Factors affecting cardiolipin antibody assays: modification with polyethylene glycol compound.

abstract：:We report a Lancashire family with mild haemophilia B associated with a -6 G to A mutation in the factor IX promoter. This mutation has been reported previously in Britain in one other affected family. The factor IX haplotype of these two unrelated patients was determined by PCR analysis of seven polymorphic sites wit...

journal_title：British journal of haematology

authors： Stowell KM,Figueiredo MS,Brownlee GG,Jones P,Bolton-Maggs PH

更新日期：1993-09-01 00:00:00

abstract：:During the 3 years 1984-86, 314 cases of multiple myeloma were diagnosed in the Health Care Region of Western Sweden. 180 of these cases were included in a clinical trial; 71 were notified to the trial but excluded; 49 cases were not reported to the trial; 14 were diagnosed post mortem. The crude incidence rate of mye...

journal_title：British journal of haematology

authors： Hjorth M,Holmberg E,Rödjer S,Westin J

更新日期：1992-01-01 00:00:00

abstract：:The Medical Research Council acute lymphoblastic leukaemia trials (UKALL X and XI) recruited 3,702 children with ALL between January 1985 and March 1997. Seventy-nine children had central nervous system (CNS) involvement in their first two relapses. Fourteen children survived at a median follow-up of 22 months from se...

journal_title：British journal of haematology

authors： Morris EC,Harrison G,Bailey CC,Hann IM,Hill FG,Gibson BE,Richards S,Webb DK,Medical Research Council Childhood Leukaemia Working Party.

更新日期：2003-03-01 00:00:00

abstract：:Transient leukaemia (TL) in neonates with Down syndrome (DS) is characterized by the transient appearance of blast cells in the peripheral blood that resolves spontaneously. Some TL patients die at an early age due to organ failure. Seventy DS patients with TL were studied retrospectively to identify clinical and labo...

journal_title：British journal of haematology

authors： Muramatsu H,Kato K,Watanabe N,Matsumoto K,Nakamura T,Horikoshi Y,Mimaya J,Suzuki C,Hayakawa M,Kojima S

更新日期：2008-08-01 00:00:00

abstract：:Sickle cell disease (SCD) in Saudi patients from the Eastern Province is associated with the Arab-Indian (AI) HBB (β-globin gene) haplotype. The phenotype of AI SCD in children was described as benign and was attributed to their high fetal haemoglobin (HbF). We conducted a hospital-based study to assess the pattern of...

journal_title：British journal of haematology

authors： Alsultan A,Alabdulaali MK,Griffin PJ,Alsuliman AM,Ghabbour HA,Sebastiani P,Albuali WH,Al-Ali AK,Chui DH,Steinberg MH

更新日期：2014-02-01 00:00:00

abstract：:Future progress in the treatment of multiple myeloma (MM) requires both the characterisation of key drivers of the disease and novel, innovative approaches to tackle these vulnerabilities. The present study focussed on the pre-clinical evaluation of a novel drug class, BMI-1 modulators, in MM. We demonstrate potent ac...

journal_title：British journal of haematology

authors： Bolomsky A,Muller J,Stangelberger K,Lejeune M,Duray E,Breid H,Vrancken L,Pfeiffer C,Hübl W,Willheim M,Weetall M,Branstrom A,Zojer N,Caers J,Ludwig H

更新日期：2020-09-01 00:00:00

abstract：:The number of granulocyte-macrophage clones formed in agar culture of bone marrow is dependent on levels of colony stimulating activity (CSA) a proposed in vivo haemopoietic regulator. A dose-response relationship for stimulation of human haemopoietic cells by CSA is demonstrated, which could be explained by threshold...

journal_title：British journal of haematology

authors： Francis GE,Berney JJ,Hoffebrand AV

更新日期：1977-04-01 00:00:00

abstract：:In this study, quiescent bone marrow-derived CD34+ erythroid burst-forming units (BFU-E) were found to be resistant to the inhibitory effects of tumour necrosis factor (TNF)-alpha and -beta as well as interferon (IFN)-alpha, -beta and -gamma, in contrast to those stimulated by a combination of erytrhropoietin (Epo) pl...

journal_title：British journal of haematology

authors： Ratajczak J,Kucia M,Reca R,Zhang J,Machalinski B,Ratajczak MZ

更新日期：2003-10-01 00:00:00

abstract：:In countries with a good standard of health care, intracranial haemorrhage (ICH) during the neonatal period affects 3.5-4.0% of all haemophilia boys, which is considerably (40-80 times) higher than expected in the normal population. ICHs are also frequent after the neonatal period, affecting 3-10% of the haemophilia p...

journal_title：British journal of haematology

authors： Ljung RC

更新日期：2008-02-01 00:00:00

abstract：:Laboratory screening for lupus anticoagulant (LA) has been shown to be suboptimal in several studies. Guidelines have recently been published by an expert group for the British Committee for Standards in Haematology, in an attempt to standardize and improve screening procedures. The value of using screening tests conf...

journal_title：British journal of haematology

authors： Jennings I,Greaves M,Mackie IJ,Kitchen S,Woods TA,Preston FE,UK National External Quality Assessment Scheme for Blood Coagulation.

更新日期：2002-11-01 00:00:00

abstract：:Two cases of Ph1-positive chronic granulocytic leukaemia with hitherto undescribed translocations are presented. In case 1 the deleted part of chromosome number 22q- was translocated to the short arm of the X chromosome, t(X;22)(p22;q11). Pronounced basophilia, trisomy 19 in the majority of metaphases, and a partial c...

journal_title：British journal of haematology

authors： Hossfeld DK,Köhler S

更新日期：1979-02-01 00:00:00

abstract：:Platelets in an infant with Chediak-Higashi (C-H) syndrome without bleeding manifestations and not in the accelerated phase showed abnormal function consistent with storage pool disorder as shown by abnormal aggregation, decreased storage capacity and release of [14C]5-HT, low endogenous 5-HT, reduced ATP and ADP with...

journal_title：British journal of haematology

authors： Boxer GJ,Holmsen H,Robkin L,Bang NU,Boxer LA,Baehner RL

更新日期：1977-04-01 00:00:00

abstract：:Bortezomib in combination with cyclophosphamide and dexamethasone (CyBorD, is a well-established frontline chemotherapy regimen for patients with multiple myeloma, but prospective data on elderly non-transplant eligible patients is limited. A total of 155 patients aged 70 years or older with newly diagnosed multiple m...

journal_title：British journal of haematology

authors： Chan H,Chai K,Shih S,Lewsey R,Chen K,McDiarmid B,Jackson S,Simpson D

更新日期：2019-11-01 00:00:00

abstract：:Smouldering multiple myeloma (SMM) presents without MM defining symptoms. We aimed to identify patients with SMM with an 80% risk of progression within 2 years using only serum parameters. In total, 527 patients with SMM were included and divided into a training group (287 patients from the Czech Myeloma Group [CMG]) ...

journal_title：British journal of haematology

authors： Hájek R,Sandecka V,Špička I,Raab M,Goldschmidt H,Beck S,Minařík J,Pavlíček P,Radocha J,Heindorfer A,Jelínek T,Stejskal L,Brožová L,Ševčíková S,Straub J,Pika T,Pour L,Maisnar V,Seckinger A,Hose D

更新日期：2020-07-01 00:00:00

abstract：:To examine the role of human DNA topoisomerase IIalpha (topo IIalpha) in drug resistance, we selectively inhibited topo IIalpha gene expression in U937 human monocytic leukaemia cells stably transfected with a plasmid that allowed for Zn-mediated conditional expression of a human alpha-topo IIalpha antisense sequence....

journal_title：British journal of haematology

authors： Towatari M,Adachi K,Marunouchi T,Saito H

更新日期：1998-06-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF)-induced alteration of phosphoprotein during differentiation of HL-60 cells was studied. From the two-dimensional gel electrophoresis analysis of phosphoproteins, a 45 kD phosphoprotein in the cytosolic fraction of DMSO-pretreated HL-60 cells was rapidly dephosphorylated by...

journal_title：British journal of haematology

authors： Yamaguchi T,Oshizawa T,Yamaguchi T,Suzuki K,Yamamoto Y,Hayakawa T

更新日期：1998-08-01 00:00:00

abstract：:Minimal (i.e. submicroscopic) residual disease (MRD) predicts outcome in childhood acute lymphoblastic leukaemia (ALL). To be used clinically, MRD assays must be reliable and accurate. Two well-established techniques, flow cytometry (FC) and polymerase chain reaction (PCR), can detect leukaemic cells with a sensitivit...

journal_title：British journal of haematology

authors： Kerst G,Kreyenberg H,Roth C,Well C,Dietz K,Coustan-Smith E,Campana D,Koscielniak E,Niemeyer C,Schlegel PG,Müller I,Niethammer D,Bader P

更新日期：2005-03-01 00:00:00

abstract：:We studied the activity and stage of chronic liver disease in 45 HCV-seropositive/HIV-seronegative patients with severe haemophilia followed for at least 10 years. HCV-RNA was detected in serum in 36 patients (80%) Viraemic cases were further analysed for HCV genotypes: 10 (28%) were infected by type 1a, 10 (28%) by t...

journal_title：British journal of haematology

authors： Tagariello G,Pontisso P,Davoli PG,Ruvoletto MG,Traldi A,Alberti A

更新日期：1995-11-01 00:00:00

abstract：:Human IgG monoclonal antibodies (mabs) against the Rh D antigen have considerable potential for the prophylaxis of haemolytic disease of the newborn. We have carried out in vitro testing for cross-reactions with tissue components by screening two such mabs against animal tissues and a wide panel of human organs from n...

journal_title：British journal of haematology

authors： Thorpe SJ,Bailey SW

更新日期：1993-02-01 00:00:00

abstract：:Human umbilical vein endothelial cells (HUVEC) in primary confluent cultures lost their normal polygonal shape and assumed a 'contracted' appearance as judged by phase contrast microscopy when exposed to highly purified bovine thrombin (2 N.I.H. u/ml). Total actin in thrombin-exposed cells did not differ from that of ...

journal_title：British journal of haematology

authors： Galdal KS,Evensen SA,Høglund AS,Nilsen E

更新日期：1984-12-01 00:00:00

abstract：:Fetal haemoglobin levels have been measured prospectively in 135 autopsy cases of sudden, unexpected infant deaths (31 pre-term, 104 full term) using standard laboratory methods. These results have been compared with Hb F values from a normal control group of 570 living infants (145 pre-term, 425 full-term) with a pos...

journal_title：British journal of haematology

authors： Fagan DG,Walker A

更新日期：1992-10-01 00:00:00

abstract：:Reduced-intensity conditioning (RIC) regimens for allogeneic haematopoietic stem cell transplantation (SCT) have been shown to lead to engraftment of donor stem cells without the severe extra-haematological toxicities of traditional myeloablative transplants. Between December 1998 and December 2000, 76 patients underw...

journal_title：British journal of haematology

authors： Martino R,Caballero MD,Canals C,Simón JA,Solano C,Urbano-Ispízua A,Bargay J,Rayón C,Léon A,Sarrá J,Odriozola J,Conde JG,Sierra J,San Miguel J,ALLOPBSCT Subcommittee of the Spanish Group for Haematopoietic Transplantation (GET

更新日期：2001-12-01 00:00:00

abstract：:The sensitivity to cytosine arabinoside (Ara-C) of blast progenitors from 22 acute myeloblastic leukaemia (AML) patients was studied in methylcellulose and suspension cultures. Primary colony-formation (PE1) in methylcellulose reflects the terminal divisions of blast progenitors, while secondary colony formation (PE2)...

journal_title：British journal of haematology

authors： Nara N,Suzuki T,Nagata K,Yamashita Y,Murohashi I,Adachi Y

更新日期：1988-10-01 00:00:00

abstract：:Genetic variation in innate immunity may alter host-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population-based case-control studies of NHL from the San Franc...

journal_title：British journal of haematology

authors： Forrest MS,Skibola CF,Lightfoot TJ,Bracci PM,Willett EV,Smith MT,Holly EA,Roman E

更新日期：2006-07-01 00:00:00

abstract：:The success of genetically engineered T cells that express chimeric antigen receptors (CARTs) has been a momentous step forward in harnessing the potent cancer fighting abilities of the immune system. The efficacy seen in relapsed/refractory (r/r) acute lymphoblastic leukaemia (ALL), not only by inducing remission, bu...

journal_title：British journal of haematology

authors： Orlowski RJ,Porter DL,Frey NV

更新日期：2017-04-01 00:00:00

abstract：:We describe a familial study of AT III, a type III antithrombin III variant which was identified in the propositus by gene analysis as Pro 41 Leu heterozygous mutation. None of the four members of the family who presented with defective heparin cofactor (hep-cofactor) activity, and therefore probably carried the mutat...

journal_title：British journal of haematology

authors： de Roux N,Chadeuf G,Molho-Sabatier P,Plouin PF,Aiach M

更新日期：1990-06-01 00:00:00

abstract：:A case of Evans' syndrome with IgM deficiency and lymphopenia was studied before and after splenectomy. The lymphopenia was as a result of profound reduction of CD4 and CD8 cells. Study of cytokine secretion before splenectomy revealed a spontaneous Th1- and Th2-type cytokine production, and complete suppression of tr...

journal_title：British journal of haematology

authors： Karakantza M,Mouzaki A,Theodoropoulou M,Bussel JB,Maniatis A

更新日期：2000-09-01 00:00:00

abstract：:MHC-unrestricted cytotoxic lymphocytes, namely natural killer (NK) and lymphokine activated killer (LAK) cells, have been implicated in the regulation of haemopoiesis. To investigate the possible role of these lymphocytes in the pathogenesis of aplastic anaemia (AA), we studied their functions in the peripheral blood ...

journal_title：British journal of haematology

authors： Myint AA,Malkovska V,Morgan S,Luckit J,Wonke B,Gordon-Smith EC

更新日期：1990-08-01 00:00:00

abstract：:The role of factor XI (FXI) in blood coagulation has been clarified in recent years by descriptions of FXI-deficient patients who are prone to excessive bleeding after haemostatic challenge. We have studied a large kindred of an Italian FXI-deficient patient with a previously undescribed mutation. The propositus, a 68...

journal_title：British journal of haematology

authors： Alhaq A,Mitchell M,Sethi M,Rahman S,Flynn G,Boulton P,Caeno G,Smith M,Savidge G

更新日期：1999-01-01 00:00:00

abstract：:Givinostat, a histone-deacetylase inhibitor (HDACi), inhibits proliferation of cells bearing the JAK2 V617F mutation and has shown significant activity with good tolerability in patients with chronic myeloproliferative neoplasms (MPN). In this multicentre, open-label, phase II study, 44 patients with polycythaemia ver...

journal_title：British journal of haematology

authors： Finazzi G,Vannucchi AM,Martinelli V,Ruggeri M,Nobile F,Specchia G,Pogliani EM,Olimpieri OM,Fioritoni G,Musolino C,Cilloni D,Sivera P,Barosi G,Finazzi MC,Di Tollo S,Demuth T,Barbui T,Rambaldi A

更新日期：2013-06-01 00:00:00