Abstract:
:The molecular basis of severe type I factor (F)VII deficiency was investigated in two Algerian patients. One patient, a 13-year-old-girl who has suffered from severe bleeding since birth, was homozygous for a 7-bp deletion (nt 7774-7780) and a 251-bp insertion (nt 7773-7781) of mitochondrial origin, in IVS 4 acceptor splice site. The other patient, an infant who died from massive intracranial haemorrhage, was homozygous for a transversion in the IVS 7 donor splice site (T9726+2-->G) and a missense mutation in exon 8 (G10588-->A; Arg224-->Gln). In both cases, the deleterious mutations are probably the splice site junction abnormalities impairing mRNA processing. These three lesions have not yet been reported.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Borensztajn K,Chafa O,Alhenc-Gelas M,Salha S,Reghis A,Fischer AM,Tapon-Bretaudière Jdoi
10.1046/j.1365-2141.2002.03397.xsubject
Has Abstractpub_date
2002-04-01 00:00:00pages
168-71issue
1eissn
0007-1048issn
1365-2141pii
3397journal_volume
117pub_type
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