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Anaemia and marrow blood flow in the rat.

Abstract：

:An increase in bone marrow blood flow has been previously described in anaemic rabbits and dogs. We examined the effect of haemorrhage and haemolysis in female Sprague-Dawley rats, with the hypothesis that high blood flow was related to hyperplasia of bone marrow tissue and that the increase would affect bone as well. Blood flow was measured in tibia and femur by the microspheres trapping method. Chronic anaemia was accompanied at day 32 by a marked increase (factor of 1.7-1.9) in blood flow to bone marrow and to bone. On the other hand, no increase in blood flow was observed in chronic compensated anaemia, showing that anaemia per se and not stimulation of erythropoiesis was responsible for the increase. We then explored the effect on blood flow of two factors associated with anaemia. Erythropoietin 4 U/d for 4 d failed to induce any increase in bone and marrow blood flow. Systemic hypoxia (76 mmHg for 3 d) reduced the fraction of cardiac output conveyed to bone and marrow by 40-50%, but this decrease was more than compensated by an increase in cardiac output. We conclude that neither erythropoietin nor low tissue pO2 is the direct cause for the increase in bone and marrow blood flow observed in anaemia.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Schoutens A,Verhas M,Dourov N,Verschaeren A,Mone M,Heilporn A

doi

10.1111/j.1365-2141.1990.tb06343.x

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

514-8

issue

4

eissn

0007-1048

issn

1365-2141

journal_volume

74

pub_type

杂志文章

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