当前位置： SCI文献检索 > BRITISH JOURNAL OF HAEMATOLOGY期刊下所有文献 > A single-centre prospective study of clinical and haemostatic risk factors for venous thromboembolism following lower limb arthroplasty.

A single-centre prospective study of clinical and haemostatic risk factors for venous thromboembolism following lower limb arthroplasty.

Abstract：

:Previous studies report conflicting results concerning the potential significance of thrombophilic genotypes in postarthroplasty venous thromboembolism (VTE). This study assessed thrombophilic genotypes, haemostatic and clinical variables as independent risk factors for VTE postarthroplasty. A total number of 569 patients undergoing elective lower limb arthroplasty at a single centre were prospectively studied. All patients were interviewed and had blood samples collected preoperatively. Bilateral lower limb ultrasonography was performed at day 7 +/- 2 postoperatively in all patients (ventilation/perfusion lung scanning in symptomatic patients only). The incidence of inhospital postoperative VTE was 26%. In univariate analysis - increased age, knee arthroplasty, recent surgery, general anaesthesia, shorter operation time, non-receipt of blood transfusion and differences in surgical practice (including use of pneumatic calf compression, surgical drains and postoperative bandaging techniques) were significantly associated with VTE. Factor V Leiden, prothrombin G20210A and MTHFR C677T mutations were not significant risk factors for VTE, and of all haemostatic variables tested, only median activated partial thromboplastin time showed significant difference between VTE and non-VTE patients (34 s vs. 33 s). Multiple logistic regression analysis demonstrated that increased age, knee arthroplasty and individual surgeon's routine practices were the only significant independent risks for VTE; hence routine preoperative blood screening for a potential hypercoaguable state is not indicated in this surgical setting.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Joseph JE,Low J,Courtenay B,Neil MJ,McGrath M,Ma D

doi

10.1111/j.1365-2141.2005.05419.x

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

87-92

issue

1

eissn

0007-1048

issn

1365-2141

pii

BJH5419

journal_volume

129

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF HAEMATOLOGY文献大全
  • Haemophilia B Liverpool: a new British family with mild haemophilia B associated with a -6 G to A mutation in the factor IX promoter.

    abstract：:We report a Lancashire family with mild haemophilia B associated with a -6 G to A mutation in the factor IX promoter. This mutation has been reported previously in Britain in one other affected family. The factor IX haplotype of these two unrelated patients was determined by PCR analysis of seven polymorphic sites wit...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1993.tb08667.x

    authors： Stowell KM,Figueiredo MS,Brownlee GG,Jones P,Bolton-Maggs PH

    更新日期：1993-09-01 00:00:00

  • Tissue factor activity in human monocytes is regulated by plasma: implications for the high and low responder phenomenon.

    abstract：:The 'high and low responder phenomenon' of monocyte tissue factor (MTF) activity has been attributed to effects on monocytes by granulocytes, platelets and lipopolysaccharide (LPS). To study the possible contribution of plasma to the high and low responder phenomenon, we measured the MTF activity in isolated cryoprese...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2001.02545.x

    authors： Nijziel M,van Oerle R,van 't Veer C,van Pampus E,Lindhout T,Hamulyák K

    更新日期：2001-01-01 00:00:00

  • Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells.

    abstract：:Akt mediates growth and drug resistance in multiple myeloma (MM) cells in the bone marrow (BM) microenvironment. We have shown that a novel Akt inhibitor Perifosine induces significant cytotoxicity in MM cells in the BM milieu. This study further delineated molecular mechanisms whereby Perifosine triggered cytotoxicit...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2007.06714.x

    authors： Hideshima T,Catley L,Raje N,Chauhan D,Podar K,Mitsiades C,Tai YT,Vallet S,Kiziltepe T,Ocio E,Ikeda H,Okawa Y,Hideshima H,Munshi NC,Yasui H,Richardson PG,Anderson KC

    更新日期：2007-09-01 00:00:00

  • The correlation of cold agglutinin titrations in saline and albumin with haemolytic anaemia.

    abstract：:Cold agglutinin syndrome (CAS) is usually associated with IgM cold agglutinins with titres exceeding 1000 at 4 degrees C and a thermal amplitude of 30-32 degrees C. Occasionally patients are encountered who although having clinical and laboratory findings compatible with CAS do not have the characteristic serological ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1977.tb00623.x

    authors： Garratty G,Petz LD,Hoops JK

    更新日期：1977-04-01 00:00:00

  • Monosomy 7 in two patients with a myeloproliferative disorder.

    abstract：:Clinical and laboratory data are presented for two patients with a dyshaematopoietic disorder, and monosomy 7 in their bone marrow cells. The first patient, a 55-year-old woman, had been treated with chlorambucil for an ovarian carcinoma. After 4 years an oligoblastic myeloid leukaemia was diagnosed and she later died...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1977.tb08767.x

    authors： Boetius G,Hustinx TW,Smits AP,Scheres JM,Rutten FJ,Haanen C

    更新日期：1977-09-01 00:00:00

  • Molecular mechanisms of pathology and treatment in Diamond Blackfan Anaemia.

    abstract：:Diamond Blackfan Anaemia (DBA) is a rare congenital pure red cell aplasia that may be associated with facio-skeletal developmental defects. The disease is caused by mutations in one of at least ten ribosomal proteins, which results in haploinsufficiency and an imbalance between the synthesis of rRNA and ribosomal prot...

    journal_title：British journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/bjh.12058

    authors： Horos R,von Lindern M

    更新日期：2012-12-01 00:00:00

  • Factor VIII antibody in a patient with mild haemophilia.

    abstract：:We present the rare occurrence of an inhibitor of factor VIII procoagulant arising in a patient with mild haemophilia A and rheumatoid arthritis. The inhibitor was transient and behaved like a low titre, type II factor VIII procoagulant inhibitor similar to previously reported cases (Biggs et al, 1972b). In vitro stud...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1985.tb02832.x

    authors： Bovill EG,Burns SL,Golden EA

    更新日期：1985-10-01 00:00:00

  • Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15.

    abstract：:Early T-cell precursor acute lymphoblastic leukaemia (ETP-ALL) is a recently identified subtype of T-ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT-ALL using ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2011.08955.x

    authors： Inukai T,Kiyokawa N,Campana D,Coustan-Smith E,Kikuchi A,Kobayashi M,Takahashi H,Koh K,Manabe A,Kumagai M,Ikuta K,Hayashi Y,Tsuchida M,Sugita K,Ohara A

    更新日期：2012-02-01 00:00:00

  • Therapy with thalidomide in refractory multiple myeloma patients - the revival of an old drug.

    abstract：:We have treated 17 refractory or relapsed multiple myeloma patients resistant to chemotherapy with thalidomide at a dose of 200-800 mg/day. Eleven patients responded, five of whom had a very good partial response (> 75% decline in M protein) and another five exhibited a partial response (> 50% decline in M protein). E...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2000.01835.x

    authors： Kneller A,Raanani P,Hardan I,Avigdor A,Levi I,Berkowicz M,Ben-Bassat I

    更新日期：2000-02-01 00:00:00

  • Successful treatment of transfusion-associated graft-versus-host disease.

    abstract：:We present an immunocompetent patient with transfusion-associated graft-versus-host disease (GVHD), in which chimaerism of peripheral blood lymphocytes was demonstrated by analysis of a highly polymorphic genome. The patient was treated successfully with anti-CD3 monoclonal antibody, OKT3 and cyclosporin A. Although i...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1994.tb04838.x

    authors： Yasukawa M,Shinozaki F,Hato T,Takada K,Ishii Y,Tamai T,Takamatsu H,Shiobara S,Yoshizaki K,Fujita S

    更新日期：1994-04-01 00:00:00

  • Lymphocytes from multi-transfused patients exhibit cytotoxicity against autologous cells.

    abstract：:We previously demonstrated that multitransfused patients with severe aplastic anaemia (SAA) exhibit high numbers of alloreactive cytotoxic T lymphocyte precursors directed against their HLA identical siblings. In this study a group of patients who had received multiple blood transfusions for SAA, other haematological ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1992.tb08165.x

    authors： Kaminski ER,Hows JM,Goldman JM,Batchelor JR

    更新日期：1992-05-01 00:00:00

  • A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ib alpha associated with a variant of Bernard-Soulier syndrome (Nancy I).

    abstract：:Leucine-rich repeats are conserved structural motifs present in the four components of the human platelet glycoprotein Ib/IX/V complex receptor for the adhesive protein von Willebrand factor. The absence or abnormality of this complex is responsible for Bernard-Soulier disease, an autosomal recessive bleeding disorder...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1995.tb03316.x

    authors： de la Salle C,Baas MJ,Lanza F,Schwartz A,Hanau D,Chevalier J,Gachet C,Briquel ME,Cazenave JP

    更新日期：1995-02-01 00:00:00

  • Adrenal extramedullary haemopoiesis: diagnosis by a non-invasive method.

    abstract：:Bilateral adrenal masses were discovered incidentally in a patient with beta-thalassaemia intermedia. Endocrine investigations showed that the adrenal lesion was hormonally inactive. Extramedullary haemopoiesis involving the adrenal glands was suggested by the presence of reticuloendothelial tissue as demonstrated by ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.1998.00619.x

    authors： Wat NM,Tse KK,Chan FL,Lam KS

    更新日期：1998-03-01 00:00:00

  • Polycythaemia vera. IV. Specific binding of stem cell factor to normal and polycythaemia vera highly purified erythroid progenitor cells.

    abstract：:Polycythaemia vera (PV) patients' blood burst-forming units-erythroid (BFU-E) have an enhanced sensitivity to stem cell factor (SCF) compared to normal BFU-E. To characterize SCF receptors on erythroid progenitors from normal individuals and PV patients, we performed binding experiments using radioiodinated recombinan...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1994.tb05065.x

    authors： Dai CH,Krantz SB,Koury ST,Kollar K

    更新日期：1994-11-01 00:00:00

  • Platelets release active matrix metalloproteinase-2 in vivo in humans at a site of vascular injury: lack of inhibition by aspirin.

    abstract：:When stimulated in vitro, human platelets release matrix metalloproteinase-2 (MMP-2) that, in turn, potentiates platelet activation. The present study investigated if MMP-2 is released from activated platelets in vivo in humans and whether aspirin inhibits this release. MMP-2 levels were measured by zymography, immuno...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2007.06632.x

    authors： Falcinelli E,Giannini S,Boschetti E,Gresele P

    更新日期：2007-07-01 00:00:00

  • Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia in the UK: a population-based study of incidence and survival.

    abstract：:We aimed to identify and classify cases of paediatric myelodysplastic syndromes (MDS) occurring in Britain to estimate the incidence of this rare group of diseases, investigate the results of therapy and identify prognostic risk factors. Patients aged below 15 years at diagnosis were collected from England, Scotland a...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2003.04361.x

    authors： Passmore SJ,Chessells JM,Kempski H,Hann IM,Brownbill PA,Stiller CA

    更新日期：2003-06-01 00:00:00

  • In vivo 'purging' of residual disease in CLL with Campath-1H.

    abstract：:We assessed the role of human CD52 antibody (Campath-1H) in six patients with chronic lymphocytic leukaemia (CLL) treated to maximal response with purine analogues (fludarabine/deoxycoformycin) in whom persistent leukaemic infiltration of blood and bone marrow had precluded autologous stem cell transplantation. Five p...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.1997.1062924.x

    authors： Dyer MJ,Kelsey SM,Mackay HJ,Emmett E,Thornton P,Hale G,Waldmann H,Newland AC,Catovsky D

    更新日期：1997-06-01 00:00:00

  • Biosynthesis of FVIII in megakaryocytic cells: improved production and biochemical characterization.

    abstract：:Haemophilia A is an attractive target for gene therapy. We designed a haemophilia A gene therapy strategy involving the genetic modification of haematopoietic stem cells to achieve tissue-specific expression of a factor VIII (FVIII) transgene in the megakaryocytic lineage. Platelets would then serve as vehicles to sto...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2004.05244.x

    authors： Rodriguez MH,Plantier JL,Enjolras N,Réa M,Leboeuf M,Uzan G,Négrier C

    更新日期：2004-12-01 00:00:00

  • Continuous complete remission in adult patients with acute lymphocytic leukaemia at a median observation of 12 years after autologous bone marrow transplantation.

    abstract：:We report our long-term experience with autologous bone marrow transplantation (ABMT) for 32 adult patients with acute lymphocytic leukaemia (ALL) in second or later remission (CR), or in first CR but with high-risk. Bone marrow was purged with mafosfamide (n = 25) or with immunomagnetic beads and monoclonal antibodie...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2001.02634.x

    authors： Abdallah A,Egerer G,Goldschmidt H,Wannenmacher M,Körbling M,Ho AD

    更新日期：2001-03-01 00:00:00

  • Erythrocyte adenosine deaminase: diagnostic value for Diamond-Blackfan anaemia.

    abstract：:Diamond-Blackfan anaemia (DBA) is an inherited bone marrow failure syndrome (IBMFS) characterized by red cell aplasia. Mutations in ribosomal genes are found in more than 50% of cases. Elevated erythrocyte adenosine deaminase (eADA) was first noted in DBA in 1983. In this study we determined the value of eADA for the ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.12167

    authors： Fargo JH,Kratz CP,Giri N,Savage SA,Wong C,Backer K,Alter BP,Glader B

    更新日期：2013-02-01 00:00:00

  • Differential gene expression analysis in early and late erythroid progenitor cells in β-thalassaemia.

    abstract：:β- thalassaemia is a disorder of globin gene synthesis resulting in reduced or absent production of the β-globin chain in red blood cells. In this study, haematopoietic stem cells were isolated from the peripheral blood of six transfusion dependent β-thalassaemia patients and six healthy controls. Following 7 and 14 d...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.13432

    authors： Forster L,McCooke J,Bellgard M,Joske D,Finlayson J,Ghassemifar R

    更新日期：2015-07-01 00:00:00

  • Chromosomal aberrations are shared by malignant plasma cells and a small fraction of circulating CD19+ cells in patients with myeloma and monoclonal gammopathy of undetermined significance.

    abstract：:In the present study, we aimed to identify distinct structural and numerical chromosomal aberrations in peripheral blood B cells of patients with myeloma and monoclonal gammopathy of undetermined significance (MGUS), which reflect changes thought to occur at different stages of the disease process. Peripheral blood fr...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2002.03529.x

    authors： Zojer N,Schuster-Kolbe J,Assmann I,Ackermann J,Strasser K,Hübl W,Drach J,Ludwig H

    更新日期：2002-06-01 00:00:00

  • Treatment of acute lymphoblastic leukaemia with the second generation of CD19 CAR-T containing either CD28 or 4-1BB.

    abstract：:T cells modified with anti-CD19 chimeric antigen receptor (CAR) containing either CD28 or 4-1BB (also termed TNFRSF9, CD137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia (ALL). However, the difference between CD28 and 4-1BB costimulatory signalling in CAR-T trea...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.15195

    authors： Li S,Zhang J,Wang M,Fu G,Li Y,Pei L,Xiong Z,Qin D,Zhang R,Tian X,Wei Z,Chen R,Chen X,Wan J,Chen J,Wei X,Xu Y,Zhang P,Wang P,Peng X,Yang S,Shen J,Yang Z,Chen J,Qian C

    更新日期：2018-05-01 00:00:00

  • Diagnosis of paroxysmal nocturnal haemoglobinuria by phenotypic analysis of erythrocytes using two-colour flow cytometry with monoclonal antibodies to DAF and CD59/MACIF.

    abstract：:We investigated the relationship between the complement lysis sensitivity test and two-colour flow cytometric analysis using monoclonal antibodies to decay accelerating factor (DAF) and CD59/membrane attack complex inhibitory factor (MACIF) in patients with paroxysmal nocturnal haemoglobinuria (PNH) and other haematol...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1993.tb03182.x

    authors： Shichishima T,Terasawa T,Saitoh Y,Hashimoto C,Ohto H,Maruyama Y

    更新日期：1993-10-01 00:00:00

  • A multi-centre study of therapeutic efficacy and safety of platelet components treated with amotosalen and ultraviolet A pathogen inactivation stored for 6 or 7 d prior to transfusion.

    abstract：:Bacteria in platelet components (PC) may result in transfusion-related sepsis (TRS). Pathogen inactivation of PC with amotosalen (A-PC) can abrogate the risk of TRS and hence facilitate storage to 7 d. A randomized, controlled, double-blinded trial to evaluate the efficacy and safety of A-PC stored for 6-7 d was condu...

    journal_title：British journal of haematology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1365-2141.2011.08635.x

    authors： Lozano M,Knutson F,Tardivel R,Cid J,Maymó RM,Löf H,Roddie H,Pelly J,Docherty A,Sherman C,Lin L,Propst M,Corash L,Prowse C

    更新日期：2011-05-01 00:00:00

  • Platelet hyperactivation in multiple myeloma is also evident in patients with premalignant monoclonal gammopathy of undetermined significance.

    abstract：:Thrombotic events are common in patients with multiple myeloma (MM), smouldering myeloma (SM) and monoclonal gammopathy of undetermined significance (MGUS). Previous studies have indicated platelet hyperactivation as a feature of thrombotic risk in MM, but there is a dearth of data in MGUS. In the present study, multi...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.16774

    authors： O'Sullivan LR,Meade-Murphy G,Gilligan OM,Mykytiv V,Young PW,Cahill MR

    更新日期：2021-01-01 00:00:00

  • Blast cells in child and adult AML: comparative study of morphocytochemical, immunological and cytogenetic characteristics.

    abstract：:Bone marrow blast cells of 174 child and 188 adult patients with AML were examined and characterized in terms of their FAB type, immunological phenotype (102 children, 123 adults) and karyotype (69 children, 95 adults). The incidence of FAB variants of AML proved similar in children and adults. In patients under 15 an...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1994.tb06727.x

    authors： Frenkel MA,Tupitsyn NN,Protasova AK,Kadagidze ZG,Konstantinova LN,Fleischman EW

    更新日期：1994-08-01 00:00:00

  • The effect of cytotoxic drugs on neutrophil phagocytosis in vitro and in patients with acute myelogenous leukaemia.

    abstract：:The in vitro effects of a range of concentrations of cyclophosphamide, doxorubicin, actinomycin D, cytarabine and methotrexate on neutrophil phagocytosis of C. albicans was studied. The reduction in phagocytic index (PI) was inversely proportional to the dilution of the drug and there was some inhibition of phagocytos...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1976.tb01871.x

    authors： Davies JE,Whittaker JA,Khurshid M

    更新日期：1976-01-01 00:00:00

  • Two novel polyadenylation mutations leading to beta(+)-thalassemia.

    abstract：:In an ongoing effort to identify point mutations causing beta-thalassaemia, we have found two previously unreported mutations which are located in the Poly A site of the beta-globin gene. The screening programme used amplified DNA and dot-blot hybridization with several 32P-labelled oligonucleotide probes. DNA samples...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1990.tb02627.x

    authors： Jankovic L,Efremov GD,Petkov G,Kattamis C,George E,Yang KG,Stoming TA,Huisman TH

    更新日期：1990-05-01 00:00:00

  • Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways.

    abstract：:Erythropoietin (EPO) and stem cell factor (SCF) are two important factors in human erythropoiesis. We have recently demonstrated that SCF and EPO synergistically activate mitogen-activated protein (MAP) kinase, thereby promoting growth of human erythroid colony-forming cells (ECFCs). In the present study, we have exam...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2000.02145.x

    authors： Sui X,Krantz SB,Zhao ZJ

    更新日期：2000-07-01 00:00:00