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Influence of demographic factors on antithrombin III activity in a healthy population.

Abstract：

:Antithrombin III (AT III) activity has been measured in 9669 healthy blood donors (5525 male and 4144 female). The distribution of AT III is approximately 'normal' with mean 105.6 IU/dl and standard deviation 11.2; however, definite age and sex related variations are evident. Pre-menopausal females have lower mean AT III compared to their male contemporaries who have remarkably stable mean AT III until 45 years, after which there is a gradual decline. In contrast, post-menopausal females have higher mean AT III than both males of the same age and younger pre-menopausal females. Concurrent hormone replacement therapy inhibits this rise. The use of hormonal preparations is associated with a 4 IU/dl reduction of mean AT III in younger females but not in those over 30 years. Smoking may result in a mild increase in AT III of doubtful clinical significance. On-going genetic and family studies are expected to predict a prevalence rate of congenital AT III deficiency in excess of the previously reported figure of 0.02%. The authors consider these observed variations as minor and recommend the use of a single reference range for AT III activity, but that particular care be taken when interpreting results in pill-taking females and the elderly.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Tait RC,Walker ID,Islam SI,McCall F,Conkie JA,Mitchell R,Davidson JF

doi

10.1111/j.1365-2141.1993.tb03104.x

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

476-80

issue

3

eissn

0007-1048

issn

1365-2141

journal_volume

84

pub_type

杂志文章

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