Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma.


:Genetic variation in innate immunity may alter host-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population-based case-control studies of NHL from the San Francisco Bay Area (308 cases, 684 controls) and UK (596 cases, 758 controls). The caspase recruitment domain-containing protein 1007fs homozygote variant was positively associated with NHL risk (odds ratios (OR) = 3.1, 95% confidence intervals (CI) 1.1-8.8), whereas the toll-like receptor 4 1063A>G variant allele was inversely associated with diffuse large cell lymphoma (OR = 0.67, 95% CI 0.45-0.99). These results suggest that variation in innate immune genes may alter NHL susceptibility.


Br J Haematol


Forrest MS,Skibola CF,Lightfoot TJ,Bracci PM,Willett EV,Smith MT,Holly EA,Roman E




Has Abstract


2006-07-01 00:00:00














  • Cellular and humoral immune responses in haemophiliacs after vaccination against tick-borne encephalitis.

    abstract::The primary immune response to a viral antigen (tick-borne encephalitis, TBE) has been determined in haemophiliacs. Twelve HIV-negative and four clinically asymptomatic, HIV-positive haemophiliacs as well as 16 age-matched healthy controls were included in the study. Antibody responses after TBE vaccination were compa...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Wolf HM,Pum M,Jáger R,István L,Mannhalter JW,Eibl MM

    更新日期:1992-10-01 00:00:00

  • Roles for both cyclic GMP and cyclic AMP in the inhibition of collagen-induced platelet aggregation by nitroprusside.

    abstract::In studies on human platelets, nitroprusside (NP) alone at 1-10 micromol/l increased platelet cyclic AMP (cAMP) by 40-70%, whereas increases in cyclic GMP (cGMP) were much larger in percentage though not in concentration terms. Collagen enhanced these increases in cAMP up to fourfold, without affecting cGMP. This effe...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Jang EK,Azzam JE,Dickinson NT,Davidson MM,Haslam RJ

    更新日期:2002-06-01 00:00:00

  • Autologous stem cell transplantation: evaluation of erythropoietic reconstitution by highly fluorescent reticulocyte counts, erythropoietin, soluble transferrin receptors, ferritin, TIBC and iron dosages.

    abstract::The plasma concentrations of erythropoietin (Ep), soluble transferrin receptors (sTfRs), iron, total iron binding capacity (TIBC) and ferritin were monitored in five leukaemia patients undergoing autologous bone marrow stem cell transplantation (BMSCT) and in 10 lymphoma and 21 ovarian cancer patients undergoing autol...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Testa U,Rutella S,Martucci R,Scambia G,D'Onofrio G,Pierelli L,Sica S,Benedetti Panici PL,Menichella G,Foti E,Mastroberardino G,Mancuso S,Leone G,Peschle C

    更新日期:1997-03-01 00:00:00

  • CD34+-selected peripheral blood progenitor cell transplantation in patients with multiple myeloma: tumour cell contamination and outcome.

    abstract::Thirty-six patients with multiple myeloma (23 PR1, nine PR2, four stable disease) were entered into a pilot study evaluating the use of CD34+-selected peripheral blood progenitor cell transplantation (PBPCT) following high-dose melphalan alone or high-dose melphalan and total body irradiation. Peripheral blood progeni...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Gupta D,Bybee A,Cooke F,Giles C,Davis JG,McDonald C,Armitage SE,McGuigan D,Lyttelton MP,Kanfer EJ,Apperley JF,Samson D

    更新日期:1999-01-01 00:00:00

  • Co-administration of Flt-3 ligand counteracts the actions of thrombopoietin in myelosuppressed rhesus monkeys.

    abstract::This placebo-controlled study evaluated the efficacy of Flt-3 ligand (FL) combined with TPO in myelosuppressed rhesus monkeys. The monkeys were subjected to 5 Gy total body irradiation (TBI), resulting in 3 weeks of profound pancytopenia, and received either 5 microg/kg of rhesus TPO i.v. on d 1 (n = 4) and 100 microg...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Hartong SC,Neelis KJ,Wagemaker G

    更新日期:2003-04-01 00:00:00

  • In vivo folic acid supplementation partially corrects in vitro methotrexate toxicity in patients with Down syndrome.

    abstract::Patients with Down syndrome have been found to have characteristic in vivo and in vitro methotrexate toxicity. The in vitro methotrexate toxicity characteristic of Down syndrome can be diminished by the in vivo administration of supplemental high doses of folic acid. A possible explanation for the increased sensitivit...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Peeters MA,Rethore MO,Lejeune J

    更新日期:1995-03-01 00:00:00

  • Mutations of the p53 tumour suppressor gene in haematologic neoplasms.

    abstract::Mutations of the p53 tumour suppressor gene have frequently been observed in several types of solid tumours and are believed to be implicated in the development of these tumours. To determine the relevance of p53 mutations in haematologic neoplasms, we performed polymerase chain reaction-single strand conformation pol...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Mori N,Wada M,Yokota J,Terada M,Okada M,Teramura M,Masuda M,Hoshino S,Motoji T,Oshimi K

    更新日期:1992-06-01 00:00:00

  • Effective lysis of lymphoma cells with a stabilised bispecific single-chain Fv antibody against CD19 and FcgammaRIII (CD16).

    abstract::A recombinant bispecific single-chain fragment variable antibody (bsscFv), directed against the B-cell antigen CD19 and the low affinity Fc-receptor FcgammaRIII (CD16), was designed for use in the treatment of patients with leukaemias and lymphomas. The Fc-portions of whole antibodies were deliberately eliminated in t...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Bruenke J,Barbin K,Kunert S,Lang P,Pfeiffer M,Stieglmaier K,Niethammer D,Stockmeyer B,Peipp M,Repp R,Valerius T,Fey GH

    更新日期:2005-07-01 00:00:00

  • CD48 as a novel molecular target for antibody therapy in multiple myeloma.

    abstract::Monoclonal antibody (mAb) drugs are desirable for the improvement of multiple myeloma (MM) treatment. In this study, we found for the first time that CD48 was highly expressed on MM plasma cells. In 22 out of 24 MM patients, CD48 was expressed on more than 90% of MM plasma cells at significantly higher levels than it ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Hosen N,Ichihara H,Mugitani A,Aoyama Y,Fukuda Y,Kishida S,Matsuoka Y,Nakajima H,Kawakami M,Yamagami T,Fuji S,Tamaki H,Nakao T,Nishida S,Tsuboi A,Iida S,Hino M,Oka Y,Oji Y,Sugiyama H

    更新日期:2012-01-01 00:00:00

  • No evidence for a major role of heterozygous deletion 657del5 within the NBS1 gene in the pathogenesis of non-Hodgkin's lymphoma of childhood and adolescence.

    abstract::Nijmegen breakage syndrome (NBS) is an autosomal recessive DNA repair disorder with a high predisposition for lymphoid malignancies. The majority of NBS patients carry a homozygous founder mutation (657del5) within the NBS1 gene. The observation of a high incidence of cancer in close relatives of NBS patients suggests...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Stanulla M,Stümm M,Dieckvoss BO,Seidemann K,Schemmel V,Müller Brechlin A,Schrappe M,Welte K,Reiter A

    更新日期:2000-04-01 00:00:00

  • Haemophilia B Liverpool: a new British family with mild haemophilia B associated with a -6 G to A mutation in the factor IX promoter.

    abstract::We report a Lancashire family with mild haemophilia B associated with a -6 G to A mutation in the factor IX promoter. This mutation has been reported previously in Britain in one other affected family. The factor IX haplotype of these two unrelated patients was determined by PCR analysis of seven polymorphic sites wit...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Stowell KM,Figueiredo MS,Brownlee GG,Jones P,Bolton-Maggs PH

    更新日期:1993-09-01 00:00:00

  • New translocations in chronic granulocytic leukaemia: t(X;22)(p22;q11) and t(15;22)(q26;q11).

    abstract::Two cases of Ph1-positive chronic granulocytic leukaemia with hitherto undescribed translocations are presented. In case 1 the deleted part of chromosome number 22q- was translocated to the short arm of the X chromosome, t(X;22)(p22;q11). Pronounced basophilia, trisomy 19 in the majority of metaphases, and a partial c...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Hossfeld DK,Köhler S

    更新日期:1979-02-01 00:00:00

  • A dose of 75 microg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 microg/kg/d in adults with immune thrombocytopenic purpura.

    abstract::Treatment with 75 microg/kg/d intravenous (i.v.) anti-D was compared with 50 microg/kg/d in a prospective randomized study of 27 RhD-positive, human immunodeficiency virus-negative, adult, acute, non-splenectomized patients with immune thrombocytopenic purpura (ITP) and platelet counts < or = 30 x 109/l. The higher do...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Newman GC,Novoa MV,Fodero EM,Lesser ML,Woloski BM,Bussel JB

    更新日期:2001-03-01 00:00:00

  • Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids.

    abstract::Inhibition of apoptosis (genetically programmed active cell death) by p210 BCR-ABL expression is a mechanism that might contribute to clonal expansion in chronic myeloid leukaemia (CML). Since cell death following exposure to ionizing radiation and many chemotherapeutic agents can occur by the apoptotic pathway, inhib...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Amos TA,Lewis JL,Grand FH,Gooding RP,Goldman JM,Gordon MY

    更新日期:1995-10-01 00:00:00

  • Heterocellular hereditary persistence of fetal haemoglobin affects the haematological parameters of beta-thalassaemia trait.

    abstract::To assess and define the effects of heterocellular hereditary persistence of fetal haemoglobin (HPFH) on the haematological phenotype of heterozygous beta-thalassaemia, we have studied a large kindred that included a total of 204 subjects with 60 beta-thalassaemia carriers, of whom 35 were also heterozygous, and five ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Garner C,Dew TK,Sherwood R,Rees D,Thein SL

    更新日期:2003-10-01 00:00:00

  • Binding of low-molecular-weight canine factor VIII coagulant from von Willebrand plasma to canine factor VIII-related antigen.

    abstract::Plasmas having no detectable factor VIII-related antigen but moderate factor VIII coagulant were obtained from two unrelated dogs homozygous for von Willebrand's disease and with the severe clinical expression of the disease. when these plasmas were gel-filtered in a buffer at physiologic ionic strength, the factor VI...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Benson RE,Johnson GS,Dodds WJ

    更新日期:1981-12-01 00:00:00

  • Erythroblast iron metabolism in sideroblastic marrows.

    abstract::The uptake of iron by bone marrow erythroblasts and its intracellular distribution have been studied in 23 patients with primary sideroblastic anaemia (SA), five patients with secondary SA and one patient with only non-ringed sideroblasts. EM of erythroblasts from 18 cases showed both mitochondrial iron deposits and c...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: May A,de Souza P,Barnes K,Kaaba S,Jacobs A

    更新日期:1982-12-01 00:00:00

  • Three unrelated Gaucher's disease patients with three novel point mutations in the glucocerebrosidase gene (P266R, D315H and A318D).

    abstract::Three novel point mutations were detected in the glucocerebrosidase gene of three unrelated Gaucher's disease patients by direct sequencing of PCR products. The first is a C to G change at position 4263 in the genomic sequence (exon 7) which results in a proline to arginine change at position 266 in the mature enzyme ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Walley AJ,Ellis I,Harris A

    更新日期:1995-10-01 00:00:00

  • Immunodeficiency and IL-6 production by peripheral blood monocytes in multicentric Castleman's disease.

    abstract::To study the pathogenesis of multicentric Castleman's disease (MCD), IL-6 producing cells and immune function were investigated in four MCD patients. The expression of IL-6 mRNA in one MCD lymph node was analysed by in situ hybridization. IL-6 mRNA expressing cells were scattered in the interfollicular areas and did n...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Ishiyama T,Nakamura S,Akimoto Y,Koike M,Tomoyasu S,Tsuruoka N,Murata Y,Sato T,Wakabayashi Y,Chiba S

    更新日期:1994-03-01 00:00:00

  • European Concerted Action on Anticoagulation (ECAA): multicentre international sensitivity index calibration of two types of point-of-care prothrombin time monitor systems.

    abstract::A multicentre modified World Health Organization (WHO)-type international sensitivity index (ISI) calibration has been performed at 10 European Concerted Action on Anticoagulation (ECAA) national laboratories using non-citrated whole-blood on two point-of-care test (POCT) prothrombin time (PT) monitor systems, CoaguCh...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Poller L,Keown M,Chauhan N,van Den Besselaar AM,Tripodi A,Jespersen J,Shiach C,Horellou MH,Dias D,Egberg N,Iriarte JA,Kontopoulou-Griva I,Otridge B

    更新日期:2002-03-01 00:00:00

  • The mean fluorescence intensities of anti-HLA antibodies detected using micro-bead flow cytometry predict the risk of platelet transfusion refractoriness.

    abstract::There are no accepted methods to predict the development of platelet transfusion refractoriness (PTR) due to human leucocyte antigen (HLA)-alloimmunization. Hence, matched platelets are usually given only to patients demonstrating PTR, necessarily resulting in some ineffective random donor platelets (RDPLT) transfusio...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Beligaswatte A,Tsiopelas E,Humphreys I,Bennett G,Robinson K,Davis K,Bardy P

    更新日期:2013-08-01 00:00:00

  • Immunological evidence that human factor VIII is composed of two linked moieties.

    abstract::The relationship between the three measurable components of the factor VIII complex, procoagulant activity (VIII:C), Ristocetin cofactor (VIIIR:WF) and factor VIII related antigen (VIIR:AG), has been investigated using a solid phase immunoadsorption system in which homologous antibodies specific for VIII:C are insolu...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Koutts J,Lavergne JM,Meyer D

    更新日期:1977-11-01 00:00:00

  • Impaired microtubule assembly and polymorphonuclear leucocyte function in the Chediak-Higashi syndrome correctable by ascorbic acid.

    abstract::It was previously shown that the abnormal surface characteristics and defective bactericidal function of polymorphonuclear leucocytes (PMN) in the Chediak-Higashi syndrome (CHS) are correlated with impaired microtubule assembly, and in one patient direct electron microscopic evidence for an anomaly in microtubule asse...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Boxer LA,Albertini DF,Baehner RL,Oliver JM

    更新日期:1979-10-01 00:00:00

  • Defective spectrin dimer-dimer association in a family with transfusion dependent homozygous hereditary elliptocytosis.

    abstract::Red cell membrane proteins have been examined in a family in which three children have severe transfusion-dependent homozygous hereditary elliptocytosis. The membranes in all three show a considerable excess of spectrin dimers over tetramers in spectrin extracts. The red cell membranes of their parents with heterozygo...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Evans JP,Baines AJ,Hann IM,Al-Hakim I,Knowles SM,Hoffbrand AV

    更新日期:1983-06-01 00:00:00

  • CD34+ cell immunoselection from G-CSF-alone-primed peripheral blood in children with low body mass.

    abstract::We report the data of CD34+ cell immunoselection from peripheral blood after G-CSF-alone mobilization (10 micrograms/kg/d s.c.) in nine children with neuroblastoma (median age 4-5 years (2-8), median body weight 16 kg (10-20). Leukaphereses were carried out on a Cobe Spectra separator and two consecutive harvests (4 b...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kanold J,Berger M,Rapatel C,de Lumley L,Lutz P,Plantaz D,Vannier JP,Bergeron C,Mechinaud F,Favrot M

    更新日期:1995-10-01 00:00:00

  • CD20 expression predicts survival in paediatric post-transplant lymphoproliferative disease (PTLD) following solid organ transplantation.

    abstract::The prognostic role of CD20 expression and Epstein-Barr virus (EBV) positivity in post-transplant lymphoproliferative disease (PTLD) after solid organ transplantation (SOT) in paediatric patients is poorly understood. We retrospectively examined the relationship of CD20 and EBV with the time interval from SOT to PTLD ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Orjuela MA,Alobeid B,Liu X,Siebert AL,Kott ER,Addonizio LJ,Morris E,Garvin JH,Lobritto SJ,Cairo MS

    更新日期:2011-03-01 00:00:00

  • R-CHOP with iodine-131 tositumomab consolidation for advanced stage diffuse large B-cell lymphoma (DLBCL): SWOG S0433.

    abstract::Radiolabelled antiCD-20 antibodies have demonstrated single agent activity in relapsed diffuse large B-cell lymphoma (DLBCL). The S0433 clinical trial enrolled patients with newly diagnosed, advanced stage or bulky stage II, histologically confirmed DLBCL. Patients received six cycles of R-CHOP (rituximab, cyclophosph...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Friedberg JW,Unger JM,Burack WR,Gopal AK,Raju RN,Nademanee AP,Kaminski MS,Li H,Press OW,Miller TP,Fisher RI

    更新日期:2014-08-01 00:00:00

  • bcl-2 and immunoglobulin gene rearrangement in patients with hepatitis C virus infection.

    abstract::An association between chronic hepatitis C virus (HCV) infection and clonal proliferation of B cells, including B cell lymphoma, has recently been demonstrated. However, the mechanism of malignant transformation is still unknown. It has been shown that B cells from patients with type II mixed cryoglobulinaemia (MC), s...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Zuckerman E,Zuckerman T,Sahar D,Streichman S,Attias D,Sabo E,Yeshurun D,Rowe J

    更新日期:2001-02-01 00:00:00

  • Four new cases of stomatin-deficient hereditary stomatocytosis syndrome: association of the stomatin-deficient cryohydrocytosis variant with neurological dysfunction.

    abstract::This report concerns congenitally Na(+)-K(+) leaky red cells of the 'hereditary stomatocytosis' class. Three new isolated cases and one new pedigree are described, and one previously reported case is expanded. In all cases, Western blotting of red cell membranes revealed a deficiency in the 32 kDa membrane protein, st...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Fricke B,Jarvis HG,Reid CD,Aguilar-Martinez P,Robert A,Quittet P,Chetty M,Pizzey A,Cynober T,Lande WF,Mentzer WC,Düring M,Winter S,Delaunay J,Stewart GW

    更新日期:2004-06-01 00:00:00

  • Preliminary experience of allogeneic stem cell transplantation for lymphoproliferative disorders using BEAM-CAMPATH conditioning: an effective regimen with low procedure-related toxicity.

    abstract::Autologous transplantation has an established role in the treatment of lymphoproliferative disorders, but allogeneic transplantation remains controversial. In an attempt to reduce the high procedure-related mortality reported with allografting in lymphoma, we have used BEAM (BCNU, etoposide, cytarabine and melphalan),...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Cull GM,Haynes AP,Byrne JL,Carter GI,Miflin G,Rebello P,Hale G,Waldmann H,Russell NH

    更新日期:2000-03-01 00:00:00