Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma.

Abstract:

:Genetic variation in innate immunity may alter host-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population-based case-control studies of NHL from the San Francisco Bay Area (308 cases, 684 controls) and UK (596 cases, 758 controls). The caspase recruitment domain-containing protein 1007fs homozygote variant was positively associated with NHL risk (odds ratios (OR) = 3.1, 95% confidence intervals (CI) 1.1-8.8), whereas the toll-like receptor 4 1063A>G variant allele was inversely associated with diffuse large cell lymphoma (OR = 0.67, 95% CI 0.45-0.99). These results suggest that variation in innate immune genes may alter NHL susceptibility.

journal_name

Br J Haematol

authors

Forrest MS,Skibola CF,Lightfoot TJ,Bracci PM,Willett EV,Smith MT,Holly EA,Roman E

doi

10.1111/j.1365-2141.2006.06141.x

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

180-3

issue

2

eissn

0007-1048

issn

1365-2141

pii

BJH6141

journal_volume

134

pub_type

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