Characterization of platelet-specific alloantigens by immunoblotting: localization of Zw and Bak antigens.

abstract：:The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lympho...

journal_title：British journal of haematology

authors： Miyamura T,Moritake H,Nakayama H,Tanaka S,Tomizawa D,Shiba N,Saito AM,Tawa A,Shimada A,Iwamoto S,Hayashi Y,Koike T,Horibe K,Manabe A,Mizutani S,Taga T,Adachi S

更新日期：2019-04-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) was previously demonstrated to be a mediator of oxidative stress-induced apoptosis in irradiated neoplastic B-cells and B-cell precursors. Defective BTK expression in leukaemic B-cell precursors from infants with t(4;11) acute lymphoblastic leukaemia has been associated with radiation re...

journal_title：British journal of haematology

authors： Uckun F,Ozer Z,Vassilev A

更新日期：2007-02-01 00:00:00

abstract：:The surface markers of immunoglobulin secreting cells (ISC) in bone marrow and peripheral blood were analysed. Circulating ISC bear surface Ig and Ia-like antigens. However, these markers were not detectable on ISC in bone marrow. Fc and complement receptors were not present on circulating ISC. The areas of plaques co...

journal_title：British journal of haematology

authors： Gyotoku Y,Mori M,Nonaka Y,Nagata Y,Saito Y

更新日期：1985-04-01 00:00:00

abstract：:Human megakaryocytes have been isolated from marrow obtained from ribs removed at thoracotomy. All but one of the patients had normal pre-operative platelet and leucocyte counts. Megakaryocytes averaged 0.37% of all cells in marrow cell suspensions from nine consecutive subjects. A 283-fold purification (to 10.3%) was...

journal_title：British journal of haematology

authors： Levine RF

更新日期：1980-07-01 00:00:00

abstract：:Although the beta thalassaemia trait affects millions of people worldwide, there have been no controlled studies to determine whether it is associated with any clinical disability or abnormal physical signs. To address this question, 402 individuals were studied: 217 with beta thalassaemia trait, of whom 154 were awar...

journal_title：British journal of haematology

authors： Premawardhena A,Arambepola M,Katugaha N,Weatherall DJ

更新日期：2008-05-01 00:00:00

abstract：:Commercial preparations of ferritin inhibited reticulocyte-lysate cell-free protein synthesis and disaggregated polyribosomes to monoribosomes and ribosomal subunits. These effects were prevented by addition of reduced glutathione (GSH) to the incubation medium, but ferritin did not lower GSH concentration in the lysa...

journal_title：British journal of haematology

authors： Freedman ML,Cohen HS,Rosman J,Forte FJ

更新日期：1976-04-01 00:00:00

abstract：:The Australian Leukaemia Study Group has performed a randomized trial of interferon alpha-2A (Roferon-A) as a co-induction agent together with intensive combination chemotherapy and as maintenance following completion of 12 cycles of induction treatment. When used as a co-induction agent, interferon-alpha did not impr...

journal_title：British journal of haematology

authors： Joshua DE,Penny R,Matthews JP,Laidlaw CR,Gibson J,Bradstock K,Wolf M,Goldstein D

更新日期：1997-04-01 00:00:00

abstract：:We studied 13 patients with rheumatoid arthritis (RA) and gold-induced thrombocytopenia. Platelet-specific autoantibodies of the IgG and often also of the IgM class were detected by immunofluorescence on the patient's platelets and in ether eluates from these platelets. In nine patients we also detected autoantibodies...

journal_title：British journal of haematology

authors： von dem Borne AE,Pegels JG,van der Stadt RJ,van der Plas-van Dalen CM,Helmerhorst FM

更新日期：1986-07-01 00:00:00

abstract：:The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re-evaluation: the leukaemic cells showed signs of differentiation, and acti...

journal_title：British journal of haematology

authors： Heim S,Avanzi GC,Billström R,Kristoffersson U,Mandahl N,Bekassy AN,Garwicz S,Wiebe T,Pegoraro L,Falda M

更新日期：1987-07-01 00:00:00

abstract：:Ibrutinib is associated with response rate of 90% and median progression-free survival (PFS) in excess of 5 years in Waldenström macroglobulinaemia (WM) patients. CXCR4 mutations are detected in 30-40% of patients with WM and associate with lower rates of response and shorter PFS to ibrutinib therapy. Both frameshift ...

journal_title：British journal of haematology

authors： Castillo JJ,Xu L,Gustine JN,Keezer A,Meid K,Dubeau TE,Liu X,Demos MG,Kofides A,Tsakmaklis N,Chen JG,Munshi M,Guerrera ML,Chan GG,Patterson CJ,Yang G,Hunter ZR,Treon SP

更新日期：2019-11-01 00:00:00

abstract：:We describe a patient with a 9-year history of thrombotic thrombocytopenic purpura (TTP) who exhibited four relapses. Intravenous immunoglobulin (IVIg) was effective for these four episodes. The patient was well and the laboratory findings were within normal ranges between each episode, although unusually large von Wi...

journal_title：British journal of haematology

authors： Kondo H,Imamura T

更新日期：2000-03-01 00:00:00

abstract：:Fibroblast-like cells may be grown from human bone marrow. Adherent cultures show a logarithmic phase of growth lasting 6 d. Hydrocortisone (1 x 10(-8) M) decreases cell growth in 40-60% when measured as cell number and DNA synthesis. Fibroblasts bind the hormone by a high affinity, saturable process showing a Kd of 2...

journal_title：British journal of haematology

authors： Minguell JJ,Martínez J,Walter T

更新日期：1982-10-01 00:00:00

abstract：:In recent years there has been a paradigm shift in our understanding of the epidemiology and clinical features of hepatitis E virus (HEV) infection. Once classically described as an acute hepatitis associated with waterborne outbreaks in areas of poor sanitation, HEV is now recognised to be endemic in Europe and is pr...

journal_title：British journal of haematology

authors： O'Gorman J,Burke Á,O'Flaherty N

更新日期：2018-06-01 00:00:00

abstract：:The aim of this study was to analyse the expression of NK-associated antigens in both peripheral blood and bone marrow lymphocytes from a large series of newly diagnosed multiple myeloma patients. 112 patients with untreated multiple myeloma (MM) were included in the study. 36 sex- and age-matched healthy volunteers w...

journal_title：British journal of haematology

authors： García-Sanz R,González M,Orfão A,Moro MJ,Hernández JM,Borrego D,Carnero M,Casanova F,Bárez A,Jiménez R,Portero JA,San Miguel JF

更新日期：1996-04-01 00:00:00

abstract：:The molecular basis of severe type I factor (F)VII deficiency was investigated in two Algerian patients. One patient, a 13-year-old-girl who has suffered from severe bleeding since birth, was homozygous for a 7-bp deletion (nt 7774-7780) and a 251-bp insertion (nt 7773-7781) of mitochondrial origin, in IVS 4 acceptor ...

journal_title：British journal of haematology

authors： Borensztajn K,Chafa O,Alhenc-Gelas M,Salha S,Reghis A,Fischer AM,Tapon-Bretaudière J

更新日期：2002-04-01 00:00:00

abstract：:A 14-month-old child who had a haemolytic episode when he was 5 years old, and with psychomotor retardation, was found to have decreased red cell hexokinase activity. The mutant enzyme was characterized by an increased affinity for glucose associated with an increased inhibition constant for glucose-1,6-diphosphate. A...

journal_title：British journal of haematology

authors： Magnani M,Stocchi V,Canestrari F,Dachà M,Balestri P,Farnetani MA,Giorgi D,Fois A,Fornaini G

更新日期：1985-09-01 00:00:00

abstract：:A new putative hepatitis virus has recently been discovered and termed GB virus C (GBV-C). We investigated the prevalence of this virus among 50 haemophiliacs treated with non-virus-inactivated clotting factor concentrates prior to 1985 and 21 haemophiliacs treated exclusively with virus-inactivated clotting factor co...

journal_title：British journal of haematology

authors： Uhle C,Zimmermann R,Goeser T,Seelig R

更新日期：1997-12-01 00:00:00

abstract：:This study compared the diagnostic value of Whole-Body Ultra Low-Dose computed tomography (WBULDCT) with that of Spinal Magnetic Resonance Imaging (SMRI) in identification of spinal bone marrow involvement in patients with Multiple Myeloma (MM). Thirty-five patients with histologically proven MM underwent WBULDCT and ...

journal_title：British journal of haematology

authors： Ippolito D,Talei Franzesi C,Spiga S,Besostri V,Pezzati S,Rossini F,Sironi S

更新日期：2017-05-01 00:00:00

abstract：:Bendamustine + rituximab (BR) is the current first-line standard-of-care for chronic lymphocytic leukaemia (CLL) in fit patients aged 66-70 years, whereas chlorambucil + CD20 antibody is recommended in older patients with co-morbidities. This retrospective real-world study investigated whether risk-adapted BR was safe...

journal_title：British journal of haematology

authors： Mattsson A,Sylvan SE,Asklid A,Wiggh J,Winqvist M,Lundin J,Mansouri L,Rosenquist R,Johansson H,Österborg A,Hansson L

更新日期：2020-11-01 00:00:00

abstract：:Two children affected by severe aplastic anaemia (SAA) underwent allogeneic bone marrow transplantation (BMT) using partially matched family donors. In both cases there was a successful engraftment of donor haemopoietic stem cells. However, after an initial erythropoietic recovery, 5 months following BMT both children...

journal_title：British journal of haematology

authors： Locatelli F,Pedrazzoli P,Barosi G,Zecca M,Porta F,Liberato L,Gambarana D,Nespoli L,Cazzola M

更新日期：1992-04-01 00:00:00

abstract：:Dendritic cells (DC) are attractive candidates for use in vaccine-based immunotherapy. We have analysed the functional capability of DC generated in vitro from blood CD14(+) cells of chronic lymphocytic leukaemia (CLL) patients and healthy donors by culturing for 10 d with granulocyte-macrophage colony-stimulating fac...

journal_title：British journal of haematology

authors： Rezvany MR,Jeddi-Tehrani M,Biberfeld P,Söderlund J,Mellstedt H,Osterborg A,Rabbani H

更新日期：2001-11-01 00:00:00

abstract：:This is an historical account of the randomised trials in chronic lymphocytic leukaemia in the UK between the years 1978 to 2004, describing their gestation, the treatments used and the main lessons learnt. Those lessons include: (1) how best to use chlorambucil, which was the first effective treatment for CLL; (2) th...

journal_title：British journal of haematology

authors： Catovsky D,Else M

更新日期：2020-11-01 00:00:00

abstract：:Measurements were made of levels of D-dimer in plasma and serum, thrombin-antithrombin complex (TAT) in plasma and fibrinogen/fibrin fragment E antigen (FgE) in serum in a normal healthy control group and in patients with a range of disorders associated with hypercoagulability. Levels were determined in 31 normal heal...

journal_title：British journal of haematology

authors： Boisclair MD,Lane DA,Wilde JT,Ireland H,Preston FE,Ofosu FA

更新日期：1990-04-01 00:00:00

abstract：:Since grey zone lymphoma (GZL) was originally included in the 2008 World Health Organization classification as a B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL), new biological and clinical knowledge have been learned. It is i...

journal_title：British journal of haematology

authors： Kritharis A,Pilichowska M,Evens AM

更新日期：2016-08-01 00:00:00

abstract：:Bone marrow angiogenesis is suggested to play a role in the pathogenesis of acute myeloid leukaemia (AML) and endothelial cells may mediate chemosensitivity. This study investigated in vitro endothelial effects of coculture of microvascular endothelial cells (MVEC) with AML cells derived from 33 consecutive AML patien...

journal_title：British journal of haematology

authors： Hatfield K,Øyan AM,Ersvaer E,Kalland KH,Lassalle P,Gjertsen BT,Bruserud Ø

更新日期：2009-01-01 00:00:00

abstract：:We report a 22-year-old woman with acute, plasma refractory thrombotic thrombocytopenic purpura (TTP) in whom splenectomy led to consistent stabilization of platelet counts, but who showed complete inhibition of vonWillebrand factor-cleaving protease (VWF-cp) after 6 months of follow up. Persistent protease deficiency...

journal_title：British journal of haematology

authors： Langer F,Bergmann F,Budde U,Hegewisch-Becker S,Hossfeld DK

更新日期：2002-07-01 00:00:00

abstract：:While proteasome inhibition is a validated therapeutic approach for multiple myeloma (MM), inhibition of individual constitutive proteasome (c20S) and immunoproteasome (i20S) subunits has not been fully explored owing to a lack of effective tools. We utilized the novel proteasome constitutive/immunoproteasome subunit ...

journal_title：British journal of haematology

authors： Lee SJ,Levitsky K,Parlati F,Bennett MK,Arastu-Kapur S,Kellerman L,Woo TF,Wong AF,Papadopoulos KP,Niesvizky R,Badros AZ,Vij R,Jagannath S,Siegel D,Wang M,Ahmann GJ,Kirk CJ

更新日期：2016-06-01 00:00:00

abstract：:We report a case of indolent B-chronic lymphocytic leukaemia (B-CLL) in a stage A patient, treated for 10 years only by theophylline for bronchial asthma. As suggested by the spontaneous apoptosis in the patient's blood (10%), theophylline at 50 micrograms/ml increased spontaneous apoptosis after 72 h in culture by a ...

journal_title：British journal of haematology

authors： Mentz F,Merle-Beral H,Ouaaz F,Binet JL

更新日期：1995-08-01 00:00:00

abstract：:Patients with Down syndrome have been found to have characteristic in vivo and in vitro methotrexate toxicity. The in vitro methotrexate toxicity characteristic of Down syndrome can be diminished by the in vivo administration of supplemental high doses of folic acid. A possible explanation for the increased sensitivit...

journal_title：British journal of haematology

authors： Peeters MA,Rethore MO,Lejeune J

更新日期：1995-03-01 00:00:00

abstract：:The aim of the present work was to investigate the effect of selective beta-I-blockade on the exchangeable splenic platelet pool (ESPP). Therefore, 50 mg of metoprolol (a selective beta-I-receptor blocking agent) was given by mouth to three groups of subjects: (1) 15 healthy volunteers, (2) five asplenic subjects, and...

journal_title：British journal of haematology

authors： Kutti J,Fredén K,Melberg PE,Lundborg P

更新日期：1977-10-01 00:00:00