Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma.

abstract：:Three male patients (two of whom were brothers) with Shwachman-Diamond (SDS) syndrome presented with acute myeloid leukaemia in adulthood. In all three cases there was trilineage myelodysplasia and the morphology was consistent with FAB subtype M6. SDS is an inherited bone marrow failure syndrome with a high propensit...

journal_title：British journal of haematology

authors： Dokal I,Rule S,Chen F,Potter M,Goldman J

更新日期：1997-10-01 00:00:00

abstract：:With the aim of producing unique targets for malignant cells we have identified peptide ligands for the clonal surface immunoglobulin isolated from the B cells of a chronic lymphocytic leukaemia (CLL) patient. The peptides were identified from random-peptide phage-display libraries. The obtained ligands bound specific...

journal_title：British journal of haematology

authors： Buhl L,Szecsi PB,Gisselø GG,Schafer-Nielsen C

更新日期：2002-03-01 00:00:00

abstract：:Eculizumab is the first and only medication approved for paroxysmal nocturnal haemoglobinuria (PNH) and atypical haemolytic uraemic syndrome (aHUS) treatment. However, eculizumab safety based on long-term pharmacovigilance is unknown. This analysis summarises safety data collected from spontaneous and solicited source...

journal_title：British journal of haematology

authors： Socié G,Caby-Tosi MP,Marantz JL,Cole A,Bedrosian CL,Gasteyger C,Mujeebuddin A,Hillmen P,Vande Walle J,Haller H

更新日期：2019-04-01 00:00:00

abstract：:Factor VIII (FVIII) inhibitors appear in 3-20% of haemophilia A patients after injection of FVIII concentrates. However, autoantibodies to FVIII are also reported in non-haemophiliacs. In these patients FVIII inhibitor disappears spontaneously or diminishes in response to immunosuppressive therapy. However, a few pati...

journal_title：British journal of haematology

authors： Sunagawa T,Uezu Y,Kadena K,Tokuyama K,Kinjo F,Saito A

更新日期：1999-03-01 00:00:00

abstract：:T-cell large granular lymphocytic leukaemia (T-LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T-LGLL seen at our institution over the last 10 years, we encountered 15 cas...

journal_title：British journal of haematology

authors： Awada H,Mahfouz RZ,Durrani J,Kishtagari A,Jagadeesh D,Lichtin AE,Hill BT,Hamilton BK,Carraway HE,Nazha A,Majhail NS,Sobecks R,Visconte V,Kalaycio M,Sekeres MA,Maciejewski JP

更新日期：2020-04-01 00:00:00

abstract：:Thrombocytopenia absent radii (TAR) syndrome is clearly defined by the combination of radial aplasia and reduced platelet counts. The genetics of TAR syndrome has recently been resolved and comprises a microdeletion on Chromosome 1 including the RBM8A gene and a single nucleotide polymorphism (SNP) either at the 5' un...

journal_title：British journal of haematology

authors： Manukjan G,Bösing H,Schmugge M,Strauß G,Schulze H

更新日期：2017-11-01 00:00:00

abstract：:We describe a simple approach for molecular characterization and locus assignment of structural mutants by direct sequencing of enzymatically amplified DNA selective to alpha 1 and alpha 2 globin gene regions. Nucleotide substitution of two structural variants (Stanleyville II alpha 2(78Lys) and J Mexico alpha 2(54Glu...

journal_title：British journal of haematology

authors： Dodé C,Rochette J,Krishnamoorthy R

更新日期：1990-10-01 00:00:00

abstract：:We describe a patient with a 9-year history of thrombotic thrombocytopenic purpura (TTP) who exhibited four relapses. Intravenous immunoglobulin (IVIg) was effective for these four episodes. The patient was well and the laboratory findings were within normal ranges between each episode, although unusually large von Wi...

journal_title：British journal of haematology

authors： Kondo H,Imamura T

更新日期：2000-03-01 00:00:00

abstract：:Anaplastic large cell lymphomas (ALCLs) are rare CD30+ peripheral T-cell lymphomas (PTCLs) classified according to the expression of the anaplastic lymphoma kinase (ALK+) protein or not (ALK-). We have analysed the outcome and risk factors for survival in a population-based bi-national cohort of patients with systemic...

journal_title：British journal of haematology

authors： Cederleuf H,Bjerregård Pedersen M,Jerkeman M,Relander T,d'Amore F,Ellin F

更新日期：2017-09-01 00:00:00

abstract：:In this study, quiescent bone marrow-derived CD34+ erythroid burst-forming units (BFU-E) were found to be resistant to the inhibitory effects of tumour necrosis factor (TNF)-alpha and -beta as well as interferon (IFN)-alpha, -beta and -gamma, in contrast to those stimulated by a combination of erytrhropoietin (Epo) pl...

journal_title：British journal of haematology

authors： Ratajczak J,Kucia M,Reca R,Zhang J,Machalinski B,Ratajczak MZ

更新日期：2003-10-01 00:00:00

abstract：:Recent findings have indicated the importance of factor V (FV) in causing resistance to activated protein C (APC) in a high proportion of patients with venous thrombosis. This prompted us to investigate whether resistance could be due to defective inactivation of FVa by APC. Consequently, we amplified a 3.2 kb fragmen...

journal_title：British journal of haematology

authors： Beauchamp NJ,Daly ME,Hampton KK,Cooper PC,Preston FE,Peake IR

更新日期：1994-09-01 00:00:00

abstract：:It is widely recognized that thrombosis is the major event in the evolution of stable vascular disease to unstable ischaemic syndromes including myocardial infarction and stroke. The purpose of this case-control study was to establish clinical and laboratory data on the possible relationship between specific component...

journal_title：British journal of haematology

authors： Freeburn JC,Wallace JM,Strain JJ,Sinnamon DG,Craig BM,Johnson D,Gilmore WS

更新日期：1998-07-01 00:00:00

abstract：:Allogeneic haematopoietic stem cell transplantation (HSCT) after a reduced-intensity conditioning (RIC) regimen with fludarabine, melphalan and alemtuzmab is an effective therapy for haematological malignancies. Alemtuzumab, a monoclonal antibody against CD52, a glycosylphosphatidylinositol-anchor-bound surface protei...

journal_title：British journal of haematology

authors： Woelfinger P,Epp K,Schaefer L,Kriege D,Theobald M,Bopp T,Wagner-Drouet EM

更新日期：2020-10-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) and the mixed myelodysplastic/myeloproliferative disorder juvenile myelomonocytic leukaemia (JMML) are rare haematopoietic stem cell diseases in children. While MDS-initiating events remain largely obscure, a growing body of clinical, genetic and laboratory evidence suggests that JMML i...

journal_title：British journal of haematology

authors： Niemeyer CM,Kratz CP

更新日期：2008-03-01 00:00:00

abstract：:The EGFP-tk retroviral vector, encoding enhanced green fluorescent protein (EGFP) and the herpes simplex virus thymidine kinase (HSV-tk) packaged in a Phoenix amphotropic cell line, was used to transduce healthy donor T lymphocytes. Infection yielded a mean of 41.8 +/- 9.3% SD (range 31.1-48.4%) EGFP-positive cells an...

journal_title：British journal of haematology

authors： Di Florio S,Sebastiani C,Fagioli M,Di Ianni M,Alfonsi D,Venditti G,Pelicci PG,Tabilio A

更新日期：2000-09-01 00:00:00

abstract：:The clinical significance of Aspergillus fungaemia in the setting of a deep-seated aspergillosis has not been clearly established. Among 107 microbiologically documented Aspergillus infections in patients with haematological diseases observed over a 17-year period, blood cultures grew Aspergillus species from 10 cases...

journal_title：British journal of haematology

authors： Girmenia C,Nucci M,Martino P

更新日期：2001-07-01 00:00:00

abstract：:Peripheral blood stem cell autografts for the treatment of chronic myeloid leukaemia (CML) are currently under evaluation. A patient with CML received intensive chemotherapy followed by granulocyte colony-stimulating factor prior to the collection of peripheral blood derived stem cells. He developed unusually severe, ...

journal_title：British journal of haematology

authors： Clark RE,Lee ES

更新日期：1995-06-01 00:00:00

abstract：:The prognostic relevance of karyotype has been established in adult acute lymphoblastic leukaemia (ALL) patients treated with chemotherapy but not definitively evaluated in an allogeneic bone marrow transplantation (BMT) setting. To determine the factors affecting the outcome of allogeneic BMT for adults with precurso...

journal_title：British journal of haematology

authors： Lee S,Kim DW,Kim YJ,Park YH,Min CK,Lee JW,Min WS,Kim CC

更新日期：2002-04-01 00:00:00

abstract：:Eltrombopag has been added to first-line treatment of immune aplastic anaemia (AA), resulting in higher responses. We analysed marrow samples of AA patients who responded to immunosuppressive therapy (IST) alone or in combination with eltrombopag for the composition of the haematopoietic stem and progenitor cell (HSPC...

journal_title：British journal of haematology

authors： Quintino de Oliveira B,Catto LFB,Santana BAA,Tellechea MF,Scheucher PS,Scheinberg P,Calado RT

更新日期：2020-11-20 00:00:00

abstract：:Post-transplant lymphoproliferative disorder (PTLD) after haemopoietic stem cell transplantation is a serious complication that occurs in 8-22% of patients with high-risk factors. We retrospectively investigated tolerance and efficacy of humanized anti-CD20 monoclonal antibody (rituximab) as first-line treatment in 12...

journal_title：British journal of haematology

authors： Faye A,Quartier P,Reguerre Y,Lutz P,Carret AS,Dehée A,Rohrlich P,Peuchmaur M,Matthieu-Boué A,Fischer A,Vilmer E

更新日期：2001-10-01 00:00:00

abstract：:We present a new method to detect the major beta-thalassaemia mutations of the Mediterranean countries (IVS I-1, IVS I-6, IVS I-110, CD-37 and CD-39). The procedure is based upon real-time polymerase chain reaction (PCR), using specific fluorescently labelled hybridization probes. The melting curves for each of the sp...

journal_title：British journal of haematology

authors： Moreno I,Bolufer P,Perez ML,Barragán E,Sanz MA

更新日期：2002-11-01 00:00:00

abstract：:We report two cases of acute myeloid leukaemia FAB classification M4Eo with high white cell counts at presentation, who developed acute respiratory failure with pulmonary infiltrates on chest radiograph soon after commencing conventional cytotoxic chemotherapy plus all-trans retinoic acid (ATRA). We suggest that in pa...

journal_title：British journal of haematology

authors： Lester WA,Hull DR,Fegan CD,Morris TC

更新日期：2000-06-01 00:00:00

abstract：:We studied erythrocyte calcium levels and uptake in a group of patients with sickle haemoglobinopathies of different clinical severity in an attempt to relate these measurements to the production of irreversibly sickled cells and disease severity. Erythrocyte calcium levels were measured by atomic absorption spectrosc...

journal_title：British journal of haematology

authors： Steinberg MH,Eaton JW,Berger E,Coleman MB,Oelshlegel FJ

更新日期：1978-12-01 00:00:00

abstract：:In a 61-year-old man with glucose-6-phosphate dehydrogenase (G6PD) deficiency and poorly controlled non-insulin-dependent diabetes mellitus, an episode of acute haemolysis occurred after the administration of glyburide (glibenclamide). Erythrocyte fragmentation, with haemoglobin condensation zones next to clear zones,...

journal_title：British journal of haematology

authors： Meloni G,Meloni T

更新日期：1996-01-01 00:00:00

abstract：:We evaluated the additional benefit of Technetium(99)-sestamibi (99mTc-MIBI) scanning in comparison with standard X-ray techniques for multiple myeloma patients either at diagnosis or during follow-up. Between February 2001 and January 2005, 397 whole body scans were acquired. On 229 scans performed at diagnosis, 146 ...

journal_title：British journal of haematology

authors： Mele A,Offidani M,Visani G,Marconi M,Cambioli F,Nonni M,Catarini M,Brianzoni E,Berbellini A,Ascoli G,Brunori M,Agostini V,Corvatta L,Isidori A,Spinelli A,Gradari M,Leoni P

更新日期：2007-03-01 00:00:00

abstract：:Severe congenital neutropenia (SCN) is an inherited disorder characterized by severe neutropenia and recurrent infections from an early age, with bone marrow showing a maturational arrest of granulopoiesis at the promyelocyte stage. Since the introduction of G-CSF therapy the prognosis for affected children has improv...

journal_title：British journal of haematology

authors： Ryan M,Will AM,Testa N,Hayworth C,Darbyshire PJ

更新日期：1995-09-01 00:00:00

abstract：:This study was designed to assess the efficacy and safety of substituting cisplatin with oxaliplatin in the DHAP (dexamethasone, cytarabine and cisplatin) regimen for patients with relapsed or refractory non-Hodgkin's lymphoma. Twenty-four evaluable patients with intermediate or high-grade non-Hodgkin's lymphoma were ...

journal_title：British journal of haematology

authors： Chau I,Webb A,Cunningham D,Hill M,Rao S,Ageli S,Norman A,Gill K,Howard A,Catovsky D

更新日期：2001-12-01 00:00:00

abstract：:Dogs affected with cyclic haematopoiesis (CH) and experiencing recurrent 12-day cycles of neutropenia were supralethally irradiated and transplanted with marrow from their normal littermates. Following transplantation of the normal marrow, dogs with CH experienced no further cycles of neutropenia. Platelet and reticul...

journal_title：British journal of haematology

authors： Jones JB,Yang TJ,Dale JB,Lange RD

更新日期：1975-06-01 00:00:00

abstract：:Membrane glycoprotein (GP) Ia/IIa mediates platelet adhesion to collagen. The linked C807T/G873A polymorphisms in the GP Ia gene are correlated with a variable expression of the platelet surface receptor, the 807 TT/873 AA genotype being associated with a higher receptor density. Our study aimed to evaluate the possib...

journal_title：British journal of haematology

authors： Casorelli I,De Stefano V,Leone AM,Chiusolo P,Burzotta F,Paciaroni K,Rossi E,Andreotti F,Leone G,Maseri A

更新日期：2001-07-01 00:00:00

abstract：:Two new variants of erythrocytic glucose-6-phosphate dehydrogenase have been found in one German patient and in another patient of Turkish origin. The enzymes were partially purified 165-fold and 111-fold respectively. Both revealed reduced activity, increased thermolability and a pH-optimum in the alkaline region (8....

journal_title：British journal of haematology

authors： Gahr M,Bornhalm D,Schröter W

更新日期：1976-07-01 00:00:00