non-DBA patients with other bone marrow failure syndromes, eADA had a sensitivity of 84%, specificity 95%, and positive and negative predictive values of 91%. In patients with DBA there was no association between eADA and gender, age, or other haematological parameters. Erythrocyte ADA segregated with, as well as independent of, known DBA gene mutations. While eADA was an excellent confirmatory test for DBA, 16% of patients with classical clinical DBA had a normal eADA.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Fargo JH,Kratz CP,Giri N,Savage SA,Wong C,Backer K,Alter BP,Glader Bdoi
10.1111/bjh.12167subject
Has Abstractpub_date
2013-02-01 00:00:00pages
547-54issue
4eissn
0007-1048issn
1365-2141journal_volume
160pub_type
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