Chimaeric anti-CD20 monoclonal antibody (rituximab) in post-transplant B-lymphoproliferative disorder following stem cell transplantation in children.

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells at different stages of maturation that play a role in cancer tolerance and function as an immune-suppressive cell subpopulation. They utilize different mechanisms to block both innate and adaptive arms of anti-tumour immu...

journal_title：British journal of haematology

authors： Tadmor T,Attias D,Polliack A

更新日期：2011-06-01 00:00:00

abstract：:Adult survivors of childhood acute lymphoblastic leukaemia (ALL) have a four-fold excess risk of mortality from cardiovascular disease. This cardiovascular risk has not been fully characterized. ALL survivors [n = 784, median age 31·7 years (18·9-59·1)] in the St. Jude Lifetime Cohort Study underwent evaluation for ca...

journal_title：British journal of haematology

authors： Nottage KA,Ness KK,Li C,Srivastava D,Robison LL,Hudson MM

更新日期：2014-05-01 00:00:00

abstract：:Polymerase chain reaction protocols were designed specifically to amplify regions of the alpha globin complex that contain the nine common polymorphic haplotyping sites. These reactions provided a quicker and more sensitive approach to determining alpha globin haplotypes than Southern blotting methods. ...

journal_title：British journal of haematology

authors： Miles KL,Norwich JT,Martinson JJ,Clegg JB

更新日期：2001-06-01 00:00:00

abstract：:Increased osteoclastic bone resorption is the major causal factor of bone disease in multiple myeloma. Recently, non-invasive methods have been developed for the estimation of bone resorptive activity. To evaluate the biological sensitivity and clinical usefulness of five biochemical assays for measuring the C-termina...

journal_title：British journal of haematology

authors： Abildgaard N,Brixen K,Kristensen JE,Eriksen EF,Nielsen JL,Heickendorff L

更新日期：2003-01-01 00:00:00

abstract：:This report describes a case of chronic myelomonocytic leukaemia (CMML) in whom a complete remission was achieved and sustained 15 months after treatment with 25-OH vitamin D3. No side-effects were observed. Although vitamin D1 has been used in the treatment of myelodysplastic syndromes, to our knowledge this is the f...

journal_title：British journal of haematology

authors： Mellibovsky L,Díez A,Aubia J,Nogues X,Pérez-Vila E,Serrano S,Recker RR

更新日期：1993-12-01 00:00:00

abstract：:Demand for anticoagulation management is increasing due to an expansion of clinical indications for therapy. One possible model of care to meet demand is patient self-management (PSM), beneficial to patients who need control over their condition. This study aimed to determine the cost and cost-effectiveness of PSM of ...

journal_title：British journal of haematology

authors： Jowett S,Bryan S,Murray E,McCahon D,Raftery J,Hobbs FD,Fitzmaurice D

更新日期：2006-09-01 00:00:00

abstract：:FOXP2 mutation causes a severe inherited speech and language defect, while the related transcription factors FOXP1, FOXP3 and FOXP4 are implicated in cancer. FOXP2 mRNA and protein expression were characterised in normal human tissues, haematological cell lines and multiple myeloma (MM) patients' samples. FOXP2 mRNA a...

journal_title：British journal of haematology

authors： Campbell AJ,Lyne L,Brown PJ,Launchbury RJ,Bignone P,Chi J,Roncador G,Lawrie CH,Gatter KC,Kusec R,Banham AH

更新日期：2010-04-01 00:00:00

abstract：:We investigated the molecular basis of factor VII deficiency in a Japanese patient and identified a novel missense mutation in the signal sequence of the gene. Factor VII activity and antigen level measured in the patient were 10.7% and 11% of normal, respectively. All exons except 1B and the 5'-flanking region contai...

journal_title：British journal of haematology

authors： Ozawa T,Takikawa Y,Niiya K,Ejiri N,Suzuki K,Sato S,Sakuragawa N

更新日期：1998-04-01 00:00:00

abstract：:We have determined the causative mutation in 12 cases of glucose-6-phosphate dehydrogenase deficiency associated with chronic non-spherocytic haemolytic anaemia. In 11 of them the mutation we found had been previously reported in unrelated individuals. These mutations comprise seven different missense mutations and a ...

journal_title：British journal of haematology

authors： Vulliamy TJ,Kaeda JS,Ait-Chafa D,Mangerini R,Roper D,Barbot J,Mehta AB,Athanassiou-Metaxa M,Luzzatto L,Mason PJ

更新日期：1998-06-01 00:00:00

abstract：:Haemophilia A is an attractive target for gene therapy. We designed a haemophilia A gene therapy strategy involving the genetic modification of haematopoietic stem cells to achieve tissue-specific expression of a factor VIII (FVIII) transgene in the megakaryocytic lineage. Platelets would then serve as vehicles to sto...

journal_title：British journal of haematology

authors： Rodriguez MH,Plantier JL,Enjolras N,Réa M,Leboeuf M,Uzan G,Négrier C

更新日期：2004-12-01 00:00:00

abstract：:Between 1994 and 1999, 88 multiple myeloma (MM) patients were included in a phase II study to evaluate a tandem autologous stem cell transplantation (ASCT) programme. The first was conditioned with melphalan 200 mg/m2 (MEL200-ASCT1), and the second with cyclophosphamide, etoposide and BCNU (CBV-ASCT2). All patients we...

journal_title：British journal of haematology

authors： Lahuerta JJ,Grande C,Martínez-Lopez J,De La Serna J,Toscano R,Ortiz MC,Larregla S,Conde E,Insunza A,Gonzalez-San Miguel JD,Bargay J,Cabrera R,García-Ruiz JC,Albó C,García-Alonso L,Solano F,Vivancos P,León A,San Miguel

更新日期：2003-01-01 00:00:00

abstract：:The thiol isomerase enzymes protein disulphide isomerase (PDI) and endoplasmic reticulum protein 5 (ERp5) are released by resting and activated platelets. These re-associate with the cell surface where they modulate a range of platelet responses including adhesion, secretion and aggregation. Recent studies suggest the...

journal_title：British journal of haematology

authors： Holbrook LM,Watkins NA,Simmonds AD,Jones CI,Ouwehand WH,Gibbins JM

更新日期：2010-02-01 00:00:00

abstract：:Diagnosing central nervous system (CNS) lymphoma remains a challenge. Most patients have to undergo brain biopsy to obtain tissue for diagnosis, with associated risks of serious complications. Diagnostic markers in blood or cerebrospinal fluid (CSF) could facilitate early diagnosis with low complication rates. We perf...

journal_title：British journal of haematology

authors： van Westrhenen A,Smidt LCA,Seute T,Nierkens S,Stork ACJ,Minnema MC,Snijders TJ

更新日期：2018-08-01 00:00:00

abstract：:Guidelines for the use of polymerase chain reaction (PCR)-based assays to aid the diagnosis of invasive aspergillosis (IA) in high-risk haematology patients have not been formulated. We prospectively evaluated a nested PCR assay to detect Aspergillus in blood during 95 febrile neutropenic episodes, in patients with ha...

journal_title：British journal of haematology

authors： Halliday C,Hoile R,Sorrell T,James G,Yadav S,Shaw P,Bleakley M,Bradstock K,Chen S

更新日期：2006-02-01 00:00:00

abstract：:We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resul...

journal_title：British journal of haematology

authors： Specchia G,Albano F,Anelli L,Storlazzi CT,Cimino G,Liso A,Zagaria A,Liso V,Rocchi M

更新日期：2002-11-01 00:00:00

abstract：:We studied the outcome of 24 peripheral blood stem cell (PBSC) graft recipients, who were T-cell depleted (TCD) with either 20 mg (n = 14) or 10 mg (n = 10) Campath-1H in vitro, in comparison with a retrospective cohort of 23 unmanipulated (UM) PBSC recipients. While the neutrophil engraftment was similar, the platele...

journal_title：British journal of haematology

authors： Chakrabarti S,MacDonald D,Hale G,Holder K,Turner V,Czarnecka H,Thompson J,Fegan C,Waldmann H,Milligan DW

更新日期：2003-04-01 00:00:00

abstract：:Panobinostat in combination with bortezomib and dexamethasone demonstrated a significant and clinically meaningful progression-free survival benefit compared with placebo, bortezomib and dexamethasone in the phase 3 PANORAMA 1 (Panobinostat Oral in Multiple Myeloma 1) trial. Despite this benefit, patients in the panob...

journal_title：British journal of haematology

authors： San-Miguel JF,Hungria VTM,Yoon SS,Beksac M,Dimopoulos MA,Elghandour A,Jedrzejczak WW,Guenther A,Na Nakorn T,Siritanaratkul N,Schlossman RL,Hou J,Moreau P,Lonial S,Lee JH,Einsele H,Salwender H,Sopala M,Redhu S,Paul S

更新日期：2017-10-01 00:00:00

abstract：:Inhibitors of heat-shockprotein 90 (Hsp90) have been proposed as a novel therapeutic option for Chronic Lymphocytic Leukaemia (CLL), particularly as their mechanism of action appears independent of mutations of ATM or TP53. We investigated the activity of a novel Hsp90 inhibitor, SNX7081, against a panel of eight haem...

journal_title：British journal of haematology

authors： Best OG,Singh N,Forsyth C,Mulligan SP

更新日期：2010-10-01 00:00:00

abstract：:Coagulation factor concentrates are known to inhibit a variety of immune reactions when assessed in vitro. This study assessed the immunomodulatory activity of a wide range of coagulation factor concentrates by measuring their inhibition of PHA-stimulated lymphocyte proliferation and reduction in IL-2 secretion. The h...

journal_title：British journal of haematology

authors： Pearson HJ,Stirling D,Ludlam CA,Steel CM

更新日期：1999-09-01 00:00:00

abstract：:The International Extranodal Lymphoma Study Group (IELSG) promoted this study to determine the inter-observer agreement in the application of the Groupe d' Etude des Lymphomes de l' Adulte (GELA) histological scoring system for evaluating residual disease in post-treatment gastric biopsies of patients with gastric Muc...

journal_title：British journal of haematology

authors： Copie-Bergman C,Wotherspoon AC,Capella C,Motta T,Pedrinis E,Pileri SA,Bertoni F,Conconi A,Zucca E,Ponzoni M,Ferreri AJ

更新日期：2013-01-01 00:00:00

abstract：:Data on outcome, prognostic factors, and treatment for very elderly non-Hodgkin lymphomas (NHL) is sparse. We conducted a multicentre retrospective analysis of NHL patients ≥80 years (at diagnosis) treated between 1999 and 2009. Detailed characteristics were obtained including geriatric syndromes, activities of daily ...

journal_title：British journal of haematology

authors： Nabhan C,Smith SM,Helenowski I,Ramsdale E,Parsons B,Karmali R,Feliciano J,Hanson B,Smith S,McKoy J,Larsen A,Hantel A,Gregory S,Evens AM

更新日期：2012-01-01 00:00:00

abstract：:The pattern of distribution of von Willebrand factor (VWF) in relatively large sheets of rat aortic endothelial cells (EC) obtained by the Häutchen technique were analysed by immunocytochemistry and light microscopy. EC were examined pre and post administration of a procoagulant mixture of factor Xa (F.Xa) and phospho...

journal_title：British journal of haematology

authors： Senis YA,Richardson M,Tinlin S,Maurice DH,Giles AR

更新日期：1996-04-01 00:00:00

abstract：:Since grey zone lymphoma (GZL) was originally included in the 2008 World Health Organization classification as a B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL), new biological and clinical knowledge have been learned. It is i...

journal_title：British journal of haematology

authors： Kritharis A,Pilichowska M,Evens AM

更新日期：2016-08-01 00:00:00

abstract：:Previous studies report conflicting results concerning the potential significance of thrombophilic genotypes in postarthroplasty venous thromboembolism (VTE). This study assessed thrombophilic genotypes, haemostatic and clinical variables as independent risk factors for VTE postarthroplasty. A total number of 569 pati...

journal_title：British journal of haematology

authors： Joseph JE,Low J,Courtenay B,Neil MJ,McGrath M,Ma D

更新日期：2005-04-01 00:00:00

abstract：:Previous studies have established that protein kinase C-zeta (PKC-zeta) is critical for neuronal cell differentiation. However, the role of PKC-zeta in haematopoietic cell differentiation is less clear. In this study, we have investigated the influence of PKC-zeta overexpression on the phenotype of the human monocytic...

journal_title：British journal of haematology

authors： Mansat-De Mas V,de Thonel A,Gaulin V,Demur C,Laurent G,Quillet-Mary A

更新日期：2002-08-01 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is an autosomal recessive DNA repair disorder with a high predisposition for lymphoid malignancies. The majority of NBS patients carry a homozygous founder mutation (657del5) within the NBS1 gene. The observation of a high incidence of cancer in close relatives of NBS patients suggests...

journal_title：British journal of haematology

authors： Stanulla M,Stümm M,Dieckvoss BO,Seidemann K,Schemmel V,Müller Brechlin A,Schrappe M,Welte K,Reiter A

更新日期：2000-04-01 00:00:00

abstract：:To examine any role of macrophage colony-stimulating factor (M-CSF), in the immune responses in Kawasaki disease (KD), we serially assayed M-CSF and several related cytokines using ELISA. In 10 paediatric patients with KD the level of M-CSF was significantly higher in the acute phase than in the convalescent phase (14...

journal_title：British journal of haematology

authors： Igarashi H,Hatake K,Tomizuka H,Yamada M,Gunji Y,Momoi MY

更新日期：1999-06-01 00:00:00

abstract：:To assess and define the effects of heterocellular hereditary persistence of fetal haemoglobin (HPFH) on the haematological phenotype of heterozygous beta-thalassaemia, we have studied a large kindred that included a total of 204 subjects with 60 beta-thalassaemia carriers, of whom 35 were also heterozygous, and five ...

journal_title：British journal of haematology

authors： Garner C,Dew TK,Sherwood R,Rees D,Thein SL

更新日期：2003-10-01 00:00:00

abstract：:It was hypothesized that contact between chronic lymphocytic leukaemia (CLL) B-cells and marrow stromal cells impact both cell types. To test this hypothesis, we utilized a long-term primary culture system from bone biopsies that reliably generates a mesenchymal stem cell (MSC). Co-culture of MSC with CLL B-cells prot...

journal_title：British journal of haematology

authors： Ding W,Nowakowski GS,Knox TR,Boysen JC,Maas ML,Schwager SM,Wu W,Wellik LE,Dietz AB,Ghosh AK,Secreto CR,Medina KL,Shanafelt TD,Zent CS,Call TG,Kay NE

更新日期：2009-11-01 00:00:00

abstract：:We performed a retrospective analysis of outcome in 45 patients with multiple myeloma receiving unrelated donor stem cell transplants (UD-SCT) in the UK between 1993 and 2002; 17 received myeloablative conditioning regimens and 28 received reduced intensity conditioning (RIC) protocols. Forty patients received pretran...

journal_title：British journal of haematology

authors： Shaw BE,Peggs K,Bird JM,Cavenagh J,Hunter A,Alejandro Madrigal J,Russell NH,Sirohi B,Towlson K,Williams CD,Marks DI,Clinical Trials Committee of the British Society of Blood and Marrow Transplantation.

更新日期：2003-12-01 00:00:00