Antibodies to factor XII and recurrent fetal loss in patients with the anti-phospholipid syndrome.

Abstract:

:Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one patients had a history of recurrent fetal loss (> 2, mean = 2.6). Lupus anticoagulant positivity showed a weak association with recurrent fetal loss (odds ratio = 1.1). While there was no association between the presence of antibodies to cardiolipin or beta 2-glycoprotein I with recurrent fetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5.4, P = 0.025).

journal_name

Br J Haematol

authors

Jones DW,MacKie IJ,Gallimore MJ,Winter M

doi

10.1046/j.1365-2141.2001.02776.x

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

550-2

issue

2

eissn

0007-1048

issn

1365-2141

pii

bjh2776

journal_volume

113

pub_type

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